ITMI971523A0 - - Google Patents

Info

Publication number
ITMI971523A0
ITMI971523A0 ITMI971523A ITMI971523A ITMI971523A0 IT MI971523 A0 ITMI971523 A0 IT MI971523A0 IT MI971523 A ITMI971523 A IT MI971523A IT MI971523 A ITMI971523 A IT MI971523A IT MI971523 A0 ITMI971523 A0 IT MI971523A0
Authority
IT
Italy
Application number
ITMI971523A
Other languages
Italian (it)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITMI971523A0 publication Critical patent/ITMI971523A0/it
Priority to IT97MI001523A priority Critical patent/IT1292426B1/it
Priority to BRPI9810459-4A priority patent/BR9810459A/pt
Priority to IL13269198A priority patent/IL132691A/en
Priority to DK98938668T priority patent/DK1019370T3/da
Priority to AT98938668T priority patent/ATE230393T1/de
Priority to AU87300/98A priority patent/AU740411B2/en
Priority to PCT/EP1998/003946 priority patent/WO1999000361A1/en
Priority to CA002292794A priority patent/CA2292794A1/en
Priority to EP98938668A priority patent/EP1019370B1/en
Priority to HU0003133A priority patent/HUP0003133A3/hu
Priority to US09/423,287 priority patent/US6218417B1/en
Priority to CNB988062763A priority patent/CN1205186C/zh
Priority to SI9830175T priority patent/SI1019370T1/xx
Priority to DE69810498T priority patent/DE69810498T2/de
Priority to JP50529499A priority patent/JP2002506456A/ja
Priority to ES98938668T priority patent/ES2190095T3/es
Priority to RU2000100825/04A priority patent/RU2194037C2/ru
Priority to KR10-1999-7011984A priority patent/KR100512892B1/ko
Publication of ITMI971523A1 publication Critical patent/ITMI971523A1/it
Application granted granted Critical
Publication of IT1292426B1 publication Critical patent/IT1292426B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0217—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IT97MI001523A 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori IT1292426B1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori
EP98938668A EP1019370B1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
US09/423,287 US6218417B1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
DK98938668T DK1019370T3 (da) 1997-06-27 1998-06-24 Nitratsalte af ACE-inhibitorer
AT98938668T ATE230393T1 (de) 1997-06-27 1998-06-24 Ace-inhibitoren stickstoffsalze
AU87300/98A AU740411B2 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
PCT/EP1998/003946 WO1999000361A1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
CA002292794A CA2292794A1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
BRPI9810459-4A BR9810459A (pt) 1997-06-27 1998-06-24 sais nìtricos dos inibidores de ace
HU0003133A HUP0003133A3 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts and use of them for producing pharmaceutical compositions
IL13269198A IL132691A (en) 1997-06-27 1998-06-24 Ace-inhibitor nitrate salts and pharmaceutical compositions containing them
CNB988062763A CN1205186C (zh) 1997-06-27 1998-06-24 Ace－抑制剂硝酸盐
SI9830175T SI1019370T1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
DE69810498T DE69810498T2 (de) 1997-06-27 1998-06-24 Ace-inhibitoren stickstoffsalze
JP50529499A JP2002506456A (ja) 1997-06-27 1998-06-24 Ａｃｅ（アンギオテンシン変換酵素）阻害剤硝酸塩
ES98938668T ES2190095T3 (es) 1997-06-27 1998-06-24 Sales nitricas de inhibidores del enzima de conversion.
RU2000100825/04A RU2194037C2 (ru) 1997-06-27 1998-06-24 Нитрат асе-ингибитора
KR10-1999-7011984A KR100512892B1 (ko) 1997-06-27 1998-06-24 에이스저해제 질산염

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori

Publications (3)

Publication Number Publication Date
ITMI971523A0 true ITMI971523A0 (en0) 1997-06-27
ITMI971523A1 ITMI971523A1 (it) 1998-12-27
IT1292426B1 IT1292426B1 (it) 1999-02-08

Family

ID=11377450

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori

Country Status (17)

