|
US6908910B2
(en)
|
1993-08-06 |
2005-06-21 |
The Children's Medical Center Corporation |
Estrogenic compounds as anti-mitotic agents
|
|
US20040214807A1
(en)
*
|
1993-08-06 |
2004-10-28 |
D'amato Robert J. |
Estrogenic compounds as anti-mitotic agents
|
|
US5504074A
(en)
*
|
1993-08-06 |
1996-04-02 |
Children's Medical Center Corporation |
Estrogenic compounds as anti-angiogenic agents
|
|
US6346510B1
(en)
*
|
1995-10-23 |
2002-02-12 |
The Children's Medical Center Corporation |
Therapeutic antiangiogenic endostatin compositions
|
|
DE69734149T2
(de)
*
|
1996-03-15 |
2006-07-06 |
Astrazeneca Ab |
Cinoline derivate und verwendung als heilmittel
|
|
GB9707800D0
(en)
|
1996-05-06 |
1997-06-04 |
Zeneca Ltd |
Chemical compounds
|
|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
IL128994A
(en)
|
1996-09-25 |
2004-12-15 |
Zeneca Ltd |
History of quinoline and naphthyridine and their salts, processes for their preparation, pharmaceutical preparations containing them and their use as medicines
|
|
ES2289791T3
(es)
|
1997-08-22 |
2008-02-01 |
Astrazeneca Ab |
Derivados de oxindolilquinazolina como inhibidores de la angiogenesis.
|
|
US20020002294A1
(en)
*
|
1997-09-24 |
2002-01-03 |
D' Amato Robert J. |
Estrogenic compounds as antiangiogenic agents
|
|
BR9912938B1
(pt)
*
|
1998-08-11 |
2011-06-28 |
|
derivados de isoquinolina, composição que os compreende, processo para preparação e uso dos mesmos.
|
|
AR028802A1
(es)
*
|
1998-08-13 |
2003-05-28 |
Novartis Ag |
El uso de ciertos compuestos de ftalazina para el tratamiento de enfermedades neovasculares oculares
|
|
UA71971C2
(en)
|
1999-06-04 |
2005-01-17 |
Agoron Pharmaceuticals Inc |
Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
|
|
TWI262914B
(en)
|
1999-07-02 |
2006-10-01 |
Agouron Pharma |
Compounds and pharmaceutical compositions for inhibiting protein kinases
|
|
US7141581B2
(en)
|
1999-07-02 |
2006-11-28 |
Agouron Pharmaceuticals, Inc. |
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
|
|
PE20010306A1
(es)
*
|
1999-07-02 |
2001-03-29 |
Agouron Pharma |
Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
|
|
US6271233B1
(en)
|
1999-08-10 |
2001-08-07 |
Ciba Vision Corporation |
Method for treating ocular neovascular diseases
|
|
US7087592B1
(en)
*
|
1999-08-23 |
2006-08-08 |
Entre Med, Inc. |
Compositions comprising purified 2-methoxyestradiol and methods of producing same
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
AU769222B2
(en)
|
1999-11-05 |
2004-01-22 |
Genzyme Corporation |
Quinazoline derivatives as VEGF inhibitors
|
|
YU54202A
(sh)
|
2000-01-18 |
2006-01-16 |
Agouron Pharmaceuticals Inc. |
Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
|
|
HN2001000008A
(es)
|
2000-01-21 |
2003-12-11 |
Inc Agouron Pharmaceuticals |
Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
|
|
JP2003521543A
(ja)
|
2000-02-07 |
2003-07-15 |
アボット ゲーエムベーハー ウント カンパニー カーゲー |
２−ベンゾチアゾリル尿素誘導体およびそのプロテインキナーゼ阻害剤としての使用
|
|
DE60110749T2
(de)
*
|
2000-02-09 |
2006-02-02 |
Novartis Ag |
Pyridinderivative als angiogenese- und/oder vegf-rezeptor-tyrosinkinase-inhibitoren
|
|
WO2001066099A2
(en)
|
2000-03-06 |
2001-09-13 |
Astrazeneca Ab |
Use of quinazoline derivatives as angiogenesis inhibitors
|
|
GB0008269D0
(en)
*
|
2000-04-05 |
2000-05-24 |
Astrazeneca Ab |
Combination chemotherapy
|
|
PT1274692E
(pt)
|
2000-04-07 |
2006-11-30 |
Astrazeneca Ab |
Compostos de quinazolina
|
|
MXPA02010222A
(es)
|
2000-04-18 |
2003-05-23 |
Agouron Pharma |
Pirazoles para inhibir proteina cinasa.
