|
US6060608A
(en)
*
|
1996-05-31 |
2000-05-09 |
The Scripps Research Institute |
Analogs of CC-1065 and the duocarmycins
|
|
DE69734722T2
(de)
*
|
1996-09-12 |
2006-07-20 |
Auckland Uniservices Ltd. |
Kondensierte n-acylindole als antitumormittel
|
|
US6130237A
(en)
*
|
1996-09-12 |
2000-10-10 |
Cancer Research Campaign Technology Limited |
Condensed N-aclyindoles as antitumor agents
|
|
WO1998025900A1
(en)
*
|
1996-12-13 |
1998-06-18 |
Shionogi & Co., Ltd. |
Compounds having antitumor activity
|
|
JP3649617B2
(ja)
|
1999-03-26 |
2005-05-18 |
独立行政法人科学技術振興機構 |
2本鎖dnaを切断できる化合物及びその使用方法
|
|
DK1320522T3
(da)
*
|
2000-09-19 |
2006-04-03 |
Moses Lee |
Achirale analoger af CC-1065 og af duocarmyciner samt præparater og metoder til anvendelse deraf
|
|
US7192977B2
(en)
*
|
2001-02-22 |
2007-03-20 |
School Of Pharmacy |
Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment
|
|
JP2004529887A
(ja)
*
|
2001-02-22 |
2004-09-30 |
スクール オブ ファーマシー, ユニヴァーシティ オブ ロンドン |
腫瘍治療のためのプロドラッグとしてのピロロ−インドールおよびピロロ−キノリン誘導体
|
|
US7087600B2
(en)
|
2001-05-31 |
2006-08-08 |
Medarex, Inc. |
Peptidyl prodrugs and linkers and stabilizers useful therefor
|
|
JP2006505571A
(ja)
*
|
2002-10-15 |
2006-02-16 |
リゲル ファーマシューテイカルズ、インコーポレイテッド |
置換されたインドール及びhcv阻害剤としてのその使用
|
|
AU2005221959C1
(en)
*
|
2004-03-13 |
2010-06-17 |
Kyoto University |
Novel indole derivative for alkylating specific base sequence of DNA and alkylating agent and drug each comprising the same
|
|
US7517903B2
(en)
*
|
2004-05-19 |
2009-04-14 |
Medarex, Inc. |
Cytotoxic compounds and conjugates
|
|
US7691962B2
(en)
|
2004-05-19 |
2010-04-06 |
Medarex, Inc. |
Chemical linkers and conjugates thereof
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
CN101365679B
(zh)
*
|
2005-10-26 |
2012-11-14 |
梅达莱克斯公司 |
制备cc-1065类似物的方法和化合物
|
|
CA2627190A1
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
梅達雷克斯有限責任公司 |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
KR20090122439A
(ko)
|
2007-02-21 |
2009-11-30 |
메다렉스, 인코포레이티드 |
단일 아미노산을 갖는 화학적 링커 및 이의 접합체
|
|
US9901567B2
(en)
|
2007-08-01 |
2018-02-27 |
Syntarga B.V. |
Substituted CC-1065 analogs and their conjugates
|
|
MX2011004625A
(es)
|
2008-11-03 |
2011-07-20 |
Syntarga Bv |
Analogos cc-1065 novedosos y sus conjugados.
|
|
CA2956934C
(en)
|
2010-04-21 |
2019-07-09 |
Syntarga B.V. |
Novel conjugates of cc-1065 analogs and bifunctional linkers
|
|
WO2013048177A2
(ko)
*
|
2011-09-28 |
2013-04-04 |
세종대학교산학협력단 |
셀레노펜-접합 방향족 화합물, 및 이의 제조 방법
|
|
AU2012395148B2
(en)
|
2012-11-24 |
2016-10-27 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
|
|
KR20150119848A
(ko)
|
2012-12-21 |
2015-10-26 |
바이오얼라이언스 씨.브이. |
친수성 자기-희생 링커 및 그것의 포합체
|
|
AU2015205574B2
(en)
|
2014-01-10 |
2019-08-15 |
Byondis B.V. |
Method for purifying Cys-linked antibody-drug conjugates
|
|
FI3122757T3
(fi)
|
2014-02-28 |
2023-10-10 |
Hangzhou Dac Biotech Co Ltd |
Varautuneita linkkereitä ja niiden konjugointikäyttötapoja
|
|
CN106661124A
(zh)
|
2014-06-20 |
2017-05-10 |
荷商台医(有限合伙)公司 |
抗叶酸受体α(FRA)抗体‑药物缀合物及其使用方法
|
|
EP3319936B1
(en)
|
2015-07-12 |
2025-12-17 |
Hangzhou Dac Biotech Co., Ltd. |
Bridge linkers for conjugation of cell-binding molecules
|
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
|
JP7078536B2
(ja)
|
2016-01-08 |
2022-05-31 |
アルトゥルバイオ, インコーポレイテッド |
四価抗psgl-1抗体とその使用
|
|
AU2016429272A1
(en)
|
2016-11-14 |
2019-05-02 |
Hangzhou Dac Biotech Co., Ltd. |
Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
|
|
KR102894542B1
(ko)
|
2020-01-30 |
2025-12-03 |
(주)에임드바이오 |
벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체
|
|
CN117980327A
(zh)
|
2021-11-03 |
2024-05-03 |
杭州多禧生物科技有限公司 |
抗体的特异性偶联
|