JP2000506168A5 - - Google Patents

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Publication number
JP2000506168A5
JP2000506168A5 JP1997531987A JP53198797A JP2000506168A5 JP 2000506168 A5 JP2000506168 A5 JP 2000506168A5 JP 1997531987 A JP1997531987 A JP 1997531987A JP 53198797 A JP53198797 A JP 53198797A JP 2000506168 A5 JP2000506168 A5 JP 2000506168A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1997531987A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000506168A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/003641 external-priority patent/WO1997032850A1/en
Publication of JP2000506168A publication Critical patent/JP2000506168A/ja
Publication of JP2000506168A5 publication Critical patent/JP2000506168A5/ja
Ceased legal-status Critical Current

Links

JP9531987A 1996-03-08 1997-03-07 Cc―1065及びデュオカマイシンのmcbi類似体 Ceased JP2000506168A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1302496P 1996-03-08 1996-03-08
US60/013,024 1996-03-08
PCT/US1997/003641 WO1997032850A1 (en) 1996-03-08 1997-03-07 Mcbi analogs of cc-1065 and the duocarmycins

Publications (2)

Publication Number Publication Date
JP2000506168A JP2000506168A (ja) 2000-05-23
JP2000506168A5 true JP2000506168A5 (enExample) 2004-12-02

Family

ID=21757922

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9531987A Ceased JP2000506168A (ja) 1996-03-08 1997-03-07 Cc―1065及びデュオカマイシンのmcbi類似体

Country Status (9)

Country Link
US (1) US5985908A (enExample)
EP (1) EP0888301B1 (enExample)
JP (1) JP2000506168A (enExample)
AT (1) ATE301639T1 (enExample)
AU (1) AU711974B2 (enExample)
CA (1) CA2246783C (enExample)
DE (1) DE69733942T2 (enExample)
ES (1) ES2244991T3 (enExample)
WO (1) WO1997032850A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ332960A (en) * 1996-05-31 2000-05-26 Scripps Research Inst tetrahydro-cyclopropan[c]benz[e]-indol-4-one and tetrahydro-cyclopropan[c]benzo[e]-indole derivatives and medicaments
DE69734722T2 (de) * 1996-09-12 2006-07-20 Auckland Uniservices Ltd. Kondensierte n-acylindole als antitumormittel
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
WO1998025900A1 (en) * 1996-12-13 1998-06-18 Shionogi & Co., Ltd. Compounds having antitumor activity
JP3649617B2 (ja) 1999-03-26 2005-05-18 独立行政法人科学技術振興機構 2本鎖dnaを切断できる化合物及びその使用方法
DK1320522T3 (da) * 2000-09-19 2006-04-03 Moses Lee Achirale analoger af CC-1065 og af duocarmyciner samt præparater og metoder til anvendelse deraf
JP4862120B2 (ja) * 2001-02-22 2012-01-25 ユニヴァーシティ オブ ブラッドフォード 腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体
WO2002068412A1 (en) * 2001-02-22 2002-09-06 School Of Pharmacy, University Of London Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs for tumour treatment
NZ529788A (en) * 2001-05-31 2003-12-19 Medarex Inc Cytotoxins, prodrugs, linkers and stabilizers useful therefor
WO2004035571A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
US7745473B2 (en) 2004-03-13 2010-06-29 Kyoto University Indole derivative for alkylating specific base sequence of DNA and alkylating agent and drug containing the derivative
RU2402548C2 (ru) 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
NZ550934A (en) * 2004-05-19 2010-05-28 Medarex Inc Chemical linkers and conjugates thereof
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
SI1940789T1 (sl) * 2005-10-26 2012-03-30 Medarex Inc Postopki in spojine za pripravo cc analogov
CA2627190A1 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
TW200900059A (en) 2007-02-21 2009-01-01 Medarex Inc Chemical linkers with single amino acids and conjugates thereof
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
RU2562232C2 (ru) 2008-11-03 2015-09-10 Синтарга Б.В. Новые аналоги сс-1065 и их конъюгаты
MX374267B (es) 2010-04-21 2025-03-06 Syntarga Bv Conjugados novedosos de analogos cc-1065 y ligaduras bifuncionales.
CN103906742A (zh) * 2011-09-28 2014-07-02 世宗大学校产学协力团 硒吩稠合芳族化合物和其制备方法
JP6133431B2 (ja) 2012-11-24 2017-05-24 ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
CN108546283A (zh) 2012-12-21 2018-09-18 荷商台医(有限合伙)公司 亲水性自消耗连接子及其缀合物
RU2680404C2 (ru) 2014-01-10 2019-02-21 Синтон Байофармасьютикалс Б. В. Способ очистки cys-связанных конъюгатов антитело-лекарственное средство
CA2938919C (en) 2014-02-28 2020-12-29 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
US9950077B2 (en) 2014-06-20 2018-04-24 Bioalliance C.V. Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof
AU2015242213A1 (en) 2015-07-12 2018-03-08 Hangzhou Dac Biotech Co., Ltd Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US10472422B2 (en) 2016-01-08 2019-11-12 Abgenomics International Inc. Tetravalent anti-PSGL-1 antibodies and uses thereof
MX2019005583A (es) 2016-11-14 2019-10-21 Hangzhou Dac Biotech Co Ltd Vinculantes de conjugacion, conjugados de molecula de union a celulas que contienen los vinculantes, metodos de creacion y usos de dichos conjugados con los vinculantes.
KR102894542B1 (ko) 2020-01-30 2025-12-03 (주)에임드바이오 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

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