ATE364629T1 - Methoden zur herstellung von op-1 morphogen analoge - Google Patents

Methoden zur herstellung von op-1 morphogen analoge

Info

Publication number
ATE364629T1
ATE364629T1 AT97905604T AT97905604T ATE364629T1 AT E364629 T1 ATE364629 T1 AT E364629T1 AT 97905604 T AT97905604 T AT 97905604T AT 97905604 T AT97905604 T AT 97905604T AT E364629 T1 ATE364629 T1 AT E364629T1
Authority
AT
Austria
Prior art keywords
methods
morphogen
analogs
producing
morphogen analogs
Prior art date
Application number
AT97905604T
Other languages
German (de)
English (en)
Inventor
Peter Keck
Diana Griffith
William Carlson
David Rueger
Kuber Sampath
Original Assignee
Curis Inc
Univ Brandeis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc, Univ Brandeis filed Critical Curis Inc
Application granted granted Critical
Publication of ATE364629T1 publication Critical patent/ATE364629T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97905604T 1996-01-22 1997-01-22 Methoden zur herstellung von op-1 morphogen analoge ATE364629T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58955296A 1996-01-22 1996-01-22

Publications (1)

Publication Number Publication Date
ATE364629T1 true ATE364629T1 (de) 2007-07-15

Family

ID=24358486

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97905604T ATE364629T1 (de) 1996-01-22 1997-01-22 Methoden zur herstellung von op-1 morphogen analoge

Country Status (8)

Country Link
US (2) US6273598B1 (enExample)
EP (1) EP0876401B1 (enExample)
JP (1) JP2000501744A (enExample)
AT (1) ATE364629T1 (enExample)
AU (1) AU725295B2 (enExample)
CA (1) CA2244228A1 (enExample)
DE (1) DE69737809T2 (enExample)
WO (1) WO1997026277A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030185792A1 (en) * 1996-01-22 2003-10-02 Curis, Inc. Morphogen analogs of bone morphogenic proteins
US20040006011A1 (en) * 1996-07-12 2004-01-08 Gour Barbara J. Peptidomimetic modulators of cell adhesion
US7122623B2 (en) 1996-07-12 2006-10-17 Adherex Technologies, Inc. Compounds and methods for modulating cell adhesion
US5922558A (en) * 1997-09-12 1999-07-13 Lumigen, Inc. Methods and compositions for generating chemiluminescence with a peroxidase
DE19831758A1 (de) * 1998-07-15 2000-02-03 Jerini Bio Tools Gmbh Ligandenbestimmung für Proteine
WO2001053331A2 (en) * 2000-01-24 2001-07-26 Adherex Technologies, Inc. Peptidomimetic modulators of cell adhesion
US20040005309A1 (en) * 2002-05-29 2004-01-08 Symbiontics, Inc. Targeted therapeutic proteins
US7560424B2 (en) 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
JP4641705B2 (ja) 2001-04-30 2011-03-02 ザイストール セラピューティクス， インコーポレイテッド 治療的タンパク質の亜細胞標的化
US7629309B2 (en) * 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US20030072761A1 (en) * 2001-10-16 2003-04-17 Lebowitz Jonathan Methods and compositions for targeting proteins across the blood brain barrier
CA2472472A1 (en) * 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
WO2003106656A2 (en) * 2002-06-17 2003-12-24 Thrasos, Inc. Single domain tdf-related compounds and analogs thereof
AU2002950183A0 (en) * 2002-07-12 2002-09-12 The Council Of The Queensland Institute Of Medical Research Expression of hydrophobic proteins
US20040093164A1 (en) * 2002-11-08 2004-05-13 Carlson William D. Computer system and methods for producing morphogen analogs of human TDF-1
EP1593060A2 (en) * 2003-01-21 2005-11-09 The Trustees Of The University Of Pennsylvania Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel kcsa
US20040204862A1 (en) * 2003-04-11 2004-10-14 Wainer Irving W. Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
WO2005000308A2 (en) * 2003-05-15 2005-01-06 Rigel Pharmaceuticals, Inc. Methods of identifying hcv ns5b polymerase inhibitors and use against hepatitis c
ES2344302T3 (es) * 2004-02-10 2010-08-24 Zystor Therapeutics , Inc. Alfa glucosidasa acida y fragmentos de la misma.
US7459527B2 (en) * 2004-03-31 2008-12-02 Xencor, Inc. BMP-7 variants with improved properties
EP2789342A1 (en) * 2004-06-17 2014-10-15 Thrasos Innovation, Inc. TDF-related compounds and analogs thereof
AU2012201060B2 (en) * 2005-09-20 2015-01-22 Thrasos Innovation, Inc. TDF-related compounds and analogs thereof
US8299212B2 (en) 2005-09-20 2012-10-30 Thrasos Therapeutics, Inc. TDF-related compounds and analogs thereof, analogs and bioactive fragments
US7659250B2 (en) * 2005-12-22 2010-02-09 Centocor, Inc. BMP-7 variant compositions, methods and uses
JP5100662B2 (ja) * 2005-12-22 2012-12-19 セントカー・インコーポレーテツド Ｂｍｐ−７変異体組成物、方法および使用
WO2008063511A2 (en) * 2006-11-13 2008-05-29 Zystor Therapeutics, Inc. Methods for treating pompe disease
AU2009214629A1 (en) 2008-02-13 2009-08-20 Eric T. Choi BMP-7 for use in treating vascular sclerosis
US20090291967A1 (en) * 2008-03-05 2009-11-26 Adherex Technologies, Inc. Small molecule modulators of cell adhesion
CN102066422B (zh) 2008-05-07 2015-07-22 宝玛瑞制药公司 溶酶体靶向肽及其应用
WO2010148253A2 (en) 2009-06-17 2010-12-23 Zystor Therapeutics, Inc. Formulations for lysosomal enzymes
US9721070B2 (en) 2013-12-19 2017-08-01 Chevron Phillips Chemical Company Lp Selective oligomerization catalysts and methods of identifying same
EP4541810A2 (en) * 2015-08-25 2025-04-23 Histide AG COMPOUNDS FOR INDUCING TISSUE REGENERATION AND THEIR USES

