JP2000513214A - 軟骨内及び骨軟骨欠損を修復するための軟骨組織及びインプラントの製造方法並びにその方法を実施するための配置 - Google Patents
軟骨内及び骨軟骨欠損を修復するための軟骨組織及びインプラントの製造方法並びにその方法を実施するための配置Info
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- JP2000513214A JP2000513214A JP10500061A JP50006198A JP2000513214A JP 2000513214 A JP2000513214 A JP 2000513214A JP 10500061 A JP10500061 A JP 10500061A JP 50006198 A JP50006198 A JP 50006198A JP 2000513214 A JP2000513214 A JP 2000513214A
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- JP
- Japan
- Prior art keywords
- cartilage
- cell
- cells
- plate
- bone substitute
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 軟骨組織及び軟骨組織を含有するインプラントを生体外で製造する方法 であって、前記方法が細胞外軟骨基質を産生する能力を有する生体の細胞から出 発しており、細胞が細胞隙1cm3当たり約5×107〜109cellの細胞密 度で細胞隙(1)内に持ち込まれること、細胞外基質を形成するために細胞が細 胞隙(1)内に残されること、それによって細胞隙(1)が少なくとも部分的に これを取り囲んでいる培地隙(2)から半透膜壁又は対流障壁として機能する開 放有孔性壁によって分離されることを特徴とする方法。 2. 細胞隙(1)内に持ち込まれる細胞が軟骨細胞、間葉幹細胞、線維芽細 胞又は前記細胞の混合物であること、又は少なくとも1つの前記細胞の型を含有 している組織粒子が細胞隙(1)内に持ち込まれることを特徴とする請求項1に 記載の方法。 3. 細胞が細胞隙(1)内に持ち込まれる前に細胞培養で増殖させられるこ とを特徴とする請求項2に記載の方法。 4. 培養期間中に細胞隙(1)が培地隙(2)内に静止して配置される又は その中で運動させられること、及び少なくとも細胞隙壁の一部が10.000〜 100.000ダルトンの透過性を有する半透膜からなることを特徴とする請求 項1〜3のいずれか1項に記載の方法。 5. 骨代用物質から作られている開放有孔性の剛性又は可塑性に変形可能な プレート7が細胞隙内に配置されていることを特徴とする請求項4に記載の方法 。 6. 細胞隙(1)が培養期間中に培地隙(2)内に静止して配置されている こと、及び少なくとも細胞隙壁の一部が約20μmの径の孔を有する開放有孔層 として設計されていることを特徴とする請求項1〜3のいずれか1項に記載の方 法。 7. 開放有孔層が骨代用物質から作られているプレート(7)であること、 及び細胞隙(1)内に持ち込まれた細胞がプレート(7)上で定着するようにプ レート(7)が配置されるように細胞隙(1)が配置されていることを特徴とす る請求項6に記載の方法。 8. 半透膜(3)によって又は対流障壁として機能する開放有孔層によって 、取り囲んでいる培地隙(2)から少なくとも部分的に分離されている細胞隙( 1)を含んでいることを特徴とする請求項1〜7のいずれか1項に記載の方法を 実施するための配置。 9. 半透膜(3)が10.000〜100.000ダルトンの透過性を有す ることを特徴とする請求項8に記載の配置。 10. 対流障壁として機能する層が1〜20μmの開放有孔性及び0.5〜 30mmの厚さを有することを特徴とする請求項8に記載の配置。 11. 細胞隙(1)が実質的に平行な2つの面を備えた扁平な形状を有して いること、及びこれら2つの面が半透膜(3)又は開放有孔層によって形成され ていることを特徴とする請求項8〜10のいずれか1項に記載の配置。 12. 開放有孔層が生物学的に分解可能な又は分解不可能な骨代用物質から 作られた剛性又は可塑性に変形可能なプレート(7)であること、代用骨プレー ト(7)が細胞隙の底部を形成するように培地隙(2)内の細胞隙が配置されて いることを特徴とする請求項10又は11に記載の配置。 13. 代用骨プレート(7)が細胞隙の内側に面して少なくとも20μmの 範囲の粗さを備えた面を有していることを特徴とする請求項12に記載の配置。 14. 代用骨プレート(7)が細胞隙に面していない側で300〜700μ mの有孔性を有していることを特徴とする請求項12又は13に記載の配置。 15. 細胞隙が代用骨プレート(7)の外側でさらに透過性壁を含有してい ることを特徴とする請求項12〜14のいずれか1項に記載の配置。 16. 細胞隙が請求項12〜15のいずれか1項に記載の配置の一部である 、少なくとも部分的に開放有孔性骨代用物質からなる壁によって限定されている 細胞隙。 