ITMI971371A0 - - Google Patents
Info
- Publication number
- ITMI971371A0 ITMI971371A0 ITMI971371A ITMI971371A ITMI971371A0 IT MI971371 A0 ITMI971371 A0 IT MI971371A0 IT MI971371 A ITMI971371 A IT MI971371A IT MI971371 A ITMI971371 A IT MI971371A IT MI971371 A0 ITMI971371 A0 IT MI971371A0
- Authority
- IT
- Italy
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001371A IT1292128B1 (it) | 1997-06-11 | 1997-06-11 | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
| CNB988060035A CN1166649C (zh) | 1997-06-11 | 1998-06-03 | 大环螯合剂及其与顺磁性金属离子的螯合物的制备方法 |
| ES98930787T ES2252845T3 (es) | 1997-06-11 | 1998-06-03 | Procedimiento para la preparacion de quelantes macrociclicos y los quelatos de los mismos con iones de metales paramagneticos. |
| AT98930787T ATE308528T1 (de) | 1997-06-11 | 1998-06-03 | Ein verfahren zur herstellung von makrocyclischen chelatbildnern und deren chelaten mit paramagnetischen metallionen |
| DE69832170T DE69832170T2 (de) | 1997-06-11 | 1998-06-03 | Ein verfahren zur herstellung von makrocyclischen chelatbildnern und deren chelaten mit paramagnetischen metallionen |
| IL13339498A IL133394A (en) | 1997-06-11 | 1998-06-03 | Process for the preparation of macrocylic chelants and the chelates thereof with paramagnetic metal ions |
| PCT/EP1998/003308 WO1998056775A1 (en) | 1997-06-11 | 1998-06-03 | A process for the preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions |
| AU81100/98A AU8110098A (en) | 1997-06-11 | 1998-06-03 | A process for the preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions |
| EP98930787A EP0988294B1 (en) | 1997-06-11 | 1998-06-03 | A process for the preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions |
| JP50149799A JP4351299B2 (ja) | 1997-06-11 | 1998-06-03 | 大環状キレート化剤の製造方法およびその常磁性金属イオンとのキレート化合物 |
| DK98930787T DK0988294T3 (da) | 1997-06-11 | 1998-06-03 | Fremgangsmåde til fremstilling af makrocykliske chelatdannere samt chelaterne deraf med paramagnetiske metalioner |
| US09/095,015 US5925752A (en) | 1997-06-11 | 1998-06-10 | Process for the preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions |
| IN1251MA1998 IN185469B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-06-11 | 1998-06-10 | |
| ZA985025A ZA985025B (en) | 1997-06-11 | 1998-06-10 | A process for the preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions |
| US09/317,272 US6046324A (en) | 1997-06-11 | 1999-05-24 | Process for preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions |
| US09/317,271 US6042810A (en) | 1997-06-11 | 1999-05-24 | Process for the preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions |
| NO19996077A NO313140B1 (no) | 1997-06-11 | 1999-12-09 | Fremgangsmåte ved fremstilling av makrosykliske chelatdannere og chelater derav med paramagnetiske metallioner |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001371A IT1292128B1 (it) | 1997-06-11 | 1997-06-11 | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI971371A0 true ITMI971371A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-06-11 |
| ITMI971371A1 ITMI971371A1 (it) | 1998-12-11 |
| IT1292128B1 IT1292128B1 (it) | 1999-01-25 |
Family
ID=11377336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT97MI001371A IT1292128B1 (it) | 1997-06-11 | 1997-06-11 | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
Country Status (15)
