JP2001515712A - 増殖効果を有する新規タンパク質−ａｐｒｉｌ - Google Patents
増殖効果を有する新規タンパク質−ａｐｒｉｌInfo
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- JP2001515712A JP2001515712A JP2000510770A JP2000510770A JP2001515712A JP 2001515712 A JP2001515712 A JP 2001515712A JP 2000510770 A JP2000510770 A JP 2000510770A JP 2000510770 A JP2000510770 A JP 2000510770A JP 2001515712 A JP2001515712 A JP 2001515712A
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5878697P | 1997-09-12 | 1997-09-12 | |
| US60/058,786 | 1997-09-12 | ||
| US7938498P | 1998-03-26 | 1998-03-26 | |
| US60/079,384 | 1998-03-26 | ||
| PCT/US1998/019191 WO1999012965A2 (en) | 1997-09-12 | 1998-09-11 | April- a novel protein with growth effects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001515712A true JP2001515712A (ja) | 2001-09-25 |
| JP2001515712A5 JP2001515712A5 (https=) | 2006-01-05 |
Family
ID=26738027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000510770A Pending JP2001515712A (ja) | 1997-09-12 | 1998-09-11 | 増殖効果を有する新規タンパク質−ａｐｒｉｌ |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20030138884A1 (https=) |
| EP (1) | EP1027431A2 (https=) |
| JP (1) | JP2001515712A (https=) |
| KR (1) | KR100618492B1 (https=) |
| CN (1) | CN1195849C (https=) |
| AU (1) | AU759717B2 (https=) |
| BR (1) | BR9812634A (https=) |
| CA (1) | CA2303615A1 (https=) |
| CZ (1) | CZ294615B6 (https=) |
| EA (1) | EA005411B1 (https=) |
| EE (1) | EE200000147A (https=) |
| HU (1) | HUP0004611A3 (https=) |
| IL (1) | IL134537A0 (https=) |
| IS (1) | IS5378A (https=) |
| NO (1) | NO20001242L (https=) |
| NZ (1) | NZ503850A (https=) |
| PL (1) | PL339463A1 (https=) |
| SK (1) | SK3542000A3 (https=) |
| TR (1) | TR200000669T2 (https=) |
| WO (1) | WO1999012965A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003522800A (ja) * | 2000-02-16 | 2003-07-29 | ジェネンテック・インコーポレーテッド | Ｔｎｆ関連分子の活性を調節するためのアゴニスト及びアンタゴニストの使用 |
| JP2009509948A (ja) * | 2005-09-26 | 2009-03-12 | アポテック コーポレーション | リンパ腫患者の早期予後用のバイオマーカーとしてのａｐｒｉｌに対する抗体 |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6541224B2 (en) | 1996-03-14 | 2003-04-01 | Human Genome Sciences, Inc. | Tumor necrosis factor delta polypeptides |
| US7217788B2 (en) | 1996-03-14 | 2007-05-15 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta polypeptides |
| AU5201399A (en) * | 1997-09-30 | 1999-10-18 | Pharmacia & Upjohn Company | Tnf-related death ligand |
| WO1999026976A1 (en) * | 1997-11-26 | 1999-06-03 | Eli Lilly And Company | Tnf ligand family gene |
| US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| IL144202A0 (en) | 1999-01-25 | 2002-05-23 | Biogen Inc | Baff, related blocking agents and their use in the stimulation and inhibition of b-cells and immunoglobulins in immune responses |
| US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
| CN100447244C (zh) | 1999-08-17 | 2008-12-31 | 比奥根艾迪克Ma公司 | Baff受体(bcma),一种免疫调节剂 |
| WO2001025256A2 (en) * | 1999-10-06 | 2001-04-12 | University Of Utah Research Foundation | Trdl-1-gamma, a novel tumor necrosis-like ligand |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| CA2897626C (en) | 2000-02-11 | 2020-03-24 | Biogen Ma Inc. | Heterologous polypeptide of the tnf family |
| AU2006201471B2 (en) * | 2000-02-16 | 2009-07-23 | Genentech, Inc. | Uses of agonists and antagonists to modulate activity of TNF-related molecules |
| WO2001087977A2 (en) * | 2000-05-12 | 2001-11-22 | Amgen Inc. | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
| EP2431054A3 (en) * | 2000-06-15 | 2013-03-06 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
| UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| GB2370273A (en) * | 2000-12-20 | 2002-06-26 | Viaxxel Biotech Gmbh | Compounds that affect CD83 expression |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| EP1401870A4 (en) | 2001-05-24 | 2006-04-19 | Human Genome Sciences | ANTIBODIES AGAINST TUMOR NECROSIS FACTOR DELTA (APRIL) |
| US7381792B2 (en) | 2002-01-04 | 2008-06-03 | Xencor, Inc. | Variants of RANKL protein |
| US20030166559A1 (en) | 2002-01-04 | 2003-09-04 | Desjarlais John R. | Dominant negative proteins and methods thereof |
| US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
| WO2004089982A2 (en) * | 2003-01-06 | 2004-10-21 | Xencor | April variants and methods thereof |
| US7700317B2 (en) | 2003-03-28 | 2010-04-20 | Biogen Idec Ma Inc. | Truncated baff receptors |
| US20070249530A1 (en) * | 2004-01-29 | 2007-10-25 | Genentech, Inc. | Bcma Polypeptides and Uses Thereof |
| US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
| WO2005113598A2 (en) * | 2004-05-21 | 2005-12-01 | Xencor, Inc. | Tnf super family members with altered immunogenicity |
| US7947805B2 (en) | 2004-12-23 | 2011-05-24 | Merck Serono S.A. | BCMA polypeptides and uses thereof |
| EP1922080A2 (en) | 2005-08-09 | 2008-05-21 | ZymoGenetics, Inc. | Methods for treating b-cell malignancies using taci-ig fusion molecule |
| WO2007019573A2 (en) | 2005-08-09 | 2007-02-15 | Zymogenetics, Inc. | Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules |
| WO2007142667A2 (en) | 2005-10-13 | 2007-12-13 | Human Genome Sciences, Inc. | Treatment of patients with autoantibody positive disease |
| ES2618543T3 (es) | 2005-11-23 | 2017-06-21 | Genentech, Inc. | Métodos y composiciones relacionados con ensayos de linfocitos B |
| BRPI0711823A2 (pt) | 2006-05-15 | 2012-01-17 | Ares Trading Sa | métodos para tratamento de doenças auto-imunes com uma molécula de fusão taci-ig |
| CA2754127C (en) | 2009-03-02 | 2017-04-18 | Stichting Top Institute Pharma | Antibodies against a proliferating inducing ligand (april) |
| WO2011109280A1 (en) | 2010-03-05 | 2011-09-09 | Lerner Research Institute | Methods and compositions to treat immune-mediated disorders |
| EP2542679A1 (en) * | 2010-03-05 | 2013-01-09 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | B-cell stimulating fusion proteins of an antigen with baff or april |
| NL2011406C2 (en) | 2013-09-06 | 2015-03-10 | Bionovion Holding B V | Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides. |
| TR201901782T4 (tr) * | 2013-09-23 | 2019-03-21 | Regeneron Pharma | İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar. |
| GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| RU2671101C1 (ru) * | 2013-11-19 | 2018-10-29 | Регенерон Фармасьютикалс, Инк. | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда |
| NL2014108B1 (en) | 2015-01-09 | 2016-09-30 | Aduro Biotech Holdings Europe B V | Altered april binding antibodies. |
| FI3380522T3 (fi) | 2015-11-25 | 2024-01-16 | Visterra Inc | Vasta-ainemolekyylejä april-proteiinille ja niiden käyttöjä |
| EP4237121A1 (en) | 2020-10-29 | 2023-09-06 | Industrial Polymers and Chemicals, Inc. | Air filter with pathogen monitoring and inactivation |
| KR20240053675A (ko) | 2021-08-11 | 2024-04-24 | 악소 바이오파마슈티컬 인코포레이티드 | sBCMA 변이체 및 이의 FC 융합 단백질을 이용한 IgA, IgM 및/또는 IgG의 생산 감소 방법 |
| AU2024239150A1 (en) | 2023-03-21 | 2025-10-02 | Biograph 55, Inc. | Cd19/cd38 multispecific antibodies |
| CN118909083A (zh) * | 2024-07-30 | 2024-11-08 | 江苏省农业科学院 | 一种猪b细胞增殖诱导配体蛋白及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5256775A (en) * | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5264564A (en) * | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| WO1996040774A1 (en) * | 1995-06-07 | 1996-12-19 | Biogen, Inc. | Complexes of modified lymphotoxins as pharmaceutical preparations |
| US6509170B1 (en) * | 1996-03-14 | 2003-01-21 | Human Genome Sciences, Inc. | Polynucleotides encoding human tumor necrosis factor delta |
| AU726486C (en) * | 1996-03-14 | 2004-02-05 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
| US6171787B1 (en) * | 1997-06-26 | 2001-01-09 | Abbott Laboratories | Member of the TNF family useful for treatment and diagnosis of disease |
-
1998
- 1998-09-11 CZ CZ2000869A patent/CZ294615B6/cs not_active IP Right Cessation
- 1998-09-11 PL PL98339463A patent/PL339463A1/xx unknown
- 1998-09-11 SK SK354-2000A patent/SK3542000A3/sk unknown
- 1998-09-11 JP JP2000510770A patent/JP2001515712A/ja active Pending
- 1998-09-11 WO PCT/US1998/019191 patent/WO1999012965A2/en not_active Ceased
- 1998-09-11 CN CNB988090384A patent/CN1195849C/zh not_active Expired - Fee Related
- 1998-09-11 NZ NZ503850A patent/NZ503850A/xx unknown
- 1998-09-11 EE EEP200000147A patent/EE200000147A/xx unknown
- 1998-09-11 HU HU0004611A patent/HUP0004611A3/hu unknown
- 1998-09-11 BR BR9812634-2A patent/BR9812634A/pt not_active Application Discontinuation
- 1998-09-11 IL IL13453798A patent/IL134537A0/xx unknown
- 1998-09-11 TR TR2000/00669T patent/TR200000669T2/xx unknown
- 1998-09-11 EA EA200000310A patent/EA005411B1/ru unknown
- 1998-09-11 KR KR1020007002577A patent/KR100618492B1/ko not_active Expired - Fee Related
- 1998-09-11 EP EP98946066A patent/EP1027431A2/en not_active Withdrawn
- 1998-09-11 CA CA002303615A patent/CA2303615A1/en not_active Abandoned
- 1998-09-11 AU AU93162/98A patent/AU759717B2/en not_active Ceased
-
2000
- 2000-02-18 IS IS5378A patent/IS5378A/is unknown
- 2000-03-09 NO NO20001242A patent/NO20001242L/no unknown
-
2002
- 2002-05-01 US US10/138,073 patent/US20030138884A1/en not_active Abandoned
-
2004
- 2004-02-12 US US10/778,890 patent/US20050112596A1/en not_active Abandoned
-
2005
- 2005-12-06 US US11/296,049 patent/US20060084148A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003522800A (ja) * | 2000-02-16 | 2003-07-29 | ジェネンテック・インコーポレーテッド | Ｔｎｆ関連分子の活性を調節するためのアゴニスト及びアンタゴニストの使用 |
| JP2009509948A (ja) * | 2005-09-26 | 2009-03-12 | アポテック コーポレーション | リンパ腫患者の早期予後用のバイオマーカーとしてのａｐｒｉｌに対する抗体 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010023893A (ko) | 2001-03-26 |
| EA200000310A1 (ru) | 2000-10-30 |
| NZ503850A (en) | 2002-12-20 |
| NO20001242L (no) | 2000-05-11 |
| SK3542000A3 (en) | 2000-08-14 |
| CN1270632A (zh) | 2000-10-18 |
| PL339463A1 (en) | 2000-12-18 |
| CN1195849C (zh) | 2005-04-06 |
| NO20001242D0 (no) | 2000-03-09 |
| CA2303615A1 (en) | 1999-03-18 |
| IS5378A (is) | 2000-02-18 |
| KR100618492B1 (ko) | 2006-08-31 |
| WO1999012965A2 (en) | 1999-03-18 |
| CZ294615B6 (cs) | 2005-02-16 |
| EA005411B1 (ru) | 2005-02-24 |
| HUP0004611A3 (en) | 2002-04-29 |
| HUP0004611A2 (hu) | 2001-04-28 |
| BR9812634A (pt) | 2000-08-22 |
| EE200000147A (et) | 2001-02-15 |
| AU759717B2 (en) | 2003-04-17 |
| WO1999012965A3 (en) | 1999-06-03 |
| AU9316298A (en) | 1999-03-29 |
| TR200000669T2 (tr) | 2000-08-21 |
| CZ2000869A3 (cs) | 2000-09-13 |
| EP1027431A2 (en) | 2000-08-16 |
| US20030138884A1 (en) | 2003-07-24 |
| IL134537A0 (en) | 2001-04-30 |
| US20060084148A1 (en) | 2006-04-20 |
| US20050112596A1 (en) | 2005-05-26 |
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