JP2000511043A - ノッチ経路を用いる最終未分化細胞の操作 - Google Patents
ノッチ経路を用いる最終未分化細胞の操作Info
- Publication number
- JP2000511043A JP2000511043A JP09513747A JP51374797A JP2000511043A JP 2000511043 A JP2000511043 A JP 2000511043A JP 09513747 A JP09513747 A JP 09513747A JP 51374797 A JP51374797 A JP 51374797A JP 2000511043 A JP2000511043 A JP 2000511043A
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- cells
- notch
- cell
- progenitor cells
- progenitor
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0601—Invertebrate cells or tissues, e.g. insect cells; Culture media therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US08/537,210 US5780300A (en) | 1995-09-29 | 1995-09-29 | Manipulation of non-terminally differentiated cells using the notch pathway |
| US537,210 | 1995-09-29 | ||
| PCT/US1996/015651 WO1997011716A1 (en) | 1995-09-29 | 1996-09-27 | Manipulation of non-terminally differentiated cells using the notch pathway |
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| JP2009001970A Division JP2009143934A (ja) | 1995-09-29 | 2009-01-07 | ノッチ経路を用いる最終未分化細胞の操作 |
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| JP2000511043A true JP2000511043A (ja) | 2000-08-29 |
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| JP09513747A Withdrawn JP2000511043A (ja) | 1995-09-29 | 1996-09-27 | ノッチ経路を用いる最終未分化細胞の操作 |
| JP2009001970A Pending JP2009143934A (ja) | 1995-09-29 | 2009-01-07 | ノッチ経路を用いる最終未分化細胞の操作 |
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| JP2009001970A Pending JP2009143934A (ja) | 1995-09-29 | 2009-01-07 | ノッチ経路を用いる最終未分化細胞の操作 |
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|---|---|
| US (4) | US5780300A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0948348B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2000511043A (cg-RX-API-DMAC7.html) |
| AU (1) | AU732629B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2233534C (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997011716A1 (cg-RX-API-DMAC7.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015004762A1 (ja) * | 2013-07-10 | 2015-01-15 | 株式会社日立製作所 | 細胞培養方法、装置、及び細胞シート |
| JP2018506293A (ja) * | 2015-02-24 | 2018-03-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 結合誘発型転写スイッチ及びその使用方法 |
| JP2020072694A (ja) * | 2014-06-04 | 2020-05-14 | フレッド ハッチンソン キャンサー リサーチ センター | Ｎｏｔｃｈ １および／またはＮｏｔｃｈ ２アゴニストを用いた幹細胞の増殖および生着 |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5786158A (en) * | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| US20030225019A1 (en) * | 2002-05-30 | 2003-12-04 | Freier Susan M. | Notch1 inhibitors for inducing apoptosis |
| DE69638023D1 (de) * | 1995-06-28 | 2009-10-22 | Univ Yale | Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden |
| US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
| WO1997048694A1 (en) | 1996-06-20 | 1997-12-24 | Board Of Regents, The University Of Texas System | Compounds and methods for providing pharmacologically active preparations and uses thereof |
| CN1524583A (zh) * | 1996-11-07 | 2004-09-01 | 能够表达Notch-配体的基因在制备用于免疫治疗的药物中的应用 | |
| US6887475B1 (en) | 1996-11-07 | 2005-05-03 | Lorantis Limited | Notch |
| US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
| US20060122373A1 (en) * | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
| US6136952A (en) * | 1997-06-25 | 2000-10-24 | University Of Washington | Human jagged polypeptide, encoding nucleic acids and methods of use |
| US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
| US6692919B1 (en) | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
| SE9802264D0 (sv) * | 1998-06-25 | 1998-06-25 | Neuronova Ab | A method of isolating cells |
| US6541247B1 (en) | 1998-06-25 | 2003-04-01 | Neuronova Ab | Method of isolating ependymal neural stem cells |