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908773A (en) 1987-04-06 1990-03-13 Genex Corporation Computer designed stabilized proteins and method for producing same
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
DE68927153T2 (de) * 1988-04-08 1997-03-06 Stryker Corp., Kalamazoo, Mich. Biosynthetische osteogene proteine und sie enthaltende osteogene vorrichtungen
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5061786A (en) 1989-05-25 1991-10-29 Genentech, Inc. Biologically active polypeptides based on transforming growth factor-β
US5118791A (en) 1989-05-25 1992-06-02 Genentech, Inc. Biologically active polypeptides based on transforming growth factor-β
GB8914122D0 (en) * 1989-06-20 1989-08-09 Wellcome Found Polypeptide expression
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
WO1992001933A1 (en) 1990-07-20 1992-02-06 E.I. Du Pont De Nemours And Company Generation of a complete set of structural coordinates of a molecule from a set of partial coordinates
ATE229974T1 (de) 1990-09-14 2003-01-15 Univ Pennsylvania Design von bioaktiven peptiden auf der basis von immunglobulin strukturen
WO1992007073A1 (en) 1990-10-18 1992-04-30 Creative Biomolecules, Inc. Osteogenic peptides
US5824647A (en) * 1990-12-12 1998-10-20 Postlethwaite; Arnold E. Chemotactic wound healing peptides
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
CA2108263A1 (en) * 1991-06-19 1992-12-20 Amrit K. Judd M-protein peptides of influenza virus as antiviral agents
AU3320193A (en) 1991-07-22 1993-02-23 Regents Of The University Of California, The Methods of designing specific affectors using three-dimensional conformation of enzyme/affector complex
JPH05262788A (ja) 1991-09-03 1993-10-12 Hitachi Chem Co Ltd ペプチド類、その設計方法及び製造方法並びに受容体上の生理活性ペプチドの結合部位の決定方法
US5353236A (en) 1992-04-23 1994-10-04 The Board Of Trustees Of The Leland Stanford University High-resolution crystallographic modelling of a macromolecule
US5322933A (en) 1992-05-07 1994-06-21 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Crystal structure of TGF-β-2
AU4801393A (en) * 1992-08-03 1994-03-03 New York University Cloning, expression and uses for neurocan as a chondroitin sulfate proteoglycan
WO1994015949A1 (en) * 1993-01-12 1994-07-21 Johns Hopkins University School Of Medicine Growth differentiation factor-5
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
WO1994018236A1 (en) 1993-02-03 1994-08-18 Amrad Corporation Limited Receptor-binding determinant from leukaemia inhibitory factor
US5453937A (en) 1993-04-28 1995-09-26 Immunex Corporation Method and system for protein modeling
US5637480A (en) * 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
US6194544B1 (en) 1993-07-09 2001-02-27 Smithkline Beecham Corporation Cyclic semi-random peptide libraries
GB9317120D0 (en) 1993-08-17 1993-09-29 Royal Postgrad Med School Human serum amyloid p component
US5856122A (en) 1993-08-24 1999-01-05 University Of Alberta Modification of pertussis toxin
US5652334A (en) 1993-09-08 1997-07-29 City Of Hope Method for design of substances that enhance memory and improve the quality of life
US5565352A (en) * 1993-11-24 1996-10-15 Arch Development Corporation Deubiquitinating enzyme: compositions and methods
DE69433935D1 (de) 1993-11-26 2004-09-09 Lawrence B Hendry Der entwurf von medikamenten, die in die rezeptor-ligand-dna wechselwirkungen eingreifen
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
US5932716A (en) * 1995-07-26 1999-08-03 Creative Biomolecules, Inc. Morphogen-responsive regulatory elements
US6677432B1 (en) * 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
JP3786533B2 (ja) * 1998-11-12 2006-06-14 善彦 西村 ペプチド及び骨形成促進剤
CA2431552A1 (en) * 2000-11-06 2002-05-16 Thrasos, Inc. Screening methods for bone morphogenetic mimetics

Also Published As

Publication number Publication date
WO1997026277A3 (en) 1997-09-25
EP0876401A2 (en) 1998-11-11
DE69737809D1 (de) 2007-07-26
US6273598B1 (en) 2001-08-14
CA2244228A1 (en) 1997-07-24
DE69737809T2 (de) 2008-02-21
AU2244997A (en) 1997-08-11
WO1997026277A2 (en) 1997-07-24
JP2000501744A (ja) 2000-02-15
US20020028453A1 (en) 2002-03-07
EP0876401B1 (en) 2007-06-13
AU725295B2 (en) 2000-10-12

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