JP4689600B2 - 軟骨修復用人工器官 - Google Patents
軟骨修復用人工器官 Download PDFInfo
- Publication number
- JP4689600B2 JP4689600B2 JP2006515972A JP2006515972A JP4689600B2 JP 4689600 B2 JP4689600 B2 JP 4689600B2 JP 2006515972 A JP2006515972 A JP 2006515972A JP 2006515972 A JP2006515972 A JP 2006515972A JP 4689600 B2 JP4689600 B2 JP 4689600B2
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- JP
- Japan
- Prior art keywords
- prosthesis
- prosthesis according
- fiber
- cells
- fibers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Manufacturing & Machinery (AREA)
- Rheumatology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Description
これらの目的は請求項1に記載の人工器官により解決される。
従属項は、本発明の人工器官の好適な実施形態に関する。
第1工程において、欠損領域は清潔にされ、及び骨軟骨プラグがチゼルで取り除かれる。特別な機器により深さ及び幅に合わせて底部、及び壁部を正確に整えることができる。請求項1に記載の人工器官は、基底成分(4)の上端が軟骨及び骨を分ける石灰化帯域と同じ高さになるような位置に注意深く圧入される。繊維層(2)の上面は、周囲の軟骨の高さと均等でなければならない。高差は修正し整えても構わない。
手術は、切開、又は関節鏡視下手術のどちらかで実行される。
実施例1
直径5mm、及び高さ10mmの円柱形のβ−リン酸三カルシウム連続多孔質体を軟骨下アンカー(subchondral anchor)として、及び直径25μmのポリメタクリル酸ヒドロキシエチル(pHEMA)配向繊維の4mm層をセメント反応によりアンカーに移植される配向繊維層として、人工器官を作製する。pHEMA繊維の垂直配置はランダムであるが、ぎっしり詰まっている。得られる人工器官は、軟骨修復用の理想的な移植片である。
直径8mm、及び高さ15mmの円柱形のヒドロキシアパタイト連続多孔質体を軟骨下アンカー(subchondral anchor)として、及び直径1μmから50μmの配向したメチルセルロースの化学的誘導体化繊維の4mm層を配向繊維層として、人工器官を作製する。繊維層は縫込みで得られ、及び包埋によりアンカーに化学的に移植される。メチルセルロースの垂直配置は明確な2次元パターンである。得られる人工器官は、軟骨修復用の理想的な移植片である。
直径12mm、及び高さ10mmの円柱形のβ−リン酸三カルシウムと硫酸カルシウム組成物の連続多孔質体を軟骨下アンカー(subchondral anchor)として、及び直径0.5μmから30μmのポリプロピレンとポリエーテルエーテルケトンの高配向繊維の5mm混合層を配向繊維層として、人工器官を作製する。繊維の垂直配置はランダムであるが、ぎっしり詰まっている。得られる人工器官は、軟骨修復用の理想的な移植片である。
直径30mm、及び高さ25mmの凸面湾曲している円柱形のβ−リン酸三カルシウム連続多孔質体を軟骨下アンカー(subchondral anchor)として、及び直径約10μmのプルロニック(R)高配向繊維の6mm層を配向繊維層として、人工器官を作製する。繊維の垂直配置はランダムであるが、繊維の5%から80%が最近隣の繊維と架橋する。得られる人工器官は、軟骨修復用の理想的な移植片である。
直径8mm、及び高さ10mmの円柱形のβ−リン酸三カルシウム連続多孔質体を軟骨下アンカー(subchondral anchor)として、及び直径1μmから30μmのアルギン酸塩高配向繊維の3mm層を配向繊維層として、人工器官を作製する。繊維の垂直配置はランダムであるが、繊維の50%から95%が最近隣の繊維と架橋する。層の繊維は繊維層とアンカーの間の境界として機能するセラミック層に包埋される。得られる人工器官は、軟骨修復用の理想的な移植片である。
直径4mm、及び高さ5mmの円柱形のカルシウム欠損ハイドロキシアパタイト(CDHA)連続多孔質体を軟骨下アンカー(subchondral anchor)として、及び直径0.5μmから50μmの高配向キトサン繊維の3mm層を配向繊維層として、人工器官を作製する。繊維の垂直配置はランダムである。層の繊維は繊維層とアンカーの間の選択的境界として機能するセラミック層に包埋される。得られる人工器官は、軟骨修復用の理想的な移植片である。
直径10mm、及び高さ10mmの円柱形のβ−リン酸三カルシウム連続多孔質体を軟骨下アンカー(subchondral anchor)として、及び直径が最大50μmのポリエチレングリコール(PEG)高配向繊維の3mm層を配向繊維層として、人工器官を作製する繊維の垂直配置は、所定のパターンに準じる。繊維の約50%が最近隣の繊維と架橋する。層の繊維は繊維層とアンカーの間の境界として機能するセラミック層に包埋される。得られる人工器官は、軟骨修復用の理想的な移植片である。
