JP2000501744A - モルホゲン類似体およびその製法 - Google Patents

モルホゲン類似体およびその製法

Info

Publication number
JP2000501744A
JP2000501744A JP9526303A JP52630397A JP2000501744A JP 2000501744 A JP2000501744 A JP 2000501744A JP 9526303 A JP9526303 A JP 9526303A JP 52630397 A JP52630397 A JP 52630397A JP 2000501744 A JP2000501744 A JP 2000501744A
Authority
JP
Japan
Prior art keywords
human
morphogen
cells
hop
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9526303A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000501744A5 (enExample
Inventor
ケック,ピーター
エル. グリフィス,ダイアナ
デイ カールソン,ウィリアム
シー. ルーガー,デビッド
テイ. サンパス,クーバー
Original Assignee
クリエイティブ バイオモレキゥルズ,インコーポレーテッド
ブランダイス ユニバーシティー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クリエイティブ バイオモレキゥルズ,インコーポレーテッド, ブランダイス ユニバーシティー filed Critical クリエイティブ バイオモレキゥルズ,インコーポレーテッド
Publication of JP2000501744A publication Critical patent/JP2000501744A/ja
Publication of JP2000501744A5 publication Critical patent/JP2000501744A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP9526303A 1996-01-22 1997-01-22 モルホゲン類似体およびその製法 Ceased JP2000501744A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58955296A 1996-01-22 1996-01-22
US08/589,552 1996-01-22
PCT/US1997/001071 WO1997026277A2 (en) 1996-01-22 1997-01-22 Morphogen analogs and methods for producing them

Publications (2)

Publication Number Publication Date
JP2000501744A true JP2000501744A (ja) 2000-02-15
JP2000501744A5 JP2000501744A5 (enExample) 2004-11-11

Family

ID=24358486

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9526303A Ceased JP2000501744A (ja) 1996-01-22 1997-01-22 モルホゲン類似体およびその製法

Country Status (8)

Country Link
US (2) US6273598B1 (enExample)
EP (1) EP0876401B1 (enExample)
JP (1) JP2000501744A (enExample)
AT (1) ATE364629T1 (enExample)
AU (1) AU725295B2 (enExample)
CA (1) CA2244228A1 (enExample)
DE (1) DE69737809T2 (enExample)
WO (1) WO1997026277A2 (enExample)

Cited By (2)

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JP2006507804A (ja) * 2002-06-17 2006-03-09 トラソス インコーポレイテッド 単一ドメインtdf関連化合物およびその類似体
JP2019502674A (ja) * 2015-08-25 2019-01-31 ヒスタイド アクツィエンゲゼルシャフト 組織形成誘導用化合物及びその使用

