JP2001505765A - 組織型プラスミノーゲンアクチベーター（ｔ―ＰＡ）の変異体：組成物およびその使用方法 - Google Patents

組織型プラスミノーゲンアクチベーター（ｔ―ＰＡ）の変異体：組成物およびその使用方法

Info

Publication number
JP2001505765A
JP2001505765A JP52266198A JP52266198A JP2001505765A JP 2001505765 A JP2001505765 A JP 2001505765A JP 52266198 A JP52266198 A JP 52266198A JP 52266198 A JP52266198 A JP 52266198A JP 2001505765 A JP2001505765 A JP 2001505765A
Authority
JP
Japan
Prior art keywords
protein
fibrin
factor
chain
wild
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP52266198A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001505765A5 (fr
Inventor
エル． マディスン、エドウィン
Original Assignee
ザ スクリプス リサーチ インスティテュート
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ スクリプス リサーチ インスティテュート filed Critical ザ スクリプス リサーチ インスティテュート
Publication of JP2001505765A publication Critical patent/JP2001505765A/ja
Publication of JP2001505765A5 publication Critical patent/JP2001505765A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP52266198A 1996-11-12 1997-11-12 組織型プラスミノーゲンアクチベーター（ｔ―ＰＡ）の変異体：組成物およびその使用方法 Ceased JP2001505765A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3065596P 1996-11-12 1996-11-12
US60/030,655 1996-11-12
PCT/US1997/020226 WO1998021320A2 (fr) 1996-11-12 1997-11-12 VARIANTES D'ACTIVATEUR PLASMINOGENE DE TYPE TISSULAIRE (t-PA): COMPOSITIONS ET TECHNIQUES D'UTILISATION

Publications (2)

Publication Number Publication Date
JP2001505765A true JP2001505765A (ja) 2001-05-08
JP2001505765A5 JP2001505765A5 (fr) 2004-10-28

Family

ID=21855292

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52266198A Ceased JP2001505765A (ja) 1996-11-12 1997-11-12 組織型プラスミノーゲンアクチベーター（ｔ―ＰＡ）の変異体：組成物およびその使用方法

Country Status (6)

Country Link
EP (1) EP0950095A2 (fr)
JP (1) JP2001505765A (fr)
CN (1) CN1244894A (fr)
AU (1) AU735519B2 (fr)
CA (1) CA2271697C (fr)
WO (1) WO1998021320A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8864398A (en) * 1997-08-13 1999-03-08 Boehringer Mannheim Gmbh Plasminogen activator with enhanced zymogenic power and reduced fibrin linking
WO2014116706A1 (fr) * 2013-01-22 2014-07-31 University Of Tennessee Research Foundation Anticorps activateurs du plasminogène tissulaire et leurs méthodes d'utilisation
CN114736948B (zh) * 2022-06-10 2022-11-08 深圳市帝迈生物技术有限公司 一种α2-抗纤溶酶活性测定试剂盒

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199574B1 (fr) * 1985-04-22 1991-10-23 Genentech, Inc. Mutants d'activateur de plasminogène tissulaire humain, méthodes et intermédiaires pour ceux-ci et compositions utilisant ces mutants
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties

Also Published As

Publication number Publication date
CN1244894A (zh) 2000-02-16
WO1998021320A2 (fr) 1998-05-22
AU735519B2 (en) 2001-07-12
CA2271697C (fr) 2007-10-23
AU5585098A (en) 1998-06-03
CA2271697A1 (fr) 1998-05-22
EP0950095A2 (fr) 1999-10-20
WO1998021320A3 (fr) 1998-07-09

Similar Documents

Publication Publication Date Title
Zhang et al. A novel plasminogen activator from snake venom: Purification, characterization, and molecular cloning (∗)
JP2851423B2 (ja) 活性化可能なフィブリン溶解および抗血栓症タンパク質
JP2610783B2 (ja) ポリクリングルプラスミノーゲン活性化因子をコードする遺伝子およびそれを含有するベクター
Browne et al. A tissue-type plasminogen activator mutant with prolonged clearance in vivo. Effect of removal of the growth factor domain.
IE67508B1 (en) Tissue plasminogen activator having zymogenic or fibrin specific properties
CA2071630C (fr) Proteine c hybride
EP0424405B1 (fr) Variants d'activateurs de plasminogene et leurs procede de production
EP0323149B1 (fr) Vecteurs et composés pour l'expression de formes zymogéniques de protéine C
US6869778B2 (en) Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
JP2001505765A (ja) 組織型プラスミノーゲンアクチベーター（ｔ―ＰＡ）の変異体：組成物およびその使用方法
JP3329340B2 (ja) トロンビン活性化プラスミノーゲン誘導体
US5688664A (en) Thrombin activatable plasminogen analogues
EP0316068A1 (fr) Activateur du plasminogène modifié de bas poids moléculaire et méthode pour sa préparation
WO1998021320A9 (fr) VARIANTES D'ACTIVATEUR PLASMINOGENE DE TYPE TISSULAIRE (t-PA): COMPOSITIONS ET TECHNIQUES D'UTILISATION
CA2162986A1 (fr) Proteines possedant des proprietes fibrinolytiques et anticoagulantes
JPH03505276A (ja) 再配列された組織プラスミノーゲン活性化因子及びその産生方法
EP0400054A1 (fr) Sequences de genes modifiees codant pour des activateurs de plasminogenes tissulaires modifies et molecules ainsi produites
JP2000504941A (ja) トロンビンによって活性化され得るプラスミノーゲンアクチベーター
HU211335A9 (en) New polipeptide compounds
US8329168B2 (en) Compositions and methods for modulating hemostasis
HUT52559A (en) Process for production of proteins with trombolitic effect
JPH04252184A (ja) プロウロキナーゼ誘導体
JPH01160481A (ja) 新規なポリペプチド、その製法及び用途
HU210541A9 (hu) Zimogén- vagy fibrin-specifikus tulajdonságú, a 296-299 aminosav-tartományban helyettesített szöveti plazminogén aktivátor, ezt kódoló DNS-molekulák, vektorok és gazdasejtek
JPH0670767A (ja) ヒト低分子プロウロキナーゼ様ポリペプチド及びその製造法

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20061128

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070220

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070409

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070528

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090310

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20090629

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090804