JP2001506668A5 - - Google Patents
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- Publication number
- JP2001506668A5 JP2001506668A5 JP1998528380A JP52838098A JP2001506668A5 JP 2001506668 A5 JP2001506668 A5 JP 2001506668A5 JP 1998528380 A JP1998528380 A JP 1998528380A JP 52838098 A JP52838098 A JP 52838098A JP 2001506668 A5 JP2001506668 A5 JP 2001506668A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogenolysis
- tosyl
- benzyloxycarbonyl
- acyl
- groups include
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002252 acyl group Chemical group 0.000 description 2
- 125000006242 amine protecting group Chemical group 0.000 description 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 2
- 238000007327 hydrogenolysis reaction Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 2
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000004744 butyloxycarbonyl group Chemical group 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9626845.3 | 1996-12-24 | ||
| GBGB9626845.3A GB9626845D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
| GB9626852.9 | 1996-12-24 | ||
| GBGB9626852.9A GB9626852D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
| GBGB9626846.1A GB9626846D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
| GB9626846.1 | 1996-12-24 | ||
| GB9720536.3 | 1997-09-27 | ||
| GBGB9720536.3A GB9720536D0 (en) | 1997-09-27 | 1997-09-27 | Chemical compounds |
| GBGB9722730.0A GB9722730D0 (en) | 1997-10-29 | 1997-10-29 | Chemical compounds |
| GB9722730.0 | 1997-10-29 | ||
| PCT/EP1997/007197 WO1998028319A1 (en) | 1996-12-24 | 1997-12-22 | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001506668A JP2001506668A (ja) | 2001-05-22 |
| JP2001506668A5 true JP2001506668A5 (enExample) | 2007-11-08 |
| JP4156035B2 JP4156035B2 (ja) | 2008-09-24 |
Family
ID=27517393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52838098A Expired - Fee Related JP4156035B2 (ja) | 1996-12-24 | 1997-12-22 | ２−（プリン−９−イル）−テトラヒドロフラン−３，４−ジオール誘導体 |
Country Status (36)
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
| CO4990969A1 (es) * | 1998-02-14 | 2000-12-26 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| GB9813554D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
| GB9813540D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
| GB9813565D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
| BR9911482A (pt) * | 1998-06-23 | 2002-01-22 | Glaxo Group Ltd | Composto, composição farmacêutica, uso do composto, e, processos para o tratamento ou profilaxia de doenças inflamatórias, e para a preparação de um composto |
| GB9930082D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
| US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| GB0022695D0 (en) | 2000-09-15 | 2000-11-01 | Pfizer Ltd | Purine Derivatives |
| GB0104555D0 (en) * | 2001-02-23 | 2001-04-11 | Glaxo Group Ltd | New Therapeutic method |
| AU2002238748A1 (en) * | 2001-03-12 | 2002-09-24 | Glaxo Group Limited | Pharmaceutical aerosol formulation |
| JP2002338593A (ja) * | 2001-05-22 | 2002-11-27 | Ajinomoto Co Inc | β−Ｄ−リボフラノース誘導体又はその光学異性体の製造方法 |
| PE20030008A1 (es) * | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| TWI346109B (en) * | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
| HRP20161751T1 (hr) | 2004-05-13 | 2017-04-07 | Icos Corporation | Kinazolinoni kao inhibitori humane fosfatidilinozitol 3-kinaze delta |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| AU2005249430B2 (en) * | 2004-05-26 | 2011-06-23 | Inotek Pharmaceuticals Corporation | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof |
| CA2581132A1 (en) * | 2004-09-20 | 2006-03-30 | Inotek Pharmaceuticals Corporation | Purine 5'-carboxamide derivatives and their use as adenosine receptor agonists |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| EP1957530A2 (en) | 2005-10-21 | 2008-08-20 | Novartis AG | Human antibodies against il13 and therapeutic uses |