直径4mm、及び高さ5mmの円柱形のカルシウム欠損ハイドロキシアパタイト連続多孔質体を軟骨下アンカー(subchondral anchor)として、及びヒアルロン酸繊維をコラーゲン繊維と混合した、どちらの材料も直径が0.1μmから25μmの高配向繊維の3mm層を配向繊維層として、人工器官を作製する。繊維の垂直配置はランダムであるが、繊維の約70%から100%が架橋する。層の繊維は繊維層とアンカーの間の選択的境界として機能するセラミック層に包埋される。得られる人工器官は、軟骨修復用の理想的な移植片である。
2 繊維
3 安定化領域
4 基底成分
Claims (30)
- 軟骨、又は軟骨状組織を修復若しくは置換するための人工器官(1)であって、
少なくとも部分的な配向繊維(2)を含む少なくとも1層、
前記繊維(2)の少なくとも1層を軟骨下環境で固定するための基底成分(4)、及び
前記繊維(2)を含む少なくとも1層と前記基底成分(4)の間に提供される安定化領域(3)
を含み、
前記安定化領域(3)は、前記基底成分(4)及び前記繊維(2)を保持するために前記基底成分(4)と前記繊維(2)との間に機械、物理、又は化学結合で提供され、
前記安定化領域(3)は、追加的材料、化学物質、前記基底成分(4)材料そのもの、前記繊維(2)そのもの、又はこれらの組合せからなり、
前記安定化領域(3)によって定位置に保持される前記繊維(2)は、繊維に面する基底成分の上面に対して垂直方向である人工器官の挿入軸に原則的に並行に配列され、
前記繊維(2)は、ブラシのような構造を形成し、
前記繊維(2)は、50%を超えて人工器官の挿入軸に原則的に並行に配列されることを特徴とする軟骨、又は軟骨状組織を修復若しくは置換するための人工器官(1)。 - 前記繊維(2)は、90%を超えて人工器官の挿入軸に原則的に並行に配列される請求項1に記載の人工器官。
- 前記繊維材料(2)は、鉱物、合成高分子、合成分子、天然高分子、天然分子、生物工学由来の高分子、若しくは分子、生体高分子、又はこれらの組合せを含む請求項1又は2に記載の人工器官。
- 前記繊維径は、50nmから1mmの範囲内である請求項3に記載の人工器官。
- 前記繊維径は、1μmから250μmの範囲内である請求項4に記載の人工器官。
- 前記繊維(2)は、0.1%から99.9%の範囲内の液体吸収能力を有する請求項3から5のいずれかに記載の人工器官。
- 前記液体吸収能力は、20.0%から99.0%の範囲内である請求項6に記載の人工器官。
- 液体は、水溶液、及び/又は体液である請求項6、又は7に記載の人工器官。
- 前記基底成分(4)は、代用骨として使用される材料を含む請求項1から8の少なくとも1つに記載の人工器官。
- 前記代用骨は、請求項3に記載の材料である請求項9に記載の人工器官。
- 前記材料は、次の成分、リン酸カルシウム、硫酸カルシウム、炭酸カルシウム、又はこれらの混合物の少なくとも1つを含む合成セラミックである請求項9に記載の人工器官。
- 前記リン酸カルシウムは、次の成分の少なくとも1つを含む請求項11に記載の人工器官:第二リン酸カルシウム(CaHPO4・2H2O)、無水第二リン酸カルシウム(CaHPO4)、α−リン酸三カルシウム(α−Ca3(PO4)2)、β−リン酸三カルシウム(β−Ca3(PO4)2)、カルシウム欠損ハイドロキシアパタイト(Ca9(PO4)5(HPO4)OH)、ハイドロキシアパタイト(Ca10(PO4)6(OH)2)、炭酸アパタイト(Ca10(PO4)3(CO3)3)(OH)2)、フルオロアパタイト(Ca10(PO4)6(F,OH)2)、クロロアパタイト(Ca10(PO4)6(Cl,OH)2)、ホワイトロッカイト((Ca,Mg)3(PO4)2)、リン酸四カルシウム(Ca4(PO4)2O)、オキシアパタイト(Ca10(PO4)6O)、β−ピロリン酸カルシウム(β−Ca2(P2O7)、α−ピロリン酸カルシウム、γ−ピロリン酸カルシウム、リン酸八カルシウム(Ca8H2(PO4)6・5H2O)。
- 前記材料は、金属、半金属、及び/又は非金属イオン、好ましくはマグネシウム、珪素、ナトリウム、カリウム、及び/又はリチウムを含む合成セラミックである請求項9に記載の人工器官。
- 前記材料は、少なくとも高分子成分、及び鉱物相を含む複合材料である請求項9から11のいずれかに記載の人工器官。
- 前記代用骨材料は、連続孔を伴う高多孔性である請求項9から14のいずれかに記載の人工器官。
- 前記基底成分(4)の形状は、略円筒形又は円錐形である請求項9から15のいずれかに記載の人工器官。
- 前記基底成分(4)の直径は2mmから30mm、高さは1mmから30mmの間で変動する請求項16に記載の人工器官。
- 前記基底成分(4)の直径は4mmから20mm、好適な高さは1mmから6mmの間で変動する請求項16に記載の人工器官。
- 前記安定化領域(3)は、少なくとも1層を含む帯域である請求項1から18の少なくとも1つに記載の人工器官。
- 前記帯域は、1nmから1mmの厚さを有する請求項19に記載の人工器官。
- 前記帯域は、多孔性である請求項19又は20に記載の人工器官。
- 層システムは化学物質からなる請求項19から21のいずれかに記載の人工器官。
- 少なくとも1つの外部から添加される成分を更に含む請求項1から22の少なくとも1つに記載の人工器官。
- 前記成分は、様々な源の細胞である請求項23に記載の人工器官。
- 前記細胞は、自己細胞、同種異系細胞、外因性細胞、トランスフェクト細胞、及び/又は遺伝子組み換え細胞である請求項24に記載の人工器官。
- 軟骨細胞、軟骨前駆細胞、多能性細胞、全能性細胞、又はこれらの組合せは、繊維層(2)中に存在する請求項23、24、又は25に記載の人工器官。
- 骨芽細胞、骨前駆細胞、多能性細胞、全能性細胞、及びこれらの組合せは、基底成分(4)中に存在する請求項23、24、又は25に記載の人工器官。
- 血液、又は血液の1部は基底成分(4)中に存在する請求項23、24、又は25に記載の人工器官。
- 医薬組成物が含まれる請求項23に記載の人工器官。
- 安定化領域(3)は、基底成分(4)からブラシのような繊維構造(2)に細胞、及び血液が拡散するのを防ぐための選択的又は非選択的な細胞境界層である請求項1から29のいずれかに記載の人工器官。
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JP2002501418A (ja) * | 1997-05-30 | 2002-01-15 | オステオバイオロジックス,インコーポレイテッド | 繊維強化多孔性生体分解性移植デバイス |
JP2003102755A (ja) * | 2001-06-28 | 2003-04-08 | Ethicon Inc | ポスト状アンカーを有する組織の修復および再生のための複合スキャフォールド |
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US4553272A (en) * | 1981-02-26 | 1985-11-19 | University Of Pittsburgh | Regeneration of living tissues by growth of isolated cells in porous implant and product thereof |
US5306311A (en) * | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
JPH07503869A (ja) * | 1992-02-14 | 1995-04-27 | ボード・オヴ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム | 多相生侵食性の移植材料または担体並びにその製造および使用方法 |
US6626945B2 (en) * | 2000-03-14 | 2003-09-30 | Chondrosite, Llc | Cartilage repair plug |
US20020091444A1 (en) * | 2001-01-05 | 2002-07-11 | Jun Yang | Vascular tissue composition |
DE10135275A1 (de) * | 2001-07-13 | 2003-01-30 | Jotec Gmbh | Implantat und Verfahren zu seiner Herstellung |
FR2827506A1 (fr) * | 2001-07-20 | 2003-01-24 | Oreal | Composition pulverulente et son utilisation en cosmetique |
DE10312144B4 (de) * | 2003-03-13 | 2006-12-14 | Technische Universität Dresden | Trägermaterial für die Gewebe- und Zellkultur und die Herstellung von Implantatmaterialien |
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JP2002501418A (ja) * | 1997-05-30 | 2002-01-15 | オステオバイオロジックス,インコーポレイテッド | 繊維強化多孔性生体分解性移植デバイス |
JPH11267193A (ja) * | 1998-01-30 | 1999-10-05 | Norbert M Dr Meenen | バイオハイブリッド型関節表面置換物 |
JP2003102755A (ja) * | 2001-06-28 | 2003-04-08 | Ethicon Inc | ポスト状アンカーを有する組織の修復および再生のための複合スキャフォールド |
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WO2005000169A2 (en) | 2005-01-06 |
AU2004251011B2 (en) | 2009-06-18 |
WO2005000169A3 (en) | 2005-02-10 |
AU2004251011A1 (en) | 2005-01-06 |
ATE396669T1 (de) | 2008-06-15 |
ES2322764T3 (es) | 2009-06-26 |
JP2007526779A (ja) | 2007-09-20 |
US20070244484A1 (en) | 2007-10-18 |
EP1635741B1 (en) | 2009-04-15 |
EP1491164A1 (en) | 2004-12-29 |
ES2306826T3 (es) | 2008-11-16 |
DE60321328D1 (de) | 2008-07-10 |
ATE428378T1 (de) | 2009-05-15 |
CA2530307C (en) | 2012-01-03 |
US8163033B2 (en) | 2012-04-24 |
CA2530307A1 (en) | 2005-01-06 |
DE602004020615D1 (de) | 2009-05-28 |
EP1635741A2 (en) | 2006-03-22 |
EP1491164B1 (en) | 2008-05-28 |
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