GB9916018D0 - Chitosan-gelatin a microparticles - Google Patents
Chitosan-gelatin a microparticlesInfo
- Publication number
- GB9916018D0 GB9916018D0 GBGB9916018.6A GB9916018A GB9916018D0 GB 9916018 D0 GB9916018 D0 GB 9916018D0 GB 9916018 A GB9916018 A GB 9916018A GB 9916018 D0 GB9916018 D0 GB 9916018D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- chitosan
- gelatin
- bioadhesive
- microparticles
- microspheres
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
Abstract
A drug delivery composition for nasal administration is provided which comprises the antiviral agent ICAM-1 and a bioadhesive material. The bioadhesive material may be a chitosan solution, a liquid formulation comprising a polymeric material or a plurality of bioadhesive microspheres. The polymeric material is preferably gellan gum or alginate. The microspheres may comprise starch, chitosan, hyaluronic acid, or gelatin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9700624.1A GB9700624D0 (en) | 1997-01-14 | 1997-01-14 | Drug delivery composition |
PCT/GB1998/000108 WO1998030207A1 (en) | 1997-01-14 | 1998-01-14 | Chitosan-gelatin a microparticles |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9916018D0 true GB9916018D0 (en) | 1999-09-08 |
GB2335357A GB2335357A (en) | 1999-09-22 |
GB2335357B GB2335357B (en) | 2000-12-13 |
Family
ID=10805925
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB9700624.1A Pending GB9700624D0 (en) | 1997-01-14 | 1997-01-14 | Drug delivery composition |
GB9916018A Expired - Fee Related GB2335357B (en) | 1997-01-14 | 1998-01-14 | Chitosan-gelatin a microparticles |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB9700624.1A Pending GB9700624D0 (en) | 1997-01-14 | 1997-01-14 | Drug delivery composition |
Country Status (15)
Country | Link |
---|---|
US (1) | US6465626B1 (en) |
EP (1) | EP0952822B1 (en) |
JP (1) | JP2001508061A (en) |
AT (1) | ATE235889T1 (en) |
AU (1) | AU725460B2 (en) |
CA (1) | CA2275717C (en) |
DE (1) | DE69812887T2 (en) |
DK (1) | DK0952822T3 (en) |
ES (1) | ES2200306T3 (en) |
GB (2) | GB9700624D0 (en) |
NO (1) | NO993195D0 (en) |
NZ (1) | NZ335815A (en) |
PT (1) | PT952822E (en) |
WO (1) | WO1998030207A1 (en) |
ZA (1) | ZA98273B (en) |
Families Citing this family (76)
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US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
JP4533531B2 (en) * | 1998-04-03 | 2010-09-01 | ビーエム リサーチ エイ/エス | Controlled release composition |
US7022683B1 (en) | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
US6916490B1 (en) | 1998-07-23 | 2005-07-12 | UAB Research Center | Controlled release of bioactive substances |
WO2000004876A2 (en) * | 1998-07-23 | 2000-02-03 | Johns Hopkins University School Of Medicine | Controlled release of bioactive substances |
ATE258777T1 (en) * | 1999-07-02 | 2004-02-15 | Cognis Iberia Sl | MICRO CAPSULES - II |
GB9924797D0 (en) * | 1999-10-20 | 1999-12-22 | West Pharm Serv Drug Res Ltd | Compound |
US20030206958A1 (en) * | 2000-12-22 | 2003-11-06 | Cattaneo Maurizio V. | Chitosan biopolymer for the topical delivery of active agents |
GB0008411D0 (en) * | 2000-04-05 | 2000-05-24 | Vectura Ltd | Pharmaceutical preparations and their manufacture |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
US7527807B2 (en) | 2000-06-21 | 2009-05-05 | Cubist Pharmaceuticals, Inc. | Compositions and methods for increasing the oral absorption of antimicrobials |
EP2263654B1 (en) * | 2000-06-21 | 2012-10-10 | Cubist Pharmaceuticals, Inc. | Compositions for improving the oral absorption of antimicrobial agents |
IT1318618B1 (en) * | 2000-07-10 | 2003-08-27 | A C R Applied Coating Res S A | QUICK RELEASE BIOADHESIVE MICROSPHERES FOR SUBLINGUAL ADMINISTRATION OF ACTIVE INGREDIENTS. |
ITMI20010347A1 (en) * | 2001-02-21 | 2002-08-21 | Grisotech S A | IMMUNOGLOBULIN AND POLYSACCHARID COMPLEXES FOR ORAL ABSORPTION ETRANS-MUCOSAL |
US6777000B2 (en) | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
WO2003015744A1 (en) | 2001-08-16 | 2003-02-27 | Medical Research Council | Chitin microparticles and their medical uses |
EP1443944A1 (en) * | 2001-11-12 | 2004-08-11 | Johannes Reinmüller | Pharmaceutical applications of hyaluronic acid preparations |
JP2005514393A (en) | 2001-12-19 | 2005-05-19 | ネクター セラピューティクス | Supplying aminoglycosides to the lung |
US6830556B2 (en) | 2002-01-08 | 2004-12-14 | Zimmer Orthopaedic Surgical Products, Inc. | Debridement extension providing irrigation and mechanical scrubbing for removal of dead, devitalized, or contaminated tissue from a wound |
WO2003059848A2 (en) * | 2002-01-10 | 2003-07-24 | Northeastern University | Hybrid immobilized catalytic system with controlled permeability |
WO2004073729A1 (en) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | Compositions for nasal administration of drug |
AU2003220808B2 (en) | 2003-03-27 | 2008-08-21 | Bioactis Limited | Powder medicine applicator for nasal cavity |
CA2524286A1 (en) * | 2003-05-01 | 2004-11-18 | West Pharmaceutical Services Drug Delivery & Clinical Research Centre Li Mited | Nasal administration of the lh-rh analog leuprolide |
CN1835723B (en) * | 2003-06-16 | 2011-06-22 | 洛马林达大学医学中心 | Deployable multifunctional hemostatic agent |
US20050118238A1 (en) * | 2003-06-16 | 2005-06-02 | Zhu Yong H. | Deployable hemostatic agent |
CN100381110C (en) * | 2003-06-16 | 2008-04-16 | 洛马林达大学医学中心 | Deployable hemostatic agent |
GB0315632D0 (en) * | 2003-07-04 | 2003-08-13 | West Pharm Serv Drug Res Ltd | Pharmaceutical formulations |
DE10332160A1 (en) * | 2003-07-15 | 2005-02-03 | Röhm GmbH & Co. KG | Multiparticulate dosage form containing mucoadhesively formulated peptide or protein active substances, and a method for producing the dosage form |
GB0328186D0 (en) | 2003-12-05 | 2004-01-07 | West Pharm Serv Drug Res Ltd | Intranasal compositions |
GB0329918D0 (en) | 2003-12-24 | 2004-01-28 | West Pharm Serv Drug Res Ltd | Intranasal compositions |
US20050175679A1 (en) * | 2004-02-10 | 2005-08-11 | Michael Moshman | Controlled release formulations |
JP4694214B2 (en) * | 2004-02-20 | 2011-06-08 | ローム株式会社 | Comparator, AD conversion circuit, semiconductor device, and imaging device |
US8703176B2 (en) | 2004-02-23 | 2014-04-22 | Loma Linda University Medical Center | Hemostatic agent for topical and internal use |
AU2004318688A1 (en) * | 2004-03-23 | 2005-11-03 | Lytone Enterprise, Inc. | Chitosan embedded or encapsulated capsule |
US7740883B2 (en) * | 2004-03-28 | 2010-06-22 | University Of Debrecen | Nanoparticles from chitosan |
CA2565236A1 (en) * | 2004-05-06 | 2005-11-17 | Ivrea Pharmaceuticals, Inc. | Particles for the delivery of active agents |
EP1758633B1 (en) * | 2004-05-13 | 2015-03-18 | Medtronic Vascular, Inc. | Methods for compounding a therapeutic agent to the adventitia of a vessel |
GB0416328D0 (en) * | 2004-07-21 | 2004-08-25 | Univ Cardiff | Use of dry powder compositions for pulmonary delivery |
US8673360B2 (en) | 2004-08-10 | 2014-03-18 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions that enable rapid-acting and highly absorptive intranasal administration |
DE102004059792A1 (en) * | 2004-12-10 | 2006-06-14 | Röhm GmbH & Co. KG | Multiparticulate dosage form containing mucoadhesively formulated nucleic acid active ingredients, and a method for producing the dosage form |
EP1824459A1 (en) * | 2004-12-17 | 2007-08-29 | Medipol S.A. | Hydrophilic particles based on cationic chitosan derivatives |
US20090136505A1 (en) | 2005-02-23 | 2009-05-28 | Johanna Bentz | Intranasal Administration of Active Agents to the Central Nervous System |