| GB0523845D0 (en) * | 2005-11-23 | 2006-01-04 | Glaxo Group Ltd | Novel salts |
| AU2006320578B2 (en) * | 2005-11-30 | 2013-01-31 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| EP1889846A1 (en) * | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
| MX2009003185A (es) | 2006-09-29 | 2009-04-03 | Novartis Ag | Pirazolopirimidinas como inhibidores de lipido cinasa pi3k. |
| CN101522682A (zh) | 2006-10-30 | 2009-09-02 | 诺瓦提斯公司 | 作为抗炎剂的杂环化合物 |
| JP5584138B2 (ja) | 2008-01-11 | 2014-09-03 | ノバルティス アーゲー | キナーゼ阻害剤としてのピリミジン類 |
| PT2355828T (pt) | 2008-11-13 | 2018-07-02 | Gilead Calistoga Llc | Terapias para malignidades hematológicas |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| PL2391366T3 (pl) | 2009-01-29 | 2013-04-30 | Novartis Ag | Podstawione benzimidazole do leczenia gwiaździaków |
| US8546409B2 (en) * | 2009-04-20 | 2013-10-01 | Gilead Calistoga Llc | Methods of treatment for solid tumors |
| BR112012001325A2 (pt) | 2009-07-21 | 2017-05-02 | Gilead Calistoga Llc | tratamento de distúrbios do fígado com inibidaores de pi3k |
| US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| EA201200260A1 (ru) | 2009-08-12 | 2012-09-28 | Новартис Аг | Гетероциклические гидразоны и их применение для лечения рака и воспаления |
| KR101721280B1 (ko) | 2009-08-17 | 2017-03-29 | 인텔리카인, 엘엘씨 | 헤테로사이클릭 화합물 및 이의 용도 |
| IN2012DN01453A (enExample) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
| EP2509606A1 (en) * | 2009-12-09 | 2012-10-17 | Glaxo Group Limited | Novel medical use |
| ME02608B (me) | 2010-01-11 | 2017-06-20 | Inotek Pharmaceuticals Corp | Kombinacija, komplet i postupak snižavanja intraokularnog pritiska |
| CN102933593A (zh) | 2010-03-26 | 2013-02-13 | 伊诺泰克制药公司 | 使用n6-环戊基腺苷（cpa）、cpa衍生物或其前药降低人眼内压的方法 |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| JP6527305B2 (ja) * | 2011-01-10 | 2019-06-05 | インヴィオン， インコーポレイテッド | 禁煙のためのβ−アドレナリン作動性インバースアゴニストの使用 |
| EP2673277A1 (en) | 2011-02-10 | 2013-12-18 | Novartis AG | [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase |
| US9127000B2 (en) | 2011-02-23 | 2015-09-08 | Intellikine, LLC. | Heterocyclic compounds and uses thereof |
| GEP20156285B (en) | 2011-02-25 | 2015-05-11 | Aierem Elelsi | Compounds and compositions as trk inhibitors |
| EP2755976B1 (en) | 2011-09-15 | 2018-07-18 | Novartis AG | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors |
| EP2793893A4 (en) | 2011-11-23 | 2015-07-08 | Intellikine Llc | IMPROVED TREATMENT REGIMES USING MTOR INHIBITORS |
| US9278991B2 (en) | 2012-01-26 | 2016-03-08 | Inotek Pharmaceuticals Corporation | Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof |
| US8865730B2 (en) | 2012-03-05 | 2014-10-21 | Gilead Calistoga Llc | Polymorphic forms of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one |
| CN110507654A (zh) | 2012-04-03 | 2019-11-29 | 诺华有限公司 | 有酪氨酸激酶抑制剂的组合产品和其应用 |
| HK1208805A1 (zh) * | 2012-09-21 | 2016-03-18 | 罗得岛医院 | 用於治療癌症的β-水解酶抑制劑 |
| BR112015021870A2 (pt) | 2013-03-15 | 2017-07-18 | Inotek Pharmaceuticals Corp | formulações oftálmicas |
| EP2968340A4 (en) | 2013-03-15 | 2016-08-10 | Intellikine Llc | COMBINING KINASE INHIBITORS AND USES THEREOF |
| WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
| EP3083623A1 (en) | 2013-12-20 | 2016-10-26 | Gilead Calistoga LLC | Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one |
| ES2752552T3 (es) | 2013-12-20 | 2020-04-06 | Gilead Calistoga Llc | Métodos de proceso para inhibidores de fosfatidilinositol 3-quinasa |
| JP6455995B2 (ja) | 2014-06-13 | 2019-01-23 | ギリアード サイエンシーズ， インコーポレイテッド | ホスファチジルイノシトール３−キナーゼ阻害剤 |
| WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
| BR112017001695A2 (pt) | 2014-07-31 | 2017-11-21 | Novartis Ag | terapia de combinação |
| US10472364B2 (en) | 2016-09-09 | 2019-11-12 | Calithera Biosciences, Inc. | Ectonucleotidase inhibitors and methods of use thereof |
| US11078228B2 (en) | 2018-06-21 | 2021-08-03 | Calithera Biosciences, Inc. | Ectonucleotidase inhibitors and methods of use thereof |
| WO2020257429A1 (en) * | 2019-06-20 | 2020-12-24 | Calithera Biosciences, Inc. | Ectonucleotidase inhibitors and methods of use thereof |
| TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3796700A (en) | 1970-06-30 | 1974-03-12 | Takedo Chem Ind Ltd | Adenosine derivatives and the production thereof |
| DE2034785A1 (de) | 1970-07-14 | 1972-01-20 | Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof | Adenosin 5 carbonsäurederivate |
| CA1019727A (en) | 1971-03-18 | 1977-10-25 | Abbott Laboratories | Adenosine-5'-carboxylic acid amides |
| BE789773A (fr) | 1971-10-08 | 1973-04-06 | Schering Ag | Adenosines n6 -substituees et leur procede de |
| US3864483A (en) | 1972-03-22 | 1975-02-04 | Abbott Lab | Adenosine-5{40 -carboxylic acid amides |
| CA1082695A (en) | 1972-04-10 | 1980-07-29 | Francis E. Fischer | Process for preparing adenosine-5'-carboxamides |
| US3966917A (en) | 1974-07-30 | 1976-06-29 | Abbott Laboratories | Platelet aggregation inhibitors |
| DE2621470A1 (de) | 1976-05-14 | 1977-12-01 | Pharma Waldhof Gmbh & Co | Nucleosidcarbonsaeurenitrile und ihre derivate, und verfahren zu ihrer herstellung |
| US4167565A (en) | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
| AU8379182A (en) | 1981-06-04 | 1982-12-09 | Procter & Gamble Company, The | Composition of salicylates and purine derivatives |
| CA1239397A (en) | 1983-08-01 | 1988-07-19 | James A. Bristol | N.sup.6-substituted adenosines |
| DE3406533A1 (de) | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
| US4496643A (en) | 1984-03-23 | 1985-01-29 | Eastman Kodak Company | Two-component dry electrostatic developer composition containing onium charge control agent |
| EP0300145A3 (en) | 1984-04-18 | 1989-08-30 | Whitby Research Incorporated | N-6 phenyl substituted adenosine derivatives as cardiac vasodilators |
| US5310731A (en) | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
| AU575438B2 (en) | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
| US4663313A (en) | 1984-10-26 | 1987-05-05 | Warner-Lambert Company | N6 -tricyclic adenosines for treating hypertension |
| US4738954A (en) | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
| US4755594A (en) | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
| US5106837A (en) | 1988-03-16 | 1992-04-21 | The Scripps Research Institute | Adenosine derivatives with therapeutic activity |
| US4767747A (en) | 1986-08-28 | 1988-08-30 | Warner-Lambert Company | Method for treating congestive heart failure with N6 -acenaphthyl adenosine |
| AU8276187A (en) | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
| WO1988003148A2 (en) | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Heteroaromatic derivatives of adenoside |
| HU198950B (en) | 1986-12-15 | 1989-12-28 | Sandoz Ag | Process for producing new furanuronic acid derivatives and pharmaceutical compositions comprising such compounds |
| US4968697A (en) | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
| FI880405A7 (fi) | 1987-02-04 | 1988-08-05 | Ciba Geigy Ag | Adenosin-5'-karboxamidderivat. |
| US4962194A (en) | 1987-04-02 | 1990-10-09 | Warner-Lambert Company | Method of preparing 51,N6-disubstituted adenosines from inosines |
| LU87181A1 (fr) | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
| US5219840A (en) | 1987-04-06 | 1993-06-15 | Sandoz Ltd. | Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives |
| JPH0725785B2 (ja) | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
| US5055569A (en) | 1989-10-19 | 1991-10-08 | G. D. Searle & Co. | N-(6)-substituted adenosine compounds |
| PT95628A (pt) | 1989-10-19 | 1991-09-30 | Searle & Co | Metodo de tratamento de perturbacoes de mobilidade gastrointestinal com composto de adenosina |
| US5140015A (en) | 1990-02-20 | 1992-08-18 | Whitby Research, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
| US5280015A (en) | 1990-09-05 | 1994-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides |
| ES2095960T3 (es) | 1990-09-25 | 1997-03-01 | Rhone Poulenc Rorer Int | Compuestos que tienen propiedades antihipertensivas y antiisquemicas. |
| FR2685918B1 (fr) | 1992-01-08 | 1995-06-23 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| FR2687678B1 (fr) | 1992-01-31 | 1995-03-31 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| US5424297A (en) | 1992-04-27 | 1995-06-13 | University Of Virginia Alumni Patents Foundation | Adenosine dextran conjugates |
| WO1994002497A1 (en) | 1992-07-15 | 1994-02-03 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Sulfo-derivatives of adenosine |
| GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
| CA2154681A1 (en) | 1993-02-03 | 1994-08-18 | Mark David Erion | Adenosine kinase inhibitors comprising lyxofuranosyl derivatives |
| WO1995002604A1 (en) | 1993-07-13 | 1995-01-26 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor agonists |
| US5446046A (en) | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| WO1995018817A1 (fr) | 1994-01-07 | 1995-07-13 | Laboratoires Upsa | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant |
| GB9414208D0 (en) | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
| GB9414193D0 (en) * | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
-
1997
- 1997-12-16 TW TW086118941A patent/TW528755B/zh active
- 1997-12-22 EE EEP199900312A patent/EE04019B1/xx not_active IP Right Cessation
- 1997-12-22 CN CN97181854A patent/CN1246124A/zh active Pending
- 1997-12-22 GE GEAP19974870A patent/GEP20022656B/en unknown
- 1997-12-22 US US09/331,526 patent/US6426337B1/en not_active Expired - Lifetime
- 1997-12-22 ID IDW990575A patent/ID22271A/id unknown
- 1997-12-22 BR BR9714082-1A patent/BR9714082A/pt not_active IP Right Cessation
- 1997-12-22 PT PT97953888T patent/PT948509E/pt unknown
- 1997-12-22 EA EA199900494A patent/EA001714B1/ru not_active IP Right Cessation
- 1997-12-22 EP EP97953888A patent/EP0948509B1/en not_active Expired - Lifetime
- 1997-12-22 PL PL97334218A patent/PL334218A1/xx unknown
- 1997-12-22 DE DE69716468T patent/DE69716468T2/de not_active Expired - Lifetime
- 1997-12-22 YU YU29099A patent/YU29099A/sh unknown
- 1997-12-22 IL IL13054797A patent/IL130547A0/xx unknown
- 1997-12-22 SI SI9730455T patent/SI0948509T1/xx unknown
- 1997-12-22 KR KR1019997005729A patent/KR20000069682A/ko not_active Ceased
- 1997-12-22 AT AT97953888T patent/ATE226212T1/de not_active IP Right Cessation
- 1997-12-22 HU HU0000673A patent/HUP0000673A3/hu unknown
- 1997-12-22 WO PCT/EP1997/007197 patent/WO1998028319A1/en not_active Ceased
- 1997-12-22 AU AU57622/98A patent/AU733684B2/en not_active Ceased
- 1997-12-22 AR ARP970106111A patent/AR011044A1/es not_active Application Discontinuation
- 1997-12-22 ES ES97953888T patent/ES2186015T3/es not_active Expired - Lifetime
- 1997-12-22 NZ NZ336332A patent/NZ336332A/xx unknown
- 1997-12-22 TR TR1999/01905T patent/TR199901905T2/xx unknown
- 1997-12-22 AP APAP/P/1999/001572A patent/AP1105A/en active
- 1997-12-22 SK SK865-99A patent/SK86599A3/sk unknown
- 1997-12-22 CA CA002275271A patent/CA2275271A1/en not_active Abandoned
- 1997-12-22 DK DK97953888T patent/DK0948509T3/da active
- 1997-12-22 CZ CZ992309A patent/CZ230999A3/cs unknown
- 1997-12-22 JP JP52838098A patent/JP4156035B2/ja not_active Expired - Fee Related
- 1997-12-23 PE PE1997001160A patent/PE27499A1/es not_active Application Discontinuation
- 1997-12-23 CO CO97074732A patent/CO4940488A1/es unknown
-
1999
- 1999-06-22 BG BG103518A patent/BG63310B1/bg unknown
- 1999-06-22 IS IS5089A patent/IS5089A/is unknown
- 1999-06-22 OA OA9900139A patent/OA11071A/en unknown
- 1999-06-23 NO NO19993114A patent/NO312840B1/no unknown
-
2001
- 2001-12-19 US US10/025,678 patent/US6528494B2/en not_active Expired - Fee Related
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