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US7122623B2 (en) 1996-07-12 2006-10-17 Adherex Technologies, Inc. Compounds and methods for modulating cell adhesion
US20040006011A1 (en) * 1996-07-12 2004-01-08 Gour Barbara J. Peptidomimetic modulators of cell adhesion
US5922558A (en) * 1997-09-12 1999-07-13 Lumigen, Inc. Methods and compositions for generating chemiluminescence with a peroxidase
DE19831758A1 (de) * 1998-07-15 2000-02-03 Jerini Bio Tools Gmbh Ligandenbestimmung für Proteine
WO2001053331A2 (en) * 2000-01-24 2001-07-26 Adherex Technologies, Inc. Peptidomimetic modulators of cell adhesion
US7629309B2 (en) * 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US20040005309A1 (en) * 2002-05-29 2004-01-08 Symbiontics, Inc. Targeted therapeutic proteins
US7560424B2 (en) * 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
EP1974752B1 (en) 2001-04-30 2012-09-26 BioMarin Pharmaceutical Inc. Subcellular targeting of therapeutic proteins
US20030072761A1 (en) * 2001-10-16 2003-04-17 Lebowitz Jonathan Methods and compositions for targeting proteins across the blood brain barrier
US7015195B2 (en) * 2002-01-10 2006-03-21 Osteotrophin, Llc Treatment of bone disorders with skeletal anabolic drugs
AU2002950183A0 (en) * 2002-07-12 2002-09-12 The Council Of The Queensland Institute Of Medical Research Expression of hydrophobic proteins
US20040093164A1 (en) * 2002-11-08 2004-05-13 Carlson William D. Computer system and methods for producing morphogen analogs of human TDF-1
AU2004205643A1 (en) * 2003-01-21 2004-08-05 The Trustees Of The University Of Pennsylvania Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel KcsA
US20040204862A1 (en) * 2003-04-11 2004-10-14 Wainer Irving W. Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
WO2005000308A2 (en) * 2003-05-15 2005-01-06 Rigel Pharmaceuticals, Inc. Methods of identifying hcv ns5b polymerase inhibitors and use against hepatitis c
EP1716232B9 (en) * 2004-02-10 2010-10-13 ZyStor Therapeutics , Inc. Acid alpha-glucosidase and fragments thereof
EP1730186A2 (en) * 2004-03-31 2006-12-13 Xencor, Inc. Bmp-7 variants with improved properties
CA2897218A1 (en) * 2004-06-17 2006-01-26 Thrasos Innovation, Inc. Tdf-related compounds and analogs thereof
AU2012201060B2 (en) * 2005-09-20 2015-01-22 Thrasos Innovation, Inc. TDF-related compounds and analogs thereof
HUE026634T2 (en) * 2005-09-20 2016-07-28 Thrasos Innovation Inc TDF-related compounds and analogues thereof
US7659250B2 (en) * 2005-12-22 2010-02-09 Centocor, Inc. BMP-7 variant compositions, methods and uses
EP1978994B1 (en) * 2005-12-22 2012-02-01 Janssen Biotech, Inc. Bmp-7 variant compositions, methods and uses
WO2008063511A2 (en) * 2006-11-13 2008-05-29 Zystor Therapeutics, Inc. Methods for treating pompe disease
EP2268302B1 (en) * 2008-02-13 2014-04-09 Keith Hruska Bmp-7 for use in treating neointimal hyperplasia
US20090291967A1 (en) * 2008-03-05 2009-11-26 Adherex Technologies, Inc. Small molecule modulators of cell adhesion
EP3187508A1 (en) 2008-05-07 2017-07-05 BioMarin Pharmaceutical Inc. Lysosomal targeting peptides and uses thereof
EP2475376B1 (en) 2009-06-17 2016-03-30 BioMarin Pharmaceutical Inc. Formulations for lysosomal enzymes
US9721070B2 (en) 2013-12-19 2017-08-01 Chevron Phillips Chemical Company Lp Selective oligomerization catalysts and methods of identifying same

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JPH03500655A (ja) * 1988-04-08 1991-02-14 ストライカー・コーポレーション 骨形成デバイス
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
JPH07500487A (ja) * 1990-10-18 1995-01-19 ストライカー コーポレイション 骨形成ペプチド
JPH08506018A (ja) * 1993-01-28 1996-07-02 アムジエン・インコーポレーテツド G−csf類似体組成物及び方法

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JPH07500487A (ja) * 1990-10-18 1995-01-19 ストライカー コーポレイション 骨形成ペプチド
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
JPH08506018A (ja) * 1993-01-28 1996-07-02 アムジエン・インコーポレーテツド G−csf類似体組成物及び方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006507804A (ja) * 2002-06-17 2006-03-09 トラソス インコーポレイテッド 単一ドメインtdf関連化合物およびその類似体
JP2019502674A (ja) * 2015-08-25 2019-01-31 ヒスタイド アクツィエンゲゼルシャフト 組織形成誘導用化合物及びその使用
JP2022043261A (ja) * 2015-08-25 2022-03-15 ヒスタイド アクツィエンゲゼルシャフト 組織形成誘導用化合物及びその使用

Also Published As

Publication number Publication date
US6273598B1 (en) 2001-08-14
DE69737809D1 (de) 2007-07-26
CA2244228A1 (en) 1997-07-24
EP0876401B1 (en) 2007-06-13
WO1997026277A3 (en) 1997-09-25
EP0876401A2 (en) 1998-11-11
ATE364629T1 (de) 2007-07-15
US20020028453A1 (en) 2002-03-07
WO1997026277A2 (en) 1997-07-24
AU2244997A (en) 1997-08-11
AU725295B2 (en) 2000-10-12
DE69737809T2 (de) 2008-02-21

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