JOP20210035A1 - توليفات تشتمل على بريكس ببرازول أو ملح منه وعقار ثاني للاستخدام في علاج اضطراب cns - Google Patents
توليفات تشتمل على بريكس ببرازول أو ملح منه وعقار ثاني للاستخدام في علاج اضطراب cnsInfo
- Publication number
- JOP20210035A1 JOP20210035A1 JOP/2021/0035A JOP20210035A JOP20210035A1 JO P20210035 A1 JOP20210035 A1 JO P20210035A1 JO P20210035 A JOP20210035 A JO P20210035A JO P20210035 A1 JOP20210035 A1 JO P20210035A1
- Authority
- JO
- Jordan
- Prior art keywords
- drug
- salt
- reuptake inhibitor
- antidepressant
- brexpiprazole
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Abstract
يتعلق الاختراع الحالي بدواء له نطاق علاجي أوسع، ويتسبب في آثار جانبية أقل ويكون أقوى من حيث التحمل والأمان، مقارنةً بالعوامل المضادة للذهان النمطية المعروفة والعوامل المضادة للذهان غير النمطية. يتعلق الاختراع الحالي بدواء يشتمل على (1) مركب يتمثل في 7-[4-(4-بنزو[b]ثيوفين-4-يل-بيبرازين-1-يل)بيوتوكسي]-1H-كينولين-2-أون أو ملح منه، و(2) عقار واحد على الأقل يتم اختياره من المجموعة المؤلفة من مثبت الحالة المزاجية، مثبط إعادة امتصاص السيرُوتُونين، مثبط إعادة امتصاص النورأَبِينِفْرين، مثبط إعادة امتصاص السيرُوتُونين والنورأَبِينِفْرين، مضاد للاكتئاب نُورأَدْرينيّ وسيروتونيني التأثير نوعي، عقار مضاد للقلق، مضاد للاكتئاب ثلاثي الحلقة، مضاد للاكتئاب رباعي الحلقة، وعقار مضاد للذهان وعقار مضاد لـ ADHD، في توليفة.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161471911P | 2011-04-05 | 2011-04-05 | |
US201161580540P | 2011-12-27 | 2011-12-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20210035A1 true JOP20210035A1 (ar) | 2023-01-30 |
Family
ID=46045045
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2012/0083A JOP20120083B1 (ar) | 2011-04-05 | 2012-04-03 | توليفات تشتمل على بريكس ببرازول أو ملح منه وعقار ثاني للاستخدام في علاج اضطراب cns |
JOP/2021/0035A JOP20210035A1 (ar) | 2011-04-05 | 2021-02-25 | توليفات تشتمل على بريكس ببرازول أو ملح منه وعقار ثاني للاستخدام في علاج اضطراب cns |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2012/0083A JOP20120083B1 (ar) | 2011-04-05 | 2012-04-03 | توليفات تشتمل على بريكس ببرازول أو ملح منه وعقار ثاني للاستخدام في علاج اضطراب cns |
Country Status (31)
Country | Link |
---|---|
US (5) | US20140120185A1 (ar) |
EP (4) | EP2694043B1 (ar) |
JP (2) | JP5992924B2 (ar) |
KR (1) | KR101890450B1 (ar) |
CN (2) | CN108042808B (ar) |
AR (1) | AR085840A1 (ar) |
AU (1) | AU2012240864B2 (ar) |
BR (1) | BR112013025420B1 (ar) |
CA (1) | CA2832157C (ar) |
CO (1) | CO6801769A2 (ar) |
CY (1) | CY1120567T1 (ar) |
DK (1) | DK2694043T3 (ar) |
EA (1) | EA035837B1 (ar) |
ES (1) | ES2654851T3 (ar) |
HK (1) | HK1246159A1 (ar) |
HR (1) | HRP20180098T1 (ar) |
HU (1) | HUE035542T2 (ar) |
IL (1) | IL228669B (ar) |
JO (2) | JOP20120083B1 (ar) |
LT (1) | LT2694043T (ar) |
MX (2) | MX370670B (ar) |
MY (1) | MY166936A (ar) |
NZ (1) | NZ615591A (ar) |
PL (1) | PL2694043T3 (ar) |
PT (1) | PT2694043T (ar) |
RS (1) | RS56802B1 (ar) |
SG (2) | SG10201602326RA (ar) |
SI (1) | SI2694043T1 (ar) |
TW (1) | TWI636784B (ar) |
WO (1) | WO2012137971A1 (ar) |
ZA (1) | ZA201306981B (ar) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3753B1 (ar) * | 2011-10-14 | 2021-01-31 | Otsuka Pharma Co Ltd | قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه |
TWI632921B (zh) * | 2011-10-19 | 2018-08-21 | 大塚製藥股份有限公司 | 口服溶液 |
TW201332572A (zh) * | 2011-12-28 | 2013-08-16 | Otsuka Pharma Co Ltd | 具有經取代的β-環糊精之藥物製劑 |
JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
JOP20210047A1 (ar) * | 2012-10-25 | 2017-06-16 | Otsuka Pharma Co Ltd | عامل وقائي و/أو علاجي للأعراض السلوكية والنفسية المصحوبة بمرض تنكسي عصبي أو الأعراض الإندفاعية المصحوبة بمرض ذهني، يحتوي على بريكسبيرازول أو ملحه |
SG11201608766TA (en) | 2014-04-22 | 2016-11-29 | Otsuka Pharma Co Ltd | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
WO2015188092A1 (en) * | 2014-06-06 | 2015-12-10 | Rhodes Pharmaceuticals, L.P. | Methods for treating attention deficit hyperactivity disorder with methylphenidate |
CA2936748C (en) | 2014-10-31 | 2017-08-08 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
AU2017240259A1 (en) | 2016-04-01 | 2018-10-18 | Upmc | Regulatory device and associated method |
US11123300B2 (en) | 2016-08-16 | 2021-09-21 | Hexal Ag | Immediate release tablet of a benzothiophene compound |
EP3500249A1 (en) | 2016-08-16 | 2019-06-26 | Hexal Aktiengesellschaft | Pharmaceutical compositions of a benzothiophene compound |
DK3532064T3 (da) * | 2016-10-28 | 2020-08-24 | H Lundbeck As | Kombinationsbehandlinger omfattende imidazopyrazinoner til behandlingen af psykiatriske og/eller kognitive lidelser |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
EP3501506B1 (en) * | 2017-12-19 | 2019-10-09 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising brexpiprazole |
JP6831354B2 (ja) * | 2018-08-16 | 2021-02-17 | 株式会社Dnpファインケミカル | 接着性組成物からなる錠剤、その製造方法、及び該錠剤を用いた部材又は部品の製造方法 |
JP2019183095A (ja) * | 2018-08-16 | 2019-10-24 | 株式会社Dnpファインケミカル | 接着性粉体、接着性錠剤の製造方法、接着性錠剤、並びに該接着性粉体及び錠剤を用いた部材又は部品の製造方法 |
BR112021007745A2 (pt) * | 2018-10-24 | 2021-07-27 | Effector Therapeutics, Inc. | formas cristalinas de inibidores de mnk |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
TW202103699A (zh) | 2019-04-17 | 2021-02-01 | 英商康派斯百事威公司 | 賽洛西賓(psilocybin)於憂鬱及其他各種失調症之治療 |
JPWO2021029020A1 (ar) * | 2019-08-13 | 2021-02-18 | ||
US11229644B1 (en) * | 2020-12-31 | 2022-01-25 | Lake O'hara Llc | Methods of treating psychiatric disorders in obese patients with brexpiprazole |
CN113322299A (zh) * | 2021-05-28 | 2021-08-31 | 南昌大学 | 一种抑郁症和药物成瘾疾病的药物靶点识别方法 |
US20240009181A1 (en) * | 2022-07-08 | 2024-01-11 | Jason Eric Schiffman | Method for the treatment and prophylaxis of substance-related and/or addictive disorders including substance/medication-induced depressive disorders, bipolar and related disorders, and anxiety disorders and compositions useful for the same |
US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
IL121076A (en) * | 1996-06-19 | 2000-10-31 | Akzo Nobel Nv | Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors |
IL123716A (en) * | 1997-03-27 | 2001-03-19 | Akzo Nobel Nv | Therapeutic combinations of mirtazapine and an antipsychotic agent |
US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
US20040176466A1 (en) * | 2001-08-08 | 2004-09-09 | Allen Albert John | Combination therapy for the treatment of neurological disorders |
MXPA05006857A (es) * | 2002-12-27 | 2005-08-18 | Otsuka Pharma Co Ltd | Derivados de carbostirilo e inhibidores de la recaptacion de serotonina para el tratamiento de desordenes en el humor. |
CA2601716C (en) * | 2004-06-25 | 2011-05-31 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia |
JP4315393B2 (ja) * | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
JP4540700B2 (ja) * | 2006-10-13 | 2010-09-08 | 大塚製薬株式会社 | 医薬 |
DE602007010818D1 (de) * | 2006-10-27 | 2011-01-05 | Janssen Pharmaceutica Nv | Verfahren zur behandlung disruptiver verhaltensstörungen |
JP2008189616A (ja) * | 2007-02-07 | 2008-08-21 | Mitsubishi Tanabe Pharma Corp | 注意欠陥多動性障害の治療薬 |
