NZ336971A - 5-Aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones useful as dopamine agonists - Google Patents

5-Aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones useful as dopamine agonists

Info

Publication number
NZ336971A
NZ336971A NZ336971A NZ33697198A NZ336971A NZ 336971 A NZ336971 A NZ 336971A NZ 336971 A NZ336971 A NZ 336971A NZ 33697198 A NZ33697198 A NZ 33697198A NZ 336971 A NZ336971 A NZ 336971A
Authority
NZ
New Zealand
Prior art keywords
dihydroquinoxaline
aminoalkoxy
dopamine agonists
useful
tetrahydroquinolin
Prior art date
Application number
NZ336971A
Inventor
James Albert Nelson
Uresh Shantilal Shah
Richard Eric Mewshaw
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of NZ336971A publication Critical patent/NZ336971A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The quinoxaline 2,3-dione compound or a pharmaceutically acceptable salt thereof has the formula I wherein: R1 and R2 are independently H, alkyl or -(CH2)mAr or together with the nitrogen atom R1 and R2 form a 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroquinolin-2-yl; Ar is optionally substituted phenyl, naphthyl or thienyl; m is 1 to 5; n is 1 or 2; Y is H, halo, alkyl or alkoxy. A pharmaceutical composition thereof is useful for treating diseases that respond to treatment with dopamine D2 agonists.
NZ336971A 1997-02-18 1998-01-13 5-Aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones useful as dopamine agonists NZ336971A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80132497A 1997-02-18 1997-02-18
PCT/US1998/001170 WO1998035948A1 (en) 1997-02-18 1998-01-13 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists

Publications (1)

Publication Number Publication Date
NZ336971A true NZ336971A (en) 2000-10-27

Family

ID=25180799

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ336971A NZ336971A (en) 1997-02-18 1998-01-13 5-Aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones useful as dopamine agonists

Country Status (14)

Country Link
EP (1) EP0963372A1 (en)
JP (1) JP2001511805A (en)
KR (1) KR20000071162A (en)
CN (1) CN1248249A (en)
AR (1) AR011669A1 (en)
AU (1) AU722616B2 (en)
BR (1) BR9807230A (en)
CA (1) CA2278757A1 (en)
HU (1) HUP0001311A3 (en)
IL (1) IL131160A0 (en)
NZ (1) NZ336971A (en)
TW (1) TW434230B (en)
WO (1) WO1998035948A1 (en)
ZA (1) ZA981306B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2285786B1 (en) 2008-06-16 2013-10-09 Merck Patent GmbH Quinoxalinedione derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179551C (en) * 1987-11-10 1996-10-30 Novo Nordisk As Analogous Process for Preparing Therapeutically Effective Quinoxaline Compounds
DK715888D0 (en) * 1988-12-22 1988-12-22 Ferrosan As QUINOXAL COMPOUNDS, THEIR PREPARATION AND USE
US4975430A (en) * 1989-06-16 1990-12-04 The State Of Oregon Acting By And Through The State Board Of Education On Behalf Of The Oregon Health Sciences University CNQX and its analogs as therapeutics for degenerative neural diseases
PT99864B (en) * 1990-12-21 1999-06-30 Schering Ag METHOD FOR PREPARING NEW PHARMACEUTICAL COMPOSITIONS CONTAINING QUISQUALATE RECEPTOR ANTAGONISTS
US5159083A (en) * 1990-12-28 1992-10-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
AU672617B2 (en) * 1992-06-22 1996-10-10 Regents Of The University Of California, The Glycine receptor antagonists and the use thereof
GB9419318D0 (en) * 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists

Also Published As

Publication number Publication date
BR9807230A (en) 2000-04-25
CN1248249A (en) 2000-03-22
KR20000071162A (en) 2000-11-25
ZA981306B (en) 1999-08-17
HUP0001311A2 (en) 2001-05-28
EP0963372A1 (en) 1999-12-15
AR011669A1 (en) 2000-08-30
AU722616B2 (en) 2000-08-10
AU6035098A (en) 1998-09-08
JP2001511805A (en) 2001-08-14
HUP0001311A3 (en) 2001-07-30
IL131160A0 (en) 2001-01-28
WO1998035948A1 (en) 1998-08-20
TW434230B (en) 2001-05-16
CA2278757A1 (en) 1998-08-20

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