JO2410B1 - 6. Replaced pyrido-pyrimidines - Google Patents

6. Replaced pyrido-pyrimidines

Info

Publication number
JO2410B1
JO2410B1 JO200212A JOP20020012A JO2410B1 JO 2410 B1 JO2410 B1 JO 2410B1 JO 200212 A JO200212 A JO 200212A JO P20020012 A JOP20020012 A JO P20020012A JO 2410 B1 JO2410 B1 JO 2410B1
Authority
JO
Jordan
Prior art keywords
pyrido
pyrimidines
substituted
Prior art date
Application number
JO200212A
Other languages
Arabic (ar)
English (en)
Inventor
مارتين ستوهل كريستوف
جيفري تشين جيان
باتريك دن جيمس
ميشيل جولدشتاين ديفيد
Original Assignee
اف. هوفمان- لاروش أيه جي‏
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by اف. هوفمان- لاروش أيه جي‏ filed Critical اف. هوفمان- لاروش أيه جي‏
Application granted granted Critical
Publication of JO2410B1 publication Critical patent/JO2410B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JO200212A 2001-02-12 2002-02-06 6. Replaced pyrido-pyrimidines JO2410B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
JO2410B1 true JO2410B1 (en) 2007-06-17

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
JO200212A JO2410B1 (en) 2001-02-12 2002-02-06 6. Replaced pyrido-pyrimidines

Country Status (32)

Country Link
US (3) US6696566B2 (xx)
EP (1) EP1361880B1 (xx)
JP (1) JP4064818B2 (xx)
KR (1) KR100639772B1 (xx)
CN (1) CN100376571C (xx)
AR (1) AR035854A1 (xx)
AT (1) ATE305303T1 (xx)
AU (1) AU2002256615B2 (xx)
BR (1) BRPI0207172B8 (xx)
CA (1) CA2434834C (xx)
CZ (1) CZ20032416A3 (xx)
DE (1) DE60206363T2 (xx)
DK (1) DK1361880T3 (xx)
ES (1) ES2249574T3 (xx)
HK (1) HK1066170A1 (xx)
HR (1) HRP20030624B1 (xx)
HU (1) HU229604B1 (xx)
IL (2) IL156872A0 (xx)
JO (1) JO2410B1 (xx)
MA (1) MA26993A1 (xx)
MX (1) MXPA03007166A (xx)
MY (1) MY131518A (xx)
NO (1) NO326133B1 (xx)
NZ (1) NZ526961A (xx)
PA (1) PA8539201A1 (xx)
PE (1) PE20020976A1 (xx)
PL (1) PL366918A1 (xx)
RU (1) RU2269527C2 (xx)
SK (1) SK11322003A3 (xx)
WO (1) WO2002064594A2 (xx)
YU (1) YU63703A (xx)
ZA (1) ZA200305938B (xx)

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IL156872A0 (en) 2001-02-12 2004-02-08 Hoffmann La Roche 6-substituted pyrido-pyrimidines
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JP2006503802A (ja) 2002-04-03 2006-02-02 エフ.ホフマン−ラ ロシュ アーゲー イミダゾ縮合化合物
MXPA05001332A (es) * 2002-08-06 2005-04-28 Hoffmann La Roche 6-alcoxi-pirido-pirimidinas como inhibidores de cinasa del map p-38.
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
AP2114A (en) * 2003-02-26 2010-03-04 Sugen Inc Aminoheteroaryl compounds as protein kinase inhibitors
JP2006523640A (ja) * 2003-04-16 2006-10-19 エフ.ホフマン−ラ ロシュ アーゲー 置換7−アザ−キナゾリン化合物
PL1685131T3 (pl) * 2003-11-13 2007-08-31 Hoffmann La Roche Hydroksyalkilo-podstawione pirydo-7-pirymidyn-7-ony
US20090131430A1 (en) * 2004-11-23 2009-05-21 Palle Venkata P Pyrido'2,3-dipyrimidines as anti-inflammatory agents
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
EP1846403A1 (en) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
EP1885369B1 (en) * 2005-05-04 2015-09-23 Evotec AG Fused heterocyclic compounds, and compositions and uses thereof
ATE449097T1 (de) * 2005-07-21 2009-12-15 Hoffmann La Roche Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer
JP2009504665A (ja) * 2005-08-09 2009-02-05 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼ阻害剤としての化合物および組成物
EP1917245A1 (de) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
JO2783B1 (en) * 2005-09-30 2014-03-15 نوفارتيس ايه جي Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones
WO2008150260A1 (en) * 2007-06-06 2008-12-11 Gpc Biotech, Inc. 8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents
WO2008078249A1 (en) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Anti-inflammatory agents
WO2008136948A1 (en) 2007-05-07 2008-11-13 Amgen Inc. Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as p38 modulators, process for their preparation, and their pharmaceutical use
CA2690327A1 (en) 2007-06-15 2008-12-18 Thomas P. Cleary A novel process for the preparation of 3-amino-pentan-1,5-diol
US8367671B2 (en) 2008-03-21 2013-02-05 Amgen Inc. Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
EP2344502A2 (en) * 2008-10-22 2011-07-20 F. Hoffmann-La Roche AG Pyrimidinyl pyridone inhibitors of jnk
WO2010071846A2 (en) 2008-12-19 2010-06-24 Afraxis, Inc. Compounds for treating neuropsychiatric conditions
WO2011044535A2 (en) 2009-10-09 2011-04-14 Afraxis, Inc. 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders
US8889696B2 (en) * 2009-12-18 2014-11-18 Temple University—Of the Commonwealth System of Higher Education Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
JP6631616B2 (ja) 2014-07-26 2020-01-15 ノース・アンド・サウス・ブラザー・ファーマシー・インベストメント・カンパニー・リミテッド CDK阻害剤としての2−アミノ−ピリド[2,3−d]ピリミジン−7(8H)−オン誘導体及びその使用
HUE053648T2 (hu) * 2016-06-08 2021-07-28 Support Venture Gmbh Gyógyászati kombinációk rák kezelésére
HUE055978T2 (hu) 2016-08-15 2022-01-28 Pfizer Piridopirimidinon CDK2/4/6 inhibitorok
EP3500258A1 (en) 2016-08-17 2019-06-26 Support-Venture GmbH Method of preventing or treating hearing loss
WO2018132550A1 (en) 2017-01-11 2018-07-19 The General Hospital Corporation Voltage gated sodium channel imaging agents
SG10202110804WA (en) 2017-04-04 2021-11-29 Kinarus Ag Methods of preventing or treating ophthalmic diseases
EP3676267A4 (en) 2017-08-31 2021-04-14 Dana Farber Cancer Institute, Inc. EGFR AND / OR HER2 INHIBITORS AND METHODS OF USE
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
PT3691620T (pt) 2017-10-05 2022-10-06 Fulcrum Therapeutics Inc Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd
WO2020006210A1 (en) * 2018-06-27 2020-01-02 Tufts Medical Center, Inc. Pyridopyrimidine compounds and methods of their use
MA53114A (fr) 2018-07-13 2021-05-19 Kinarus Ag Combinaisons d'agonistes de ppar et d'inhibiteurs de kinase p38 pour prévenir ou traiter des maladies fibrotiques
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
US20230263803A1 (en) 2020-08-11 2023-08-24 Kinarus Ag Methods of preventing or treating covid-19 and related viral diseases or disorders

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BR9809055A (pt) 1997-04-16 2000-08-08 Abbott Lab Compostos de 4-amino-pirido(2,3-d)pirimidina 5,7-dissubstituìda e seu uso como inibidores de adenosinocinase
AU763839B2 (en) 1998-05-26 2003-07-31 Warner-Lambert Company Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
EA005852B1 (ru) 1998-06-19 2005-06-30 Пфайзер Продактс Инк. ПИРРОЛО[2,3-d]ПИРИМИДИНЫ
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US7053070B2 (en) * 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
WO2001070741A1 (en) * 2000-03-06 2001-09-27 Warner-Lambert Company 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
US6518276B2 (en) * 2000-08-31 2003-02-11 Syntex (U.S.A.) Llc 7-oxo-pyridopyrimidines (II)
IL156872A0 (en) 2001-02-12 2004-02-08 Hoffmann La Roche 6-substituted pyrido-pyrimidines
DK1470124T3 (da) * 2002-01-22 2006-04-18 Warner Lambert Co 2-(Pyridin-2-yl amino)-pyrido[2,3]pyrimidin-7-oner

Also Published As

Publication number Publication date
US7449581B2 (en) 2008-11-11
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
DE60206363D1 (de) 2006-02-09
NO326133B1 (no) 2008-10-06
NZ526961A (en) 2005-03-24
NO20033540L (no) 2003-08-11
ZA200305938B (en) 2005-01-26
RU2269527C2 (ru) 2006-02-10
MXPA03007166A (es) 2003-11-18
HU229604B1 (en) 2014-02-28
ES2249574T3 (es) 2006-04-01
KR100639772B1 (ko) 2006-10-30
US7169794B2 (en) 2007-01-30
BRPI0207172B1 (pt) 2019-04-09
PA8539201A1 (es) 2004-08-31
DE60206363T2 (de) 2006-07-06
EP1361880A2 (en) 2003-11-19
HRP20030624A2 (en) 2005-06-30
CZ20032416A3 (cs) 2004-07-14
US20070135458A1 (en) 2007-06-14
IL156872A (en) 2009-07-20
DK1361880T3 (da) 2006-01-23
PL366918A1 (en) 2005-02-07
BRPI0207172B8 (pt) 2021-05-25
IL156872A0 (en) 2004-02-08
US20030171584A1 (en) 2003-09-11
ATE305303T1 (de) 2005-10-15
JP2004525896A (ja) 2004-08-26
JP4064818B2 (ja) 2008-03-19
HK1066170A1 (en) 2005-03-18
NO20033540D0 (no) 2003-08-11
AU2002256615B2 (en) 2007-09-13
BR0207172A (pt) 2004-03-30
WO2002064594A3 (en) 2003-01-09
CN1503672A (zh) 2004-06-09
AR035854A1 (es) 2004-07-21
MY131518A (en) 2007-08-30
EP1361880B1 (en) 2005-09-28
CA2434834A1 (en) 2002-08-22
RU2003125887A (ru) 2005-03-20
CN100376571C (zh) 2008-03-26
HRP20030624B1 (en) 2007-03-31
HUP0303458A2 (hu) 2004-01-28
US6696566B2 (en) 2004-02-24
US20040116698A1 (en) 2004-06-17
HUP0303458A3 (en) 2012-12-28
KR20040018254A (ko) 2004-03-02
YU63703A (sh) 2006-05-25
WO2002064594A2 (en) 2002-08-22
SK11322003A3 (en) 2004-10-05
CA2434834C (en) 2010-09-14

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