JP2000501744A - モルホゲン類似体およびその製法 - Google Patents

モルホゲン類似体およびその製法

Info

Publication number
JP2000501744A
JP2000501744A JP9526303A JP52630397A JP2000501744A JP 2000501744 A JP2000501744 A JP 2000501744A JP 9526303 A JP9526303 A JP 9526303A JP 52630397 A JP52630397 A JP 52630397A JP 2000501744 A JP2000501744 A JP 2000501744A
Authority
JP
Japan
Prior art keywords
human
morphogen
cells
hop
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9526303A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000501744A5 (enExample
Inventor
ケック，ピーター
エル． グリフィス，ダイアナ
デイ カールソン，ウィリアム
シー． ルーガー，デビッド
テイ． サンパス，クーバー
Original Assignee
クリエイティブ バイオモレキゥルズ，インコーポレーテッド
ブランダイス ユニバーシティー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クリエイティブ バイオモレキゥルズ，インコーポレーテッド, ブランダイス ユニバーシティー filed Critical クリエイティブ バイオモレキゥルズ，インコーポレーテッド
Publication of JP2000501744A publication Critical patent/JP2000501744A/ja
Publication of JP2000501744A5 publication Critical patent/JP2000501744A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP9526303A 1996-01-22 1997-01-22 モルホゲン類似体およびその製法 Ceased JP2000501744A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58955296A 1996-01-22 1996-01-22
US08/589,552 1996-01-22
PCT/US1997/001071 WO1997026277A2 (en) 1996-01-22 1997-01-22 Morphogen analogs and methods for producing them

Publications (2)

Publication Number Publication Date
JP2000501744A true JP2000501744A (ja) 2000-02-15
JP2000501744A5 JP2000501744A5 (enExample) 2004-11-11

Family

ID=24358486

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9526303A Ceased JP2000501744A (ja) 1996-01-22 1997-01-22 モルホゲン類似体およびその製法

Country Status (8)

Country Link
US (2) US6273598B1 (enExample)
EP (1) EP0876401B1 (enExample)
JP (1) JP2000501744A (enExample)
AT (1) ATE364629T1 (enExample)
AU (1) AU725295B2 (enExample)
CA (1) CA2244228A1 (enExample)
DE (1) DE69737809T2 (enExample)
WO (1) WO1997026277A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006507804A (ja) * 2002-06-17 2006-03-09 トラソス インコーポレイテッド 単一ドメインｔｄｆ関連化合物およびその類似体
JP2019502674A (ja) * 2015-08-25 2019-01-31 ヒスタイド アクツィエンゲゼルシャフト 組織形成誘導用化合物及びその使用

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030185792A1 (en) * 1996-01-22 2003-10-02 Curis, Inc. Morphogen analogs of bone morphogenic proteins
US7122623B2 (en) 1996-07-12 2006-10-17 Adherex Technologies, Inc. Compounds and methods for modulating cell adhesion
US20040006011A1 (en) * 1996-07-12 2004-01-08 Gour Barbara J. Peptidomimetic modulators of cell adhesion
US20020168761A1 (en) * 2000-01-24 2002-11-14 Gour Barbara J. Peptidomimetic modulators of cell adhesion
US5922558A (en) * 1997-09-12 1999-07-13 Lumigen, Inc. Methods and compositions for generating chemiluminescence with a peroxidase
DE19831758A1 (de) * 1998-07-15 2000-02-03 Jerini Bio Tools Gmbh Ligandenbestimmung für Proteine
US7629309B2 (en) * 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
EP1436316B1 (en) * 2001-04-30 2008-01-23 ZyStor Therapeutics , Inc. Subcellular targeting of therapeutic proteins
US20040005309A1 (en) * 2002-05-29 2004-01-08 Symbiontics, Inc. Targeted therapeutic proteins
US7560424B2 (en) 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US20030072761A1 (en) * 2001-10-16 2003-04-17 Lebowitz Jonathan Methods and compositions for targeting proteins across the blood brain barrier
AU2003207512B2 (en) * 2002-01-10 2008-06-12 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
AU2002950183A0 (en) * 2002-07-12 2002-09-12 The Council Of The Queensland Institute Of Medical Research Expression of hydrophobic proteins
US20040093164A1 (en) * 2002-11-08 2004-05-13 Carlson William D. Computer system and methods for producing morphogen analogs of human TDF-1
US20040215400A1 (en) * 2003-01-21 2004-10-28 The Trustees Of The University Of Pennsylvania Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel KcsA
US20040204862A1 (en) * 2003-04-11 2004-10-14 Wainer Irving W. Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
US20050009877A1 (en) * 2003-05-15 2005-01-13 Henry Lu Methods of identifying HCV NS5B polymerase inhibitors and their uses
DE602005020745D1 (de) * 2004-02-10 2010-06-02 Zystor Therapeutics Inc Saure alpha-glukosidase und fragmente davon
CA2561809A1 (en) * 2004-03-31 2005-10-20 Xencor, Inc. Bmp-7 variants with improved properties
EP2789342A1 (en) 2004-06-17 2014-10-15 Thrasos Innovation, Inc. TDF-related compounds and analogs thereof
AU2012201060B2 (en) * 2005-09-20 2015-01-22 Thrasos Innovation, Inc. TDF-related compounds and analogs thereof
US8299212B2 (en) 2005-09-20 2012-10-30 Thrasos Therapeutics, Inc. TDF-related compounds and analogs thereof, analogs and bioactive fragments
US7659250B2 (en) * 2005-12-22 2010-02-09 Centocor, Inc. BMP-7 variant compositions, methods and uses
ATE543833T1 (de) * 2005-12-22 2012-02-15 Janssen Biotech Inc Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen
AU2007322123A1 (en) * 2006-11-13 2008-05-29 Biomarin Pharmaceutical Inc. Methods for treating Pompe disease
AU2009214629A1 (en) 2008-02-13 2009-08-20 Eric T. Choi BMP-7 for use in treating vascular sclerosis
US20090291967A1 (en) * 2008-03-05 2009-11-26 Adherex Technologies, Inc. Small molecule modulators of cell adhesion
WO2009137721A2 (en) 2008-05-07 2009-11-12 Zystor Therapeutics, Inc. Lysosomal targeting peptides and uses thereof
US8785168B2 (en) 2009-06-17 2014-07-22 Biomarin Pharmaceutical Inc. Formulations for lysosomal enzymes
US9721070B2 (en) 2013-12-19 2017-08-01 Chevron Phillips Chemical Company Lp Selective oligomerization catalysts and methods of identifying same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03500655A (ja) * 1988-04-08 1991-02-14 ストライカー・コーポレーション 骨形成デバイス
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
JPH07500487A (ja) * 1990-10-18 1995-01-19 ストライカー コーポレイション 骨形成ペプチド
JPH08506018A (ja) * 1993-01-28 1996-07-02 アムジエン・インコーポレーテツド Ｇ−ｃｓｆ類似体組成物及び方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908773A (en) 1987-04-06 1990-03-13 Genex Corporation Computer designed stabilized proteins and method for producing same
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5061786A (en) 1989-05-25 1991-10-29 Genentech, Inc. Biologically active polypeptides based on transforming growth factor-β
US5118791A (en) 1989-05-25 1992-06-02 Genentech, Inc. Biologically active polypeptides based on transforming growth factor-β
GB8914122D0 (en) * 1989-06-20 1989-08-09 Wellcome Found Polypeptide expression
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
WO1992001933A1 (en) 1990-07-20 1992-02-06 E.I. Du Pont De Nemours And Company Generation of a complete set of structural coordinates of a molecule from a set of partial coordinates
DE69133181T2 (de) 1990-09-14 2003-04-30 Colorado State University, Fort Collins Design von bioaktiven peptiden auf der basis von immunglobulin strukturen
US5824647A (en) * 1990-12-12 1998-10-20 Postlethwaite; Arnold E. Chemotactic wound healing peptides
WO1992022575A1 (en) * 1991-06-19 1992-12-23 Sri International M-protein peptides of influenza virus as antiviral agents
AU3320193A (en) 1991-07-22 1993-02-23 Regents Of The University Of California, The Methods of designing specific affectors using three-dimensional conformation of enzyme/affector complex
JPH05262788A (ja) 1991-09-03 1993-10-12 Hitachi Chem Co Ltd ペプチド類、その設計方法及び製造方法並びに受容体上の生理活性ペプチドの結合部位の決定方法
US5353236A (en) 1992-04-23 1994-10-04 The Board Of Trustees Of The Leland Stanford University High-resolution crystallographic modelling of a macromolecule
US5322933A (en) 1992-05-07 1994-06-21 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Crystal structure of TGF-β-2
CA2141600A1 (en) * 1992-08-03 1994-02-17 Richard U. Margolis Cloning, expression and uses for neurocan as a chondroitin sulfate proteoglycan
EP0690871A4 (en) * 1993-01-12 1999-10-20 Univ Johns Hopkins Med GROWTH DIFFERENTIATION FACTOR-5
EP0746569A4 (en) 1993-02-03 1999-03-24 Amrad Corp Ltd DETERMINANT FOR FIXING THE RECEPTOR FROM THE LEUKEMIA INHIBITION FACTOR
US5453937A (en) 1993-04-28 1995-09-26 Immunex Corporation Method and system for protein modeling
US5637480A (en) * 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
EP0788370A4 (en) 1993-07-09 1998-07-08 Smithkline Beecham Corp CYCLIC, PARTIAL RANDOM PEPTIDE LIBRARIES
GB9317120D0 (en) 1993-08-17 1993-09-29 Royal Postgrad Med School Human serum amyloid p component
US5856122A (en) 1993-08-24 1999-01-05 University Of Alberta Modification of pertussis toxin
US5652334A (en) 1993-09-08 1997-07-29 City Of Hope Method for design of substances that enhance memory and improve the quality of life
US5565352A (en) * 1993-11-24 1996-10-15 Arch Development Corporation Deubiquitinating enzyme: compositions and methods
US5705335A (en) 1993-11-26 1998-01-06 Hendry; Lawrence B. Design of drugs involving receptor-ligand-DNA interactions
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
US5932716A (en) * 1995-07-26 1999-08-03 Creative Biomolecules, Inc. Morphogen-responsive regulatory elements
US6677432B1 (en) * 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
JP3786533B2 (ja) * 1998-11-12 2006-06-14 善彦 西村 ペプチド及び骨形成促進剤
EP1334365B1 (en) * 2000-11-06 2007-02-21 Thrasos, Inc. Screening methods for bone morphogenetic mimetics

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03500655A (ja) * 1988-04-08 1991-02-14 ストライカー・コーポレーション 骨形成デバイス
JPH07500487A (ja) * 1990-10-18 1995-01-19 ストライカー コーポレイション 骨形成ペプチド
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
JPH08506018A (ja) * 1993-01-28 1996-07-02 アムジエン・インコーポレーテツド Ｇ−ｃｓｆ類似体組成物及び方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN4007000050, Ｊ Ｍｏｌ Ｂｉｏｌ ２４４ ｐ．６５７−６５８ （１９９４） *
JPN6010052329, Ｊ Ｍｏｌ Ｂｉｏｌ ２４４ ｐ．６５７−６５８ （１９９４） *
JPN6010052330, Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ ＵＳＡ ９３ ｐ．８７８−８８３ （１９９６ Ｊａｎ） *
JPNX007000092, Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ ＵＳＡ ９３ ｐ．８７８−８８３ （１９９６ Ｊａｎ） *
JPNX007000093, Ｎａｔｕｒｅ ４２０ ｐ．６３６ （２００２） *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006507804A (ja) * 2002-06-17 2006-03-09 トラソス インコーポレイテッド 単一ドメインｔｄｆ関連化合物およびその類似体
JP2019502674A (ja) * 2015-08-25 2019-01-31 ヒスタイド アクツィエンゲゼルシャフト 組織形成誘導用化合物及びその使用
JP2022043261A (ja) * 2015-08-25 2022-03-15 ヒスタイド アクツィエンゲゼルシャフト 組織形成誘導用化合物及びその使用

Also Published As

Publication number Publication date
WO1997026277A2 (en) 1997-07-24
AU725295B2 (en) 2000-10-12
CA2244228A1 (en) 1997-07-24
EP0876401B1 (en) 2007-06-13
DE69737809T2 (de) 2008-02-21
US6273598B1 (en) 2001-08-14
DE69737809D1 (de) 2007-07-26
AU2244997A (en) 1997-08-11
WO1997026277A3 (en) 1997-09-25
EP0876401A2 (en) 1998-11-11
US20020028453A1 (en) 2002-03-07
ATE364629T1 (de) 2007-07-15

Similar Documents

Publication Publication Date Title
EP0876401B1 (en) Methods for producing op-1 morphogen analogs
US8952130B2 (en) Designer ligands of TGF-β superfamily
WO1997026277A9 (en) Morphogen analogs and methods for producing them
AU778998B2 (en) Cystine knot growth factor mutants
KR100353579B1 (ko) 섬유아세포성장인자의표면고리구조유사체
JP2005320339A (ja) 改変型ＴＧＦ−βスーパーファミリータンパク質
JP2008500816A (ja) 改善された性質を有するｂｍｐ−７変異体
JPH11510686A (ja) ＴＧＦ−βスーパーファミリーの一本鎖類縁体（モーフォン）
JP3982995B2 (ja) 形態形成タンパク質を含むＴＧＦ−βスーパーファミリー変異体メンバー
JPH07103156B2 (ja) 再生骨髄から同定された骨形成成長ポリペプチド
HUE033025T2 (en) To induce GDF-5 mutant cartilage tissue
US20040093164A1 (en) Computer system and methods for producing morphogen analogs of human TDF-1
JPH07126181A (ja) 骨折の予防および治療剤
KR102404717B1 (ko) Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드
AU765297B2 (en) Morphogen analogs and methods for producing them
US10125168B2 (en) Synthetic peptide for adjusting balance between presence of type 1 TNF receptor and type 2 TNF receptor and use thereof
WO2003076467A1 (en) Compositions and methods for inducing and regulating bone formation
US20190135884A1 (en) Composition comprising an ab6 family designer ligand of tgf-beta superfamily for treating bone and cartilage disease and use thereof
CA2191321A1 (en) Gene coding for modified bone morphogenic protein receptor
Lee et al. Development of Refolding Process to Obtain Active Recombinant Human Bone Morphogenetic Protein-2 and its Osteogenic Efficacy on Oral Stem Cells
KR20190005239A (ko) Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드를 포함하는 간질환 치료용 조성물 및 그의 이용

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20031226

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20031226

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070116

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070416

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070604

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070516

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090526

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090928

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091022

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091217

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20100610

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100610

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20100610

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20100902

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100907

A045 Written measure of dismissal of application [lapsed due to lack of payment]

Free format text: JAPANESE INTERMEDIATE CODE: A045

Effective date: 20110125