HRP20180098T1 - Kombinacije koje obuhvaćaju brekspiprazol ili jednu njegovu sol i jedan drugi lijek za uporabu u liječenju cns-poremećaja - Google Patents
Kombinacije koje obuhvaćaju brekspiprazol ili jednu njegovu sol i jedan drugi lijek za uporabu u liječenju cns-poremećaja Download PDFInfo
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Claims (12)
1. Medikament, naznačen time, da obuhvaća sljedeće:
(I) spoj koji je 7-[4-(4-benzo[b]tiofen-4-il-piperazin-1-il)butoksi]-1H-kinolin-2-on ili jedna njegova sol, i
(II) najmanje jedan lijek odabran iz skupine koja se sastoji od inhibitora povratne apsorpcije serotonina, i inhibitora povratne apsorpcije serotonina i noradrenalina;
pri čemu se kod navedenog inhibitora povratne apsorpcije serotonina radi o najmanje jednom lijeku odabranom iz skupine koju čine fluoksetin, citalopram, fluvoksamin, paroksetin, sertralin, escitalopram i njihove soli, a
kod navedenog inhibitora povratne apsorpcije serotonina i noradrenalina, radi se o najmanje jednom lijeku odabranom iz skupine koju čine venlafaksin, duloksetin, milnacipran, desvenlafaksin i njihove soli.
2. Medikament prema zahtjevu 1, naznačen time, da medikament obuhvaća navedeni spoj (I) i navedeni lijek (II) u jedinstvenom pripravku.
3. Medikament prema zahtjevu 1, naznačen time, da medikament obuhvaća jedan sastav koji obuhvaća navedeni spoj (I) i jedan sastav koji obuhvaća navedeni lijek (II), koji su formulirani odvojeno, te se sastav od navedenog spoja (I) pripravlja za uporabu u kombinaciji sa sastavom od navedenog lijeka (II).
4. Medikament prema bilo kojem od zahtjeva 1 do 3, naznačen time, da se kod navedenog lijeka (II) radi o inhibitoru povratne apsorpcije serotonina, koji je najmanje jedan lijek odabaran iz skupine koju čine fluoksetin, citalopram, fluvoksamin, paroksetin, sertralin, escitalopram i njihove soli.
5. Medikament prema bilo kojem od zahtjeva 1 do 3, naznačen time, da se kod navedenog lijeka (II) radi o inhibitoru povratne apsorpcije serotonina i noradrenalina, koji je najmanje jedan lijek odabaran iz skupine koju čine venlafaksin, duloksetin, milnacipran, desvenlafaksin i njihove soli.
6. Medikament prema bilo kojem od zahtjeva 1 do 5, naznačen time, da se upotrebljava u profilaksi ili liječenju bolesti centralnog neurološkog sustava.
7. Medikament za uporabu prema zahtjevu 6, naznačen time, da se kod bolesti centralnog neurološkog sustava radi o bolesti centralnog neurološkog sustava odabranoj iz skupine koju čine: shizofrenija, otpornost na liječenje, uporna ili kronična shizofrenija, emocionalne povrede, psihotički poremećaj, poremećaj raspoloženja, bipolarni poremećaj (primjerice bipolarni poremećaj tipa I i bipolarni poremećaj tipa II), manija, depresija, endogena depresija, jaka depresija, melankolija i depresija otporna na liječenje, distimija, ciklotimijski poremećaj, anksioznost (primjerice napadi panike, panični poremećaj, agorafobija, socijalna fobija, opsesivno-kompulzivni poremećaj, post-traumatski stresni poremećaj, generalizirana anksioznost, akutni stresni poremećaj), somatoformni poremećaj (primjerice histerija, somatizacijski poremećaj, konverzijski poremećaj, poremećaj s bolovima, hipohondrija), fiktivni poremećaj, disocijativni poremećaj, seksualni poremećaj, (primjerice seksualna disfunkcija, poremećaj seksualne želje, poremećaj seksualne napetosti, erektilna disfunkcija), poremećaj hranjenja (primjerice anoreksija, bulimija) poremećaj spavanja, poremećaj prilagodbe, poremećaj povezan sa supstancom (primjerice zlouporaba alkohola, trovanje alkoholom i ovisnost o drogi, trovanje stimulansom, narkotizam), anhedonija (primjerice iatrogenska anhedonija, anhedonija s psihičkim ili mentalnim uzrokom, anhedonija povezana s depresijom, anhedonija povezana sa shizofrenijom), delirij, kognitivno oštećenje, kognitivno oštećenje povezano s Alzheimerovom, Parkinsonovom te ostalim neurodegenerativnim bolestima, kognitivno oštećenje uzrokovano Alzheimerovom bolešću, Parkinsonovom bolešću i s time povezanim neurodegenerativnim bolestima, kognitivno oštećenje kod shizofrenije, kognitivno oštećenje uzrokovano otpornošću na liječenje, uporna ili kronična shizofrenija, povraćanje, bolest kretanja/putovanja, pretilost, migrena, bol, mentalna retardacija, autistični poremećaj (autizam), Touretteov sindrom, poremećaj s tikovima, poremećaj hiperaktivnosti s pomanjkanjem pažnje, ozbiljan poremećaj vladanja i Downov sindrom.
