JP2001507215A - 組換え糖タンパク質のインビトロでの実用的なシアリル化 - Google Patents

組換え糖タンパク質のインビトロでの実用的なシアリル化

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Publication number
JP2001507215A
JP2001507215A JP51870998A JP51870998A JP2001507215A JP 2001507215 A JP2001507215 A JP 2001507215A JP 51870998 A JP51870998 A JP 51870998A JP 51870998 A JP51870998 A JP 51870998A JP 2001507215 A JP2001507215 A JP 2001507215A
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Prior art keywords
sialyltransferase
amino acid
acid sequence
recombinant
sialic acid
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JP51870998A
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Japanese (ja)
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JP2001507215A5 (OSRAM
Inventor
シー. ポールソン,ジェイムス
ジェイ. ベイヤー,ロバート
スジョバーグ,エリック
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サイテル コーポレイション
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Publication of JP2001507215A publication Critical patent/JP2001507215A/ja
Publication of JP2001507215A5 publication Critical patent/JP2001507215A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP51870998A 1997-01-16 1998-01-15 組換え糖タンパク質のインビトロでの実用的なシアリル化 Withdrawn JP2001507215A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3571097P 1997-01-16 1997-01-16
US60/035,710 1997-01-16
PCT/US1998/000835 WO1998031826A1 (en) 1997-01-16 1998-01-15 Practical in vitro sialylation of recombinant glycoproteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010229044A Division JP2011024597A (ja) 1997-01-16 2010-10-08 組換え糖タンパク質のインビトロでの実用的なシアリル化

Publications (2)

Publication Number Publication Date
JP2001507215A true JP2001507215A (ja) 2001-06-05
JP2001507215A5 JP2001507215A5 (OSRAM) 2005-09-08

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ID=21884346

Family Applications (2)

Application Number Title Priority Date Filing Date
JP51870998A Withdrawn JP2001507215A (ja) 1997-01-16 1998-01-15 組換え糖タンパク質のインビトロでの実用的なシアリル化
JP2010229044A Withdrawn JP2011024597A (ja) 1997-01-16 2010-10-08 組換え糖タンパク質のインビトロでの実用的なシアリル化

Family Applications After (1)

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JP2010229044A Withdrawn JP2011024597A (ja) 1997-01-16 2010-10-08 組換え糖タンパク質のインビトロでの実用的なシアリル化

Country Status (12)

Country Link
US (5) US6399336B1 (OSRAM)
EP (1) EP1015622B1 (OSRAM)
JP (2) JP2001507215A (OSRAM)
AT (1) ATE263841T1 (OSRAM)
AU (1) AU736993B2 (OSRAM)
CA (1) CA2278178C (OSRAM)
DE (1) DE69823046T2 (OSRAM)
DK (1) DK1015622T3 (OSRAM)
ES (1) ES2218806T3 (OSRAM)
IL (2) IL130964A0 (OSRAM)
NZ (1) NZ336780A (OSRAM)
WO (1) WO1998031826A1 (OSRAM)

Cited By (6)

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JP2005515974A (ja) * 2001-10-22 2005-06-02 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 卵胞形成のためのゴナドドロピン
JP2006503091A (ja) * 2002-10-17 2006-01-26 ファーミング・インテレクチュアル・プロパティー・ビー.ブイ. タンパク質の修飾
JP2009545575A (ja) * 2006-08-01 2009-12-24 エルエフビー バイオテクノロジーズ 大部分がグリカンで二触角性バイシアリル化され、フコース化されていない形態の遺伝子組み換えプロセス及び形質転換fviiの組成物
JP2010512306A (ja) * 2006-10-27 2010-04-22 ザ ロックフェラー ユニバーシティー 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法
JP4812625B2 (ja) * 2004-10-18 2011-11-09 日本たばこ産業株式会社 糖転移酵素の酵素活性を向上させる方法
JP2018515125A (ja) * 2015-05-22 2018-06-14 ツェー・エス・エル・ベーリング・レコンビナント・ファシリティ・アクチエンゲゼルシャフト 改変フォン・ヴィルブランド因子を製造するための方法