US9539410B2 (en) | 2005-04-19 | 2017-01-10 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating post-cardial infarction damage |
US20080125745A1 (en) | 2005-04-19 | 2008-05-29 | Shubhayu Basu | Methods and compositions for treating post-cardial infarction damage |
US8303972B2 (en) * | 2005-04-19 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
WO2006118948A2 (en) * | 2005-04-29 | 2006-11-09 | Cubist Pharmaceuticals, Inc. | Therapeutic compositions |
JP2007006849A (en) * | 2005-07-04 | 2007-01-18 | Japan Science & Technology Agency | Nucleic acid transfection agent consisting of 6-amino-6-deoxychitosan derivative |
CN105853394A (en) * | 2006-03-30 | 2016-08-17 | 恩根尼公司 | Non-viral compositions and methods for transfecting gut cells in vivo |
CA2653390C (en) | 2006-06-02 | 2014-07-08 | Hawaii Chitopure, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
EP2026820A1 (en) | 2006-06-20 | 2009-02-25 | CMP Therapeutics Limited | Compositions comprising chitin microparticles and their medical uses |
US20080248508A1 (en) * | 2006-08-17 | 2008-10-09 | Shenda Baker | Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials |
US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
US9005672B2 (en) | 2006-11-17 | 2015-04-14 | Abbott Cardiovascular Systems Inc. | Methods of modifying myocardial infarction expansion |
US8741326B2 (en) * | 2006-11-17 | 2014-06-03 | Abbott Cardiovascular Systems Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
ES2652415T3 (en) | 2006-12-26 | 2018-02-02 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
WO2008091588A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
GB0716907D0 (en) | 2007-08-31 | 2007-10-10 | Archimedes Dev Ltd | Pharmaceutical powder compositions |
GB0722507D0 (en) * | 2007-11-19 | 2007-12-27 | Zhao Xiaobin | Hyaluronic acid personal lubricant |
DE102008059857A1 (en) * | 2008-12-01 | 2010-06-02 | Forschungsinstitut für Leder und Kunststoffbahnen gGmbH | Composition, useful e.g. in molded body, medical technology and packaging for industrial purposes, and as cell growth promoting material and matrix material for cell culture, comprises gelatin, and polysaccharide derivatives, as additives |
WO2010131486A1 (en) | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
GB2472327B (en) | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
WO2011066471A1 (en) | 2009-11-25 | 2011-06-03 | Loma Linda University Medical Center | Chitosan-based hemostatic textile |
WO2012140392A1 (en) * | 2011-04-11 | 2012-10-18 | Ayanda Group As | Oral pharmaceutical dispersion compositions |
GB201006218D0 (en) | 2010-04-14 | 2010-06-02 | Ayanda As | Composition |
US8968790B2 (en) * | 2011-12-09 | 2015-03-03 | Shaker A. Mousa | Nanoformulation of vitamin D derivatives and/or vitamin D metabolites |
FR2991172A1 (en) * | 2012-06-01 | 2013-12-06 | Galderma Res & Dev | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING MICROCAPSULES |
US9878000B2 (en) | 2012-06-20 | 2018-01-30 | University Of Waterloo | Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof |
ES2658972T3 (en) | 2012-06-20 | 2018-03-13 | University Of Waterloo | Mucoadhesive nanoparticle administration system |
US9259357B2 (en) | 2014-04-16 | 2016-02-16 | Loma Linda University | Composition, preparation, and use of chitosan shards for biomedical applications |
US10182993B2 (en) | 2015-04-06 | 2019-01-22 | Patheon Softgels Inc. | Compositions for colonic delivery of drugs |
KR20240031326A (en) | 2016-12-31 | 2024-03-07 | 바이오엑셀 테라퓨틱스 인코포레이티드 | Use of Sublingual Dexmedetomidine for the treatment of Agitation |
US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
JP7282735B2 (en) * | 2018-02-26 | 2023-05-29 | 株式会社新日本科学 | Powder formulations, cartridges and devices |
CA3103431A1 (en) | 2018-06-27 | 2020-01-02 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