8. Farmaceutski sastav, naznačen time, da obuhvaća medikament prema bilo kojem od zahtjeva 1 do 5 te najmanje jedan farmakološki prihvatljiv nosač.
9. Medikament, naznačen time, da on obuhvaća (I) spoj koji je 7-[4-(4-benzo[b]tiofen-4-il-piperazin-1-il)butoksi]-1H-kinolin-2-on ili jedna njegova sol, za primjenu u liječenju bolesti centralnog neurološkog sustava kod pacijenta kojemu se daje (II) najmanje jedan lijek odabran iz skupine koja se sastoji od inhibitora povratne apsorpcije serotonina i inhibitora povratne apsorpcije serotonina i noradrenalina;
pri čemu je navedeni inhibitor povratne apsorpcije serotonina najmanje jedan lijek odabaran iz skupine koju čine fluoksetin, citalopram, fluvoksamin, paroksetin, sertralin, escitalopram i njihove soli, dok je navedeni inhibitor povratne apsorpcije serotonina i noradrenalina najmanje jedan lijek odabran iz skupine koju čine venlafaksin, duloksetin, milnacipran, desvenlafaksin i njihove soli.
10. Medikament za uporabu prema zahtjevu 9, naznačen time, da se kod liječenja radi o liječenju bolesti centralnog neurološkog sustava koja je odabrana iz skupine koju čine: shizofrenija, otpornost na liječenje, uporna ili kronična shizofrenija, emocionalne povrede, psihotički poremećaj, poremećaj raspoloženja, bipolarni poremećaj (primjerice bipolarni poremećaj tipa I i bipolarni poremećaj tipa II), manija, depresija, endogena depresija, jaka depresija, melankolija i depresija otporna na liječenje, distimija, ciklotimijski poremećaj, anksioznost (primjerice napadi panike, panični poremećaj, agorafobija, socijalna fobija, opsesivno-kompulzivni poremećaj, post-traumatski stresni poremećaj, generalizirana anksioznost, akutni stresni poremećaj), somatoformni poremećaj (primjerice histerija, somatizacijski poremećaj, konverzijski poremećaj, poremećaj s bolovima, hipohondrija), fiktivni poremećaj, disocijativni poremećaj, seksualni poremećaj, (primjerice seksualna disfunkcija, poremećaj seksualne želje, poremećaj seksualne napetosti, erektilna disfunkcija), poremećaj hranjenja (primjerice anoreksija, bulimija) poremećaj spavanja, poremećaj prilagodbe, poremećaj povezan sa supstancom (primjerice zlouporaba alkohola, trovanje alkoholom i ovisnost o drogi, trovanje stimulansom, narkotizam), anhedonija (primjerice iatrogenska anhedonija, anhedonija s psihičkim ili mentalnim uzrokom, anhedonija povezana s depresijom, anhedonija povezana sa shizofrenijom), delirij, kognitivno oštećenje, kognitivno oštećenje povezano s Alzheimerovom, Parkinsonovom te ostalim neurodegenerativnim bolestima, kognitivno oštećenje uzrokovano Alzheimerovom bolešću, Parkinsonovom bolešću i s time povezanim neurodegenerativnim bolestima, kognitivno oštećenje kod shizofrenije, kognitivno oštećenje uzrokovano otpornošću na liječenje, uporna ili kronična shizofrenija, povraćanje, bolest kretanja/putovanja, pretilost, migrena, bol, mentalna retardacija, autistični poremećaj (autizam), Touretteov sindrom, poremećaj s tikovima, poremećaj hiperaktivnosti s pomanjkanjem pažnje, ozbiljan poremećaj vladanja i Downov sindrom.
11. Medikament, naznačen time, da on obuhvaća (II) najmanje jedan lijek odabran iz skupine koja se sastoji od inhibitora povratne apsorpcije serotonina i inhibitora povratne apsorpcije serotonina i noradrenalina, za primjenu u liječenju bolesti centralnog neurološkog sustava kod pacijenta kojemu se daje (I) spoj koji je 7-[4-(4-benzo[b]tiofen-4-il-piperazin-1-il)butoksi]-1H-kinolin-2-on ili jedna njegova sol;
pri čemu je navedeni inhibitor povratne apsorpcije serotonina najmanje jedan lijek odabaran iz skupine koju čine fluoksetin, citalopram, fluvoksamin, paroksetin, sertralin, escitalopram i njihove soli, dok je navedeni inhibitor povratne apsorpcije serotonina i noradrenalina najmanje jedan lijek odabran iz skupine koju čine venlafaksin, duloksetin, milnacipran, desvenlafaksin i njihove soli.
12. Medikament za uporabu prema zahtjevu 11, naznačen time, da se kod liječenja radi o liječenju bolesti centralnog neurološkog sustava koja je odabrana iz skupine koju čine: shizofrenija, otpornost na liječenje, uporna ili kronična shizofrenija, emocionalne povrede, psihotički poremećaj, poremećaj raspoloženja, bipolarni poremećaj (primjerice bipolarni poremećaj tipa I i bipolarni poremećaj tipa II), manija, depresija, endogena depresija, jaka depresija, melankolija i depresija otporna na liječenje, distimija, ciklotimijski poremećaj, anksioznost (primjerice napadi panike, panični poremećaj, agorafobija, socijalna fobija, opsesivno-kompulzivni poremećaj, post-traumatski stresni poremećaj, generalizirana anksioznost, akutni stresni poremećaj), somatoformni poremećaj (primjerice histerija, somatizacijski poremećaj, konverzijski poremećaj, poremećaj s bolovima, hipohondrija), fiktivni poremećaj, disocijativni poremećaj, seksualni poremećaj, (primjerice seksualna disfunkcija, poremećaj seksualne želje, poremećaj seksualne napetosti, erektilna disfunkcija), poremećaj hranjenja (primjerice anoreksija, bulimija) poremećaj spavanja, poremećaj prilagodbe, poremećaj povezan sa supstancom (primjerice zlouporaba alkohola, trovanje alkoholom i ovisnost o drogi, trovanje stimulansom, narkotizam), anhedonija (primjerice iatrogenska anhedonija, anhedonija s psihičkim ili mentalnim uzrokom, anhedonija povezana s depresijom, anhedonija povezana sa shizofrenijom), delirij, kognitivno oštećenje, kognitivno oštećenje povezano s Alzheimerovom, Parkinsonovom te ostalim neurodegenerativnim bolestima, kognitivno oštećenje uzrokovano Alzheimerovom bolešću, Parkinsonovom bolešću i s time povezanim neurodegenerativnim bolestima, kognitivno oštećenje kod shizofrenije, kognitivno oštećenje uzrokovano otpornošću na liječenje, uporna ili kronična shizofrenija, povraćanje, bolest kretanja/putovanja, pretilost, migrena, bol, mentalna retardacija, autistični poremećaj (autizam), Touretteov sindrom, poremećaj s tikovima, poremećaj hiperaktivnosti s pomanjkanjem pažnje, ozbiljan poremećaj vladanja i Downov sindrom.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161471911P | 2011-04-05 | 2011-04-05 | |
| US201161580540P | 2011-12-27 | 2011-12-27 | |
| PCT/JP2012/059825 WO2012137971A1 (en) | 2011-04-05 | 2012-04-04 | Combinations comprising brexpiprazole or a salt thereof and a second drug for use in the treatment of a cns disorder |
| EP12719460.3A EP2694043B1 (en) | 2011-04-05 | 2012-04-04 | Combinations comprising brexpiprazole or a salt thereof and a second drug for use in the treatment of a cns disorder |
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| Publication Number | Publication Date |
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| HRP20180098T1 true HRP20180098T1 (hr) | 2018-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| HRP20180098TT HRP20180098T1 (hr) | 2011-04-05 | 2012-04-04 | Kombinacije koje obuhvaćaju brekspiprazol ili jednu njegovu sol i jedan drugi lijek za uporabu u liječenju cns-poremećaja |
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| US (7) | US20140120185A1 (hr) |
| EP (5) | EP4023223A1 (hr) |
| JP (2) | JP5992924B2 (hr) |
| KR (1) | KR101890450B1 (hr) |
| CN (2) | CN103547260B (hr) |
| AR (1) | AR085840A1 (hr) |
| AU (1) | AU2012240864B2 (hr) |
| BR (1) | BR112013025420B1 (hr) |
| CA (1) | CA2832157C (hr) |
| CO (1) | CO6801769A2 (hr) |
| CY (1) | CY1120567T1 (hr) |
| DK (1) | DK2694043T3 (hr) |
| EA (1) | EA035837B1 (hr) |
| ES (1) | ES2654851T3 (hr) |
| HK (1) | HK1246159A1 (hr) |
| HR (1) | HRP20180098T1 (hr) |
| HU (1) | HUE035542T2 (hr) |
| IL (1) | IL228669B (hr) |
| JO (2) | JOP20120083B1 (hr) |
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| MY (1) | MY166936A (hr) |
| NZ (1) | NZ615591A (hr) |
| PH (3) | PH12013501908A1 (hr) |
| PL (1) | PL2694043T3 (hr) |
| PT (1) | PT2694043T (hr) |
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| SG (2) | SG10201602326RA (hr) |
| SI (1) | SI2694043T1 (hr) |
| SM (1) | SMT201800033T1 (hr) |
| TW (1) | TWI636784B (hr) |
| WO (1) | WO2012137971A1 (hr) |
| ZA (1) | ZA201306981B (hr) |
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| JO3753B1 (ar) * | 2011-10-14 | 2021-01-31 | Otsuka Pharma Co Ltd | قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه |
| TWI679977B (zh) * | 2011-10-19 | 2019-12-21 | 大塚製藥股份有限公司 | 口服溶液 |
| TW201332572A (zh) * | 2011-12-28 | 2013-08-16 | Otsuka Pharma Co Ltd | 具有經取代的β－環糊精之藥物製劑 |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| CN112402421A (zh) * | 2012-10-25 | 2021-02-26 | 大塚制药株式会社 | 含有依匹唑派或其盐的预防和/或治疗剂 |
| EP3134090B1 (en) | 2014-04-22 | 2019-06-05 | Otsuka Pharmaceutical Co., Ltd. | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
| CA2951072A1 (en) * | 2014-06-06 | 2015-12-10 | Rhodes Pharmaceuticals, L.P. | Methods for treating attention deficit hyperactivity disorder with methylphenidate |
| CA2936740C (en) | 2014-10-31 | 2017-10-10 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| WO2017173436A1 (en) | 2016-04-01 | 2017-10-05 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Regulatory device and associated method |
| US11123300B2 (en) | 2016-08-16 | 2021-09-21 | Hexal Ag | Immediate release tablet of a benzothiophene compound |
| US20200093821A1 (en) | 2016-08-16 | 2020-03-26 | Hexal Ag | Pharmaceutical Compositions of a Benzothiophene Compound |
| AU2017350473A1 (en) * | 2016-10-28 | 2019-04-18 | H. Lundbeck A/S | Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| EP3501506B1 (en) * | 2017-12-19 | 2019-10-09 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising brexpiprazole |
| JP2019183095A (ja) * | 2018-08-16 | 2019-10-24 | 株式会社Ｄｎｐファインケミカル | 接着性粉体、接着性錠剤の製造方法、接着性錠剤、並びに該接着性粉体及び錠剤を用いた部材又は部品の製造方法 |
| JP6831354B2 (ja) * | 2018-08-16 | 2021-02-17 | 株式会社Ｄｎｐファインケミカル | 接着性組成物からなる錠剤、その製造方法、及び該錠剤を用いた部材又は部品の製造方法 |
| WO2020070267A1 (en) * | 2018-10-04 | 2020-04-09 | École Polytechnique Fédérale De Lausanne (Epfl) | Cross-linkable polymer, hydrogel, and method of preparation thereof |
| CN113286592A (zh) * | 2018-10-24 | 2021-08-20 | 效应治疗股份有限公司 | Mnk抑制剂的结晶形式 |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| US12377112B2 (en) | 2019-04-17 | 2025-08-05 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| JPWO2021029020A1 (hr) * | 2019-08-13 | 2021-02-18 | ||
| US11229644B1 (en) * | 2020-12-31 | 2022-01-25 | Lake O'hara Llc | Methods of treating psychiatric disorders in obese patients with brexpiprazole |
| CN113322299A (zh) * | 2021-05-28 | 2021-08-31 | 南昌大学 | 一种抑郁症和药物成瘾疾病的药物靶点识别方法 |
| CN116407539B (zh) * | 2021-12-30 | 2025-01-10 | 上海现代药物制剂工程研究中心有限公司 | 依匹哌唑甲基脂肪酸酯的用途 |
| US20240009181A1 (en) * | 2022-07-08 | 2024-01-11 | Jason Eric Schiffman | Method for the treatment and prophylaxis of substance-related and/or addictive disorders including substance/medication-induced depressive disorders, bipolar and related disorders, and anxiety disorders and compositions useful for the same |
| FR3142667A1 (fr) * | 2022-12-01 | 2024-06-07 | Capsum | Composition solide non pulvérulente comprenant au moins 8% en poids d’agent(s) désintégrant |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
| TR2023018024A1 (tr) * | 2023-12-22 | 2025-07-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Brekspi̇prazol i̇çeren tabletler |
| TR2023018022A1 (tr) * | 2023-12-22 | 2025-07-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Brekspi̇prazol i̇çeren bi̇r tablet |
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| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
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| TW587938B (en) * | 1997-03-27 | 2004-05-21 | Akzo Nobel Nv | Pharmaceutical composition for the treatment and/or prophylaxis of psychotic disorder |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| JP2005501070A (ja) * | 2001-08-08 | 2005-01-13 | イーライ・リリー・アンド・カンパニー | 神経障害を処置するための組み合わせ療法 |
| KR100842694B1 (ko) * | 2002-12-27 | 2008-07-01 | 오쓰까 세이야꾸 가부시키가이샤 | 기분 장애 치료용 카르보스티릴 유도체 및 세로토닌 재흡수억제제 |
| AU2005259961B2 (en) * | 2004-06-25 | 2012-05-17 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia |
| JP4315393B2 (ja) * | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
| TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| JP4540700B2 (ja) * | 2006-10-13 | 2010-09-08 | 大塚製薬株式会社 | 医薬 |
| MX2009004552A (es) * | 2006-10-27 | 2009-11-10 | Janssen Pharmaceutica Nv | Metodos de tratamiento de trastornos de comportamiento perturbador. |
| JP2008189616A (ja) * | 2007-02-07 | 2008-08-21 | Mitsubishi Tanabe Pharma Corp | 注意欠陥多動性障害の治療薬 |
| JP2011136906A (ja) * | 2008-04-18 | 2011-07-14 | Otsuka Pharmaceut Co Ltd | 複素環化合物 |
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