|
|
AU2001279090A1
(en)
|
2000-08-18 |
2002-03-04 |
Agouron Pharmaceuticals, Inc. |
Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting protein kinases
|
|
US20050192258A1
(en)
*
|
2000-08-18 |
2005-09-01 |
Agoston Gregory E. |
Antiangiogenic agents
|
|
US7135581B2
(en)
*
|
2000-08-18 |
2006-11-14 |
Entremed, Inc. |
Antiangiogenic agents
|
|
US6995278B2
(en)
*
|
2000-08-18 |
2006-02-07 |
Entre Med, Inc. |
Antiangiogenic agents
|
|
DE60140456D1
(de)
|
2000-09-01 |
2009-12-24 |
Novartis Vaccines & Diagnostic |
Aza heterocyclische derivate und ihre therapeutische verwendung
|
|
ATE386736T1
(de)
|
2000-09-11 |
2008-03-15 |
Novartis Vaccines & Diagnostic |
Verfahren zur herstellung von benzimidazol-2-yl - chinolinonderivaten
|
|
MXPA03008560A
(es)
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
|
HN2002000156A
(es)
|
2001-07-06 |
2003-11-27 |
Inc Agouron Pharmaceuticals |
Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización.
|
|
AU2003208913A1
(en)
*
|
2002-01-30 |
2003-09-02 |
Entremed, Inc. |
Non-steroidal analogs of 2-methoxyestradiol
|
|
RU2362775C1
(ru)
*
|
2002-02-01 |
2009-07-27 |
Астразенека Аб |
Хиназолиновые соединения
|
|
UA77303C2
(en)
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
|
EP2280003B1
(en)
|
2002-07-15 |
2014-04-02 |
Symphony Evolution, Inc. |
Process for preparing receptor-type kinase modulators
|
|
US7825132B2
(en)
|
2002-08-23 |
2010-11-02 |
Novartis Vaccines And Diagnostics, Inc. |
Inhibition of FGFR3 and treatment of multiple myeloma
|
|
WO2004018419A2
(en)
|
2002-08-23 |
2004-03-04 |
Chiron Corporation |
Benzimidazole quinolinones and uses thereof
|
|
DE60319410T2
(de)
*
|
2002-11-04 |
2009-02-19 |
Astrazeneca Ab |
Chinazolinderivate als src-tyrosinkinaseinhibitoren
|
|
US7268137B2
(en)
*
|
2002-11-07 |
2007-09-11 |
Campochiaro Peter A |
Ocular therapy
|
|
BR0316229A
(pt)
|
2002-11-13 |
2005-10-04 |
Chiron Corp |
Métodos de tratamento de câncer e métodos relacionados
|
|
RS20050430A
(sr)
|
2002-12-19 |
2007-08-03 |
Pfizer Inc., |
Jedinjenja 2-(1h-indazol-6-ilamino)- benzamida kao inhibitori protein kinaza, korisni u tretmanu oftalmoloških bolesti
|
|
AU2004275693A1
(en)
*
|
2003-05-28 |
2005-04-07 |
Entremed, Inc. |
Antiangiogenic agents
|
|
CA2536912C
(en)
|
2003-08-27 |
2015-03-31 |
Eyetech Pharmaceuticals, Inc. |
Combination therapy for the treatment of ocular neovascular disorders
|
|
JP2007504122A
(ja)
|
2003-08-29 |
2007-03-01 |
ファイザー・インク |
新規抗血管形成剤として有用なチエノピリジン−フェニルアセトアミドおよびその誘導体
|
|
PT2213661E
(pt)
|
2003-09-26 |
2011-12-15 |
Exelixis Inc |
Moduladores de c-met e métodos de uso
|
|
WO2005037836A2
(en)
*
|
2003-10-15 |
2005-04-28 |
Osi Pharmaceuticals, Inc. |
Imidazo ‘1, 5 - a ! pyrazine tyrosine kinase inhibitors
|
|
AU2004288709B2
(en)
|
2003-11-07 |
2011-01-06 |
Novartis Vaccines And Diagnostics, Inc. |
Methods for synthesizing quinolinone compounds
|
|
NZ547689A
(en)
|
2003-11-19 |
2009-05-31 |
Signal Pharm Llc |
Indazole compounds and methods of use thereof as protein kinase inhibitors
|
|
WO2005082340A2
(en)
|
2004-02-20 |
2005-09-09 |
Chiron Corporation |
Modulation of inflammatory and metastatic processes
|
|
US20070004689A1
(en)
*
|
2004-03-12 |
2007-01-04 |
Agoston Gregory E |
Antiangiogenic agents
|
|
JP2007529426A
(ja)
*
|
2004-03-12 |
2007-10-25 |
エントレメッド インコーポレイテッド |
抗血管新生薬
|
|
CN102924458B
(zh)
|
2004-04-02 |
2014-11-05 |
Osi制药有限责任公司 |
6,6-双环取代的杂双环蛋白激酶抑制剂
|
|
AR053090A1
(es)
|
2004-07-20 |
2007-04-25 |
Osi Pharm Inc |
Imidazotriazinas como inhibidores de proteina quinasas y su uso para la preparacion de medicamentos
|
|
AU2005282721A1
(en)
*
|
2004-09-03 |
2006-03-16 |
Memory Pharmaceuticals Corporation |
4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
|
|
CN100569773C
(zh)
|
2004-10-14 |
2009-12-16 |
霍夫曼-拉罗奇有限公司 |
作为抗癌剂的新型吖吲哚噻唑啉酮
|
|
WO2006058298A2
(en)
*
|
2004-11-29 |
2006-06-01 |
Entremed, Inc. |
A method of administering anti-angiogenic agents and a method of treating disease using same
|
|
EP1833803A4
(en)
*
|
2005-01-03 |
2009-08-05 |
Myriad Genetics Inc |
PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCTORS OF APOPTOSIS AND THEIR USE
|
|
DOP2006000051A
(es)
|
2005-02-24 |
2006-08-31 |
Lilly Co Eli |
Inhibidores de vegf-r2 y métodos
|
|
US7304074B2
(en)
|
2005-04-05 |
2007-12-04 |
Hoffmann-La Roche Inc. |
Substituted 1,5-naphthyridine azolinones
|
|
WO2006124996A2
(en)
*
|
2005-05-17 |
2006-11-23 |
Supergen, Inc. |
Inhibitors of polo-like kinase-1
|
|
KR101324863B1
(ko)
|
2005-05-17 |
2013-11-01 |
노파르티스 아게 |
헤테로고리 화합물의 합성 방법
|
|
BRPI0611375A2
(pt)
|
2005-05-23 |
2010-08-31 |
Novartis Ag |
formas cristalinas e outras de sais de ácido láctico de 4-amino-5-flúor-3-[6-(4-metilpiperazin-1-il)-1h-benzimid azol-2-il]-1h-quinolin-2-ona
|
|
US7566721B2
(en)
*
|
2005-08-08 |
2009-07-28 |
Osi Pharmaceuticals, Inc. |
Substituted thienol[2,3-d]pyrimidines as kinase inhibitors
|
|
US20070185069A1
(en)
*
|
2005-11-14 |
2007-08-09 |
Plum Stacy M |
Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
|
|
CA2627544C
(en)
|
2005-11-29 |
2015-07-07 |
Novartis Ag |
Formulations of quinolinones for the treatment of cancer
|
|
AR057960A1
(es)
*
|
2005-12-02 |
2007-12-26 |
Osi Pharm Inc |
Inhibidores de proteina quinasa biciclicos
|
|
US8575164B2
(en)
*
|
2005-12-19 |
2013-11-05 |
OSI Pharmaceuticals, LLC |
Combination cancer therapy
|
|
US20070176403A1
(en)
*
|
2006-02-01 |
2007-08-02 |
Dennis Calderone |
Air adjustable seat
|
|
WO2007109312A2
(en)
*
|
2006-03-20 |
2007-09-27 |
Entremed, Inc. |
Disease modifying anti-arthritic activity of 2-methoxyestradiol
|
|
US20070258976A1
(en)
*
|
2006-05-04 |
2007-11-08 |
Ward Keith W |
Combination Therapy for Diseases Involving Angiogenesis
|
|
US20080234243A1
(en)
*
|
2007-01-31 |
2008-09-25 |
Lavallee Theresa M |
Method of treating amyloidosis mediated diseases
|
|
US20080190689A1
(en)
*
|
2007-02-12 |
2008-08-14 |
Ballard Ebbin C |
Inserts for engine exhaust systems
|
|
US20110046144A1
(en)
*
|
2008-01-18 |
2011-02-24 |
Mulvihill Mark J |
Imidazopyrazinol derivatives for the treatment of cancers
|
|
EP2283020B8
(en)
*
|
2008-05-19 |
2012-12-12 |
OSI Pharmaceuticals, LLC |
Substituted imidazopyr-and imidazotri-azines
|
|
EP2387563B2
(en)
|
2009-01-16 |
2022-04-27 |
Exelixis, Inc. |
Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quinolin-4-yl]oxy}phenyl-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
|
|
BRPI1016245A2
(pt)
|
2009-04-20 |
2015-09-01 |
Osi Pharmaceuticals Llc |
Preparação de c-pirazina-metilaminas.
