JP2000512651A5 - - Google Patents
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- Publication number
- JP2000512651A5 JP2000512651A5 JP1998502316A JP50231698A JP2000512651A5 JP 2000512651 A5 JP2000512651 A5 JP 2000512651A5 JP 1998502316 A JP1998502316 A JP 1998502316A JP 50231698 A JP50231698 A JP 50231698A JP 2000512651 A5 JP2000512651 A5 JP 2000512651A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19624704.7 | 1996-06-20 | ||
| DE19624704A DE19624704A1 (de) | 1996-06-20 | 1996-06-20 | Neue Pyridylalkansäureamide |
| PCT/EP1997/003243 WO1997048695A1 (en) | 1996-06-20 | 1997-06-20 | New pyridyl alkane acid amides as cytostatics and immunosuppressives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000512651A JP2000512651A (ja) | 2000-09-26 |
| JP2000512651A5 true JP2000512651A5 (esLanguage) | 2005-02-10 |
| JP4225571B2 JP4225571B2 (ja) | 2009-02-18 |
Family
ID=7797525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50231698A Expired - Fee Related JP4225571B2 (ja) | 1996-06-20 | 1997-06-20 | 細胞増殖抑制剤および免疫抑制剤としての新規なピリジルアルカン酸アミド類 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6444823B1 (esLanguage) |
| EP (1) | EP0934309B1 (esLanguage) |
| JP (1) | JP4225571B2 (esLanguage) |
| AT (1) | ATE223912T1 (esLanguage) |
| AU (1) | AU3342097A (esLanguage) |
| DE (2) | DE19624704A1 (esLanguage) |
| DK (1) | DK0934309T3 (esLanguage) |
| ES (1) | ES2178779T3 (esLanguage) |
| PT (1) | PT934309E (esLanguage) |
| WO (1) | WO1997048695A1 (esLanguage) |
| ZA (1) | ZA975439B (esLanguage) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| DE19624704A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalkansäureamide |
| US6451816B1 (en) | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
| DE19756235A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
| DE19756212A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
| US6903118B1 (en) | 1997-12-17 | 2005-06-07 | Klinge Pharma Gmbh | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides |
| DE19756261A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide |
| DE19818044A1 (de) * | 1998-04-22 | 1999-10-28 | Klinge Co Chem Pharm Fab | Verwendung von Vitamin-PP-Verbindungen |
| EP1031564A1 (en) | 1999-02-26 | 2000-08-30 | Klinge Pharma GmbH | Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy |
| DE19908483A1 (de) * | 1999-02-26 | 2000-10-05 | Klinge Co Chem Pharm Fab | Inhibitoren der zellulären Niacinamidmononucleotid-Bildung |
| US6172040B1 (en) * | 1999-05-28 | 2001-01-09 | A. Satyanarayan Naidu | Immobilized lactoferrin antimicrobial agents and the use thereof |
| IL155093A0 (en) | 2000-09-29 | 2003-10-31 | Glaxo Group Ltd | Morpholin-acetamide derivatives for the treatment on inflammatory diseases |
| EP1348434A1 (en) * | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Use of pyridyl amides as inhibitors of angiogenesis |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| EA200701745A1 (ru) | 2005-03-17 | 2008-06-30 | Пфайзер, Инк. | Циклопропанкарбоксамидные производные |
| US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| AU2007207746A1 (en) * | 2006-01-17 | 2007-07-26 | Merck & Co., Inc. | 2,5 diaza-bicyclo[2.2.1]heptane derivatives as calcium channel blockers |
| EP2098231A1 (en) | 2008-03-05 | 2009-09-09 | Topotarget Switzerland SA | Use of NAD formation inhibitors for the treatment of ischemia-reperfusion injury |
| WO2010023307A1 (en) | 2008-08-29 | 2010-03-04 | Topotarget A/S | Novel urea and thiourea derivatives |
| US8207155B2 (en) * | 2009-03-31 | 2012-06-26 | Vanderbilt University | Sulfonyl-azetidin-3-yl-methylamine amide analogs as GlyTl inhibitors, methods for making same, and use of same in treating psychiatric disorders |
| EP2453883A1 (en) | 2009-07-17 | 2012-05-23 | Topo Target A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
| KR20130114119A (ko) | 2010-09-03 | 2013-10-16 | 포르마 티엠, 엘엘씨. | Ｎａｍｐｔ의 억제를 위한 신규 화합물 및 조성물 |
| CN103261160A (zh) | 2010-09-03 | 2013-08-21 | 福马Tm有限责任公司 | 用于抑制nampt的胍化合物和组合物 |
| EP2611777B1 (en) | 2010-09-03 | 2016-05-11 | Forma TM, LLC. | N-(4-{[pyridin-3-yl-methyl)carbamoyl]amino}benzene-sulfone derivatives as nampt inhibitors for therapy of diseases such as cancer |
| JP5978293B2 (ja) | 2011-05-04 | 2016-08-24 | フォーマ ティーエム， エルエルシー． | Ｎａｍｐｔを阻害するための新規な化合物および組成物 |
| AR082889A1 (es) | 2011-05-09 | 2013-01-16 | Forma Therapeutics Inc | Compuestos y composiciones para la inhibicion de nampt |
| CN109776494B (zh) * | 2018-12-25 | 2021-06-18 | 中国人民解放军第二军医大学 | 一种多靶点抗肿瘤活性的烟酰胺磷酸核糖转移酶氮芥类抑制剂及其制备与应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4283541A (en) | 1980-05-27 | 1981-08-11 | Usv Pharmaceutical Corporation | Pyridylacyl-hydroxamates |
| NL8005133A (nl) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| JPS57136518A (en) * | 1981-02-18 | 1982-08-23 | Eisai Co Ltd | Immunoregulator |
| US5326772A (en) * | 1984-09-28 | 1994-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Diaryl compounds for their use |
| US4778796A (en) | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| DE3641822A1 (de) * | 1986-12-06 | 1988-06-16 | Goedecke Ag | Verwendung von dihydrophenylaminosaeurederivaten und diese enthaltende arzneimittel zur immunmodulation und cytostase |
| JPS63179869A (ja) * | 1987-01-20 | 1988-07-23 | Dainippon Pharmaceut Co Ltd | ピペリジン誘導体 |
| JP2832979B2 (ja) * | 1988-02-15 | 1998-12-09 | 武田薬品工業株式会社 | 不飽和カルボン酸アミド誘導体 |
| EP0401256B1 (de) | 1988-02-19 | 1993-05-26 | Byk Gulden Lomberg Chemische Fabrik GmbH | Optisch reines dexniguldipin und dessen derivate zur behandlung von tumorerkrankungen |
| EP0343307A1 (en) * | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinealkanamine derivatives |
| IE903196A1 (en) * | 1989-09-05 | 1991-03-13 | Searle & Co | Substituted n-benzylpiperidine amides |
| IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| WO1991015484A1 (de) * | 1990-04-10 | 1991-10-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyridine als arzneimittel |
| EP0525023A1 (de) * | 1990-04-10 | 1993-02-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue pyridinester |
| US5260323A (en) * | 1990-06-28 | 1993-11-09 | Hoechst Aktiengesellschaft | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use |
| DE4020570A1 (de) * | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung |
| ES2069137T3 (es) * | 1990-07-30 | 1995-05-01 | Takeda Chemical Industries Ltd | Derivados de imidazopiridina y su uso. |
| DE69131842T2 (de) * | 1990-10-05 | 2000-07-27 | Ajinomoto Co., Inc. | Piperidinderivate und ihre Verwendung als antiarrhythmische Wirkstoffe |
| FR2676053B1 (fr) * | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| EP0612729B1 (en) * | 1991-05-10 | 1997-04-23 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, their production and use |
| US5208247A (en) | 1991-08-01 | 1993-05-04 | American Cyanamid Company | Pyridinium compounds which are useful as antagonists of platelet activating factor |
| CA2085954A1 (en) * | 1991-12-24 | 1993-06-25 | Klaus Weidmann | Substituted pyridine n-oxides, processes for their preparation, and their use |
| US5622976A (en) | 1991-12-31 | 1997-04-22 | Fujisawa Pharmaceutical Co., Ltd. | Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity |
| GB9200535D0 (en) | 1992-01-10 | 1992-02-26 | Fujisawa Pharmaceutical Co | New compound |
| IL111235A (en) | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| ES2164717T3 (es) | 1993-10-15 | 2002-03-01 | Schering Corp | Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas. |
| AU698313B2 (en) | 1994-03-14 | 1998-10-29 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents |
| FR2738245B1 (fr) * | 1995-08-28 | 1997-11-21 | Sanofi Sa | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
| US6451816B1 (en) * | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
| DE19624704A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalkansäureamide |
-
1996
- 1996-06-20 DE DE19624704A patent/DE19624704A1/de not_active Ceased
-
1997
- 1997-06-19 ZA ZA9705439A patent/ZA975439B/xx unknown
- 1997-06-20 WO PCT/EP1997/003243 patent/WO1997048695A1/en not_active Ceased
- 1997-06-20 AT AT97929240T patent/ATE223912T1/de active
- 1997-06-20 ES ES97929240T patent/ES2178779T3/es not_active Expired - Lifetime
- 1997-06-20 EP EP97929240A patent/EP0934309B1/en not_active Expired - Lifetime
- 1997-06-20 DK DK97929240T patent/DK0934309T3/da active
- 1997-06-20 PT PT97929240T patent/PT934309E/pt unknown
- 1997-06-20 JP JP50231698A patent/JP4225571B2/ja not_active Expired - Fee Related
- 1997-06-20 AU AU33420/97A patent/AU3342097A/en not_active Abandoned
- 1997-06-20 DE DE69715439T patent/DE69715439T2/de not_active Expired - Lifetime
-
1998
- 1998-12-18 US US09/216,075 patent/US6444823B1/en not_active Expired - Fee Related
-
2002
- 2002-07-30 US US10/208,656 patent/US20040009967A1/en not_active Abandoned
-
2003
- 2003-10-10 US US10/683,509 patent/US7276524B2/en not_active Expired - Fee Related