AR013217A1 - COMPUESTOS DERIVADOS DE 24a, 24b-DIHOMO-9,10-SECOCOLESTANO POLINSATURADO, SU USO, PROCEDIMIENTO PARA PREPARARLOS, COMPUESTOS UTILES COMO INTERMEDIARIOS,Y UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DICHO COMPUESTO DERIVADO - Google Patents

COMPUESTOS DERIVADOS DE 24a, 24b-DIHOMO-9,10-SECOCOLESTANO POLINSATURADO, SU USO, PROCEDIMIENTO PARA PREPARARLOS, COMPUESTOS UTILES COMO INTERMEDIARIOS,Y UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DICHO COMPUESTO DERIVADO

Info

Publication number
AR013217A1
AR013217A1 ARP980103432A ARP980103432A AR013217A1 AR 013217 A1 AR013217 A1 AR 013217A1 AR P980103432 A ARP980103432 A AR P980103432A AR P980103432 A ARP980103432 A AR P980103432A AR 013217 A1 AR013217 A1 AR 013217A1
Authority
AR
Argentina
Prior art keywords
compounds
derivative
dihomo
prepare
procedure
Prior art date
Application number
ARP980103432A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR013217A1 publication Critical patent/AR013217A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos derivados de 24a,24b-dihomo-9,10-secocolestano poliinsaturado de formula(I), donde: A es un enlace simple o doble; B1 y B2 son, cada unoindependientemente, CH=CH o C=C; T es CH2 o CH2CH2; X es -CH2- o >C=CH2; R1 es H, F u OH; R2 y R3 son, cada uno independientemente, alquilo inferior o CF3, oC(R2,R3) es cicloalquilo C3-6; su uso; procedimiento para prepararlos; compuestos utiles como intermediarios y composiciones farmacéuticas quecomprenden a los compuestos de formula (I). Los compuestos de formula (I) son utiles para el tratamiento o prevencion de desordenes dependientes de lavitamina D y enfermedades autoinmunes dependientes de IL-12, particularmente soriasis, carcinomas de célula basal, desordenes de laqueratinizacion yqueratosis, leucemia, osteoporosis, hiperparatiroidismo asociado con la insuficiencia renal, esclerosis multiple, rechazo de trasplantes, enfermedadde injerto contra huésped, artritis reumatoidea, diabetes mellitus insulinodependiente, enfermedad intestinal inflamatoria, choque séptico yencefalomielitis alérgica.
ARP980103432A 1997-07-17 1998-07-15 COMPUESTOS DERIVADOS DE 24a, 24b-DIHOMO-9,10-SECOCOLESTANO POLINSATURADO, SU USO, PROCEDIMIENTO PARA PREPARARLOS, COMPUESTOS UTILES COMO INTERMEDIARIOS,Y UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DICHO COMPUESTO DERIVADO AR013217A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97112225 1997-07-17

Publications (1)

Publication Number Publication Date
AR013217A1 true AR013217A1 (es) 2000-12-13

Family

ID=8227074

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103432A AR013217A1 (es) 1997-07-17 1998-07-15 COMPUESTOS DERIVADOS DE 24a, 24b-DIHOMO-9,10-SECOCOLESTANO POLINSATURADO, SU USO, PROCEDIMIENTO PARA PREPARARLOS, COMPUESTOS UTILES COMO INTERMEDIARIOS,Y UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DICHO COMPUESTO DERIVADO

Country Status (9)

Country Link
US (1) US5994569A (es)
EP (1) EP0998455B1 (es)
JP (1) JP2001510183A (es)
AR (1) AR013217A1 (es)
AU (1) AU8860298A (es)
CA (1) CA2296145A1 (es)
DE (1) DE69818673T2 (es)
ES (1) ES2206981T3 (es)
WO (1) WO1999003828A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957098A1 (en) * 1998-05-14 1999-11-17 F. Hoffmann-La Roche Ag Intermediates for the synthesis of 3-epi vitamin D3 metabolites and analogs
CA2353520C (en) * 1998-12-09 2006-04-25 Protein Design Labs, Inc. Animal model for psoriasis for the prevention and treatment of psoriasis in humans
AU4510001A (en) * 1999-12-02 2001-06-18 Penn State Research Foundation, The Treatment of inflammatory bowel disease with vitamin d compounds
TW200838544A (en) * 2007-01-25 2008-10-01 Bioxell Spa Synthesis of 1 α-fluoro-25-hydroxy-16-23E-diene-26, 27-bishomo-20-epi-cholecalciferol
CN114276284A (zh) * 2021-12-30 2022-04-05 正大制药（青岛）有限公司 一种氟骨化醇的制备方法
CN114957068A (zh) * 2022-04-19 2022-08-30 正大制药（青岛）有限公司 一种氟骨化醇20s异构体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
ATE106391T1 (de) * 1990-02-06 1994-06-15 Schering Ag Seitenketten-homologe vitamin-d-derivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische präparate, sowie deren verwendung als arzneimittel.
US5532228A (en) * 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
ATE189812T1 (de) * 1995-10-30 2000-03-15 Hoffmann La Roche 1-alpha, 26-dihydroxy-d-homo-vitamin d3
WO1998018754A1 (en) * 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
GB9622590D0 (en) * 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds

Also Published As

Publication number Publication date
DE69818673D1 (de) 2003-11-06
US5994569A (en) 1999-11-30
CA2296145A1 (en) 1999-01-28
WO1999003828A1 (en) 1999-01-28
EP0998455B1 (en) 2003-10-01
JP2001510183A (ja) 2001-07-31
AU8860298A (en) 1999-02-10
DE69818673T2 (de) 2004-08-05
ES2206981T3 (es) 2004-05-16
EP0998455A1 (en) 2000-05-10

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