JP2001503429A - （４ｒ，５ｓ，６ｓ，７ｒ）―ヘキサヒドロ―１―［５―（３―アミノインダゾール）メチル］―３―ブチル―５，６―ジヒドロキシ―４，７―ビス［フェニルメチル］―２ｈ―１，３―ジアゼピン―２―オンおよびそのｈｉｖプロテアーゼ阻害剤としての使用 - Google Patents

（４ｒ，５ｓ，６ｓ，７ｒ）―ヘキサヒドロ―１―［５―（３―アミノインダゾール）メチル］―３―ブチル―５，６―ジヒドロキシ―４，７―ビス［フェニルメチル］―２ｈ―１，３―ジアゼピン―２―オンおよびそのｈｉｖプロテアーゼ阻害剤としての使用

Info

Publication number
JP2001503429A
JP2001503429A JP52168298A JP52168298A JP2001503429A JP 2001503429 A JP2001503429 A JP 2001503429A JP 52168298 A JP52168298 A JP 52168298A JP 52168298 A JP52168298 A JP 52168298A JP 2001503429 A JP2001503429 A JP 2001503429A
Authority
JP
Japan
Prior art keywords
compound
hiv
formula
pharmaceutically acceptable
reverse transcriptase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP52168298A
Other languages
English (en)
Japanese (ja)
Inventor
ロジャース，ジェイムズ，デイヴィッド．
ラム，パトリック，ユク―スン．
Original Assignee
デュポン ファーマシューティカルズ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デュポン ファーマシューティカルズ カンパニー filed Critical デュポン ファーマシューティカルズ カンパニー
Publication of JP2001503429A publication Critical patent/JP2001503429A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP52168298A 1996-11-08 1997-11-04 （４ｒ，５ｓ，６ｓ，７ｒ）―ヘキサヒドロ―１―［５―（３―アミノインダゾール）メチル］―３―ブチル―５，６―ジヒドロキシ―４，７―ビス［フェニルメチル］―２ｈ―１，３―ジアゼピン―２―オンおよびそのｈｉｖプロテアーゼ阻害剤としての使用 Pending JP2001503429A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74710396A 1996-11-08 1996-11-08
US2974696P 1996-11-08 1996-11-08
US60/029,746 1996-11-08
US08/747,103 1996-11-08
PCT/US1997/020036 WO1998020009A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (1)

Publication Number Publication Date
JP2001503429A true JP2001503429A (ja) 2001-03-13

Family

ID=26705295

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52168298A Pending JP2001503429A (ja) 1996-11-08 1997-11-04 （４ｒ，５ｓ，６ｓ，７ｒ）―ヘキサヒドロ―１―［５―（３―アミノインダゾール）メチル］―３―ブチル―５，６―ジヒドロキシ―４，７―ビス［フェニルメチル］―２ｈ―１，３―ジアゼピン―２―オンおよびそのｈｉｖプロテアーゼ阻害剤としての使用

Country Status (19)

Country Link
EP (1) EP0937066A1 (ko)
JP (1) JP2001503429A (ko)
KR (1) KR20000053123A (ko)
CN (1) CN1235601A (ko)
AU (1) AU722489B2 (ko)
BR (1) BR9712755A (ko)
CA (1) CA2270963A1 (ko)
CZ (1) CZ157499A3 (ko)
EA (1) EA001154B1 (ko)
EE (1) EE9900187A (ko)
HU (1) HUP9904143A3 (ko)
IL (1) IL129726A0 (ko)
LV (1) LV12374B (ko)
NO (1) NO992229L (ko)
NZ (1) NZ335919A (ko)
PL (1) PL333412A1 (ko)
SI (1) SI9720071A (ko)
SK (1) SK59599A3 (ko)
WO (1) WO1998020009A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043969A1 (en) * 1997-03-31 1998-10-08 Dupont Pharmaceuticals Company Indazoles of cyclic ureas useful as hiv protease inhibitors
AU4716299A (en) * 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
FR2810039B1 (fr) 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
WO1993007128A1 (en) * 1991-10-11 1993-04-15 The Du Pont Merck Pharmaceutical Company Cyclic ureas and analogues useful as retroviral protease inhibitiors

Also Published As

Publication number Publication date
CN1235601A (zh) 1999-11-17
AU5103398A (en) 1998-05-29
SK59599A3 (en) 1999-12-10
BR9712755A (pt) 1999-10-19
EE9900187A (et) 1999-12-15
LV12374B (en) 2000-04-20
EA199900451A1 (ru) 1999-12-29
IL129726A0 (en) 2000-02-29
SI9720071A (sl) 1999-12-31
WO1998020009A1 (en) 1998-05-14
HUP9904143A2 (hu) 2000-06-28
PL333412A1 (en) 1999-12-06
KR20000053123A (ko) 2000-08-25
AU722489B2 (en) 2000-08-03
CZ157499A3 (cs) 1999-11-17
NO992229D0 (no) 1999-05-07
EP0937066A1 (en) 1999-08-25
NO992229L (no) 1999-06-07
LV12374A (lv) 1999-11-20
NZ335919A (en) 2000-09-29
EA001154B1 (ru) 2000-10-30
CA2270963A1 (en) 1998-05-14
HUP9904143A3 (en) 2002-11-28

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