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US6689604B1 (en) * 1998-03-20 2004-02-10 National Research Council Of Canada Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses
NZ512185A (en) 1998-12-09 2004-02-27 Dow Chemical Co A method for manufacturing glycoproteins having human- type glycosylation in plant cells
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
AU1738401A (en) 1999-10-26 2001-05-08 Plant Research International B.V. Mammalian-type glycosylation in plants
AU2001263149A1 (en) * 2000-05-12 2001-11-26 Neose Technologies, Inc. In vitro fucosylation recombinant glycopeptides
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
CA2434364C (en) 2001-01-19 2013-03-19 The Dow Chemical Company Method for secretory production of glycoprotein having human-type sugar chain using plant cell
US7125843B2 (en) 2001-10-19 2006-10-24 Neose Technologies, Inc. Glycoconjugates including more than one peptide
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7439043B2 (en) 2001-10-10 2008-10-21 Neose Technologies, Inc. Galactosyl nucleotide sugars
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US7265085B2 (en) 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycoconjugation methods and proteins/peptides produced by the methods
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US7399613B2 (en) 2001-10-10 2008-07-15 Neose Technologies, Inc. Sialic acid nucleotide sugars
US8008252B2 (en) * 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7265084B2 (en) 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US7226903B2 (en) 2001-10-10 2007-06-05 Neose Technologies, Inc. Interferon beta: remodeling and glycoconjugation of interferon beta
US7297511B2 (en) 2001-10-10 2007-11-20 Neose Technologies, Inc. Interferon alpha: remodeling and glycoconjugation of interferon alpha
EP2042196B1 (en) 2001-10-10 2016-07-13 ratiopharm GmbH Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF)
DE60228492D1 (de) 2001-11-28 2008-10-02 Neose Technologies Inc Remodellierung von glycoproteinen unter verwendung von endoglycanasen
US7473680B2 (en) 2001-11-28 2009-01-06 Neose Technologies, Inc. Remodeling and glycoconjugation of peptides
EP2339004B1 (en) 2002-03-19 2015-02-25 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
EP2319935B1 (en) 2002-03-19 2016-04-27 Stichting Dienst Landbouwkundig Onderzoek GnTIII (UDP-N-acetylglucosamine:Beta -D mannoside Beta (1,4)-N-acetylglucosaminyltransferase III) expression in plants.
MXPA04012496A (es) 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
BR0311978A (pt) 2002-06-21 2005-03-22 Novo Nordisk Healthcare Ag Preparação, método para preparar a mesma, formulação farmacêutica, métodos para tratar de uma sìndrome responsiva ao fator vii, para prevenir hemorragias indesejáveis, para prevenir coagulação sanguìnea indesejável e para prevenir as reações mediadas pelo fator tecidual, e, uso de uma preparação
US20040122216A1 (en) * 2002-07-01 2004-06-24 Jacob Nielsen Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs
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NZ542586A (en) 2003-04-09 2009-11-27 Biogenerix Ag Method of forming a covalent conjugate between a G-CSF peptide and PEG
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US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
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WO2005072371A2 (en) * 2004-01-26 2005-08-11 Neose Technologies, Inc. Branched polymeric sugars and nucleotides thereof
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US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US7338933B2 (en) 2004-01-08 2008-03-04 Neose Technologies, Inc. O-linked glycosylation of peptides
KR20070008645A (ko) 2004-05-04 2007-01-17 노보 노르디스크 헬스 케어 악티엔게젤샤프트 폴리펩티드의 o-연결된 단백당형 및 그들의 제조 방법
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005515974A (ja) * 2001-10-22 2005-06-02 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 卵胞形成のためのゴナドドロピン
JP2006503091A (ja) * 2002-10-17 2006-01-26 ファーミング・インテレクチュアル・プロパティー・ビー.ブイ. タンパク質の修飾
JP4812625B2 (ja) * 2004-10-18 2011-11-09 日本たばこ産業株式会社 糖転移酵素の酵素活性を向上させる方法
JP2009545575A (ja) * 2006-08-01 2009-12-24 エルエフビー バイオテクノロジーズ 大部分がグリカンで二触角性バイシアリル化され、フコース化されていない形態の遺伝子組み換えプロセス及び形質転換fviiの組成物
JP2015042678A (ja) * 2006-08-01 2015-03-05 エルエフビー バイオテクノロジーズ 大部分がグリカンで二触角性バイシアリル化され、フコース化されていない形態の遺伝子組み換えプロセス及び形質転換fviiの組成物
JP2010512306A (ja) * 2006-10-27 2010-04-22 ザ ロックフェラー ユニバーシティー 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法
JP2018515125A (ja) * 2015-05-22 2018-06-14 ツェー・エス・エル・ベーリング・レコンビナント・ファシリティ・アクチエンゲゼルシャフト 改変フォン・ヴィルブランド因子を製造するための方法

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ATE263841T1 (de) 2004-04-15
IL130964A0 (en) 2001-01-28
US20030124645A1 (en) 2003-07-03
EP1015622B1 (en) 2004-04-07
AU6242798A (en) 1998-08-07
US6399336B1 (en) 2002-06-04
DK1015622T3 (da) 2004-08-02
US20020119516A1 (en) 2002-08-29
WO1998031826A1 (en) 1998-07-23
DE69823046D1 (de) 2004-05-13
CA2278178A1 (en) 1998-07-23
DE69823046T2 (de) 2005-03-31
US20020142370A1 (en) 2002-10-03
NZ336780A (en) 2000-12-22
EP1015622A4 (en) 2002-06-19
ES2218806T3 (es) 2004-11-16
US7220555B2 (en) 2007-05-22
IL130964A (en) 2006-06-11
JP2011024597A (ja) 2011-02-10
CA2278178C (en) 2012-09-25
EP1015622A1 (en) 2000-07-05
US20020160460A1 (en) 2002-10-31

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