JP2001502297A - 医薬用化合物 - Google Patents

医薬用化合物

Info

Publication number
JP2001502297A
JP2001502297A JP10511080A JP51108098A JP2001502297A JP 2001502297 A JP2001502297 A JP 2001502297A JP 10511080 A JP10511080 A JP 10511080A JP 51108098 A JP51108098 A JP 51108098A JP 2001502297 A JP2001502297 A JP 2001502297A
Authority
JP
Japan
Prior art keywords
group
compound
alkyl
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10511080A
Other languages
English (en)
Japanese (ja)
Inventor
アル―アウォー，リマ・エス
エールハート，ウィリアム・ジェイ
ゴットゥムッカラ，サバラジュ・ブイ
マルティネリ，マイケル・ジェイ
モーアー，エリック・ディ
ムーア，リチャード・イー
マンロー，ジョン・イー
ノーマン，ブライアン・エイチ
ペイテル，ビノッド・エフ
シー，チュアン
トス，ジョン・イー
バスデバン，ベンカトラガバン
レイ，ジェイムズ・イー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii
Eli Lilly and Co
Original Assignee
University of Hawaii
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1996/013855 external-priority patent/WO1997007798A1/en
Application filed by University of Hawaii, Eli Lilly and Co filed Critical University of Hawaii
Publication of JP2001502297A publication Critical patent/JP2001502297A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP10511080A 1996-08-30 1997-08-29 医薬用化合物 Pending JP2001502297A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
PCT/US1996/013855 WO1997007798A1 (en) 1995-08-30 1996-08-30 Pharmaceutical compounds
US3898997P 1997-02-26 1997-02-26
US60/038,989 1997-02-26
US3952997P 1997-03-03 1997-03-03
US96/13855 1997-03-03
US60/039,529 1997-03-03
PCT/US1997/015245 WO1998008506A1 (en) 1996-08-30 1997-08-29 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
JP2001502297A true JP2001502297A (ja) 2001-02-20

Family

ID=27365489

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10511080A Pending JP2001502297A (ja) 1996-08-30 1997-08-29 医薬用化合物

Country Status (5)

Country Link
EP (1) EP0957912A1 (zh)
JP (1) JP2001502297A (zh)
AU (1) AU4330097A (zh)
CA (1) CA2263420A1 (zh)
WO (1) WO1998008506A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0869786B1 (en) * 1995-12-22 2003-03-05 Eli Lilly And Company Pharmaceutical compounds
JP2001500484A (ja) * 1996-08-30 2001-01-16 イーライ・リリー・アンド・カンパニー 医薬化合物の製造法
EP0929556A4 (en) * 1996-09-06 2001-04-18 Lilly Co Eli PROCESS AND NEW INTERMEDIATES
WO1998009988A1 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process to prepare pharmaceutical compounds
JP2001513775A (ja) * 1997-02-26 2001-09-04 イーライ・リリー・アンド・カンパニー トリペプチドおよびテトラペプチド医薬化合物
EA002547B1 (ru) * 1997-02-26 2002-06-27 Эли Лилли Энд Компани Способ селективного эпоксидирования для получения лекарственных соединений
US6180679B1 (en) * 1998-04-07 2001-01-30 Eli Lilly And Company Method for treating fungal infections
US6103913A (en) * 1998-10-16 2000-08-15 Eli Lilly And Company Process for preparing enollactone derivatives
US6376230B1 (en) 1998-10-16 2002-04-23 Eli Lilly And Company Stereoselective process for producing intermediates of cryptophycins
US7303749B1 (en) 1999-10-01 2007-12-04 Immunogen Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
JP2006516275A (ja) * 2003-01-22 2006-06-29 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー シクロプロピルβ−アミノ酸誘導体
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69427706T2 (de) * 1993-12-21 2001-10-25 Univ Hawaii Honolulu Cryptophycine
JP2000501067A (ja) * 1995-08-30 2000-02-02 イーライ・リリー・アンド・カンパニー 医薬化合物
ATE201018T1 (de) * 1996-02-27 2001-05-15 Lilly Co Eli Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel

Also Published As

Publication number Publication date
EP0957912A1 (en) 1999-11-24
WO1998008506A1 (en) 1998-03-05
CA2263420A1 (en) 1998-03-05
EP0957912A4 (zh) 1999-12-22
AU4330097A (en) 1998-03-19

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