CA3145388A1 (en) | 2019-07-19 | 2021-01-28 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
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Family Cites Families (15)
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---|---|---|---|---|
US4226849A (en) | 1979-06-14 | 1980-10-07 | Forest Laboratories Inc. | Sustained release therapeutic compositions |
JPS6034925B2 (en) | 1979-07-31 | 1985-08-12 | 帝人株式会社 | Long-acting nasal preparation and its manufacturing method |
CA1219201A (en) | 1983-03-07 | 1987-03-17 | Albert E. Chu | Microorganism detection test |
GB8712176D0 (en) | 1987-05-22 | 1987-06-24 | Cosmas Damian Ltd | Drug delivery system |
GB8723846D0 (en) | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
CA2004270A1 (en) * | 1988-12-29 | 1990-06-29 | William R. Michael | Perfume microcapsules for use in granular detergent compositions |
GB8904370D0 (en) | 1989-02-25 | 1989-04-12 | Cosmas Damian Ltd | Liquid delivery compositions |
BE1003677A3 (en) | 1990-01-29 | 1992-05-19 | Schacht Etienne | PROCESS FOR THE PREPARATION OF AZOBEVATTENDE POLYMERS AND THEIR USE AS A drug delivery systems. |
EP0454444A1 (en) | 1990-04-24 | 1991-10-30 | Nissan Chemical Industries Ltd. | Glutarimide derivatives and herbicides |
CA2042529C (en) * | 1990-08-10 | 2002-07-30 | Chokyun Rha | Polysaccharide article and uses therefor |
IT1243390B (en) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION. |
GB9414966D0 (en) * | 1994-07-26 | 1994-09-14 | Danbiosyst Uk | Pharmaceutical compositions for the nasal administration of antiviral agents |
GB9416884D0 (en) | 1994-08-20 | 1994-10-12 | Danbiosyst Uk | Drug delivery compositions |
GB9419979D0 (en) | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
GB9516268D0 (en) | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
-
1997
- 1997-01-14 GB GBGB9700624.1A patent/GB9700624D0/en active Pending
-
1998
- 1998-01-13 ZA ZA9800273A patent/ZA98273B/en unknown
- 1998-01-14 WO PCT/GB1998/000108 patent/WO1998030207A1/en active IP Right Grant
- 1998-01-14 AT AT98900600T patent/ATE235889T1/en active
- 1998-01-14 PT PT98900600T patent/PT952822E/en unknown
- 1998-01-14 DE DE69812887T patent/DE69812887T2/en not_active Expired - Lifetime
- 1998-01-14 JP JP53067598A patent/JP2001508061A/en not_active Ceased
- 1998-01-14 DK DK98900600T patent/DK0952822T3/en active
- 1998-01-14 GB GB9916018A patent/GB2335357B/en not_active Expired - Fee Related
- 1998-01-14 ES ES98900600T patent/ES2200306T3/en not_active Expired - Lifetime
- 1998-01-14 CA CA002275717A patent/CA2275717C/en not_active Expired - Fee Related
- 1998-01-14 AU AU55689/98A patent/AU725460B2/en not_active Ceased
- 1998-01-14 US US09/341,546 patent/US6465626B1/en not_active Expired - Lifetime
- 1998-01-14 NZ NZ335815A patent/NZ335815A/en not_active IP Right Cessation
- 1998-01-14 EP EP98900600A patent/EP0952822B1/en not_active Expired - Lifetime
-
1999
- 1999-06-28 NO NO993195A patent/NO993195D0/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE69812887T2 (en) | 2003-12-18 |
NO993195L (en) | 1999-06-28 |
EP0952822B1 (en) | 2003-04-02 |
EP0952822A1 (en) | 1999-11-03 |
DK0952822T3 (en) | 2003-07-21 |
US6465626B1 (en) | 2002-10-15 |
AU5568998A (en) | 1998-08-03 |
NZ335815A (en) | 2001-03-30 |
CA2275717A1 (en) | 1998-07-16 |
GB2335357A (en) | 1999-09-22 |
ATE235889T1 (en) | 2003-04-15 |
WO1998030207A1 (en) | 1998-07-16 |
ES2200306T3 (en) | 2004-03-01 |
DE69812887D1 (en) | 2003-05-08 |
ZA98273B (en) | 1999-07-13 |
GB9700624D0 (en) | 1997-03-05 |
GB2335357B (en) | 2000-12-13 |
PT952822E (en) | 2003-08-29 |
CA2275717C (en) | 2007-09-11 |
JP2001508061A (en) | 2001-06-19 |
NO993195D0 (en) | 1999-06-28 |
AU725460B2 (en) | 2000-10-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20070114 |