JP2001501607A - 免疫調節のためのｃｄ４５ｒ白血球抗原に対する抗体の利用 - Google Patents
免疫調節のためのｃｄ４５ｒ白血球抗原に対する抗体の利用Info
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- JP2001501607A JP2001501607A JP10514798A JP51479898A JP2001501607A JP 2001501607 A JP2001501607 A JP 2001501607A JP 10514798 A JP10514798 A JP 10514798A JP 51479898 A JP51479898 A JP 51479898A JP 2001501607 A JP2001501607 A JP 2001501607A
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- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000003153 stable transfection Methods 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000024664 tolerance induction Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/715,342 US6106834A (en) | 1993-06-02 | 1996-09-18 | Use of anti-CD45 leukocyte antigen antibodies for immunomodulation |
| US08/715,342 | 1996-09-18 | ||
| PCT/US1997/016321 WO1998011918A1 (en) | 1996-09-18 | 1997-09-17 | Use of antibodies to cd45r leukocyte antigens for immunomodulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001501607A true JP2001501607A (ja) | 2001-02-06 |
| JP2001501607A5 JP2001501607A5 (enExample) | 2005-05-12 |
Family
ID=24873646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10514798A Ceased JP2001501607A (ja) | 1996-09-18 | 1997-09-17 | 免疫調節のためのｃｄ４５ｒ白血球抗原に対する抗体の利用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6106834A (enExample) |
| EP (1) | EP0939652B1 (enExample) |
| JP (1) | JP2001501607A (enExample) |
| AT (1) | ATE301471T1 (enExample) |
| CA (1) | CA2266684A1 (enExample) |
| DE (1) | DE69733960T2 (enExample) |
| ES (1) | ES2247638T3 (enExample) |
| WO (1) | WO1998011918A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009034108A (ja) * | 2001-02-12 | 2009-02-19 | Novartis Ag | 治療用結合性分子 |
| WO2013021784A1 (ja) * | 2011-08-10 | 2013-02-14 | ナパジェン ファーマ，インコーポレテッド | 免疫寛容誘導剤 |
| JP2017527541A (ja) * | 2014-08-01 | 2017-09-21 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 薬物としての使用のための抗ｃｄ４５ｒｃ抗体 |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7014998B2 (en) | 2000-09-30 | 2006-03-21 | Yale University | Screening immunomodulatory agents by CTLA-4 upregulation |
| US20050069538A1 (en) * | 2003-09-18 | 2005-03-31 | Gregorio Aversa | Therapeutic binding molecules |
| WO2003048327A2 (en) * | 2001-12-03 | 2003-06-12 | Abgenix, Inc. | Anti-cd45rb antibodies for use in treating autoimmune disease and transplant rejection |
| EP2075256A2 (en) | 2002-01-14 | 2009-07-01 | William Herman | Multispecific binding molecules |
| WO2003061695A1 (en) * | 2002-01-17 | 2003-07-31 | Amgen Inc. | Methods of regulating cytokine receptor signaling |
| AU2003279657A1 (en) * | 2002-07-01 | 2004-01-19 | Savient Pharmaceuticals, Inc. | Compositions and methods for therapeutic treatment |
| AU2003263043A1 (en) * | 2002-08-28 | 2004-03-19 | Sangstat Medical Corporation | Methods and compostions for immune tolerance |
| US20040047858A1 (en) * | 2002-09-11 | 2004-03-11 | Blumberg Richard S. | Therapeutic anti-BGP(C-CAM1) antibodies and uses thereof |
| CA2535583A1 (en) * | 2003-08-25 | 2005-03-03 | Pangenetics B.V. | Method of inducing immune tolerance |
| KR20060079232A (ko) * | 2003-09-18 | 2006-07-05 | 노파르티스 아게 | 치료용 결합 분자 |
| WO2007092196A2 (en) * | 2006-01-27 | 2007-08-16 | Cellerant Therapeutics, Inc. | Compositions and methods for treating myeloid proliferative disorders |
| WO2007140457A2 (en) * | 2006-05-31 | 2007-12-06 | Genzyme Corporation | Methods of using anti-thymocyte globulin and related agents |
| EP2789625B1 (en) | 2006-08-18 | 2018-06-06 | Argos Therapeutics, Inc. | Use of soluble CD83 for perfusing a tissue for transplantation |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| EP2127671B1 (en) | 2007-02-07 | 2016-09-14 | Nec Corporation | Therapeutic agent for cancer |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| US9713636B2 (en) | 2011-02-28 | 2017-07-25 | Napajen Pharma, Inc. | Nucleic acid/polysaccharide complex |
| GB201409558D0 (en) | 2014-05-29 | 2014-07-16 | Ucb Biopharma Sprl | Method |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| GB201412659D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
| GB201601073D0 (en) * | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| HK1258726A1 (zh) | 2015-09-28 | 2019-11-15 | Regents Of The University Of Minnesota | 嵌合抗原受体(car)t细胞作为获得自体免疫和同种免疫的治疗性干预 |
| GB201521393D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521382D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521391D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521383D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl And Ucb Celltech | Method |
| GB201521389D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Method |
| JP2019522050A (ja) | 2016-06-17 | 2019-08-08 | マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 細胞の枯渇のための組成物および方法 |