17. その表面が生体外で培養された軟骨層(10)で少なくとも部分的に 被覆されている開放有孔性骨代用物質から作られているプレート(7)を含有し ており、それによって前記軟骨層(10)の軟骨組織が骨代用物質にこの物質の 孔及び表面不均一さ内に成長することによって固定されることを特徴とする請求 項5〜7のいずれか1項に記載の方法を用いて製造されるインプラント。 18. 骨代用物質から作られているプレート(7)が、少なくとも軟骨層( 10)に面する領域において、1〜20μmの径の孔を含有しており、0.5〜 30mmの厚さを有していることを特徴とする請求項17に記載のインプラント 。 19. 骨代用物質から作られているプレート(7)が骨代用物質から作られ ている別の部分(12)にセメント層(13)によって連結されていることを特 徴とする請求項17又は18に記載のインプラント。 20. 剛性又は可塑性に変形可能であることを特徴とする請求項17又は1 8に記載のインプラント。 21. 軟骨内又は骨軟骨関節欠損を修復するためのインプラントを製造する ための請求項1〜7のいずれか1項に記載の方法の使用。 22. 耳介骨、鼻軟骨、眼窩底、耳甲介又はそれらの部分を製造するための 請求項1〜4又は6のいずれか1項に記載の方法の使用。 23. 軟骨内又は骨軟骨関節欠損の修復のための請求項17〜20のいずれ か1項に記載のインプラントの使用。
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CH1408/96 | 1996-06-04 | ||
CH140896 | 1996-06-04 | ||
PCT/CH1997/000220 WO1997046665A1 (de) | 1996-06-04 | 1997-06-02 | Verfahren zur herstellung von knorpelgewebe und von implantaten |
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JP2000513214A true JP2000513214A (ja) | 2000-10-10 |
JP3754708B2 JP3754708B2 (ja) | 2006-03-15 |
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EP (1) | EP0922093B1 (ja) |
JP (1) | JP3754708B2 (ja) |
AT (1) | ATE250666T1 (ja) |
DE (1) | DE59710789D1 (ja) |
ES (1) | ES2210526T3 (ja) |
WO (1) | WO1997046665A1 (ja) |
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- 1997-06-02 EP EP97922797A patent/EP0922093B1/de not_active Expired - Lifetime
- 1997-06-02 US US09/194,867 patent/US6242247B1/en not_active Expired - Fee Related
- 1997-06-02 ES ES97922797T patent/ES2210526T3/es not_active Expired - Lifetime
- 1997-06-02 DE DE59710789T patent/DE59710789D1/de not_active Expired - Lifetime
- 1997-06-02 AT AT97922797T patent/ATE250666T1/de not_active IP Right Cessation
- 1997-06-02 WO PCT/CH1997/000220 patent/WO1997046665A1/de active IP Right Grant
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Also Published As
Publication number | Publication date |
---|---|
ES2210526T3 (es) | 2004-07-01 |
WO1997046665A1 (de) | 1997-12-11 |
US6387693B2 (en) | 2002-05-14 |
US20010014473A1 (en) | 2001-08-16 |
JP3754708B2 (ja) | 2006-03-15 |
EP0922093B1 (de) | 2003-09-24 |
EP0922093A1 (de) | 1999-06-16 |
US6242247B1 (en) | 2001-06-05 |
DE59710789D1 (de) | 2003-10-30 |
ATE250666T1 (de) | 2003-10-15 |
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