JP2001511805A - ドパミン作動薬である５−アミノアルコキシ−１，４−ジヒドロキノキサリン−２，３−ジオン - Google Patents

ドパミン作動薬である５−アミノアルコキシ−１，４−ジヒドロキノキサリン−２，３−ジオン

Info

Publication number
JP2001511805A
JP2001511805A JP53574298A JP53574298A JP2001511805A JP 2001511805 A JP2001511805 A JP 2001511805A JP 53574298 A JP53574298 A JP 53574298A JP 53574298 A JP53574298 A JP 53574298A JP 2001511805 A JP2001511805 A JP 2001511805A
Authority
JP
Japan
Prior art keywords
alkyl
halogen
disease
dihydro
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP53574298A
Other languages
English (en)
Japanese (ja)
Inventor
ネルソン，ジェイムズ・アルバート
シャー，ウレッシュ・シャンティラル
ミューショー，リチャード・エリック
Original Assignee
アメリカン・ホーム・プロダクツ・コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アメリカン・ホーム・プロダクツ・コーポレイション filed Critical アメリカン・ホーム・プロダクツ・コーポレイション
Publication of JP2001511805A publication Critical patent/JP2001511805A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP53574298A 1997-02-18 1998-01-13 ドパミン作動薬である５−アミノアルコキシ−１，４−ジヒドロキノキサリン−２，３−ジオン Pending JP2001511805A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80132497A 1997-02-18 1997-02-18
US08/801,324 1997-02-18
PCT/US1998/001170 WO1998035948A1 (en) 1997-02-18 1998-01-13 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists

Publications (1)

Publication Number Publication Date
JP2001511805A true JP2001511805A (ja) 2001-08-14

Family

ID=25180799

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53574298A Pending JP2001511805A (ja) 1997-02-18 1998-01-13 ドパミン作動薬である５−アミノアルコキシ−１，４−ジヒドロキノキサリン−２，３−ジオン

Country Status (14)

Country Link
EP (1) EP0963372A1 (de)
JP (1) JP2001511805A (de)
KR (1) KR20000071162A (de)
CN (1) CN1248249A (de)
AR (1) AR011669A1 (de)
AU (1) AU722616B2 (de)
BR (1) BR9807230A (de)
CA (1) CA2278757A1 (de)
HU (1) HUP0001311A3 (de)
IL (1) IL131160A0 (de)
NZ (1) NZ336971A (de)
TW (1) TW434230B (de)
WO (1) WO1998035948A1 (de)
ZA (1) ZA981306B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329698B2 (en) 2008-06-16 2012-12-11 MERCK Patent Gesellschaft mit beschränkter Haftung Quinoxalinedione derivatives which are activators of AMPK-activated protein kinase

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
DK715888D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
US4975430A (en) * 1989-06-16 1990-12-04 The State Of Oregon Acting By And Through The State Board Of Education On Behalf Of The Oregon Health Sciences University CNQX and its analogs as therapeutics for degenerative neural diseases
PT99864B (pt) * 1990-12-21 1999-06-30 Schering Ag Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato
US5159083A (en) * 1990-12-28 1992-10-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
EP0647137B1 (de) * 1992-06-22 2008-08-13 The Regents Of The University Of California Glycinrezeptorantagonisten und ihre verwendung
GB9419318D0 (en) * 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
ES2169102T3 (es) * 1994-10-14 2002-07-01 Merck Patent Gmbh (r)-(-)-2-(5-(4-fluorfenil)-3-piridilmetilaminometil)-cromano como agente activo sobre el sistema nervioso central.
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists

Also Published As

Publication number Publication date
HUP0001311A2 (hu) 2001-05-28
CA2278757A1 (en) 1998-08-20
AU6035098A (en) 1998-09-08
TW434230B (en) 2001-05-16
ZA981306B (en) 1999-08-17
EP0963372A1 (de) 1999-12-15
KR20000071162A (ko) 2000-11-25
BR9807230A (pt) 2000-04-25
NZ336971A (en) 2000-10-27
AR011669A1 (es) 2000-08-30
CN1248249A (zh) 2000-03-22
WO1998035948A1 (en) 1998-08-20
HUP0001311A3 (en) 2001-07-30
AU722616B2 (en) 2000-08-10
IL131160A0 (en) 2001-01-28

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