DK0988294T3 - Fremgangsmåde til fremstilling af makrocykliske chelatdannere samt chelaterne deraf med paramagnetiske metalioner - Google Patents

Fremgangsmåde til fremstilling af makrocykliske chelatdannere samt chelaterne deraf med paramagnetiske metalioner

Info

Publication number
DK0988294T3
DK0988294T3 DK98930787T DK98930787T DK0988294T3 DK 0988294 T3 DK0988294 T3 DK 0988294T3 DK 98930787 T DK98930787 T DK 98930787T DK 98930787 T DK98930787 T DK 98930787T DK 0988294 T3 DK0988294 T3 DK 0988294T3
Authority
DK
Denmark
Prior art keywords
paramagnetic metal
preparation
water
chelates
metal ions
Prior art date
Application number
DK98930787T
Other languages
English (en)
Inventor
Giorgio Ripa
Marcella Murru
Carlo Felice Viscardi
Marina Ausonio
Alessandro Scala
Chiara Scotti
Patrizia Cossuta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Application granted granted Critical
Publication of DK0988294T3 publication Critical patent/DK0988294T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK98930787T 1997-06-11 1998-06-03 Fremgangsmåde til fremstilling af makrocykliske chelatdannere samt chelaterne deraf med paramagnetiske metalioner DK0988294T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001371A IT1292128B1 (it) 1997-06-11 1997-06-11 Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici

Publications (1)

Publication Number Publication Date
DK0988294T3 true DK0988294T3 (da) 2006-02-13

Family

ID=11377336

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98930787T DK0988294T3 (da) 1997-06-11 1998-06-03 Fremgangsmåde til fremstilling af makrocykliske chelatdannere samt chelaterne deraf med paramagnetiske metalioner

Country Status (15)

Country Link
US (3) US5925752A (da)
EP (1) EP0988294B1 (da)
JP (1) JP4351299B2 (da)
CN (1) CN1166649C (da)
AT (1) ATE308528T1 (da)
AU (1) AU8110098A (da)
DE (1) DE69832170T2 (da)
DK (1) DK0988294T3 (da)
ES (1) ES2252845T3 (da)
IL (1) IL133394A (da)
IN (1) IN185469B (da)
IT (1) IT1292128B1 (da)
NO (1) NO313140B1 (da)
WO (1) WO1998056775A1 (da)
ZA (1) ZA985025B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080125344A1 (en) * 2006-11-28 2008-05-29 Daryle Hadley Busch Bleach compositions
BR9808840A (pt) * 1997-03-07 2000-07-04 Procter & Gamble Composições alvejantes
US20030017941A1 (en) * 1997-03-07 2003-01-23 The Procter & Gamble Company Catalysts and methods for catalytic oxidation
US20050187126A1 (en) * 2002-08-27 2005-08-25 Busch Daryle H. Catalysts and methods for catalytic oxidation
ZA981883B (en) * 1997-03-07 1998-09-01 Univ Kansas Catalysts and methods for catalytic oxidation
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
US6166201A (en) * 1999-06-25 2000-12-26 Dibra S.P.A. Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof
US20040048763A1 (en) * 2002-08-27 2004-03-11 The Procter & Gamble Co. Bleach compositions
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
CN102399199B (zh) * 2010-09-19 2014-01-08 广州康臣药物研究有限公司 一种磁共振成像造影剂的制备方法
LT2896405T (lt) * 2011-04-21 2020-03-25 Bayer Intellectual Property Gmbh Didelio grynumo gadobutrolio gamyba
WO2015117911A1 (en) * 2014-02-06 2015-08-13 Agfa Healthcare Process for purifying 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
GB201421162D0 (en) 2014-11-28 2015-01-14 Ge Healthcare As Lanthanide complex formulations
JP6840148B2 (ja) 2015-12-10 2021-03-10 ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. 造影剤
SI3753929T1 (sl) 2015-12-10 2023-01-31 Bracco Imaging Spa Dimerna kontrastna sredstva
CN109963838B (zh) 2016-12-12 2023-04-11 伯拉考成像股份公司 二聚造影剂
CN109293592A (zh) * 2017-07-24 2019-02-01 天津科伦药物研究有限公司 一种制备钆布醇的方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
CN108047151B (zh) * 2018-01-03 2020-08-04 广州康瑞泰药业有限公司 一种高收率钆布醇的制备方法
WO2020012372A1 (en) * 2018-07-10 2020-01-16 Biophore India Pharmaceuticals Pvt. Ltd Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
WO2020084504A1 (en) * 2018-10-24 2020-04-30 Biophore India Pharmaceuticals Pvt. Ltd Novel process for the preparation of macrocyclic chelant 2,2',2''-(10-(2-hydroxypropyl)-1,4,7,10-tetra azacyclododecane-1,4,7-triyl) triacetic acid and it's complexes with paramagnetic metal ions
US20200397924A1 (en) * 2019-01-28 2020-12-24 Hubei Tianshu Pharmaceutical Co., Ltd Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof
CN110776649B (zh) * 2019-11-11 2021-10-26 重庆师范大学 含蒽基的镉-有机超分子聚合物及其制备方法与应用
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
IL293806A (en) 2019-12-13 2022-08-01 Bracco Imaging Spa Production of protected do3a salts
JP2023551567A (ja) 2020-12-04 2023-12-08 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ガドテリドールの製造方法
CN113527223B (zh) * 2021-06-22 2023-05-09 安徽普利药业有限公司 一种钆布醇的精制方法
CN114085192B (zh) * 2021-12-30 2023-09-19 海南普利制药股份有限公司 一种钆特醇中间体的精制方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4085106A (en) * 1976-01-07 1978-04-18 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic trisaminomethanes
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5447635A (en) * 1991-02-26 1995-09-05 Bracco International B.V. Process of concentration and purification of organic compounds
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici

Also Published As

Publication number Publication date
NO996077D0 (no) 1999-12-09
WO1998056775A1 (en) 1998-12-17
NO313140B1 (no) 2002-08-19
EP0988294B1 (en) 2005-11-02
ZA985025B (en) 1999-01-25
CN1166649C (zh) 2004-09-15
JP4351299B2 (ja) 2009-10-28
NO996077L (no) 2000-02-10
JP2002510296A (ja) 2002-04-02
US6042810A (en) 2000-03-28
AU8110098A (en) 1998-12-30
CN1259939A (zh) 2000-07-12
ITMI971371A0 (da) 1997-06-11
IL133394A0 (en) 2001-04-30
IL133394A (en) 2004-02-08
EP0988294A1 (en) 2000-03-29
IT1292128B1 (it) 1999-01-25
ITMI971371A1 (it) 1998-12-11
US5925752A (en) 1999-07-20
US6046324A (en) 2000-04-04
DE69832170T2 (de) 2006-07-13
ES2252845T3 (es) 2006-05-16
ATE308528T1 (de) 2005-11-15
DE69832170D1 (de) 2005-12-08
IN185469B (da) 2001-01-27

Similar Documents

Publication Publication Date Title
DK0988294T3 (da) Fremgangsmåde til fremstilling af makrocykliske chelatdannere samt chelaterne deraf med paramagnetiske metalioner
IL69051A (en) Modified nucleotides capable of complexing ions
BR9202130A (pt) Composto quelante,composicao de lavagem,sistema de lavagem aquoso,metodo para utilizacao do sistema de lavagem aquoso,processo para remocao de nox de um fluido,metodo para quelar um ion de metal e processo para remocao de h2s de um fluido
PL364137A1 (en) Corrosion inhibitors for aqueous systems
MX9102116A (es) Compuestos poliazamacrociclicos para la complejacion de iones metalicos.
BR0116028B1 (pt) método para a precipitação hidrolìtica de ferro.
FI923364A (fi) Foerfarande foer framstaellning av en farmaceutisk sammansaettning som paoverkar det retikuloendotela systemet
WO2002010105A1 (fr) Methode de traitement de compose fluore et substance traitee
WO1999054257A8 (en) Inorganic composition, process of preparation and method of use
CA2425615A1 (en) Process for the purification of gabapentin using a strong cation exchange resin
GB1375845A (da)
MD960269A (ro) Procedeu de eliminare a ionilor metalelor din compoziţiile autosedimentabile, procedeu de regenerare a răşinilor schimbătoare de ioni
WO1999035133A3 (en) 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid derivatives as chelating agents
MY117183A (en) Trace metal ion reduction by ion exchange pack
ES8801392A1 (es) Un procedimiento para obtener un producto inhibidor de incrustaciones.
BR9609692A (pt) Processo para remover n-(fosfonometilglicina) (glifosato) ou um sal ou uma forma iónica da mesma de uma mistura aquosa em que ela esteja presente
EP0743283A3 (en) Recovery of gadolinium and its complexing agents from aqueous solutions containing their complexes
AU2001239591A1 (en) Process for purifying aqueous buffer solutions
DK1181247T3 (da) Pressede produkter af ikke-sammenbagende salt
PT991650E (pt) Novos compostos de n-benzenosulfonilo-1-prolina processo de preparacao e utilizacao em terapia
MY119954A (en) Process for the preparation of resols
EP0448831A3 (en) Process for purifying waste water
JPS6418492A (en) Waste liquid treatment method
FR2352069A1 (fr) Procede de phosphatation de metaux
JPS5665947A (en) Rhodium recovering method