JP2001510183A5 - - Google Patents
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- Publication number
- JP2001510183A5 JP2001510183A5 JP2000503057A JP2000503057A JP2001510183A5 JP 2001510183 A5 JP2001510183 A5 JP 2001510183A5 JP 2000503057 A JP2000503057 A JP 2000503057A JP 2000503057 A JP2000503057 A JP 2000503057A JP 2001510183 A5 JP2001510183 A5 JP 2001510183A5
- Authority
- JP
- Japan
- Prior art keywords
- cholesta
- seco
- triol
- dihomo
- trihomo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 11
- 230000001419 dependent effect Effects 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 206010020649 Hyperkeratosis Diseases 0.000 description 4
- 208000001126 Keratosis Diseases 0.000 description 4
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 3
- 206010004146 Basal cell carcinoma Diseases 0.000 description 3
- 208000009329 Graft vs Host Disease Diseases 0.000 description 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 3
- 208000001132 Osteoporosis Diseases 0.000 description 3
- 201000004681 Psoriasis Diseases 0.000 description 3
- 208000001647 Renal Insufficiency Diseases 0.000 description 3
- 206010040070 Septic Shock Diseases 0.000 description 3
- 206010052779 Transplant rejections Diseases 0.000 description 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
- 229930003316 Vitamin D Natural products 0.000 description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 3
- 208000024908 graft versus host disease Diseases 0.000 description 3
- 201000006370 kidney failure Diseases 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 201000006417 multiple sclerosis Diseases 0.000 description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 description 3
- 230000036303 septic shock Effects 0.000 description 3
- 235000019166 vitamin D Nutrition 0.000 description 3
- 239000011710 vitamin D Substances 0.000 description 3
- 150000003710 vitamin D derivatives Chemical class 0.000 description 3
- 229940046008 vitamin d Drugs 0.000 description 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 2
- -1 1-hydroxy-cyclopentyl Chemical group 0.000 description 2
- 201000002980 Hyperparathyroidism Diseases 0.000 description 2
- 230000006806 disease prevention Effects 0.000 description 2
- 230000003780 keratinization Effects 0.000 description 2
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000849 parathyroid Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97112225.4 | 1997-07-17 | ||
| EP97112225 | 1997-07-17 | ||
| PCT/EP1998/004293 WO1999003828A1 (en) | 1997-07-17 | 1998-07-10 | Dihomo-seco-cholestanes with two unsaturated bones in the side chain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001510183A JP2001510183A (ja) | 2001-07-31 |
| JP2001510183A5 true JP2001510183A5 (enExample) | 2006-01-05 |
Family
ID=8227074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000503057A Pending JP2001510183A (ja) | 1997-07-17 | 1998-07-10 | 側鎖に２つの不飽和結合を有するジホモ−セコ−コレスタン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5994569A (enExample) |
| EP (1) | EP0998455B1 (enExample) |
| JP (1) | JP2001510183A (enExample) |
| AR (1) | AR013217A1 (enExample) |
| AU (1) | AU8860298A (enExample) |
| CA (1) | CA2296145A1 (enExample) |
| DE (1) | DE69818673T2 (enExample) |
| ES (1) | ES2206981T3 (enExample) |
| WO (1) | WO1999003828A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0957098A1 (en) * | 1998-05-14 | 1999-11-17 | F. Hoffmann-La Roche Ag | Intermediates for the synthesis of 3-epi vitamin D3 metabolites and analogs |
| JP3579355B2 (ja) * | 1998-12-09 | 2004-10-20 | プロテイン デザイン ラブス インコーポレイティド | ヒトの乾癬を予防及び治療するための乾癬モデル動物 |
| WO2001042205A2 (en) * | 1999-12-02 | 2001-06-14 | The Penn State Research Foundation | Treatment of inflammatory bowel disease with vitamin d compounds |
| TW200838544A (en) * | 2007-01-25 | 2008-10-01 | Bioxell Spa | Synthesis of 1 α-fluoro-25-hydroxy-16-23E-diene-26, 27-bishomo-20-epi-cholecalciferol |
| CN114276284A (zh) * | 2021-12-30 | 2022-04-05 | 正大制药（青岛）有限公司 | 一种氟骨化醇的制备方法 |
| CN114957068A (zh) * | 2022-04-19 | 2022-08-30 | 正大制药（青岛）有限公司 | 一种氟骨化醇20s异构体的制备方法 |
| CN117018000B (zh) * | 2023-08-29 | 2025-01-28 | 东莞市东南部中心医院(东莞市东南部中医医疗服务中心) | 4-胆甾烯-3-酮在制备预防或治疗炎症性肠病药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
| PT96679B (pt) * | 1990-02-06 | 1998-07-31 | Schering Ag | Processo para a preparacao de derivados de vitamina d homologos de cadeias laterais e de composicoes farmaceuticas que os contem |
| US5532228A (en) * | 1990-02-06 | 1996-07-02 | Schering Aktiengesellschaft | Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents |
| GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| GB9314400D0 (en) * | 1993-07-12 | 1993-08-25 | Leo Pharm Prod Ltd | Produktionsaktieselskab) chemical compounds |
| IL118156A (en) * | 1995-05-09 | 2001-08-26 | Duphar Int Res | Vitamin d compounds, their preparation and pharmaceutical compositions containing them |
| PT771789E (pt) * | 1995-10-30 | 2000-05-31 | Hoffmann La Roche | 1 alfa 26-di-hidroxi-d-homo-vitamina d3 |
| WO1998018754A1 (en) * | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof |
| GB9622590D0 (en) * | 1996-10-30 | 1997-01-08 | Leo Pharm Prod Ltd | Chemical compounds |
-
1998
- 1998-07-10 AU AU88602/98A patent/AU8860298A/en not_active Abandoned
- 1998-07-10 CA CA002296145A patent/CA2296145A1/en not_active Abandoned
- 1998-07-10 JP JP2000503057A patent/JP2001510183A/ja active Pending
- 1998-07-10 EP EP98940201A patent/EP0998455B1/en not_active Expired - Lifetime
- 1998-07-10 DE DE69818673T patent/DE69818673T2/de not_active Expired - Fee Related
- 1998-07-10 ES ES98940201T patent/ES2206981T3/es not_active Expired - Lifetime
- 1998-07-10 WO PCT/EP1998/004293 patent/WO1999003828A1/en not_active Ceased
- 1998-07-14 US US09/115,188 patent/US5994569A/en not_active Expired - Fee Related
- 1998-07-15 AR ARP980103432A patent/AR013217A1/es unknown
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