JP2011136906A (ja) * | 2008-04-18 | 2011-07-14 | Otsuka Pharmaceut Co Ltd | 複素環化合物 |
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2012
- 2012-04-03 JO JOP/2012/0083A patent/JOP20120083B1/ar active
- 2012-04-03 TW TW101111875A patent/TWI636784B/zh active
- 2012-04-03 AR ARP120101135A patent/AR085840A1/es unknown
- 2012-04-04 EP EP12719460.3A patent/EP2694043B1/en not_active Revoked
- 2012-04-04 RS RS20180064A patent/RS56802B1/sr unknown
- 2012-04-04 EA EA201391450A patent/EA035837B1/ru not_active IP Right Cessation
- 2012-04-04 EP EP22155365.4A patent/EP4023223A1/en active Pending
- 2012-04-04 MY MYPI2013701740A patent/MY166936A/en unknown
- 2012-04-04 WO PCT/JP2012/059825 patent/WO2012137971A1/en active Application Filing
- 2012-04-04 EP EP17198877.7A patent/EP3299018A1/en not_active Withdrawn
- 2012-04-04 SG SG10201602326RA patent/SG10201602326RA/en unknown
- 2012-04-04 BR BR112013025420-3A patent/BR112013025420B1/pt active IP Right Grant
- 2012-04-04 US US14/009,436 patent/US20140120185A1/en not_active Abandoned
- 2012-04-04 LT LTEP12719460.3T patent/LT2694043T/lt unknown
- 2012-04-04 EP EP19205895.6A patent/EP3626243A1/en not_active Withdrawn
- 2012-04-04 AU AU2012240864A patent/AU2012240864B2/en active Active
- 2012-04-04 CN CN201810096214.1A patent/CN108042808B/zh active Active
- 2012-04-04 DK DK12719460.3T patent/DK2694043T3/en active
- 2012-04-04 JP JP2013546481A patent/JP5992924B2/ja active Active
- 2012-04-04 PL PL12719460T patent/PL2694043T3/pl unknown
- 2012-04-04 SG SG2013069273A patent/SG193468A1/en unknown
- 2012-04-04 KR KR1020137029250A patent/KR101890450B1/ko active IP Right Grant
- 2012-04-04 CA CA2832157A patent/CA2832157C/en active Active
- 2012-04-04 MX MX2013010796A patent/MX370670B/es active IP Right Grant
- 2012-04-04 ES ES12719460.3T patent/ES2654851T3/es active Active
- 2012-04-04 SI SI201231192T patent/SI2694043T1/en unknown
- 2012-04-04 HU HUE12719460A patent/HUE035542T2/hu unknown
- 2012-04-04 PT PT127194603T patent/PT2694043T/pt unknown
- 2012-04-04 NZ NZ615591A patent/NZ615591A/en unknown
- 2012-04-04 CN CN201280017329.8A patent/CN103547260B/zh active Active
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2013
- 2013-09-17 ZA ZA2013/06981A patent/ZA201306981B/en unknown
- 2013-09-20 MX MX2019015237A patent/MX2019015237A/es unknown
- 2013-10-01 IL IL228669A patent/IL228669B/en active IP Right Grant
- 2013-11-05 CO CO13261085A patent/CO6801769A2/es not_active Application Discontinuation
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2014
- 2014-05-09 HK HK18105601.0A patent/HK1246159A1/zh unknown
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2016
- 2016-08-18 JP JP2016160872A patent/JP2017031155A/ja active Pending
- 2016-12-21 US US15/386,289 patent/US20170100395A1/en not_active Abandoned
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2017
- 2017-10-19 US US15/788,102 patent/US20180042923A1/en not_active Abandoned
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2018
- 2018-01-17 CY CY20181100057T patent/CY1120567T1/el unknown
- 2018-01-18 HR HRP20180098TT patent/HRP20180098T1/hr unknown
- 2018-07-20 US US16/041,246 patent/US20180325894A1/en not_active Abandoned
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2021
- 2021-02-25 JO JOP/2021/0035A patent/JOP20210035A1/ar unknown
- 2021-03-10 US US17/197,725 patent/US20220000861A1/en not_active Abandoned
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