BR9807230A - 5-aminoalcóxi-1,4-diidroquinoxalina-2,3-dionas que são agonistas de dopamina - Google Patents
5-aminoalcóxi-1,4-diidroquinoxalina-2,3-dionas que são agonistas de dopaminaInfo
- Publication number
- BR9807230A BR9807230A BR9807230-7A BR9807230A BR9807230A BR 9807230 A BR9807230 A BR 9807230A BR 9807230 A BR9807230 A BR 9807230A BR 9807230 A BR9807230 A BR 9807230A
- Authority
- BR
- Brazil
- Prior art keywords
- dihydroquinoxaline
- aminoalkoxy
- diones
- dopamine agonists
- dopamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Patente de Invenção: <B>"5-AMINOALCóXI-1,4-DIIDROQUINOXALINA-2,3-DIONAS QUE SãO AGONISTAS DE DOPAMINA"<D>. A presente invenção refere-se a compostos de Fórmula (I) em que: R^ 1^ e R^ 2^ são independentemente selecionados dentre hidrogênio, grupo alquila de cadeia linear e ramificada, com até 10 átomos de carbono ou -(CH~ 2~)~ m~Ar, onde Ar é fenila, naftila ou tienila, cada um sendo opcionalmente substituído com um ou dois substituintes selecionados independentemente dentre C~ 1-6~ alquila, halogênio, C~ 1-6~ alcóxido e trifluormetila; ou NR^ 1^R^ 2^ é 1, 2, 3, 4-tetrahidroquinolin-1-il ou 1,2,3,4-tetrahidroisoquinolin-2-il; m é 1-5; n é 1 ou 2; Y é halogênio, C~ 1-6~ alquila e C~ 1-6~ alcóxi; ou um sal farmaceuticamente aceitável destes, os quais se tratam de agonistas D~ 2~ de dopamina e, portanto, são de utilidade no tratamento de psicose e doenças de Parkinson.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80132497A | 1997-02-18 | 1997-02-18 | |
| PCT/US1998/001170 WO1998035948A1 (en) | 1997-02-18 | 1998-01-13 | 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9807230A true BR9807230A (pt) | 2000-04-25 |
Family
ID=25180799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9807230-7A BR9807230A (pt) | 1997-02-18 | 1998-01-13 | 5-aminoalcóxi-1,4-diidroquinoxalina-2,3-dionas que são agonistas de dopamina |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0963372A1 (pt) |
| JP (1) | JP2001511805A (pt) |
| KR (1) | KR20000071162A (pt) |
| CN (1) | CN1248249A (pt) |
| AR (1) | AR011669A1 (pt) |
| AU (1) | AU722616B2 (pt) |
| BR (1) | BR9807230A (pt) |
| CA (1) | CA2278757A1 (pt) |
| HU (1) | HUP0001311A3 (pt) |
| IL (1) | IL131160A0 (pt) |
| NZ (1) | NZ336971A (pt) |
| TW (1) | TW434230B (pt) |
| WO (1) | WO1998035948A1 (pt) |
| ZA (1) | ZA981306B (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329698B2 (en) | 2008-06-16 | 2012-12-11 | MERCK Patent Gesellschaft mit beschränkter Haftung | Quinoxalinedione derivatives which are activators of AMPK-activated protein kinase |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO179551C (no) * | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser |
| DK715888D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| US4975430A (en) * | 1989-06-16 | 1990-12-04 | The State Of Oregon Acting By And Through The State Board Of Education On Behalf Of The Oregon Health Sciences University | CNQX and its analogs as therapeutics for degenerative neural diseases |
| PT99864B (pt) * | 1990-12-21 | 1999-06-30 | Schering Ag | Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato |
| US5159083A (en) * | 1990-12-28 | 1992-10-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands |
| EP0647137B1 (en) * | 1992-06-22 | 2008-08-13 | The Regents Of The University Of California | Glycine receptor antagonists and the use thereof |
| GB9419318D0 (en) * | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
| ES2169102T3 (es) * | 1994-10-14 | 2002-07-01 | Merck Patent Gmbh | (r)-(-)-2-(5-(4-fluorfenil)-3-piridilmetilaminometil)-cromano como agente activo sobre el sistema nervioso central. |
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
-
1998
- 1998-01-13 HU HU0001311A patent/HUP0001311A3/hu unknown
- 1998-01-13 NZ NZ336971A patent/NZ336971A/xx unknown
- 1998-01-13 EP EP98903628A patent/EP0963372A1/en not_active Withdrawn
- 1998-01-13 CA CA002278757A patent/CA2278757A1/en not_active Abandoned
- 1998-01-13 AU AU60350/98A patent/AU722616B2/en not_active Ceased
- 1998-01-13 KR KR1019997007452A patent/KR20000071162A/ko not_active Application Discontinuation
- 1998-01-13 WO PCT/US1998/001170 patent/WO1998035948A1/en not_active Application Discontinuation
- 1998-01-13 IL IL13116098A patent/IL131160A0/xx unknown
- 1998-01-13 JP JP53574298A patent/JP2001511805A/ja active Pending
- 1998-01-13 BR BR9807230-7A patent/BR9807230A/pt not_active Application Discontinuation
- 1998-01-13 CN CN98802636A patent/CN1248249A/zh active Pending
- 1998-02-05 TW TW087101493A patent/TW434230B/zh active
- 1998-02-11 AR ARP980100618A patent/AR011669A1/es unknown
- 1998-02-17 ZA ZA9801306A patent/ZA981306B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0001311A2 (hu) | 2001-05-28 |
| CA2278757A1 (en) | 1998-08-20 |
| AU6035098A (en) | 1998-09-08 |
| TW434230B (en) | 2001-05-16 |
| ZA981306B (en) | 1999-08-17 |
| EP0963372A1 (en) | 1999-12-15 |
| KR20000071162A (ko) | 2000-11-25 |
| JP2001511805A (ja) | 2001-08-14 |
| NZ336971A (en) | 2000-10-27 |
| AR011669A1 (es) | 2000-08-30 |
| CN1248249A (zh) | 2000-03-22 |
| WO1998035948A1 (en) | 1998-08-20 |
| HUP0001311A3 (en) | 2001-07-30 |
| AU722616B2 (en) | 2000-08-10 |
| IL131160A0 (en) | 2001-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |