JP2001508061A - キトサン−ゼラチンa微粒子 - Google Patents

キトサン−ゼラチンa微粒子

Info

Publication number
JP2001508061A
JP2001508061A JP53067598A JP53067598A JP2001508061A JP 2001508061 A JP2001508061 A JP 2001508061A JP 53067598 A JP53067598 A JP 53067598A JP 53067598 A JP53067598 A JP 53067598A JP 2001508061 A JP2001508061 A JP 2001508061A
Authority
JP
Japan
Prior art keywords
chitosan
composition
gelatin
therapeutic substance
microspheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP53067598A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001508061A5 (https=
Inventor
ワット、ピーター、ジェームズ
イルム、リズベス
Original Assignee
ウエスト・ファーマシュティカル・サービス・ドラッグ・デリバリー・エンド・クリニカル・リサーチ・センター・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウエスト・ファーマシュティカル・サービス・ドラッグ・デリバリー・エンド・クリニカル・リサーチ・センター・リミテッド filed Critical ウエスト・ファーマシュティカル・サービス・ドラッグ・デリバリー・エンド・クリニカル・リサーチ・センター・リミテッド
Publication of JP2001508061A publication Critical patent/JP2001508061A/ja
Publication of JP2001508061A5 publication Critical patent/JP2001508061A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1658Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP53067598A 1997-01-14 1998-01-14 キトサン−ゼラチンa微粒子 Ceased JP2001508061A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9700624.1 1997-01-14
GBGB9700624.1A GB9700624D0 (en) 1997-01-14 1997-01-14 Drug delivery composition
PCT/GB1998/000108 WO1998030207A1 (en) 1997-01-14 1998-01-14 Chitosan-gelatin a microparticles

Publications (2)

Publication Number Publication Date
JP2001508061A true JP2001508061A (ja) 2001-06-19
JP2001508061A5 JP2001508061A5 (https=) 2005-09-08

Family

ID=10805925

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53067598A Ceased JP2001508061A (ja) 1997-01-14 1998-01-14 キトサン−ゼラチンa微粒子

Country Status (15)

Country Link
US (1) US6465626B1 (https=)
EP (1) EP0952822B1 (https=)
JP (1) JP2001508061A (https=)
AT (1) ATE235889T1 (https=)
AU (1) AU725460B2 (https=)
CA (1) CA2275717C (https=)
DE (1) DE69812887T2 (https=)
DK (1) DK0952822T3 (https=)
ES (1) ES2200306T3 (https=)
GB (2) GB9700624D0 (https=)
NO (1) NO993195D0 (https=)
NZ (1) NZ335815A (https=)
PT (1) PT952822E (https=)
WO (1) WO1998030207A1 (https=)
ZA (1) ZA98273B (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503432A (ja) * 1999-07-02 2003-01-28 コグニス・イベリア・ソシエダッド・リミターダ マイクロカプセル−ii
JP2006525354A (ja) * 2003-05-01 2006-11-09 アルキメデス・ディヴェロップメント・リミテッド Lh−rhアナログロイプロイドの経鼻投与
JP2007006849A (ja) * 2005-07-04 2007-01-18 Japan Science & Technology Agency 6−アミノ−6−デオキシキトサン誘導体から成る核酸導入剤
JP5415769B2 (ja) * 2006-12-26 2014-02-12 株式会社新日本科学 経鼻投与用製剤
JP2014510778A (ja) * 2011-04-11 2014-05-01 アヤンダ グループ エーエス 経口医薬分散組成物
JP2017019847A (ja) * 2010-04-14 2017-01-26 アヤンダ グループ エーエス 経口医薬分散組成物
JP2022528430A (ja) * 2019-03-22 2022-06-10 ノー-キューティカルズ・ビー.ブイ. 一酸化窒素ドナー(noドナー)として使用するためのキトサン硝酸塩

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
WO1999051208A1 (en) * 1998-04-03 1999-10-14 Bm Research A/S Controlled release composition
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
AU5006999A (en) * 1998-07-23 2000-02-14 Johns Hopkins University School Of Medicine, The Controlled release of bioactive substances
US6916490B1 (en) 1998-07-23 2005-07-12 UAB Research Center Controlled release of bioactive substances
GB9924797D0 (en) * 1999-10-20 1999-12-22 West Pharm Serv Drug Res Ltd Compound
US20030206958A1 (en) * 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
GB0008411D0 (en) * 2000-04-05 2000-05-24 Vectura Ltd Pharmaceutical preparations and their manufacture
ES2525087T5 (es) 2000-05-10 2018-06-28 Novartis Ag Polvos basados en fosfolípidos para administración de fármacos
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7527807B2 (en) 2000-06-21 2009-05-05 Cubist Pharmaceuticals, Inc. Compositions and methods for increasing the oral absorption of antimicrobials
BR0112393A (pt) * 2000-06-21 2003-07-08 Internat Health Man Associates Composições e processos para aperfeiçoamento de absorção oral de agentes antimicrobiais
IT1318618B1 (it) * 2000-07-10 2003-08-27 A C R Applied Coating Res S A Microsfere bioadesive a rilascio rapido per la somministrazionesublinguale di principi attivi.
ITMI20010347A1 (it) * 2001-02-21 2002-08-21 Grisotech S A Complessi di immunoglobuline e polisaccaridi per assorbimento orale etrans-mucosale
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
US6777000B2 (en) 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
CN1543338B (zh) 2001-08-16 2010-06-16 Cmp医疗有限公司 壳多糖微粒及其医疗用途
WO2003041723A1 (de) * 2001-11-12 2003-05-22 Reinmueller Johannes Pharmazeutische anwendungen von hyaluronsäure-präparaten
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
US6830556B2 (en) 2002-01-08 2004-12-14 Zimmer Orthopaedic Surgical Products, Inc. Debridement extension providing irrigation and mechanical scrubbing for removal of dead, devitalized, or contaminated tissue from a wound
US20040266026A1 (en) * 2002-01-10 2004-12-30 Amiji Mansoor M. Hybrid immobilized catalytic system with controlled permeability
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
CA2519287A1 (en) 2003-03-27 2004-10-14 Bioactis Limited Powder medicine applicator for nasal cavity
US8383158B2 (en) 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
CN1835723B (zh) * 2003-06-16 2011-06-22 洛马林达大学医学中心 可展开的多功能止血剂
US20050118238A1 (en) * 2003-06-16 2005-06-02 Zhu Yong H. Deployable hemostatic agent
CN100381110C (zh) * 2003-06-16 2008-04-16 洛马林达大学医学中心 可展开的止血剂
GB0315632D0 (en) * 2003-07-04 2003-08-13 West Pharm Serv Drug Res Ltd Pharmaceutical formulations
DE10332160A1 (de) * 2003-07-15 2005-02-03 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Peptid- oder Protein-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
GB0328186D0 (en) 2003-12-05 2004-01-07 West Pharm Serv Drug Res Ltd Intranasal compositions
GB0329918D0 (en) 2003-12-24 2004-01-28 West Pharm Serv Drug Res Ltd Intranasal compositions
US20050175679A1 (en) * 2004-02-10 2005-08-11 Michael Moshman Controlled release formulations
JP4694214B2 (ja) * 2004-02-20 2011-06-08 ローム株式会社 比較器、ad変換回路、半導体装置、および撮像装置
US8703176B2 (en) 2004-02-23 2014-04-22 Loma Linda University Medical Center Hemostatic agent for topical and internal use
CN100496468C (zh) * 2004-03-23 2009-06-10 利统股份有限公司 甲壳素包埋或包胶胶囊
US7740883B2 (en) * 2004-03-28 2010-06-22 University Of Debrecen Nanoparticles from chitosan
WO2005107710A2 (en) * 2004-05-06 2005-11-17 Ivrea Pharmaceuticals, Inc. Particles for the delivery of active agents
WO2005112569A2 (en) * 2004-05-13 2005-12-01 Medtronic Vascular, Inc. Methods for compounding and delivering a therapeutic agent to the adventitia of a vessel
GB0416328D0 (en) * 2004-07-21 2004-08-25 Univ Cardiff Use of dry powder compositions for pulmonary delivery
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
DE102004059792A1 (de) 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
WO2006064331A1 (en) * 2004-12-17 2006-06-22 Medipol Sa Hydrophilic particles based on cationic chitosan derivatives
US20090136505A1 (en) * 2005-02-23 2009-05-28 Johanna Bentz Intranasal Administration of Active Agents to the Central Nervous System
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US8303972B2 (en) * 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
EP1877041A2 (en) * 2005-04-29 2008-01-16 Cubist Pharmaceuticals, Inc. Therapeutic compositions
AU2007285472B2 (en) * 2006-03-30 2013-10-24 Engene, Inc. Non-viral compositions and methods for transfecting gut cells in vivo
AU2007257436B2 (en) 2006-06-02 2013-05-02 Synedgen, Inc. Chitosan-derivative compounds and methods of controlling microbial populations
CA2655138C (en) 2006-06-20 2013-08-13 Cmp Therapeutics Limited Compositions comprising chitin microparticles and their medical uses
US20080248508A1 (en) * 2006-08-17 2008-10-09 Shenda Baker Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US8741326B2 (en) * 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
WO2008091592A1 (en) 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
GB0716907D0 (en) * 2007-08-31 2007-10-10 Archimedes Dev Ltd Pharmaceutical powder compositions
GB0722507D0 (en) * 2007-11-19 2007-12-27 Zhao Xiaobin Hyaluronic acid personal lubricant
DE102008059857A1 (de) * 2008-12-01 2010-06-02 Forschungsinstitut für Leder und Kunststoffbahnen gGmbH Mit Kohlenhydrat-Derivaten additivierte Gelatinezusammensetzungen
US9101539B2 (en) 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
CN102844053B (zh) 2009-11-25 2015-08-05 洛马林达大学医学中心 基于壳聚糖的止血织物
US8968790B2 (en) * 2011-12-09 2015-03-03 Shaker A. Mousa Nanoformulation of vitamin D derivatives and/or vitamin D metabolites
FR2991172A1 (fr) * 2012-06-01 2013-12-06 Galderma Res & Dev Compositions pharmaceutiques topiques comprenant des microcapsules
US9878000B2 (en) 2012-06-20 2018-01-30 University Of Waterloo Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof
KR102177557B1 (ko) 2012-06-20 2020-11-11 유니버시티 오브 워터루 점막접착성 나노입자의 전달 시스템
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
US10182993B2 (en) 2015-04-06 2019-01-22 Patheon Softgels Inc. Compositions for colonic delivery of drugs
US12427224B1 (en) * 2015-10-15 2025-09-30 Oceanit Laboratories, Inc. Hemostatic microparticles and dressing
KR102793584B1 (ko) 2016-12-31 2025-04-09 바이오엑셀 테라퓨틱스 인코포레이티드 불안의 치료를 위한 설하 덱스메데토미딘의 용도
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
AU2019225031B2 (en) * 2018-02-26 2024-04-18 Shin Nippon Biomedical Laboratories, Ltd. Powder preparation, cartridge, and device
PL3813802T3 (pl) 2018-06-27 2025-04-22 Bioxcel Therapeutics, Inc. Formulacje błony zawierające deksmedetomidynę i sposoby ich wytwarzania
EP3999058A4 (en) 2019-07-19 2023-05-03 Bioxcel Therapeutics, Inc. NON-SEDATIVE DEXMEDETOMIDINE-BASED TREATMENT REGIMEN
CN112370437B (zh) * 2020-10-20 2022-10-21 好医生药业集团有限公司 一种阿莫西林胶囊及其制备方法
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
CN118304423B (zh) * 2023-05-25 2024-10-11 无锡市第二人民医院 多层级壳聚糖明胶颗粒载P4HA1 siRNA通过抑制细胞EMT治疗脑胶质瘤的研究

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226849A (en) 1979-06-14 1980-10-07 Forest Laboratories Inc. Sustained release therapeutic compositions
JPS6034925B2 (ja) 1979-07-31 1985-08-12 帝人株式会社 持続性鼻腔用製剤およびその製造法
CA1219201A (en) 1983-03-07 1987-03-17 Albert E. Chu Microorganism detection test
GB8712176D0 (en) 1987-05-22 1987-06-24 Cosmas Damian Ltd Drug delivery system
GB8723846D0 (en) 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
CA2004270A1 (en) * 1988-12-29 1990-06-29 William R. Michael Perfume microcapsules for use in granular detergent compositions
GB8904370D0 (en) 1989-02-25 1989-04-12 Cosmas Damian Ltd Liquid delivery compositions
BE1003677A3 (nl) 1990-01-29 1992-05-19 Schacht Etienne Werkwijze voor het bereiden van azobevattende polymeren en het gebruik ervan als geneesmiddelafgiftesystemen.
EP0454444A1 (en) 1990-04-24 1991-10-30 Nissan Chemical Industries Ltd. Glutarimide derivatives and herbicides
CA2042529C (en) * 1990-08-10 2002-07-30 Chokyun Rha Polysaccharide article and uses therefor
IT1243390B (it) 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
GB9414966D0 (en) 1994-07-26 1994-09-14 Danbiosyst Uk Pharmaceutical compositions for the nasal administration of antiviral agents
GB9416884D0 (en) 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
GB9419979D0 (en) 1994-10-04 1994-11-16 Medeva Holdings Bv Vaccine compositions
GB9516268D0 (en) 1995-08-08 1995-10-11 Danbiosyst Uk Compositiion for enhanced uptake of polar drugs from the colon

