JP2000506168A5 - - Google Patents

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Publication number
JP2000506168A5
JP2000506168A5 JP1997531987A JP53198797A JP2000506168A5 JP 2000506168 A5 JP2000506168 A5 JP 2000506168A5 JP 1997531987 A JP1997531987 A JP 1997531987A JP 53198797 A JP53198797 A JP 53198797A JP 2000506168 A5 JP2000506168 A5 JP 2000506168A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1997531987A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000506168A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/003641 external-priority patent/WO1997032850A1/en
Publication of JP2000506168A publication Critical patent/JP2000506168A/ja
Publication of JP2000506168A5 publication Critical patent/JP2000506168A5/ja
Ceased legal-status Critical Current

Links

JP9531987A 1996-03-08 1997-03-07 Cc―1065及びデュオカマイシンのmcbi類似体 Ceased JP2000506168A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1302496P 1996-03-08 1996-03-08
US60/013,024 1996-03-08
PCT/US1997/003641 WO1997032850A1 (en) 1996-03-08 1997-03-07 Mcbi analogs of cc-1065 and the duocarmycins

Publications (2)

Publication Number Publication Date
JP2000506168A JP2000506168A (ja) 2000-05-23
JP2000506168A5 true JP2000506168A5 (enExample) 2004-12-02

Family

ID=21757922

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9531987A Ceased JP2000506168A (ja) 1996-03-08 1997-03-07 Cc―1065及びデュオカマイシンのmcbi類似体

Country Status (9)

Country Link
US (1) US5985908A (enExample)
EP (1) EP0888301B1 (enExample)
JP (1) JP2000506168A (enExample)
AT (1) ATE301639T1 (enExample)
AU (1) AU711974B2 (enExample)
CA (1) CA2246783C (enExample)
DE (1) DE69733942T2 (enExample)
ES (1) ES2244991T3 (enExample)
WO (1) WO1997032850A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255703A1 (en) * 1996-05-31 1997-12-04 Dale L. Boger Analogs of cc-1065 and the duocarmycins
ATE310725T1 (de) * 1996-09-12 2005-12-15 Auckland Uniservices Ltd Kondensierte n-acylindole als antitumormittel
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
WO1998025900A1 (en) * 1996-12-13 1998-06-18 Shionogi & Co., Ltd. Compounds having antitumor activity
JP3649617B2 (ja) 1999-03-26 2005-05-18 独立行政法人科学技術振興機構 2本鎖dnaを切断できる化合物及びその使用方法
DE60115265T2 (de) * 2000-09-19 2006-08-10 Lee, Moses, Holland Zusammensetzungen und verfahren zur verwendung achiraler analoge von cc-1065 und den duocarmycinen
US7626026B2 (en) 2001-02-22 2009-12-01 University Of Bradford Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs for tumour treatment
JP4862120B2 (ja) * 2001-02-22 2012-01-25 ユニヴァーシティ オブ ブラッドフォード 腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体
KR20030033007A (ko) * 2001-05-31 2003-04-26 코울터 파머수티컬, 인코포레이티드 세포독소, 약물전구체, 링커 및 이에 유용한 안정화제
JP2006505571A (ja) * 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びhcv阻害剤としてのその使用
US7745473B2 (en) 2004-03-13 2010-06-29 Kyoto University Indole derivative for alkylating specific base sequence of DNA and alkylating agent and drug containing the derivative
US7691962B2 (en) * 2004-05-19 2010-04-06 Medarex, Inc. Chemical linkers and conjugates thereof
BRPI0510909A2 (pt) 2004-05-19 2008-12-16 Medarex Inc composto de ligaÇço fÁrmaco-ligante citotàxico, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula e mÉtodo para retardar ou interromper o crescimento de tumor
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
BRPI0619331A2 (pt) * 2005-10-26 2011-09-27 Medarex Inc método para fazer um composto para preparar um análogo de cbi cc-1065, método para preparar um análogo de cbi cc-1065 e composto
WO2007059404A2 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh) 2006-12-28 2013-10-21 梅達雷克斯有限責任公司 化學鏈接劑與可裂解基質以及其之綴合物
JP2010519310A (ja) 2007-02-21 2010-06-03 メダレックス インコーポレイテッド 単一のアミノ酸を有する化学リンカーおよびその複合体
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
HUE035798T2 (en) 2008-11-03 2018-05-28 Syntarga Bv CC-1065 analogues and conjugates
NO3056203T3 (enExample) 2010-04-21 2018-05-12
EP2762472B1 (en) * 2011-09-28 2017-05-24 Industry-Academia Cooperation Group of Sejong University Selenophene-fused aromatic compound and manufacturing method thereof
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
KR20210132742A (ko) 2012-12-21 2021-11-04 알트루바이오 인코퍼레이티드 친수성 자기-희생 링커 및 그것의 포합체
TR201810856T4 (tr) 2014-01-10 2018-08-27 Synthon Biopharmaceuticals Bv CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
JP6417421B2 (ja) 2014-02-28 2018-11-07 ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. 荷電連結体及び共役体のためのその使用
KR20170020868A (ko) 2014-06-20 2017-02-24 바이오얼라이언스 씨.브이. 항-폴레이트 수용체 알파 (fra) 항체-약물 컨쥬게이트 및 그것의 사용 방법
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
WO2017120534A1 (en) 2016-01-08 2017-07-13 Bioalliance C.V. Tetravalent anti-psgl-1 antibodies and uses thereof
KR20220147719A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
KR102894542B1 (ko) 2020-01-30 2025-12-03 (주)에임드바이오 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

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