| EP1117778A2 (en) * | 1998-10-02 | 2001-07-25 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein |
| GB9824045D0 (en) * | 1998-11-03 | 1998-12-30 | European Molecular Biology Lab Embl | Regulator protein |
| US8084258B2 (en) | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
| JP4652645B2 (ja) * | 1999-07-12 | 2011-03-16 | ゲーリング、ウォルター | Ｎｏｔｃｈ経路を用いた組織型または器官型の操作 |
| US6720173B1 (en) | 1999-11-08 | 2004-04-13 | Lexicon Genetics Incorporated | Human kinase protein and polynucleotides encoding the same |
| US7560275B2 (en) * | 1999-12-30 | 2009-07-14 | Vbi Technologies, L.L.C. | Compositions and methods for generating skin |
| US7575921B2 (en) * | 1999-12-30 | 2009-08-18 | Vbi Technologies, L.L.C. | Spore-like cells and uses thereof |
| US7785882B2 (en) * | 2000-01-18 | 2010-08-31 | Cornell Research Foundation, Inc. | Neuronal progenitor cells from hippocampal tissue and a method for isolating and purifying them |
| US7037493B2 (en) | 2000-05-01 | 2006-05-02 | Cornell Research Foundation, Inc. | Method of inducing neuronal production in the brain and spinal cord |
| WO2001094541A2 (en) * | 2000-06-05 | 2001-12-13 | University Of South Florida | Human mesenchymal progenitor cell |
| US7442390B2 (en) * | 2000-06-05 | 2008-10-28 | University Of South Florida | Method for enhancing engraftment of cells using mesenchymal progenitor cells |
| US6936281B2 (en) * | 2001-03-21 | 2005-08-30 | University Of South Florida | Human mesenchymal progenitor cell |
| US7303769B2 (en) * | 2000-06-05 | 2007-12-04 | University Of South Florida | Method for purifying pluri-differentiated mesenchymal progenitor cells |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US8044259B2 (en) * | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| GB0019242D0 (en) * | 2000-08-04 | 2000-09-27 | Lorantis Ltd | Assay |
| CA2456008A1 (en) * | 2000-08-19 | 2002-02-28 | Axordia Limited | Stem cell differentiation |
| US20020151487A1 (en) * | 2000-08-31 | 2002-10-17 | Loyola University Chicago | Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway |
| WO2002059285A1 (en) * | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| US20020151050A1 (en) * | 2000-10-30 | 2002-10-17 | Vacanti Charles A. | Isolation of spore-like cells from tissues exposed to extreme conditions |
| US6458588B1 (en) | 2001-01-31 | 2002-10-01 | The General Hospital Corporation | Renal stem cells and uses thereof |
| EP1383867A2 (en) * | 2001-03-23 | 2004-01-28 | Axordia Limited | Stem cell differentiation |
| WO2002078449A2 (en) * | 2001-04-02 | 2002-10-10 | Advanced Cell Technology, Inc. | Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells |
| CN1513148A (zh) * | 2001-05-29 | 2004-07-14 | ���µ�����ҵ��ʽ���� | 烹调实绩管理方法、内容管理方法、服务器和烹调设备 |
| WO2002102988A2 (en) * | 2001-06-18 | 2002-12-27 | Psychiatric Genomics, Inc. | Method for neural stem cell differentiation using 5ht-1a agonists |
| AU2002344768A1 (en) * | 2001-06-18 | 2003-01-02 | The General Hospital Corporation | Methods and compositions based on protein interactions with mastermind |
| AU2002315337A1 (en) * | 2001-06-18 | 2003-01-02 | Psychiatric Genomics, Inc. | Method for neural stem cell differentiation using valproate |
| EP1410018A1 (en) * | 2001-07-25 | 2004-04-21 | Lorantis Limited | Method for detecting modultators of notch signalling |
| US7452532B2 (en) * | 2001-09-30 | 2008-11-18 | Scicotec Gmbh | Transluminal application of adult stem cells for body organ tissue repair |
| US20030119080A1 (en) * | 2001-10-15 | 2003-06-26 | Mangano Joseph A. | Strategies for the identification and isolation of cancer stem cells and non-cancerous stem cells |
