CA2271697C - Variantes d'activateur plasminogene de type tissulaire (t-pa): compositions et techniques d'utilisation - Google Patents
Variantes d'activateur plasminogene de type tissulaire (t-pa): compositions et techniques d'utilisation Download PDFInfo
- Publication number
- CA2271697C CA2271697C CA002271697A CA2271697A CA2271697C CA 2271697 C CA2271697 C CA 2271697C CA 002271697 A CA002271697 A CA 002271697A CA 2271697 A CA2271697 A CA 2271697A CA 2271697 C CA2271697 C CA 2271697C
- Authority
- CA
- Canada
- Prior art keywords
- protein variant
- ser
- protein
- variant
- single chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne des variantes du facteur plasminogène tissulaire qui font preuve d'une amélioration notable de la stimulation de la fibrine, d'une discrimination considérablement accrue entre cofacteurs de la fibrine, d'une résistance marquée à l'inhibition par PAI-1, et d'une zymogénicité sensiblement accrue, une combinaison de propriétés qui renforcent l'utilité thérapeutique de l'enzyme.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3065596P | 1996-11-12 | 1996-11-12 | |
US60/030,655 | 1996-11-12 | ||
PCT/US1997/020226 WO1998021320A2 (fr) | 1996-11-12 | 1997-11-12 | VARIANTES D'ACTIVATEUR PLASMINOGENE DE TYPE TISSULAIRE (t-PA): COMPOSITIONS ET TECHNIQUES D'UTILISATION |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2271697A1 CA2271697A1 (fr) | 1998-05-22 |
CA2271697C true CA2271697C (fr) | 2007-10-23 |
Family
ID=21855292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002271697A Expired - Fee Related CA2271697C (fr) | 1996-11-12 | 1997-11-12 | Variantes d'activateur plasminogene de type tissulaire (t-pa): compositions et techniques d'utilisation |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0950095A2 (fr) |
JP (1) | JP2001505765A (fr) |
CN (1) | CN1244894A (fr) |
AU (1) | AU735519B2 (fr) |
CA (1) | CA2271697C (fr) |
WO (1) | WO1998021320A2 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999009184A1 (fr) * | 1997-08-13 | 1999-02-25 | Roche Diagnostics Gmbh | Activateur du plasminogene a pouvoir zymogene ameliore et a liaison a la fibrine reduite |
WO2014116706A1 (fr) * | 2013-01-22 | 2014-07-31 | University Of Tennessee Research Foundation | Anticorps activateurs du plasminogène tissulaire et leurs méthodes d'utilisation |
CN114736948B (zh) * | 2022-06-10 | 2022-11-08 | 深圳市帝迈生物技术有限公司 | 一种α2-抗纤溶酶活性测定试剂盒 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3682104D1 (de) * | 1985-04-22 | 1991-11-28 | Genentech Inc | Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen. |
US5108901A (en) * | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
-
1997
- 1997-11-12 AU AU55850/98A patent/AU735519B2/en not_active Ceased
- 1997-11-12 JP JP52266198A patent/JP2001505765A/ja not_active Ceased
- 1997-11-12 WO PCT/US1997/020226 patent/WO1998021320A2/fr active IP Right Grant
- 1997-11-12 CA CA002271697A patent/CA2271697C/fr not_active Expired - Fee Related
- 1997-11-12 EP EP97952176A patent/EP0950095A2/fr not_active Withdrawn
- 1997-11-12 CN CN97181346A patent/CN1244894A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1998021320A2 (fr) | 1998-05-22 |
AU5585098A (en) | 1998-06-03 |
AU735519B2 (en) | 2001-07-12 |
JP2001505765A (ja) | 2001-05-08 |
CA2271697A1 (fr) | 1998-05-22 |
CN1244894A (zh) | 2000-02-16 |
EP0950095A2 (fr) | 1999-10-20 |
WO1998021320A3 (fr) | 1998-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |