|
US7597886B2
(en)
|
1994-11-07 |
2009-10-06 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US7429646B1
(en)
|
1995-06-05 |
2008-09-30 |
Human Genome Sciences, Inc. |
Antibodies to human tumor necrosis factor receptor-like 2
|
|
US7888466B2
(en)
|
1996-01-11 |
2011-02-15 |
Human Genome Sciences, Inc. |
Human G-protein chemokine receptor HSATU68
|
|
US7357927B2
(en)
|
1996-03-12 |
2008-04-15 |
Human Genome Sciences, Inc. |
Death domain containing receptors
|
|
WO1997033904A1
(en)
|
1996-03-12 |
1997-09-18 |
Human Genome Sciences, Inc. |
Death domain containing receptors
|
|
US6713061B1
(en)
|
1996-03-12 |
2004-03-30 |
Human Genome Sciences, Inc. |
Death domain containing receptors
|
|
US6635743B1
(en)
|
1996-03-22 |
2003-10-21 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule II and methods of use
|
|
US7964190B2
(en)
|
1996-03-22 |
2011-06-21 |
Human Genome Sciences, Inc. |
Methods and compositions for decreasing T-cell activity
|
|
US6812327B1
(en)
|
1996-10-25 |
2004-11-02 |
Human Genome Sciences, Inc. |
Neutrokine-alpha polypeptides
|
|
US6689579B1
(en)
|
1996-10-25 |
2004-02-10 |
Human Genome Sciences, Inc. |
Polynucleotides encoding neutrokine-α
|
|
US8212004B2
(en)
|
1999-03-02 |
2012-07-03 |
Human Genome Sciences, Inc. |
Neutrokine-alpha fusion proteins
|
|
WO1998027114A2
(en)
*
|
1996-12-17 |
1998-06-25 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
|
CA2232743A1
(en)
*
|
1997-04-02 |
1998-10-02 |
Smithkline Beecham Corporation |
A tnf homologue, tl5
|
|
IL133316A0
(en)
*
|
1997-06-06 |
2001-04-30 |
Regeneron Pharma |
Ntn-2 member of tnf ligand family
|
|
IL133315A0
(en)
*
|
1997-06-06 |
2001-04-30 |
Regeneron Pharma |
Ntn-2 member of tnf ligand family
|
|
WO1999011791A2
(en)
*
|
1997-09-05 |
1999-03-11 |
University Of Washington |
Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
|
|
EP1012270A2
(en)
*
|
1997-09-12 |
2000-06-28 |
Apotech R&D S.A. |
Kay - a novel immune system protein
|
|
WO1999026463A2
(en)
*
|
1997-11-26 |
1999-06-03 |
Eli Lilly And Company |
Tnf ligand family gene
|
|
AU2093499A
(en)
*
|
1997-12-30 |
1999-07-19 |
Chiron Corporation |
Members of tnf and tnfr families
|
|
US6297367B1
(en)
*
|
1997-12-30 |
2001-10-02 |
Chiron Corporation |
Polynucleotide encoding TNFL1
|
|
US7488590B2
(en)
|
1998-10-23 |
2009-02-10 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
GB9828628D0
(en)
|
1998-12-23 |
1999-02-17 |
Glaxo Group Ltd |
Novel ligand
|
|
CN101518648A
(zh)
*
|
1999-01-07 |
2009-09-02 |
津莫吉尼蒂克斯公司 |
可溶性受体br43×2和应用方法
|
|
US7833529B1
(en)
|
1999-01-07 |
2010-11-16 |
Zymogenetics, Inc. |
Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
|
|
BR0007719A
(pt)
*
|
1999-01-25 |
2001-11-13 |
Biogen Inc |
Baff, agentes de bloqueio relacionados e uso dosmesmos no estìmulo e na inibição de células b e deimunoglobulinas em respostas imunológicas
|
|
US20030095967A1
(en)
|
1999-01-25 |
2003-05-22 |
Mackay Fabienne |
BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
|
|
US6475986B1
(en)
*
|
1999-02-02 |
2002-11-05 |
Research Development Foundation |
Uses of THANK, a TNF homologue that activates apoptosis
|
|
JP2003526330A
(ja)
*
|
1999-02-23 |
2003-09-09 |
ヒューマン ジノーム サイエンシーズ， インコーポレイテッド |
ニュートロカイン−αおよびニュートロカイン−αスプライス改変体
|
|
CN100439499C
(zh)
*
|
1999-02-23 |
2008-12-03 |
人体基因组科学有限公司 |
Neutrokine-α和Neutrokine-α剪接变体
|
|
JP2002537769A
(ja)
|
1999-02-26 |
2002-11-12 |
ヒューマン ジノーム サイエンシーズ， インコーポレイテッド |
ヒトエンドカインαおよび使用方法
|
|
ES2421720T3
(es)
|
1999-04-12 |
2013-09-05 |
Genentech Inc |
Homólogos del factor de necrosis tumoral y ácidos nucleicos que los codifican
|
|
US20030022233A1
(en)
*
|
1999-04-30 |
2003-01-30 |
Raymond G. Goodwin |
Methods of use of the taci/taci-l interaction
|
|
WO2000068378A1
(en)
*
|
1999-05-06 |
2000-11-16 |
National Jewish Medical And Research Center |
Tall-1 nucleic acid molecules, proteins, receptors and methods of use thereof
|
|
MXPA01013236A
(es)
|
1999-06-28 |
2002-06-21 |
Genentech Inc |
Metodos para hacer ligando apo-2 mediante el uso de iones metalicos divalentes.
|
|
TR200201063T2
(tr)
|
1999-08-17 |
2002-10-21 |
Biogen Inc. |
Bağışıklığı düzenleyici bir madde olan BAFF reseptörü (BCMA)
|
|
UA74798C2
(uk)
|
1999-10-06 |
2006-02-15 |
Байоджен Айдек Ма Інк. |
Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
|
|
WO2001058949A2
(en)
|
2000-02-11 |
2001-08-16 |
Biogen, Inc. |
Heterologous polypeptide of the tnf family
|
|
DK1255558T3
(da)
|
2000-02-16 |
2006-10-23 |
Genentech Inc |
Anti-april antistoffer og hybridomaceller
|
|
US6969519B2
(en)
|
2000-03-10 |
2005-11-29 |
Human Genome Sciences, Inc. |
Methods of using an agonistic antibody human tumor necrosis factor receptor (TR17)
|
|
JP2003531588A
(ja)
|
2000-04-11 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
多価抗体とその用途
|
|
AU2001264563A1
(en)
|
2000-04-12 |
2001-10-30 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
ES2287130T3
(es)
|
2000-05-12 |
2007-12-16 |
Amgen Inc. |
Polipeptidos para inhibir la proliferacion de celulas b y t inducida por april.
|
|
AU2001282856A1
(en)
|
2000-06-15 |
2001-12-24 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor delta and epsilon
|
|
US7879328B2
(en)
|
2000-06-16 |
2011-02-01 |
Human Genome Sciences, Inc. |
Antibodies that immunospecifically bind to B lymphocyte stimulator
|
|
US7220840B2
(en)
|
2000-06-16 |
2007-05-22 |
Human Genome Sciences, Inc. |
Antibodies that immunospecifically bind to B lymphocyte stimulator protein
|
|
EP2281843B1
(en)
|
2000-06-16 |
2016-10-12 |
Human Genome Sciences, Inc. |
Antibodies that immunospecifically bind to BLyS
|
|
DK1303293T3
(da)
|
2000-07-27 |
2009-03-30 |
Genentech Inc |
Sekventiel indgivelse af CPT-11 og APO-2L-polypeptid
|
|
AU2001288260A1
(en)
*
|
2000-08-15 |
2002-03-13 |
Human Genome Sciences, Inc. |
Neutrokine-alpha and neutrokine-alpha splice variant
|
|
WO2002016411A2
(en)
|
2000-08-18 |
2002-02-28 |
Human Genome Sciences, Inc. |
Binding polypeptides and methods based thereon
|
|
UA83458C2
(uk)
|
2000-09-18 |
2008-07-25 |
Байоджен Айдек Ма Інк. |
Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
|
|
EP2301971A1
(en)
|
2001-02-20 |
2011-03-30 |
ZymoGenetics, L.L.C. |
Antibodies that bind both BCMA and TACI
|
|
JP4516719B2
(ja)
|
2001-05-11 |
2010-08-04 |
アムジエン・インコーポレーテツド |
Ｔａｌｌ−１と結合するペプチド及び関連分子
|
|
ATE542545T1
(de)
|
2001-05-24 |
2012-02-15 |
Zymogenetics Inc |
Taci-immunoglobulin-fusionsproteine
|
|
NZ529359A
(en)
|
2001-05-25 |
2007-04-27 |
Human Genome Sciences Inc |
Antibodies that immunospecifically bind to a TR4 polypeptide or polypeptide fragment or variant of TR4 and their use in a medicament for treating cancer
|
|
CA2451680C
(en)
|
2001-07-03 |
2011-04-19 |
Genentech, Inc. |
Human dr4 antibodies and uses thereof
|
|
AR035119A1
(es)
|
2001-08-16 |
2004-04-14 |
Lilly Co Eli |
Anticuerpos humanos antagonistas anti-htnfsf13b
|
|
CA2461292A1
(en)
|
2001-10-02 |
2003-04-10 |
Genentech, Inc. |
Apo-2 ligand variants and uses thereof
|
|
EP1507793A4
(en)
*
|
2001-10-17 |
2006-02-01 |
Human Genome Sciences Inc |
NEUTROKIN ALPHA AND NEUTROKIN ALPHA SPLICE VERSION
|
|
US7741282B2
(en)
|
2001-11-13 |
2010-06-22 |
Genentech, Inc. |
ApO2 ligand/TRAIL formulations
|
|
US7741285B2
(en)
|
2001-11-13 |
2010-06-22 |
Genentech, Inc. |
APO-2 ligand/trail formulations
|
|
US7842668B1
(en)
|
2001-11-13 |
2010-11-30 |
Genentech, Inc. |
Apo-2 ligand/trail formulations
|
|
ES2545090T3
(es)
|
2001-12-21 |
2015-09-08 |
Human Genome Sciences, Inc. |
Proteínas de fusión de albúmina y GCSF
|
|
CA2489348A1
(en)
|
2002-06-24 |
2003-12-31 |
Genentech, Inc. |
Apo-2 ligand/trail variants and uses thereof
|
|
AU2003299819A1
(en)
*
|
2002-12-23 |
2004-07-22 |
Human Genome Sciences, Inc. |
Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof
|
|
CA2520097C
(en)
|
2003-03-28 |
2014-10-07 |
Biogen Idec Ma Inc. |
Truncated baff receptors
|
|
NZ543712A
(en)
|
2003-06-05 |
2008-06-30 |
Genentech Inc |
Combination therapy for B cell disorders
|
|
WO2005051994A2
(en)
*
|
2003-11-21 |
2005-06-09 |
Zymogenetics, Inc. |
Ztnf11, a tumor necrosis factor
|
|
CA2554526A1
(en)
*
|
2004-01-29 |
2005-08-18 |
Genentech, Inc. |
Variants of the extracellular domain of bcma and uses thereof
|
|
WO2006002472A1
(en)
|
2004-07-02 |
2006-01-12 |
Bio-Layer Pty Ltd |
Use of metal complexes
|
|
NZ578983A
(en)
|
2004-08-06 |
2011-03-31 |
Genentech Inc |
Assays and methods to detect biomarkers predictive of sensitivity to Apo2L/TRAIL
|
|
WO2006017859A2
(en)
|
2004-08-06 |
2006-02-16 |
Genentech, Inc. |
Assays and methods using biomarkers
|
|
EP1801231B1
(en)
|
2004-09-15 |
2011-11-30 |
Kowa Co., Ltd. |
Method of screening baff suppressor or inhibitor
|
|
ZA200702335B
(en)
|
2004-10-05 |
2009-05-27 |
Genentech Inc |
Method for treating vasculitis
|
|
EP2332563A3
(en)
|
2004-10-13 |
2013-03-13 |
The Washington University |
Use of BAFF to treat sepsis
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
EP1836224A1
(en)
|
2004-12-23 |
2007-09-26 |
Laboratoires Serono S.A. |
Bcma polypeptides and uses thereof
|
|
US8029783B2
(en)
|
2005-02-02 |
2011-10-04 |
Genentech, Inc. |
DR5 antibodies and articles of manufacture containing same
|
|
ZA200801354B
(en)
|
2005-08-09 |
2009-08-26 |
Ares Trading Sa |
Methods for treating B-cell malignancies using TACI-lg fusion molecule
|
|
EP1922079A2
(en)
|
2005-08-09 |
2008-05-21 |
ZymoGenetics, Inc. |
Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules
|
|
EP1915626B1
(en)
|
2005-08-16 |
2011-11-09 |
Genentech, Inc. |
Apoptosis sensitivity to apo2l/trail by testing for galnac-t14 expression in cells/tissues
|
|
KR20140077946A
(ko)
|
2005-10-13 |
2014-06-24 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
자가항체 양성 질환 환자의 치료에 유용한 방법 및 조성물
|
|
US9168286B2
(en)
|
2005-10-13 |
2015-10-27 |
Human Genome Sciences, Inc. |
Methods and compositions for use in treatment of patients with autoantibody positive disease
|
|
MY149159A
(en)
|
2005-11-15 |
2013-07-31 |
Hoffmann La Roche |
Method for treating joint damage
|
|
CA2629306A1
(en)
|
2005-11-23 |
2007-05-31 |
Genentech, Inc. |
Methods and compositions related to b cell assays
|
|
WO2007123765A2
(en)
|
2006-03-31 |
2007-11-01 |
Human Genome Sciences Inc. |
Neutrokine-alpha and neutrokine-alpha splice variant
|
|
US8784812B2
(en)
|
2006-05-15 |
2014-07-22 |
Zymogenetics, Inc. |
Methods for treating autoimmune diseases using a TACI-Ig fusion molecule
|
|
KR102025502B1
(ko)
|
2008-09-26 |
2019-09-25 |
토카겐 인크. |
유전자 요법 벡터와 시토신 디아미나아제
|
|
BRPI0921837A2
(pt)
|
2008-11-25 |
2016-01-12 |
Biogen Idec Inc |
anticorpos isolados ou fragmentos de antígeno de ligação dos mesmos que podem se ligar especificamente a um polipeptídio dr6, métodos in vitro de promover a sobrevivência de uma célula do sistema nervoso, usos de um antagonista dr6 e métodos in vitro de inibir a ligação de dr6 com p75
|
|
WO2010075249A2
(en)
|
2008-12-22 |
2010-07-01 |
Genentech, Inc. |
A method for treating rheumatoid arthritis with b-cell antagonists
|
|
EP3211094A3
(en)
|
2009-09-03 |
2017-11-01 |
F. Hoffmann-La Roche AG |
Methods for treating, diagnosing, and monitoring rheumatoid arthritis
|
|
JP5996549B2
(ja)
|
2010-11-19 |
2016-09-21 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
中和抗ｃｃｌ２０抗体
|
|
CN103502472B
(zh)
|
2011-02-28 |
2017-06-06 |
弗·哈夫曼-拉罗切有限公司 |
生物标记物和用于预测对b‑细胞拮抗剂的响应的方法
|
|
WO2013116287A1
(en)
|
2012-01-31 |
2013-08-08 |
Genentech, Inc. |
Anti-ig-e m1' antibodies and methods using same
|
|
CN103421113B
(zh)
*
|
2012-05-22 |
2018-01-19 |
武汉华鑫康源生物医药有限公司 |
抗BLyS抗体
|
|
EP2909324B1
(en)
|
2012-10-25 |
2020-02-26 |
Tocagen Inc. |
Retroviral vector with mini-promoter cassette
|
|
PH12022550138A1
(en)
|
2013-03-13 |
2023-03-06 |
Amgen Inc |
Proteins specific for baff and b7rp1 and uses thereof
|
|
US9458246B2
(en)
|
2013-03-13 |
2016-10-04 |
Amgen Inc. |
Proteins specific for BAFF and B7RP1
|
|
DE102014018663A1
(de)
|
2014-12-13 |
2015-03-05 |
Heinz Kiefer |
Nachweis von vermehrungsfähigen Zellen zur Überprüfung von Arzneimittel-Wirkstoffangaben bei Zulassungsverfahren
|
|
AR104368A1
(es)
|
2015-04-03 |
2017-07-19 |
Lilly Co Eli |
Anticuerpos biespecíficos anti-cd20- / anti-baff
|
|
CN115812077A
(zh)
|
2020-05-08 |
2023-03-17 |
高山免疫科学股份有限公司 |
April和baff抑制性免疫调节蛋白及其使用方法
|
|
AU2022269139A1
(en)
|
2021-05-07 |
2023-11-16 |
Alpine Immune Sciences, Inc. |
Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein
|
|
CN113238061B
(zh)
*
|
2021-07-09 |
2021-10-01 |
中南大学湘雅医院 |
以cd180阴性b细胞指示重症肌无力病情的试剂盒及应用
|
|
KR20250099778A
(ko)
|
2022-10-04 |
2025-07-02 |
알파인 이뮨 사이언시즈, 인코포레이티드 |
자가항체-매개 질환의 치료에 사용하기 위한 돌연변이된 taci-fc 융합 단백질
|
|
CN119799684A
(zh)
*
|
2024-12-27 |
2025-04-11 |
深圳先进技术研究院 |
一种靶向无害梭菌的抗菌蛋白及其制备方法与应用
|