DE69832170D1 - Ein verfahren zur herstellung von makrocyclischen chelatbildnern und deren chelaten mit paramagnetischen metallionen - Google Patents

Ein verfahren zur herstellung von makrocyclischen chelatbildnern und deren chelaten mit paramagnetischen metallionen

Info

Publication number
DE69832170D1
DE69832170D1 DE69832170T DE69832170T DE69832170D1 DE 69832170 D1 DE69832170 D1 DE 69832170D1 DE 69832170 T DE69832170 T DE 69832170T DE 69832170 T DE69832170 T DE 69832170T DE 69832170 D1 DE69832170 D1 DE 69832170D1
Authority
DE
Germany
Prior art keywords
preparation
water
paramagnetic
metallions
chelates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69832170T
Other languages
English (en)
Other versions
DE69832170T2 (de
Inventor
Giorgio Ripa
Alessandro Scala
Marcella Murru
Felice Viscardi
Marina Ausonio
Chiara Scotti
Patrizia Cossuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of DE69832170D1 publication Critical patent/DE69832170D1/de
Publication of DE69832170T2 publication Critical patent/DE69832170T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69832170T 1997-06-11 1998-06-03 Ein verfahren zur herstellung von makrocyclischen chelatbildnern und deren chelaten mit paramagnetischen metallionen Expired - Lifetime DE69832170T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT97MI001371A IT1292128B1 (it) 1997-06-11 1997-06-11 Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
ITMI971371 1997-06-11
PCT/EP1998/003308 WO1998056775A1 (en) 1997-06-11 1998-06-03 A process for the preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions

Publications (2)

Publication Number Publication Date
DE69832170D1 true DE69832170D1 (de) 2005-12-08
DE69832170T2 DE69832170T2 (de) 2006-07-13

Family

ID=11377336

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69832170T Expired - Lifetime DE69832170T2 (de) 1997-06-11 1998-06-03 Ein verfahren zur herstellung von makrocyclischen chelatbildnern und deren chelaten mit paramagnetischen metallionen

Country Status (15)

Country Link
US (3) US5925752A (de)
EP (1) EP0988294B1 (de)
JP (1) JP4351299B2 (de)
CN (1) CN1166649C (de)
AT (1) ATE308528T1 (de)
AU (1) AU8110098A (de)
DE (1) DE69832170T2 (de)
DK (1) DK0988294T3 (de)
ES (1) ES2252845T3 (de)
IL (1) IL133394A (de)
IN (1) IN185469B (de)
IT (1) IT1292128B1 (de)
NO (1) NO313140B1 (de)
WO (1) WO1998056775A1 (de)
ZA (1) ZA985025B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA981883B (en) * 1997-03-07 1998-09-01 Univ Kansas Catalysts and methods for catalytic oxidation
CN1220760C (zh) * 1997-03-07 2005-09-28 普罗格特-甘布尔公司 漂白组合物
US20050187126A1 (en) * 2002-08-27 2005-08-25 Busch Daryle H. Catalysts and methods for catalytic oxidation
US20030017941A1 (en) * 1997-03-07 2003-01-23 The Procter & Gamble Company Catalysts and methods for catalytic oxidation
US20080125344A1 (en) * 2006-11-28 2008-05-29 Daryle Hadley Busch Bleach compositions
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
US6166201A (en) * 1999-06-25 2000-12-26 Dibra S.P.A. Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof
US20040048763A1 (en) * 2002-08-27 2004-03-11 The Procter & Gamble Co. Bleach compositions
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
CN102399199B (zh) * 2010-09-19 2014-01-08 广州康臣药物研究有限公司 一种磁共振成像造影剂的制备方法
EA201600272A1 (ru) * 2011-04-21 2016-12-30 Байер Интеллектчуал Проперти Гмбх Получение гадобутрола высокой чистоты
CN105939994B (zh) * 2014-02-06 2018-05-29 T2医药有限责任公司 纯化1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的方法
GB201421162D0 (en) 2014-11-28 2015-01-14 Ge Healthcare As Lanthanide complex formulations
JP6840148B2 (ja) 2015-12-10 2021-03-10 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 造影剤
EP3386954B1 (de) 2015-12-10 2020-12-02 Bracco Imaging SpA Dimere kontrastmittel
HUE056114T2 (hu) 2016-12-12 2022-01-28 Bracco Imaging Spa Dimer kontrasztanyagok
CN109293592A (zh) * 2017-07-24 2019-02-01 天津科伦药物研究有限公司 一种制备钆布醇的方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
CN108047151B (zh) * 2018-01-03 2020-08-04 广州康瑞泰药业有限公司 一种高收率钆布醇的制备方法
US20210284662A1 (en) * 2018-07-10 2021-09-16 Biophore India Pharmaceuticals Pvt. Ltd Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
EP3870569A4 (de) * 2018-10-24 2022-08-24 Biophore India Pharmaceuticals Pvt. Ltd. Neues verfahren zur herstellung von makrocyclischer chelatbildender 2,2',2''-(10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecan-1,4,7-triyl)-triessigsäure und ihren komplexen mit paramagnetischen metallionen
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
US20200397924A1 (en) 2019-01-28 2020-12-24 Hubei Tianshu Pharmaceutical Co., Ltd Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof
CN110776649B (zh) * 2019-11-11 2021-10-26 重庆师范大学 含蒽基的镉-有机超分子聚合物及其制备方法与应用
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
CA3157618A1 (en) 2019-12-13 2021-06-17 Bracco Imaging Spa Manufacturing of protected do3a
WO2022117619A1 (en) 2020-12-04 2022-06-09 Bracco Imaging Spa Manufacturing process for preparing gadoteridol
CN113527223B (zh) * 2021-06-22 2023-05-09 安徽普利药业有限公司 一种钆布醇的精制方法
CN114085192B (zh) * 2021-12-30 2023-09-19 海南普利制药股份有限公司 一种钆特醇中间体的精制方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4085106A (en) * 1976-01-07 1978-04-18 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic trisaminomethanes
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5447635A (en) * 1991-02-26 1995-09-05 Bracco International B.V. Process of concentration and purification of organic compounds
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici

Also Published As

Publication number Publication date
EP0988294B1 (de) 2005-11-02
EP0988294A1 (de) 2000-03-29
IL133394A (en) 2004-02-08
ES2252845T3 (es) 2006-05-16
ATE308528T1 (de) 2005-11-15
CN1259939A (zh) 2000-07-12
NO996077L (no) 2000-02-10
WO1998056775A1 (en) 1998-12-17
ITMI971371A0 (de) 1997-06-11
IN185469B (de) 2001-01-27
DK0988294T3 (da) 2006-02-13
DE69832170T2 (de) 2006-07-13
JP2002510296A (ja) 2002-04-02
AU8110098A (en) 1998-12-30
US6046324A (en) 2000-04-04
NO996077D0 (no) 1999-12-09
IT1292128B1 (it) 1999-01-25
ZA985025B (en) 1999-01-25
NO313140B1 (no) 2002-08-19
ITMI971371A1 (it) 1998-12-11
IL133394A0 (en) 2001-04-30
JP4351299B2 (ja) 2009-10-28
US5925752A (en) 1999-07-20
US6042810A (en) 2000-03-28
CN1166649C (zh) 2004-09-15

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