JP2001516739A5 - - Google Patents
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- JP2001516739A5 JP2001516739A5 JP2000511738A JP2000511738A JP2001516739A5 JP 2001516739 A5 JP2001516739 A5 JP 2001516739A5 JP 2000511738 A JP2000511738 A JP 2000511738A JP 2000511738 A JP2000511738 A JP 2000511738A JP 2001516739 A5 JP2001516739 A5 JP 2001516739A5
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- JP
- Japan
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- 125000004432 carbon atom Chemical group C* 0.000 description 72
- 229910052739 hydrogen Inorganic materials 0.000 description 50
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 41
- 150000001875 compounds Chemical class 0.000 description 32
- 239000001257 hydrogen Substances 0.000 description 30
- 125000003118 aryl group Chemical group 0.000 description 20
- 229910052736 halogen Inorganic materials 0.000 description 20
- 150000002367 halogens Chemical class 0.000 description 20
- 150000002431 hydrogen Chemical class 0.000 description 20
- 230000002378 acidificating effect Effects 0.000 description 15
- 125000002252 acyl group Chemical group 0.000 description 15
- 229910052794 bromium Inorganic materials 0.000 description 15
- 229910052801 chlorine Inorganic materials 0.000 description 15
- 125000006165 cyclic alkyl group Chemical group 0.000 description 15
- 229910052731 fluorine Inorganic materials 0.000 description 15
- 125000005842 heteroatom Chemical group 0.000 description 15
- 150000003839 salts Chemical class 0.000 description 15
- 125000004450 alkenylene group Chemical group 0.000 description 12
- 125000000217 alkyl group Chemical group 0.000 description 12
- 125000002947 alkylene group Chemical group 0.000 description 12
- 125000004419 alkynylene group Chemical group 0.000 description 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 12
- 125000000623 heterocyclic group Chemical group 0.000 description 11
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 10
- 125000002877 alkyl aryl group Chemical group 0.000 description 10
- 150000001408 amides Chemical class 0.000 description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 10
- 229910052757 nitrogen Inorganic materials 0.000 description 10
- 229910052760 oxygen Inorganic materials 0.000 description 10
- 239000012453 solvate Substances 0.000 description 10
- 229910052717 sulfur Inorganic materials 0.000 description 10
- 150000003536 tetrazoles Chemical class 0.000 description 10
- 125000003342 alkenyl group Chemical group 0.000 description 6
- 125000000304 alkynyl group Chemical group 0.000 description 6
- 125000002837 carbocyclic group Chemical group 0.000 description 6
- 125000006239 protecting group Chemical group 0.000 description 6
- 230000001681 protective effect Effects 0.000 description 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 5
- 229910052740 iodine Inorganic materials 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- 102000005348 Neuraminidase Human genes 0.000 description 4
- 108010006232 Neuraminidase Proteins 0.000 description 4
- -1 pivaloyl ester Chemical class 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5930897P | 1997-09-17 | 1997-09-17 | |
| US60/059,308 | 1997-09-17 | ||
| US6019597P | 1997-09-26 | 1997-09-26 | |
| US93864497A | 1997-09-26 | 1997-09-26 | |
| US60/060,195 | 1997-09-26 | ||
| US08/938,644 | 1997-09-26 | ||
| PCT/US1998/019355 WO1999014185A1 (en) | 1997-09-17 | 1998-09-15 | Compounds containing six-membered rings, processes for their preparation, and their use as medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001516739A JP2001516739A (ja) | 2001-10-02 |
| JP2001516739A5 true JP2001516739A5 (enrdf_load_html_response) | 2006-01-05 |
Family
ID=27369627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000511738A Withdrawn JP2001516739A (ja) | 1997-09-17 | 1998-09-15 | ６員環を含む化合物、それらの調製プロセス、および医薬としてのそれらの使用 |
Country Status (15)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1282316A (zh) * | 1997-12-17 | 2001-01-31 | 生物晶体药品股份有限公司 | 用作神经氨酸酶抑制剂的取代环戊烷和环戊烯化合物 |
| US6455571B1 (en) | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
| US6518305B1 (en) | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
| DK1059283T3 (da) | 1999-06-11 | 2003-09-15 | Hoffmann La Roche | Fremgangsmåde til fremstilling af neuraminidase-inhibitor ro-64-0796 |
| BR0010525A (pt) * | 1999-10-19 | 2002-11-26 | Abbott Lab | cido 1-ciclo-hexeno-1-carboxìlico e 1-ciclo-hexeno-1carboxilatos como inibidores de neuraminidase |
| US6593314B1 (en) | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
| JP2001131144A (ja) * | 1999-11-02 | 2001-05-15 | Sagami Chem Res Center | ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法 |
| US6403824B2 (en) | 2000-02-22 | 2002-06-11 | Hoffmann-La Roche Inc. | Process for the preparation for 4,5-diamino shikimic acid derivatives |
| WO2001080892A1 (fr) * | 2000-04-25 | 2001-11-01 | Sankyo Company, Limited | Substances preventives de la grippe |
| WO2002092555A1 (fr) * | 2001-05-11 | 2002-11-21 | Sankyo Company, Limited | Derives d'acides sialiques |
| US7122684B2 (en) | 2003-03-13 | 2006-10-17 | Roche Colorado Corporation | Process for preparing 1,2-diamino compounds |
| AU2006331365B2 (en) | 2005-12-28 | 2011-12-22 | F. Hoffmann-La Roche Ag | Epoxide intermediate in the TAMIFLU synthesis |
| US8334319B2 (en) * | 2008-01-04 | 2012-12-18 | Roche Palo Alto Llc | Polymorphic forms of oseltamivir phosphate |
| EP2499201B1 (en) * | 2009-11-11 | 2017-05-10 | 3M Innovative Properties Company | Polymeric compositions and method of making and articles thereof |
| DE102011117128A1 (de) | 2011-10-28 | 2013-05-02 | Christian-Albrechts-Universität Zu Kiel | Verbindungen zur Therapie der Influenza |
| RU2469020C1 (ru) * | 2011-11-08 | 2012-12-10 | Александр Васильевич Иващенко | (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения |
| CN102659615B (zh) * | 2012-05-09 | 2014-05-07 | 中国药科大学 | 奥司他韦衍生物、其制备方法及其医药用途 |
| RU2520836C1 (ru) * | 2013-02-27 | 2014-06-27 | Александр Васильевич Иващенко | (3r,4r,5s)-4-амино-5-(2,2-дифторацетиламино)-3-(1-этилпропокси)-циклогекс-1-енкарбоновая кислота и ее эфиры, способ их получения и применения |
| RU2633085C2 (ru) * | 2014-05-20 | 2017-10-11 | Российская Федерация, от имени которой выступает Федеральное государственное казенное учреждение "Войсковая часть 68240" | Противовирусное лекарственное средство в виде капсул и способ его получения |
| CN105439884A (zh) * | 2015-10-27 | 2016-03-30 | 沈阳药科大学 | 一种奥司他韦的制备方法 |
| CN108047076B (zh) * | 2017-12-26 | 2020-05-08 | 杭州新博思生物医药有限公司 | 一种奥司他韦对映异构体的制备方法 |
| CN110194728B (zh) * | 2019-06-19 | 2021-04-30 | 湖南华腾制药有限公司 | 磷酸奥司他韦中间体的连续化合成方法 |
| WO2022022448A1 (zh) * | 2020-07-29 | 2022-02-03 | 广州市恒诺康医药科技有限公司 | 神经氨酸酶抑制剂类化合物、其药物组合物及其用途 |
| CN116375595A (zh) * | 2023-03-31 | 2023-07-04 | 重庆医药高等专科学校 | 一种磷酸奥司他韦的制备方法及精制方法 |
| CN117105801A (zh) * | 2023-07-24 | 2023-11-24 | 四川青木制药有限公司 | 一种奥司他韦及其磷酸盐的制备方法及其中间体 |
| CN116666669B (zh) * | 2023-07-25 | 2023-10-03 | 四川大学 | VN负载的Ir团簇及其制备方法与其在催化剂中的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK282950B6 (sk) * | 1990-04-24 | 2003-01-09 | Biota Scientific Management Pty Ltd | Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze |
| WO1992006691A1 (en) * | 1990-10-19 | 1992-04-30 | Biota Scientific Management Pty. Ltd. | Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus |
| ATE305453T1 (de) * | 1995-02-27 | 2005-10-15 | Gilead Sciences Inc | Selektive inhibitoren viraler oder bakterieller neuraminidase |
| US5763483A (en) * | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
| PT920410E (pt) * | 1996-08-23 | 2002-07-31 | Gilead Sciences Inc | Preparacao de derivados de carboxilato de ciclo-hexeno |
-
1998
- 1998-09-15 EP EP98949356A patent/EP1015417A1/en not_active Ceased
- 1998-09-15 JP JP2000511738A patent/JP2001516739A/ja not_active Withdrawn
- 1998-09-15 BR BR9812649-0A patent/BR9812649A/pt not_active Application Discontinuation
- 1998-09-15 ID IDW20000543A patent/ID25516A/id unknown
- 1998-09-15 IL IL13469198A patent/IL134691A0/xx not_active IP Right Cessation
- 1998-09-15 AU AU95694/98A patent/AU747702B2/en not_active Expired
- 1998-09-15 WO PCT/US1998/019355 patent/WO1999014185A1/en not_active Application Discontinuation
- 1998-09-15 CA CA002303323A patent/CA2303323A1/en not_active Abandoned
- 1998-09-15 NZ NZ502988A patent/NZ502988A/xx not_active IP Right Cessation
- 1998-09-15 CN CN98809320A patent/CN1272105A/zh active Pending
- 1998-09-15 TR TR2000/00723T patent/TR200000723T2/xx unknown
- 1998-09-15 EA EA200000332A patent/EA003989B1/ru not_active IP Right Cessation
- 1998-09-15 KR KR1020007002880A patent/KR20010024123A/ko not_active Ceased
- 1998-09-17 AR ARP980104638A patent/AR013960A1/es unknown
- 1998-09-17 IN IN2791DE1998 patent/IN190983B/en unknown
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