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030017941A1 (en) * | 1997-03-07 | 2003-01-23 | The Procter & Gamble Company | Catalysts and methods for catalytic oxidation |
| ZA981883B (en) * | 1997-03-07 | 1998-09-01 | Univ Kansas | Catalysts and methods for catalytic oxidation |
| US20080125344A1 (en) * | 2006-11-28 | 2008-05-29 | Daryle Hadley Busch | Bleach compositions |
| TR199902673T2 (en) * | 1997-03-07 | 2000-04-21 | The Procter & Gamble Company | A�art�c� bile�imler. |
| IT1292130B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
| IT1292128B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
| US6166201A (en) * | 1999-06-25 | 2000-12-26 | Dibra S.P.A. | Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof |
| US20040048763A1 (en) * | 2002-08-27 | 2004-03-11 | The Procter & Gamble Co. | Bleach compositions |
| US20050192195A1 (en) * | 2002-08-27 | 2005-09-01 | Busch Daryle H. | Catalysts and methods for catalytic oxidation |
| WO2011054480A1 (de) | 2009-11-09 | 2011-05-12 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels keramischer membran |
| DE102009057274B4 (de) | 2009-12-02 | 2011-09-01 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels Trioxobicyclo-octan |
| DE102009053252B3 (de) * | 2009-11-09 | 2011-09-01 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels keramischer Membran |
| DE102010013833A1 (de) | 2010-03-29 | 2011-09-29 | Bayer Schering Pharma Aktiengesellschaft | Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal |
| CN102399199B (zh) * | 2010-09-19 | 2014-01-08 | 广州康臣药物研究有限公司 | 一种磁共振成像造影剂的制备方法 |
| EP2699556A1 (en) * | 2011-04-21 | 2014-02-26 | Bayer Intellectual Property GmbH | Preparation of high-purity gadobutrol |
| CN105939994B (zh) * | 2014-02-06 | 2018-05-29 | T2医药有限责任公司 | 纯化1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的方法 |
| GB201421162D0 (en) | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Lanthanide complex formulations |
| RU2743167C2 (ru) | 2015-12-10 | 2021-02-15 | Бракко Имэджинг Спа | Контрастные агенты |
| SI3753929T1 (sl) | 2015-12-10 | 2023-01-31 | Bracco Imaging Spa | Dimerna kontrastna sredstva |
| BR112019011123B1 (pt) | 2016-12-12 | 2024-02-06 | Bracco Imaging Spa | Agentes de contraste diméricos |
| CN109293592A (zh) * | 2017-07-24 | 2019-02-01 | 天津科伦药物研究有限公司 | 一种制备钆布醇的方法 |
| KR101971435B1 (ko) * | 2017-08-29 | 2019-04-24 | 주식회사 엔지켐생명과학 | 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법 |
| CN108047151B (zh) * | 2018-01-03 | 2020-08-04 | 广州康瑞泰药业有限公司 | 一种高收率钆布醇的制备方法 |
| EP3820853A4 (en) * | 2018-07-10 | 2022-08-17 | Biophore India Pharmaceuticals Pvt. Ltd. | PROCESS FOR THE PREPARATION OF 2,2',2''-(10-((2R,3S)-1,3,4-TRIHYDROXY BUTAN-2-YL)-1,4,7,10-TETRAAZACYCLODODECANE-1 ACID ,4,7-TRIYL) TRIACETIC AND ITS COMPLEXES |
| EP3870569A4 (en) * | 2018-10-24 | 2022-08-24 | Biophore India Pharmaceuticals Pvt. Ltd. | NEW PROCESS FOR THE PREPARATION OF MACROCYCLIC CHELATING TRIACETIC ACID 2,2',2''-(10-(2-HYDROXYPROPYL)-1,4,7,10-TETRA AZACYCLODODECANE-1,4,7-TRIYL) AND ITS COMPLEXES WITH PARAMAGNETIC METALLIC IONS |
| FR3091873B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| US20200397924A1 (en) * | 2019-01-28 | 2020-12-24 | Hubei Tianshu Pharmaceutical Co., Ltd | Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof |
| CN110776649B (zh) * | 2019-11-11 | 2021-10-26 | 重庆师范大学 | 含蒽基的镉-有机超分子聚合物及其制备方法与应用 |
| CN111039885B (zh) * | 2019-12-06 | 2021-03-05 | 广州康瑞泰药业有限公司 | 一种制备高纯度考布曲钙的方法 |
| CN114845998B (zh) | 2019-12-13 | 2024-06-25 | 伯拉考成像股份公司 | 受保护的do3a的制备 |
| ES2991736T3 (es) * | 2020-07-27 | 2024-12-04 | Bracco Imaging Spa | Fabricación de agentes de contraste diméricos |
| CN116547271A (zh) * | 2020-12-04 | 2023-08-04 | 伯拉考成像股份公司 | 用于制备钆特醇的生产方法 |
| CN113527223B (zh) * | 2021-06-22 | 2023-05-09 | 安徽普利药业有限公司 | 一种钆布醇的精制方法 |
| CN114085192B (zh) * | 2021-12-30 | 2023-09-19 | 海南普利制药股份有限公司 | 一种钆特醇中间体的精制方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4085106A (en) * | 1976-01-07 | 1978-04-18 | E. I. Du Pont De Nemours And Company | Bicyclic and tricyclic trisaminomethanes |
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| DE4035760A1 (de) * | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5447635A (en) * | 1991-02-26 | 1995-09-05 | Bracco International B.V. | Process of concentration and purification of organic compounds |
| DE4237943C2 (de) * | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
| DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
| DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
| IT1292128B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
-
1997
- 1997-06-11 IT IT97MI001371A patent/IT1292128B1/it active IP Right Grant
-
1998
- 1998-06-03 AU AU81100/98A patent/AU8110098A/en not_active Abandoned
- 1998-06-03 EP EP98930787A patent/EP0988294B1/en not_active Expired - Lifetime
- 1998-06-03 WO PCT/EP1998/003308 patent/WO1998056775A1/en active IP Right Grant
- 1998-06-03 JP JP50149799A patent/JP4351299B2/ja not_active Expired - Lifetime
- 1998-06-03 IL IL13339498A patent/IL133394A/en not_active IP Right Cessation
- 1998-06-03 CN CNB988060035A patent/CN1166649C/zh not_active Expired - Lifetime
- 1998-06-03 DE DE69832170T patent/DE69832170T2/de not_active Expired - Lifetime
- 1998-06-03 AT AT98930787T patent/ATE308528T1/de active
- 1998-06-03 DK DK98930787T patent/DK0988294T3/da active
- 1998-06-03 ES ES98930787T patent/ES2252845T3/es not_active Expired - Lifetime
- 1998-06-10 ZA ZA985025A patent/ZA985025B/xx unknown
- 1998-06-10 IN IN1251MA1998 patent/IN185469B/en unknown
- 1998-06-10 US US09/095,015 patent/US5925752A/en not_active Expired - Lifetime
-
1999
- 1999-05-24 US US09/317,272 patent/US6046324A/en not_active Expired - Lifetime
- 1999-05-24 US US09/317,271 patent/US6042810A/en not_active Expired - Lifetime
- 1999-12-09 NO NO19996077A patent/NO313140B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0988294B1 (en) | 2005-11-02 |
| ES2252845T3 (es) | 2006-05-16 |
| AU8110098A (en) | 1998-12-30 |
| ITMI971371A1 (it) | 1998-12-11 |
| IT1292128B1 (it) | 1999-01-25 |
| DE69832170D1 (de) | 2005-12-08 |
| DK0988294T3 (da) | 2006-02-13 |
| ATE308528T1 (de) | 2005-11-15 |
| IL133394A (en) | 2004-02-08 |
| IL133394A0 (en) | 2001-04-30 |
| US5925752A (en) | 1999-07-20 |
| WO1998056775A1 (en) | 1998-12-17 |
| JP4351299B2 (ja) | 2009-10-28 |
| US6046324A (en) | 2000-04-04 |
| EP0988294A1 (en) | 2000-03-29 |
| ZA985025B (en) | 1999-01-25 |
| NO313140B1 (no) | 2002-08-19 |
| IN185469B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2001-01-27 |
| CN1259939A (zh) | 2000-07-12 |
| DE69832170T2 (de) | 2006-07-13 |
| CN1166649C (zh) | 2004-09-15 |
| NO996077L (no) | 2000-02-10 |
| JP2002510296A (ja) | 2002-04-02 |
| NO996077D0 (no) | 1999-12-09 |
| US6042810A (en) | 2000-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |