JP2000169371A5 - - Google Patents
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- JP2000169371A5 JP2000169371A5 JP1999282282A JP28228299A JP2000169371A5 JP 2000169371 A5 JP2000169371 A5 JP 2000169371A5 JP 1999282282 A JP1999282282 A JP 1999282282A JP 28228299 A JP28228299 A JP 28228299A JP 2000169371 A5 JP2000169371 A5 JP 2000169371A5
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- JP
- Japan
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- reductase activity
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- 125000001424 substituent group Chemical group 0.000 description 33
- 108010063907 Glutathione Reductase Proteins 0.000 description 23
- 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 description 23
- 125000000217 alkyl group Chemical group 0.000 description 23
- 230000000694 effects Effects 0.000 description 23
- 239000003623 enhancer Substances 0.000 description 21
- 125000004432 carbon atom Chemical group C* 0.000 description 17
- 125000003710 aryl alkyl group Chemical group 0.000 description 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 12
- 125000000623 heterocyclic group Chemical group 0.000 description 11
- 125000003118 aryl group Chemical group 0.000 description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 10
- 125000004430 oxygen atom Chemical group O* 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- 125000003545 alkoxy group Chemical group 0.000 description 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 206010036790 Productive cough Diseases 0.000 description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 description 6
- 210000003802 sputum Anatomy 0.000 description 6
- 208000024794 sputum Diseases 0.000 description 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 5
- 125000002252 acyl group Chemical group 0.000 description 4
- 125000004414 alkyl thio group Chemical group 0.000 description 4
- 150000001412 amines Chemical group 0.000 description 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 125000004434 sulfur atom Chemical group 0.000 description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- GRDDHBKYNNOBJK-IENPIDJESA-N (2s)-2-[4-(dithiolan-3-yl)butylcarbamoylamino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)NCCCCC1CCSS1 GRDDHBKYNNOBJK-IENPIDJESA-N 0.000 description 2
- WIFPKJKKGOXYEU-UHFFFAOYSA-N 5-(dithiolan-3-yl)-n-methylsulfonylpentanamide Chemical compound CS(=O)(=O)NC(=O)CCCCC1CCSS1 WIFPKJKKGOXYEU-UHFFFAOYSA-N 0.000 description 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- ZGDKUCABXJGYPB-UHFFFAOYSA-N ethyl 2-[4-(dithiolan-3-yl)butylcarbamoyl-methylamino]acetate Chemical compound CCOC(=O)CN(C)C(=O)NCCCCC1CCSS1 ZGDKUCABXJGYPB-UHFFFAOYSA-N 0.000 description 2
- PCWMJJUDQHMQMD-RGURZIINSA-N methyl (2s)-2-[4-(dithiolan-3-yl)butylcarbamoylamino]propanoate Chemical compound COC(=O)[C@H](C)NC(=O)NCCCCC1CCSS1 PCWMJJUDQHMQMD-RGURZIINSA-N 0.000 description 2
- QRXWOSNLDDEQEB-UHFFFAOYSA-N methyl 2-[4-(dithiolan-3-yl)butylcarbamoylamino]acetate Chemical compound COC(=O)CNC(=O)NCCCCC1CCSS1 QRXWOSNLDDEQEB-UHFFFAOYSA-N 0.000 description 2
- IRQJPLJAYSKVCF-UHFFFAOYSA-N n-[5-(dithiolan-3-yl)pentyl]methanesulfonamide Chemical compound CS(=O)(=O)NCCCCCC1CCSS1 IRQJPLJAYSKVCF-UHFFFAOYSA-N 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004181 carboxyalkyl group Chemical group 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11282282A JP2000169371A (ja) | 1998-10-02 | 1999-10-04 | ジチオラン誘導体を含有する医薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10-280620 | 1998-10-02 | ||
| JP28062098 | 1998-10-02 | ||
| JP11282282A JP2000169371A (ja) | 1998-10-02 | 1999-10-04 | ジチオラン誘導体を含有する医薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000169371A JP2000169371A (ja) | 2000-06-20 |
| JP2000169371A5 true JP2000169371A5 (enrdf_load_stackoverflow) | 2006-11-16 |
Family
ID=26553851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11282282A Pending JP2000169371A (ja) | 1998-10-02 | 1999-10-04 | ジチオラン誘導体を含有する医薬 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2000169371A (enrdf_load_stackoverflow) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002056886A1 (fr) * | 2001-01-19 | 2002-07-25 | Santen Pharmaceutical Co., Ltd. | Inhibiteurs de l'angiogenese contenant un derive d'uree comme ingredient actif |