Country Link
US (1) US6218417B1 (en0)
EP (1) EP1019370B1 (en0)
JP (1) JP2002506456A (en0)
KR (1) KR100512892B1 (en0)
CN (1) CN1205186C (en0)
AT (1) ATE230393T1 (en0)
AU (1) AU740411B2 (en0)
BR (1) BR9810459A (en0)
CA (1) CA2292794A1 (en0)
DE (1) DE69810498T2 (en0)
DK (1) DK1019370T3 (en0)
ES (1) ES2190095T3 (en0)
HU (1) HUP0003133A3 (en0)
IL (1) IL132691A (en0)
IT (1) IT1292426B1 (en0)
RU (1) RU2194037C2 (en0)
WO (1) WO1999000361A1 (en0)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
AU7365900A (en) 1999-09-08 2001-04-10 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
US7708989B2 (en) * 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US6635273B1 (en) 1999-10-29 2003-10-21 Trustees Of Boston University Methods of treating vascular diseases characterized by nitric oxide insufficiency
WO2002087508A2 (en) 2001-05-02 2002-11-07 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
WO2003066067A2 (en) * 2002-02-04 2003-08-14 Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
US20060014828A1 (en) * 2004-07-16 2006-01-19 Nitromed, Inc. Compositions and methods related to heart failure
ATE462703T1 (de) * 2004-08-25 2010-04-15 Actelion Pharmaceuticals Ltd Bicyclononen-derivate als renin-inhibitoren
DK1679072T5 (da) * 2005-01-06 2009-04-20 Ipca Lab Ltd Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril
EP1883412A4 (en) * 2005-05-05 2008-09-03 Keryx Biopharmaceuticals Inc COMBINATION THERAPY WITH SULODEXIDE AND A BLOOD PRESSURE WRITING AGENT IN THE TREATMENT OF DIABETIC NEPHROPATHY
RU2410374C2 (ru) * 2005-05-27 2011-01-27 Актелион Фармасьютикалз Лтд Новые амидные производные пиперидинкарбоновой кислоты
GB0511686D0 (en) * 2005-06-08 2005-07-13 Novartis Ag Organic compounds
EP1934186A2 (en) * 2005-10-18 2008-06-25 NicOx S.A. Renin inhibitors nitroderivatives
WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
JP2009526767A (ja) 2006-02-02 2009-07-23 アクテリオン ファーマシューティカルズ リミテッド 新規二級アミン
WO2007097951A2 (en) * 2006-02-17 2007-08-30 Nitromed, Inc. Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
AR059886A1 (es) * 2006-03-08 2008-05-07 Actelion Pharmaceuticals Ltd Derivados de amidas como inhibidores de renina
WO2007136626A1 (en) * 2006-05-16 2007-11-29 Nitromed, Inc. Solid dosage formulations of hydralazine compounds
MX2010012067A (es) * 2008-05-05 2010-12-06 Merck Frosst Canada Ltd Derivados de 3,4-piperidina sustituida como inhibidores de la renina.
EP2699242B1 (en) 2011-04-19 2017-11-01 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
WO2013013179A1 (en) 2011-07-21 2013-01-24 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT377496B (de) * 1981-06-19 1985-03-25 Voith Gmbh J M Vorrichtung zum anwickeln einer warenbahn auf eine neu eingelegte wickelhuelse in einer doppeltragwalzen-wickelmaschine
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5328933A (en) 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
PT719253E (pt) * 1993-09-17 2004-07-30 Pfizer Piperidinas 3-amino-5-carboxi-substituidas e pirrolidinas 3-amino-4-carboxi-substituidas como antagonistas de taquicinina
EP0759899B1 (en) 1994-05-10 1999-09-15 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
AU4953796A (en) * 1995-03-15 1996-10-02 Sanyko Company, Limited Dipeptide compounds having ahpba structure
US5625083A (en) 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
US5645839A (en) * 1995-06-07 1997-07-08 Trustees Of Boston University Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis
CN1141771A (zh) * 1995-08-02 1997-02-05 贾力 巯-亚硝基化合物及其医学用途

Also Published As

Publication number Publication date
BR9810459A (pt) 2006-10-03
CN1260780A (zh) 2000-07-19
ITMI971523A1 (it) 1998-12-27
RU2194037C2 (ru) 2002-12-10
JP2002506456A (ja) 2002-02-26
US6218417B1 (en) 2001-04-17
HUP0003133A2 (en) 2001-03-28
IL132691A (en) 2004-06-01
ES2190095T3 (es) 2003-07-16
IL132691A0 (en) 2001-03-19
CA2292794A1 (en) 1999-01-07
KR100512892B1 (ko) 2005-09-07
ATE230393T1 (de) 2003-01-15
AU8730098A (en) 1999-01-19
IT1292426B1 (it) 1999-02-08
HUP0003133A3 (en) 2002-10-28
DK1019370T3 (da) 2003-05-05
CN1205186C (zh) 2005-06-08
DE69810498D1 (de) 2003-02-06
KR20010013958A (ko) 2001-02-26
AU740411B2 (en) 2001-11-01
WO1999000361A1 (en) 1999-01-07
EP1019370A1 (en) 2000-07-19
EP1019370B1 (en) 2003-01-02
DE69810498T2 (de) 2003-10-30

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Legal Events

Date Code Title Description
0001 Granted