DE69818673D1 - Dihomo-seco-cholestan-verbindungen mit zwei ungesättigten bindungen in der seitenkette - Google Patents

Dihomo-seco-cholestan-verbindungen mit zwei ungesättigten bindungen in der seitenkette

Info

Publication number
DE69818673D1
DE69818673D1 DE69818673T DE69818673T DE69818673D1 DE 69818673 D1 DE69818673 D1 DE 69818673D1 DE 69818673 T DE69818673 T DE 69818673T DE 69818673 T DE69818673 T DE 69818673T DE 69818673 D1 DE69818673 D1 DE 69818673D1
Authority
DE
Germany
Prior art keywords
cholestan
dihomo
seco
compounds
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69818673T
Other languages
English (en)
Other versions
DE69818673T2 (de
Inventor
Pierre Barbier
Peter Mohr
Marc Muller
Christopher Self
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69818673D1 publication Critical patent/DE69818673D1/de
Application granted granted Critical
Publication of DE69818673T2 publication Critical patent/DE69818673T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69818673T 1997-07-17 1998-07-10 Dihomo-seco-cholestan-verbindungen mit zwei ungesättigten bindungen in der seitenkette Expired - Fee Related DE69818673T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97112225 1997-07-17
EP97112225 1997-07-17
PCT/EP1998/004293 WO1999003828A1 (en) 1997-07-17 1998-07-10 Dihomo-seco-cholestanes with two unsaturated bones in the side chain

Publications (2)

Publication Number Publication Date
DE69818673D1 true DE69818673D1 (de) 2003-11-06
DE69818673T2 DE69818673T2 (de) 2004-08-05

Family

ID=8227074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69818673T Expired - Fee Related DE69818673T2 (de) 1997-07-17 1998-07-10 Dihomo-seco-cholestan-verbindungen mit zwei ungesättigten bindungen in der seitenkette

Country Status (9)

Country Link
US (1) US5994569A (de)
EP (1) EP0998455B1 (de)
JP (1) JP2001510183A (de)
AR (1) AR013217A1 (de)
AU (1) AU8860298A (de)
CA (1) CA2296145A1 (de)
DE (1) DE69818673T2 (de)
ES (1) ES2206981T3 (de)
WO (1) WO1999003828A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957098A1 (de) * 1998-05-14 1999-11-17 F. Hoffmann-La Roche Ag Zwischenprodukte zur Synthese von 3-epi Vitamin D3 Metaboliten und Analogen
CA2353520C (en) * 1998-12-09 2006-04-25 Protein Design Labs, Inc. Animal model for psoriasis for the prevention and treatment of psoriasis in humans
AU4510001A (en) * 1999-12-02 2001-06-18 Penn State Research Foundation, The Treatment of inflammatory bowel disease with vitamin d compounds
TW200838544A (en) * 2007-01-25 2008-10-01 Bioxell Spa Synthesis of 1 α-fluoro-25-hydroxy-16-23E-diene-26, 27-bishomo-20-epi-cholecalciferol
CN114276284A (zh) * 2021-12-30 2022-04-05 正大制药（青岛）有限公司 一种氟骨化醇的制备方法
CN114957068A (zh) * 2022-04-19 2022-08-30 正大制药（青岛）有限公司 一种氟骨化醇20s异构体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
ATE106391T1 (de) * 1990-02-06 1994-06-15 Schering Ag Seitenketten-homologe vitamin-d-derivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische präparate, sowie deren verwendung als arzneimittel.
US5532228A (en) * 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
ATE189812T1 (de) * 1995-10-30 2000-03-15 Hoffmann La Roche 1-alpha, 26-dihydroxy-d-homo-vitamin d3
WO1998018754A1 (en) * 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
GB9622590D0 (en) * 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds

Also Published As

Publication number Publication date
US5994569A (en) 1999-11-30
CA2296145A1 (en) 1999-01-28
WO1999003828A1 (en) 1999-01-28
EP0998455B1 (de) 2003-10-01
JP2001510183A (ja) 2001-07-31
AU8860298A (en) 1999-02-10
DE69818673T2 (de) 2004-08-05
ES2206981T3 (es) 2004-05-16
EP0998455A1 (de) 2000-05-10
AR013217A1 (es) 2000-12-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee