DE60013021D1 - Herstellung von S,S und R,S Aminosäuren-Isosteren - Google Patents

Herstellung von S,S und R,S Aminosäuren-Isosteren

Info

Publication number
DE60013021D1
DE60013021D1 DE60013021T DE60013021T DE60013021D1 DE 60013021 D1 DE60013021 D1 DE 60013021D1 DE 60013021 T DE60013021 T DE 60013021T DE 60013021 T DE60013021 T DE 60013021T DE 60013021 D1 DE60013021 D1 DE 60013021D1
Authority
DE
Germany
Prior art keywords
production
amino acid
acid isosteres
isosteres
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60013021T
Other languages
English (en)
Other versions
DE60013021T2 (de
Inventor
Aslam A Malik
Todd E Clement
Hasan Palandoken
James Robinson Iii
Joy A Stringer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ampac Fine Chemicals LLC
Original Assignee
Aerojet Fine Chemicals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerojet Fine Chemicals LLC filed Critical Aerojet Fine Chemicals LLC
Publication of DE60013021D1 publication Critical patent/DE60013021D1/de
Application granted granted Critical
Publication of DE60013021T2 publication Critical patent/DE60013021T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
DE60013021T 1999-05-03 2000-05-03 Herstellung von S,S und R,S Aminosäuren-Isosteren Expired - Lifetime DE60013021T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13227899P 1999-05-03 1999-05-03
US132278P 1999-05-03
US09/321,645 US6605732B1 (en) 1999-05-03 1999-05-28 Clean, high-yield preparation of S,S and R,S amino acid isosteres
US321645 1999-05-28

Publications (2)

Publication Number Publication Date
DE60013021D1 true DE60013021D1 (de) 2004-09-23
DE60013021T2 DE60013021T2 (de) 2005-09-01

Family

ID=26830230

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60013021T Expired - Lifetime DE60013021T2 (de) 1999-05-03 2000-05-03 Herstellung von S,S und R,S Aminosäuren-Isosteren

Country Status (3)

Country Link
US (5) US6605732B1 (de)
EP (1) EP1050532B1 (de)
DE (1) DE60013021T2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605732B1 (en) * 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres
JP4143787B2 (ja) * 1999-07-28 2008-09-03 味の素株式会社 α−アミノハロメチルケトン誘導体の製造方法
KR100708221B1 (ko) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
ATE321024T1 (de) * 2000-10-17 2006-04-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von oxazolidinonverbindungen
JPWO2002044136A1 (ja) * 2000-11-30 2004-04-02 味の素株式会社 Ｎ保護−β−アミノアルコールの製造法およびＮ保護−β−アミノエポキシドの製造法
DE602004009344T2 (de) * 2004-04-19 2008-07-10 Symed Labs Ltd., Hyderabad Neues verfahren zur herstellung von linezolid und verwandten verbindungen
US7582468B2 (en) * 2005-05-25 2009-09-01 Bristol-Myers Squibb Company Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
DE602008005896D1 (de) * 2007-06-22 2011-05-12 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
KR20100033378A (ko) * 2007-06-22 2010-03-29 브리스톨-마이어스 스큅 컴퍼니 아타자나비르를 함유하는 정제 조성물
DK2170292T3 (da) * 2007-06-22 2014-04-07 Bristol Myers Squibb Holdings Ireland Atazanavirholdige sammensætninger i tabletform
DE602008005462D1 (de) * 2007-06-22 2011-04-21 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
US20090203928A1 (en) * 2008-01-24 2009-08-13 Thompson David M Organometallic compounds, processes for the preparation thereof and methods of use thereof
US20090209777A1 (en) * 2008-01-24 2009-08-20 Thompson David M Organometallic compounds, processes for the preparation thereof and methods of use thereof
US20090203917A1 (en) * 2008-01-24 2009-08-13 Thompson David M Organometallic compounds, processes for the preparation thereof and methods of use thereof
WO2009136365A1 (en) * 2008-05-08 2009-11-12 Ranbaxy Laboratories Limited Process for the preparation of 3,4-epoxy-2-amino-1-substituted butane derivatives and intermediate compounds thereof
CN102276545B (zh) * 2010-06-10 2015-06-10 浙江九洲药业股份有限公司 环氧丁烷类化合物及其中间体的制备方法
TWI429620B (zh) 2011-02-28 2014-03-11 Scinopharm Taiwan Ltd 還原α－醯氧基硫化物衍生物之方法
CN102766074B (zh) * 2012-08-07 2014-05-07 江西东邦药业有限公司 抗艾滋病药物中间体的制备方法
CN103044361B (zh) * 2012-12-30 2014-08-06 江苏八巨药业有限公司 一种（2r,3s）-环氧化氨基苯丁烷的制备方法
CN104860903B (zh) * 2015-04-30 2017-05-24 上海应用技术学院 一种沙奎那韦中间体的制备方法
CN106966927B (zh) * 2017-04-13 2018-10-09 菲立化学工程（上海）有限公司 一种抗艾滋病药物中间体重氮酮与氯酮的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5418966A (en) * 1992-10-16 1995-05-23 International Business Machines Corporation Updating replicated objects in a plurality of memory partitions
FR2711988B1 (fr) * 1993-11-05 1996-01-05 Oreal Nouveaux dérivés de la lysine à groupement Nepsilon-alkoxy ou alcénoxy carbonyle, leur préparation et leur utilisation, dans des compositions cosmétiques, pharmaceutiques, hygiéniques ou alimentaires.
US5591885A (en) 1994-09-23 1997-01-07 Hoffman-La Roche Inc. Process for the preparation of halogenated α-aminoketone compounds
US5481011A (en) * 1994-12-13 1996-01-02 Bristol-Myers Squibb Company Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters
JPH09323960A (ja) * 1996-06-05 1997-12-16 Ajinomoto Co Inc ３−アミノ−１，２−オキシランの製造方法
US6130348A (en) * 1997-04-10 2000-10-10 Hoffmann-La Roche Inc. Process for a phenylthiobutyl-isoquinoline and intermediates therefor
US5854405A (en) 1997-11-13 1998-12-29 Aerojet-General Corporation Continuous process for diazomethane from an n-methyl-n-nitrosoamine and from methylurea through n-methyl-n-nitrosourea
US5817778A (en) 1997-11-13 1998-10-06 Aerojet-General Corporation Large scale batch process for diazomethane
US6605732B1 (en) * 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres

Also Published As

Publication number Publication date
US20030225292A1 (en) 2003-12-04
US6605732B1 (en) 2003-08-12
US6867311B2 (en) 2005-03-15
US20050171170A1 (en) 2005-08-04
EP1050532A3 (de) 2001-12-19
DE60013021T2 (de) 2005-09-01
US20130116457A1 (en) 2013-05-09
US8163933B2 (en) 2012-04-24
US20090012303A1 (en) 2009-01-08
EP1050532B1 (de) 2004-08-18
EP1050532A2 (de) 2000-11-08
US7309803B2 (en) 2007-12-18

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AMPAC FINE CHEMICALS LLC, RANCHO CORDOVA, CALI, US