| EP1371640B1 (en) | 2001-03-19 | 2009-10-28 | Senju Pharmaceutical Co., Ltd. | Novel a-lipoic acid derivative and use thereof |
| AU2003264412A1 (en) | 2002-09-13 | 2004-04-30 | Oga Research, Incorporated | Melanin extinguisher |
| WO2009014343A2 (en) * | 2007-07-20 | 2009-01-29 | Biogenics, Inc. | Ascorbic acid derivatives having alpha-lipoyl groups and process for preparing the same |
| FR2936146B1 (fr) * | 2008-09-24 | 2010-10-08 | Oreal | Utilisations de composes dithiolanes pour la photoprotection de la peau ; nouveaux composes dithiolanes ; compositions les contenant. |
| FR2936153B1 (fr) * | 2008-09-24 | 2010-10-08 | Oreal | Utilisations de composes dithiolanes pour la photoprotection de la peau ; nouveaux composes dithiolanes ; compositions les contenant. |
| JP2012508165A (ja) * | 2008-11-07 | 2012-04-05 | イスティテュート ビオキーミコ ナッツィオナーレ サーヴィオ エスアールエル | α−リポ酸誘導体及び薬物製剤へのそれらの使用 |
| US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| JP5601872B2 (ja) * | 2010-04-21 | 2014-10-08 | 株式会社松風 | 含イオウ重合性化合物およびそれを含有する接着性組成物 |
| AU2011329215C1 (en) * | 2010-11-18 | 2016-08-11 | Ischemix Llc | Lipoyl compounds and their use for treating ischemic injury |
| ES2952834T3 (es) | 2017-04-25 | 2023-11-06 | Ischemix Llc | Lipoil-Glu-Ala para el tratamiento de daño neurodegenerativo producido por traumatismo craneoencefálico |
| WO2021124272A1 (en) * | 2019-12-19 | 2021-06-24 | Liminal Biosciences Limited | Cycloalkyl-containing carboxylic acids and uses thereof |
| JPWO2021241582A1 (enrdf_load_stackoverflow) * | 2020-05-26 | 2021-12-02 | ||
| WO2023058673A1 (ja) * | 2021-10-06 | 2023-04-13 | 参天製薬株式会社 | 老視等の治療または予防に有用な含硫黄化合物 |
| WO2024101918A1 (ko) * | 2022-11-11 | 2024-05-16 | 주식회사 메디치바이오 | 리포-하이드록삼산 유도체 및 이의 약학적 용도 |
| CN116407557A (zh) * | 2023-05-29 | 2023-07-11 | 四川大学华西医院 | 一种防治出血性脑卒中的药物组合物及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5581865A (en) * | 1978-10-30 | 1980-06-20 | Fujisawa Pharmaceut Co Ltd | 5-fluorouracil derivatives and their preparation |
| CH656382A5 (de) * | 1983-10-24 | 1986-06-30 | Sandoz Ag | Sulfoxide, verfahren zu ihrer herstellung und ihre verwendung. |
| JPH0673005B2 (ja) * | 1985-01-24 | 1994-09-14 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
| IT1252865B (it) * | 1991-12-31 | 1995-06-28 | Lifegroup Spa | N-acilderivati di aminoalcooli attivi come autocoidi locali ed utilizzabili nella terapia dei processi autoimmuni |
| FR2707983A1 (fr) * | 1993-07-21 | 1995-01-27 | Pf Medicament | Nouveaux dérivés de l'acide lipoïque et dihydrolipoïque, leur préparation et leur application en thérapeutique humaine. |
| DE4327462A1 (de) * | 1993-08-16 | 1995-02-23 | Carl Heinrich Dr Weischer | Neue N-Acetyl-p-Aminophenol-Derivate zur Bekämpfung von Schmerzzuständen |
| DE4343593C2 (de) * | 1993-12-21 | 1998-05-20 | Asta Medica Ag | Verwendung von R-(+)-alpha-Liponsäure, R-(-)-Dihydroliponsäure oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung kompensierter und dekompensierter Insulinresistenz |
| ATE214936T1 (de) * | 1995-12-14 | 2002-04-15 | Novelos Therapeutics Inc | Oxidiertes glutathion als mittel zur verbesserung der endogenen produktion von cytokinen und haematopoietischen faktoren |
| WO1998023606A1 (fr) * | 1996-11-27 | 1998-06-04 | Fuji Kagaku Kogyo Kabushiki Kaisha | Derives dithio cycliques, remedes contre des maladies renales diabetiques, agents hypoglycemiques, agents hypolipidemiques et agents lenitifs contre les troubles digestifs |
| EP0855396A1 (en) * | 1997-01-22 | 1998-07-29 | ASTA Medica Aktiengesellschaft | Thioctic acid metabolites and methods of use thereof |
| US6090842A (en) * | 1998-03-10 | 2000-07-18 | The Regents Of The University Of California | Lipoic acid analogs |
| JP3603177B2 (ja) * | 1998-03-26 | 2004-12-22 | 参天製薬株式会社 | 新規ウレア誘導体 |
-
1999
- 1999-10-04 JP JP11282282A patent/JP2000169371A/ja active Pending
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