EP1883412A4 - Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy - Google Patents

Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy

Info

Publication number
EP1883412A4
EP1883412A4 EP06759150A EP06759150A EP1883412A4 EP 1883412 A4 EP1883412 A4 EP 1883412A4 EP 06759150 A EP06759150 A EP 06759150A EP 06759150 A EP06759150 A EP 06759150A EP 1883412 A4 EP1883412 A4 EP 1883412A4
Authority
EP
European Patent Office
Prior art keywords
sulodexide
treatment
reducing agent
blood pressure
pressure reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06759150A
Other languages
German (de)
French (fr)
Other versions
EP1883412A1 (en
Inventor
Michael Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Keryx Biopharmaceuticals Inc
Original Assignee
Keryx Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keryx Biopharmaceuticals Inc filed Critical Keryx Biopharmaceuticals Inc
Publication of EP1883412A1 publication Critical patent/EP1883412A1/en
Publication of EP1883412A4 publication Critical patent/EP1883412A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
EP06759150A 2005-05-05 2006-05-05 Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy Withdrawn EP1883412A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67909605P 2005-05-05 2005-05-05
US73697305P 2005-11-14 2005-11-14
PCT/US2006/017403 WO2006121853A1 (en) 2005-05-05 2006-05-05 Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy

Publications (2)

Publication Number Publication Date
EP1883412A1 EP1883412A1 (en) 2008-02-06
EP1883412A4 true EP1883412A4 (en) 2008-09-03

Family

ID=37396874

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06759150A Withdrawn EP1883412A4 (en) 2005-05-05 2006-05-05 Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy

Country Status (6)

Country Link
EP (1) EP1883412A4 (en)
JP (1) JP2008540448A (en)
AU (1) AU2006244446A1 (en)
CA (1) CA2606880A1 (en)
IL (1) IL187142A0 (en)
WO (1) WO2006121853A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007125385A2 (en) 2005-12-22 2007-11-08 Neurochem (International) Limited Treatment of renal disorders, diabetic nephopathy and dyslipidemias
CN101632686A (en) * 2008-04-04 2010-01-27 马斯特里赫特大学 Use of glycosaminoglycan for restoring glycocalyx
CN104017102B (en) * 2014-06-19 2016-02-24 深圳市海普瑞药业股份有限公司 Ethanol precipitation prepares the method for Sulodexide raw material from heparin byproduct

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001093850A2 (en) * 2000-06-07 2001-12-13 Alfa Wassermann, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270846B (en) * 1993-05-10 1997-05-13 Alfa Wassermann Spa USE OF SULODEXIDE AND MEDICINAL SPECIALTIES THAT CONTAIN IT IN THE TREATMENT OF DIABETIC NEPHROPATHY.
IT1292426B1 (en) * 1997-06-27 1999-02-08 Nicox Sa NITRATED SALTS OF ACE-INHIBITORS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001093850A2 (en) * 2000-06-07 2001-12-13 Alfa Wassermann, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANDIDO RICCARDO ET AL: "Treatment for diabetic nephropathy - a review of the recent patent literature.", IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL MAR 2002, vol. 5, no. 3, March 2002 (2002-03-01), pages 237 - 265, XP002486359, ISSN: 1369-7056 *
GAMBARO GIOVANNI ET AL: "Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric type 1 and type 2 diabetic patients: The Di.N.A.S. randomized trial", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 13, no. 6, June 2002 (2002-06-01), pages 1615 - 1625, XP002486358, ISSN: 1046-6673 *
See also references of WO2006121853A1 *

Also Published As

Publication number Publication date
CA2606880A1 (en) 2006-11-16
IL187142A0 (en) 2008-06-05
AU2006244446A1 (en) 2006-11-16
EP1883412A1 (en) 2008-02-06
JP2008540448A (en) 2008-11-20
WO2006121853A1 (en) 2006-11-16

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RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 13/12 20060101ALI20080722BHEP

Ipc: A61K 45/06 20060101ALI20080722BHEP

Ipc: A61K 31/41 20060101ALI20080722BHEP

Ipc: A61K 31/40 20060101ALI20080722BHEP

Ipc: A61K 31/727 20060101ALI20080722BHEP

Ipc: A61K 31/737 20060101AFI20061201BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20080731

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