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503432A (ja) * 1999-07-02 2003-01-28 コグニス・イベリア・ソシエダッド・リミターダ マイクロカプセル−ii
JP4822642B2 (ja) * 1999-07-02 2011-11-24 コグニス・アイピー・マネージメント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング マイクロカプセル−ii
JP2006525354A (ja) * 2003-05-01 2006-11-09 アルキメデス・ディヴェロップメント・リミテッド Lh−rhアナログロイプロイドの経鼻投与
JP2007006849A (ja) * 2005-07-04 2007-01-18 Japan Science & Technology Agency 6−アミノ−6−デオキシキトサン誘導体から成る核酸導入剤
JP5415769B2 (ja) * 2006-12-26 2014-02-12 株式会社新日本科学 経鼻投与用製剤
JP2017019847A (ja) * 2010-04-14 2017-01-26 アヤンダ グループ エーエス 経口医薬分散組成物
US10966926B2 (en) 2010-04-14 2021-04-06 Vitux Group As Oral pharmaceutical dispersion compositions
JP2014510778A (ja) * 2011-04-11 2014-05-01 アヤンダ グループ エーエス 経口医薬分散組成物
JP2022528430A (ja) * 2019-03-22 2022-06-10 ノー-キューティカルズ・ビー.ブイ. 一酸化窒素ドナー(noドナー)として使用するためのキトサン硝酸塩
JP7618241B2 (ja) 2019-03-22 2025-01-21 ノー-キューティカルズ・ビー.ブイ. 一酸化窒素ドナー(noドナー)として使用するためのキトサン硝酸塩

Also Published As

Publication number Publication date
GB2335357B (en) 2000-12-13
DK0952822T3 (da) 2003-07-21
NO993195L (no) 1999-06-28
AU725460B2 (en) 2000-10-12
CA2275717A1 (en) 1998-07-16
NO993195D0 (no) 1999-06-28
US6465626B1 (en) 2002-10-15
GB2335357A (en) 1999-09-22
DE69812887T2 (de) 2003-12-18
EP0952822A1 (en) 1999-11-03
WO1998030207A1 (en) 1998-07-16
ZA98273B (en) 1999-07-13
AU5568998A (en) 1998-08-03
NZ335815A (en) 2001-03-30
GB9700624D0 (en) 1997-03-05
PT952822E (pt) 2003-08-29
CA2275717C (en) 2007-09-11
ATE235889T1 (de) 2003-04-15
ES2200306T3 (es) 2004-03-01
EP0952822B1 (en) 2003-04-02
GB9916018D0 (en) 1999-09-08
DE69812887D1 (de) 2003-05-08

Similar Documents

Publication Publication Date Title
EP0952822B1 (en) Chitosan-gelatin a microparticles
US5707644A (en) Small particle compositions for intranasal drug delivery
JP2914671B2 (ja) 薬剤組成物
AU688566B2 (en) Drug delivery composition containing chitosan or derivative thereof having a defined z. potential
US5384124A (en) Solid porous unitary form comprising micro-particles and/or nano-particles, and its preparation
JP5491119B2 (ja) 薬物含有微粒子を含む医薬組成物およびその製造方法
WO1998052547A1 (en) Gastroretentive controlled release microspheres for improved drug delivery
CN102083419A (zh) 包含表面被覆了的微粒的医药组合物
WO2003020241A9 (en) Functional powders for oral delivery
JP2002521346A (ja) 多糖類を利用した大腸選択性薬物伝達組成物および医薬製剤
WO1995003789A1 (en) Controlled release of pharmaceutically active substances from coacervate microcapsules
JPH09295933A (ja) 放出制御組成物
JP2005513098A (ja) 徐放性組成物
JP2003517440A (ja) 微小粒子組成物
CN115025292A (zh) 一种药物涂层、药物涂层球囊及其制备方法
EP0487562B1 (en) Pharmaceutical compositions
CN1956707B (zh) 包含n-(2-(2-苯二酰亚氨基乙氧基)-乙酰基)-l-丙氨酰基-d-谷氨酸(lk-423)的耐胃酸的药物剂型
Hejazi et al. Chitosan-based delivery systems: Physicochemical properties and pharmaceutical applications
JP2025533837A (ja) 胃腸管の炎症の治療及び予防のための長時間作用型フルチカゾンプロピオン酸エステル注入用懸濁液の使用
WO1998015265A1 (en) Colonic delivery of weak acid drugs
CA2197062C (en) Drug delivery composition containing chitosan or derivative thereof having a defined z. potential
Verma et al. RecentAdvances in Microspheres Technology for Drug Delivery
Gowri Different Methods of Formulation and Evaluation of Mucoadhesive Microspheres by using Various Polymers for H2 Receptor Antagonist Drug
Bhange et al. A review on microsphere as a nasal drug delivery system
CN1491102A (zh) 新的眼科用组合物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050112

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050112

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080819

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20090106

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090317