| US10111966B2 (en) | 2016-06-17 | 2018-10-30 | Magenta Therapeutics, Inc. | Methods for the depletion of CD117+ cells |
| US20190315878A1 (en) | 2016-11-07 | 2019-10-17 | Argos Therapeutics Inc. | Bispecific antibodies that modulate tlr-4 signaling and uses thereof |
| US10576161B2 (en) | 2017-01-20 | 2020-03-03 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD137+ cells |
| EP3514541A1 (de) * | 2018-01-17 | 2019-07-24 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors |
| CA3128518A1 (en) * | 2019-02-01 | 2020-08-06 | Actinium Pharmaceuticals, Inc. | Molecules and their derivatives directed against cd45 |
| CN111707833A (zh) * | 2020-06-19 | 2020-09-25 | 徐州医科大学 | 小鼠血管内外淋巴细胞识别的方法及其应用 |
| JP2024500189A (ja) | 2020-12-21 | 2024-01-04 | アロジーン セラピューティクス，インコーポレイテッド | プロテアーゼ活性化ｃｄ４５ゲートｃａｒ |
| MX2023009100A (es) | 2021-02-03 | 2023-09-25 | Mozart Therapeutics Inc | Agentes aglutinantes y métodos para usar los mismos. |
| CN116997654A (zh) | 2021-03-17 | 2023-11-03 | 第一三共株式会社 | 编码抗乙酰胆碱受体自身抗体的嵌合受体的基因 |
| WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
| US20230399375A1 (en) | 2022-04-15 | 2023-12-14 | Kyverna Therapeutics, Inc. | Methods and compositions for treating autoimmune disease |
| WO2023240064A1 (en) | 2022-06-08 | 2023-12-14 | Kyverna Therapeutics, Inc. | Methods and compositions for treating autoimmune disease |
| CN120554513B (zh) * | 2025-07-28 | 2025-11-21 | 杭州华大生命科学研究院 | 一种抗cd45抗体及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4626507A (en) * | 1980-09-25 | 1986-12-02 | The Salk Institute For Biological Studies | Hybridomas producing monoclonal antibodies specific for a human cell surface glycoprotein |
| US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
| EP0496806A1 (en) * | 1989-10-20 | 1992-08-05 | Lynxvale Limited | Materials and methods for the treatment of foreign tissue |
| HUT60768A (en) * | 1990-03-16 | 1992-10-28 | Sandoz Ag | Process for producing cd25 fixing molecules |
| DK0606217T4 (da) * | 1991-06-27 | 2009-03-30 | Bristol Myers Squibb Co | CTL4-receptor, fusionsproteiner indeholdende den samt anvendelse deraf |
| US6024957A (en) * | 1993-06-02 | 2000-02-15 | Research Corporation Technologies, Inc. | Immunomodulators and methods for the prevention and reversal of organ transplant rejection using same |
| GB9323542D0 (en) * | 1993-11-15 | 1994-01-05 | Univ Alberta | Lymphocyte marker specific for corhn's disease |
| US5565491A (en) * | 1994-01-31 | 1996-10-15 | Bristol-Myers Squibb Company | Use of phosphotyrosine phospatase inhibitors for controlling cellular proliferation |
| US6174710B1 (en) | 1994-08-09 | 2001-01-16 | Pfizer Inc. | Spirolaxine derivatives for treating gastrobuodenal diseases |
-
1996
- 1996-09-18 US US08/715,342 patent/US6106834A/en not_active Expired - Fee Related
-
1997
- 1997-09-17 WO PCT/US1997/016321 patent/WO1998011918A1/en not_active Ceased
- 1997-09-17 DE DE69733960T patent/DE69733960T2/de not_active Expired - Fee Related
- 1997-09-17 ES ES97943316T patent/ES2247638T3/es not_active Expired - Lifetime
- 1997-09-17 AT AT97943316T patent/ATE301471T1/de not_active IP Right Cessation
- 1997-09-17 CA CA002266684A patent/CA2266684A1/en not_active Abandoned
- 1997-09-17 JP JP10514798A patent/JP2001501607A/ja not_active Ceased
- 1997-09-17 EP EP97943316A patent/EP0939652B1/en not_active Expired - Lifetime
-
1999
- 1999-06-17 US US09/335,865 patent/US6379668B1/en not_active Expired - Fee Related
-
2002
- 2002-03-19 US US10/102,072 patent/US7160987B2/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009034108A (ja) * | 2001-02-12 | 2009-02-19 | Novartis Ag | 治療用結合性分子 |
| WO2013021784A1 (ja) * | 2011-08-10 | 2013-02-14 | ナパジェン ファーマ，インコーポレテッド | 免疫寛容誘導剤 |
| JPWO2013021784A1 (ja) * | 2011-08-10 | 2015-03-05 | ナパジェン ファーマ, インコーポレテッドNapaJen Pharma, Inc. | 免疫寛容誘導剤 |
| JP2017527541A (ja) * | 2014-08-01 | 2017-09-21 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 薬物としての使用のための抗ｃｄ４５ｒｃ抗体 |
| JP2020055843A (ja) * | 2014-08-01 | 2020-04-09 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 薬物としての使用のための抗ｃｄ４５ｒｃ抗体 |
| JP7015820B2 (ja) | 2014-08-01 | 2022-02-03 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 薬物としての使用のための抗ｃｄ４５ｒｃ抗体 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0939652A1 (en) | 1999-09-08 |
| EP0939652B1 (en) | 2005-08-10 |
| CA2266684A1 (en) | 1998-03-26 |
| WO1998011918A1 (en) | 1998-03-26 |
| US6106834A (en) | 2000-08-22 |
| US7160987B2 (en) | 2007-01-09 |
| DE69733960D1 (de) | 2005-09-15 |
| US6379668B1 (en) | 2002-04-30 |
| ES2247638T3 (es) | 2006-03-01 |
| ATE301471T1 (de) | 2005-08-15 |
| DE69733960T2 (de) | 2006-05-24 |
| US20020168362A1 (en) | 2002-11-14 |
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