| AU2002364537A1 (en) * | 2001-12-07 | 2003-06-23 | Regents Of The University Of Michigan | Prospective identification and characterization of breast cancer stem cells |
| CN101584869B (zh) | 2002-02-06 | 2013-03-27 | 桑比欧公司 | 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法 |
| AU2003215297A1 (en) * | 2002-02-15 | 2003-09-09 | Cornell Research Foundation, Inc. | Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein |
| US20050124572A1 (en) * | 2002-06-17 | 2005-06-09 | Freier Susan M. | Compositions and their uses directed to signal tranducers |
| US20040102390A1 (en) * | 2002-11-21 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of Notch3 expression |
| US20040101847A1 (en) * | 2002-11-22 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of Notch2 expression |
| US20040028661A1 (en) * | 2002-08-07 | 2004-02-12 | Bartelmez Stephen H. | Expansion of cells using thrombopoietin and anti-transforming growth factor-beta |
| US20060019256A1 (en) * | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2005014854A1 (en) * | 2003-08-08 | 2005-02-17 | Licentia, Ltd. | Materials and methods for colorectal cancer screening, diagnosis, and therapy |
| US7897384B2 (en) * | 2003-09-08 | 2011-03-01 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US7927599B2 (en) * | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US8257963B2 (en) | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
| WO2005074633A2 (en) * | 2004-02-03 | 2005-08-18 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
| US7837993B2 (en) * | 2004-03-19 | 2010-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for regeneration of aged skeletal muscle tissues |
| AU2006220696B2 (en) | 2005-03-07 | 2010-08-19 | Sanbio, Inc. | Use of neuronal precursor cells for treatment of central nervous system lesions |
| US20060252073A1 (en) * | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
| AU2006259583A1 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US20070099209A1 (en) * | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2007030693A2 (en) * | 2005-09-08 | 2007-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for promoting stem cell proliferation and survival |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| CA2628255C (en) * | 2005-10-31 | 2016-04-19 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| CA2628221A1 (en) | 2005-10-31 | 2007-05-10 | Oncomed Pharmaceuticals, Inc. | Anti-frizzled receptor antibodies for treating cancer |
| US20080019961A1 (en) * | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| PE20080891A1 (es) | 2006-10-19 | 2008-08-25 | Genentech Inc | Anticuerpos anti-notch3 y composiciones que los comprenden |
| RU2461569C2 (ru) | 2006-10-19 | 2012-09-20 | Дженентек, Инк. | Агонистические антитела против notch3 и их применение для лечения notch3-ассоциированных заболеваний |
| AU2007333805B2 (en) | 2006-12-18 | 2013-07-25 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
| WO2008092002A2 (en) * | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| PE20090321A1 (es) * | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
| WO2009026106A1 (en) * | 2007-08-16 | 2009-02-26 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Methods for promoting stem cell proliferation and survival |
| SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| AR073717A1 (es) * | 2008-10-01 | 2010-11-24 | Genentech Inc | Anticuerpos anti-notch2 de murino y humano, y metodos de uso |
| US20100125265A1 (en) * | 2008-11-20 | 2010-05-20 | Medtronic Vascular, Inc. | Cell Delivery System to Induce Cell Growth and Angiogenesis |
| EP2499240A1 (en) | 2009-11-12 | 2012-09-19 | Vbi Technologies, LLC | Subpopulations of spore-like cells and uses thereof |
| WO2011063237A2 (en) | 2009-11-19 | 2011-05-26 | Oncomed Pharmaceuticals, Inc. | Jagged-binding agents and uses thereof |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| CA2795627C (en) | 2010-04-09 | 2023-03-14 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| JP2013523842A (ja) | 2010-04-09 | 2013-06-17 | フレッド ハッチンソン キャンサー リサーチ センター | 造血機能を提供するための組成物および方法 |
| WO2012012803A2 (en) | 2010-07-23 | 2012-01-26 | Advanced Cell Technology, Inc. | Methods for detection of rare subpopulations of cells and highly purified compositions of cells |
| JP2011019520A (ja) * | 2010-08-13 | 2011-02-03 | Walter Gehring | Ｎｏｔｃｈ経路を用いた組織型または器官型の操作 |
| WO2012048276A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| EP2788476B1 (en) | 2011-12-08 | 2019-05-22 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| EP2864476A4 (en) * | 2012-06-14 | 2016-04-06 | Hutchinson Fred Cancer Res | EX-VIVO EXPANSION OF MYOGENIC STEM CELLS THROUGH NOTCH ACTIVATION |
| AU2013334790A1 (en) | 2012-10-23 | 2015-04-30 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
| EP2943566A1 (en) | 2013-01-08 | 2015-11-18 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| CN105873952A (zh) | 2013-10-31 | 2016-08-17 | 弗莱德哈钦森癌症研究中心 | 经修饰的造血干细胞/祖细胞和非t效应细胞及其用途 |
| WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
| WO2016123100A1 (en) | 2015-01-26 | 2016-08-04 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| EP3288569A4 (en) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| KR20250141836A (ko) | 2015-11-04 | 2025-09-29 | 페이트 세러퓨틱스, 인코포레이티드 | 만능 세포의 유전자 조작 |
| SG11201803145RA (en) | 2015-11-04 | 2018-05-30 | Fate Therapeutics Inc | Methods and compositions for inducing hematopoietic cell differentiation |
| RU2747728C2 (ru) | 2015-12-04 | 2021-05-13 | Фред Хатчинсон Кэнсер Рисерч Сентер | Применение размноженных популяций гематопоэтических стволовых клеток/клеток-предшественников |
| WO2017193059A1 (en) | 2016-05-06 | 2017-11-09 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| CN109843929B (zh) | 2016-08-23 | 2024-07-05 | 加利福尼亚大学董事会 | 蛋白水解可切割的嵌合多肽及其使用方法 |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| EP3741861A4 (en) * | 2018-01-19 | 2021-12-08 | Cafa Therapeutics Limited | SYNNOTCH RECEPTOR REGULATED EXPRESSION OF IL12 |
| CA3110089A1 (en) | 2018-08-28 | 2020-03-05 | Fred Hutchinson Cancer Research Center | Methods and compositions for adoptive t cell therapy incorporating induced notch signaling |
| WO2020056170A1 (en) | 2018-09-12 | 2020-03-19 | Fred Hutchinson Cancer Research Center | Reducing cd33 expression to selectively protect therapeutic cells |
| EP4314244B1 (en) | 2021-03-23 | 2025-07-23 | Terumo BCT, Inc. | Cell capture and expansion |
| US20250135039A1 (en) | 2022-02-07 | 2025-05-01 | Ensoma, Inc. | Inhibitor-resistant mgmt modifications and modification of mgmt-encoding nucleic acids |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| CN115925925B (zh) * | 2022-08-23 | 2024-02-06 | 江苏芯超生物科技(集团)有限公司 | 一种诱导脐带间充质干细胞分化并生产细胞因子的方法 |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| IE20030749A1 (en) * | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| IL101728A (en) * | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| US5856441A (en) * | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| WO1992022584A1 (en) * | 1991-06-18 | 1992-12-23 | Caplan Arnold I | Monoclonal antibodies specific for marrow-derived mesenchymal cells |
| WO1993012141A1 (en) * | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US6004924A (en) * | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
| US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5786158A (en) * | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| WO1994007522A1 (en) * | 1992-09-30 | 1994-04-14 | Yale University | Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids |
| AU5168193A (en) * | 1992-09-30 | 1994-04-26 | Medical Research Council | Human homologs of the transducin-like enhancer of split gene and methods based thereon |
| WO1994011401A1 (en) * | 1992-11-17 | 1994-05-26 | Yale University | Human homolog of the e-cadherin gene and methods based thereon |
| JPH08509358A (ja) * | 1992-12-11 | 1996-10-08 | アメリカ合衆国 | 神経内分泌腫瘍で発現されるδ様遺伝子 |
| US5750652A (en) * | 1994-01-21 | 1998-05-12 | Yale University | Deltex proteins |
| US5599576A (en) * | 1995-02-06 | 1997-02-04 | Surface Solutions Laboratories, Inc. | Medical apparatus with scratch-resistant coating and method of making same |
| DE69638023D1 (de) * | 1995-06-28 | 2009-10-22 | Univ Yale | Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden |
| US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
| US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| EP0869802A4 (en) * | 1995-11-22 | 2001-11-14 | Univ Yale | DELTEX PROTEINS, NUCLEIC ACIDS, AND ANTIBODIES OF VERTEBRATES, AS WELL AS THESE PROCEDURES AND COMPOSITIONS |
| CA2256481A1 (en) * | 1996-05-31 | 1997-12-04 | The National American Red Cross | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids |
| WO1998017793A1 (en) * | 1996-10-21 | 1998-04-30 | Hsc Research And Development Limited Partnership | Fringe proteins and notch signalling |
| CN1524583A (zh) * | 1996-11-07 | 2004-09-01 | 能够表达Notch-配体的基因在制备用于免疫治疗的药物中的应用 | |
| AU6952498A (en) * | 1997-04-04 | 1998-10-30 | Millenium Pharmaceuticals, Inc. | Novel human delta3 compositions and therapeutic and diagnostic uses therefor |
| US6664098B1 (en) * | 1997-05-14 | 2003-12-16 | Asahi Kasei Kabushiki Kaisha | Differentiation inhibitory agent |
| US6136952A (en) * | 1997-06-25 | 2000-10-24 | University Of Washington | Human jagged polypeptide, encoding nucleic acids and methods of use |
| US6436650B1 (en) * | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
| US6692919B1 (en) * | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
| US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
| WO2002059285A1 (en) * | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
-
1995
- 1995-09-29 US US08/537,210 patent/US5780300A/en not_active Expired - Lifetime
-
1996
- 1996-09-27 AU AU72649/96A patent/AU732629B2/en not_active Expired
- 1996-09-27 CA CA2233534A patent/CA2233534C/en not_active Expired - Lifetime
- 1996-09-27 EP EP96933960.5A patent/EP0948348B1/en not_active Expired - Lifetime
- 1996-09-27 WO PCT/US1996/015651 patent/WO1997011716A1/en not_active Ceased
- 1996-09-27 JP JP09513747A patent/JP2000511043A/ja not_active Withdrawn
-
1998
- 1998-07-10 US US09/113,825 patent/US6149902A/en not_active Expired - Lifetime
-
2003
- 2003-04-18 US US10/419,026 patent/US20040058443A1/en not_active Abandoned
-
2006
- 2006-11-28 US US11/605,536 patent/US20070166824A1/en not_active Abandoned
-
2009
- 2009-01-07 JP JP2009001970A patent/JP2009143934A/ja active Pending
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| JP7719836B6 (ja) | 2015-02-24 | 2025-09-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 結合誘発型転写スイッチ及びその使用方法 |
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| EP0948348A1 (en) | 1999-10-13 |
| AU7264996A (en) | 1997-04-17 |
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| JP2009143934A (ja) | 2009-07-02 |
| US6149902A (en) | 2000-11-21 |
| US20040058443A1 (en) | 2004-03-25 |
| EP0948348B1 (en) | 2014-01-01 |
| AU732629B2 (en) | 2001-04-26 |
| EP0948348A4 (en) | 2002-05-22 |
| US20070166824A1 (en) | 2007-07-19 |
| US5780300A (en) | 1998-07-14 |
| CA2233534C (en) | 2012-06-05 |
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