|
|
EP2427192A1
(en)
*
|
2009-05-07 |
2012-03-14 |
OSI Pharmaceuticals, LLC |
Use of osi-906 for treating adrenocortical carcinoma
|
|
UA108618C2
(uk)
|
2009-08-07 |
2015-05-25 |
|
Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
|
|
US20110189174A1
(en)
|
2010-02-01 |
2011-08-04 |
Afshin Shafiee |
Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization
|
|
US10968290B2
(en)
|
2017-03-28 |
2021-04-06 |
Exxonmobil Chemical Patents Inc. |
Metallocene-catalyzed polyalpha-olefins
|
|
EP3752540A4
(en)
|
2018-02-12 |
2021-12-01 |
ExxonMobil Chemical Patents Inc. |
CATALYST SYSTEMS AND PROCESSES FOR POLY ALPHA-OLEFIN WITH HIGH VINYLIDENE CONTENT
|
|
US11078308B2
(en)
|
2018-02-12 |
2021-08-03 |
Exxonmobil Chemical Patents Inc. |
Processes to produce poly alpha-olefin trimers
|
|
US11021553B2
(en)
|
2018-02-12 |
2021-06-01 |
Exxonmobil Chemical Patents Inc. |
Metallocene dimer selective catalysts and processes to produce poly alpha-olefin dimers
|
|
US11117908B2
(en)
|
2018-04-26 |
2021-09-14 |
Exxonmobil Chemical Patents Inc. |
Process to make non-coordinating anion type activators in aliphatic and alicyclic hydrocarbon solvents
|
|
US11059791B2
(en)
|
2019-04-25 |
2021-07-13 |
Exxonmobil Chemical Patents Inc. |
Non-coordinating anion type benzimidazolium activators
|
|
WO2021030045A1
(en)
|
2019-08-09 |
2021-02-18 |
Exxonmobil Chemical Patents Inc. |
Process to produce low viscosity polyalphaolefins using non-aromatic-hydrocarbon soluble activators
|
|
CN112694474B
(zh)
*
|
2019-10-23 |
2022-03-18 |
四川大学 |
吲唑类衍生物及其制备方法和用途
|
|
EP4051656A1
(en)
|
2019-10-28 |
2022-09-07 |
ExxonMobil Chemical Patents Inc. |
Dimer selective metallocene catalysts, non-aromatic hydrocarbon soluble activators, and processes to produce poly alpha-olefin oligmers therewith
|
|
US11572423B2
(en)
|
2019-12-11 |
2023-02-07 |
Exxonmobil Chemicals Patents Inc. |
Processes for introduction of liquid activators in olefin polymerization reactions
|
|
US11584707B2
(en)
|
2019-12-16 |
2023-02-21 |
Exxonmobil Chemical Patents Inc. |
Non-coordinating anion type activators containing cation having aryldiamine groups and uses thereof
|
|
CN115485311B
(zh)
|
2020-02-24 |
2024-12-06 |
埃克森美孚化学专利公司 |
用于生产乙烯叉基封端的聚α-烯烃的柄型-双(茚-2-基)催化剂
|
|
US11746163B2
(en)
|
2021-01-05 |
2023-09-05 |
Exxonmobil Chemical Patents Inc. |
Isohexane-soluble unsaturated alkyl anilinium tetrakis(perfluoroaryl)borate activators
|
|
CN119638634B
(zh)
*
|
2023-09-18 |
2026-01-30 |
上海赛默罗生物科技有限公司 |
噌啉-2-氧化物类化合物及其制备方法和用途
|