IT9021795A0 - Composizioni farmaceutiche e cosmetiche depigmentanti a base di acido caffeico. - Google Patents
Composizioni farmaceutiche e cosmetiche depigmentanti a base di acido caffeico.Info
- Publication number
- IT9021795A0 IT9021795A0 IT9021795A IT2179590A IT9021795A0 IT 9021795 A0 IT9021795 A0 IT 9021795A0 IT 9021795 A IT9021795 A IT 9021795A IT 2179590 A IT2179590 A IT 2179590A IT 9021795 A0 IT9021795 A0 IT 9021795A0
- Authority
- IT
- Italy
- Prior art keywords
- pharmaceutical
- compositions based
- caffeic acid
- depigmenting compositions
- cosmetic
- Prior art date
Links
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 title 2
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 title 1
- 229940074360 caffeic acid Drugs 0.000 title 1
- 235000004883 caffeic acid Nutrition 0.000 title 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 title 1
- 239000002537 cosmetic Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8913774A FR2653336B1 (fr) | 1989-10-20 | 1989-10-20 | Composition pharmaceutique et cosmetiques depigmentantes a base d'acide cafeique. |
Publications (3)
Publication Number | Publication Date |
---|---|
IT9021795A0 true IT9021795A0 (it) | 1990-10-19 |
IT9021795A1 IT9021795A1 (it) | 1992-04-19 |
IT1251741B IT1251741B (it) | 1995-05-23 |
Family
ID=9386619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT02179590A IT1251741B (it) | 1989-10-20 | 1990-10-19 | Composizioni farmaceutiche e cosmetiche depigmentanti a base di acido caffeico. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5164185A (it) |
EP (1) | EP0450040B1 (it) |
JP (1) | JP2659618B2 (it) |
AR (1) | AR244545A1 (it) |
AT (1) | ATE200977T1 (it) |
AU (1) | AU638768B2 (it) |
BE (1) | BE1003833A3 (it) |
BR (1) | BR9006960A (it) |
CA (1) | CA2044269C (it) |
CH (1) | CH682129A5 (it) |
DE (1) | DE69033731T2 (it) |
ES (1) | ES2085192B1 (it) |
FR (1) | FR2653336B1 (it) |
GB (1) | GB2244005B (it) |
IT (1) | IT1251741B (it) |
MX (1) | MX173203B (it) |
WO (1) | WO1991005543A1 (it) |
ZA (1) | ZA908398B (it) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69321285T2 (de) * | 1992-05-15 | 1999-03-04 | Shiseido Co. Ltd., Tokio/Tokyo | Äusserliches Hautpräparat |
FR2693105B1 (fr) * | 1992-07-01 | 1994-09-02 | Oreal | Composition cosmétique et/ou dermatologique à action dépigmentante contenant un acide di- ou tri-caféoylquinique ou un mélange de ceux-ci. |
FR2697159B1 (fr) * | 1992-10-22 | 1995-01-13 | Oreal | Composition cosmétique ou dermo-pharmaceutique contenant en association un lauroylméthionate d'un amino acide basique et au moins un polyphénol. |
FR2699072B1 (fr) * | 1992-12-11 | 1995-03-10 | Lvmh Rech | Utilisation d'un extrait de Simarouba pour l'atténuation des taches pigmentaires cutanées. |
FR2699080B1 (fr) * | 1992-12-11 | 1995-04-07 | Lvmh Rech | Utilisation d'un extrait de Simarouba pour l'atténuation des taches pigmentaires cutanées ou pour renforcer la fonction protectrice de la peau, ou pour la préparation d'un milieu de culture de cellules de peau, et composition ainsi obtenue. |
EP0643035B1 (en) * | 1993-03-25 | 1999-09-01 | Kao Corporation | Dermatologic preparation and novel benzoic acid derivative |
FR2715844B1 (fr) * | 1994-02-04 | 1996-03-29 | Oreal | Emulsion contenant de l'acide ascorbique stabilisé, procédé de traitement cosmétique la mettant en Óoeuvre, ses utilisations. |
IL109012A (en) * | 1994-03-17 | 1998-09-24 | Fischer Pharma Ltd | Skin whitening composition comprising glycyrrhyza glabra and hydroxy acids |
US5874463A (en) | 1994-10-24 | 1999-02-23 | Ancira; Margaret | Hydroxy-kojic acid skin peel |
FR2732594B1 (fr) * | 1995-04-07 | 1997-06-06 | Oreal | Utilisation de derives d'acide salicylique pour la depigmentation de la peau |
FR2736263B1 (fr) * | 1995-07-07 | 1997-09-26 | C3D Sarl | Composition dermocosmetique depigmentante et son utilisation |
US6303106B1 (en) * | 1995-12-07 | 2001-10-16 | Zylepsis Limited | Allomelanin production |
FR2754253A1 (fr) * | 1996-10-07 | 1998-04-10 | Roche Posay Lab Pharma | Nouvelle association de derives d'acide salicylique et d'hydroquinone comme inhibiteur de la tyrosinase pour la depigmentation de la peau, et composition la comprenant |
US6982091B2 (en) * | 2001-08-29 | 2006-01-03 | Umd, Inc. | Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy |
EP1260212A1 (de) * | 2001-05-21 | 2002-11-27 | Cognis France S.A. | Kosmetische Mittel |
DE10215055A1 (de) * | 2002-04-03 | 2003-10-30 | Univ Schiller Jena | Verwendung von Kaffeesäureestern zur Herstellung von kosmetischen nutrazeutischen sowie pharmazeutischen Präparaten und Arzneimitteln |
US8343519B2 (en) * | 2003-02-19 | 2013-01-01 | L'oreal S.A. | Chemical enhancer and method |
CA2550863C (en) * | 2003-12-23 | 2011-04-26 | Clr Chemisches Laboratorium Dr. Kurt Richter Gmbh | Topical depigmenting formulations comprising an extract of bellis perennis |
TW200534875A (en) * | 2004-04-23 | 2005-11-01 | Lonza Ag | Personal care compositions and concentrates for making the same |
FR2870122A1 (fr) * | 2004-05-14 | 2005-11-18 | Galderma Res & Dev | Composition pharmaceutique ou cosmetique comprenant du mequinol et au moins un agent depigmentant |
US20080214669A1 (en) * | 2005-01-14 | 2008-09-04 | Lipo Chemicals Inc. | Composition and Method For Treating Hyperpigmented Skin |
FR2892923B1 (fr) | 2005-11-08 | 2009-01-16 | Engelhard Lyon Sa | Utilisatiion des derives de l'acide para-coumarique ou para- hydroxycinnamique dans des compositions cosmetiques ou dermatologiques. |
US20090246292A1 (en) * | 2006-02-21 | 2009-10-01 | Syntopix Limited | Antimicrobial formulations comprising a quinone and a copper salt |
FR2918570B1 (fr) * | 2007-07-09 | 2012-10-05 | Engelhard Lyon | DIGLYCATION DES AGEs. |
CA2734523A1 (en) * | 2008-09-03 | 2010-03-11 | Bionovo, Inc. | Methods and compositions for the treatment of cancer |
CA2803463C (en) * | 2010-06-30 | 2019-07-16 | Nestec S.A. | Use of chicoric acid and lactic bacterium in food supplement for regulating skin pigmentation |
US9491962B2 (en) * | 2010-06-30 | 2016-11-15 | Nestec S.A. | Use of chicoric acid and derivatives for regulating skin pigmentation |
RU2012155854A (ru) * | 2010-06-30 | 2014-06-27 | Нестек С.А. | Применение кафтаровой кислоты и ее производных в биологически активной добавке к пище для регулирования пигментации кожи |
WO2012000959A1 (en) * | 2010-06-30 | 2012-01-05 | Nestec S.A. | Use of caftaric acid and lactic bacterium in food or beverages for regulating skin pigmentation |
GB2497985B (en) * | 2011-12-28 | 2014-03-12 | Pangaea Lab Ltd | A composition to stabilise kojic acid |
JP2015140309A (ja) * | 2014-01-28 | 2015-08-03 | 一丸ファルコス株式会社 | カフェ酸又はカフェ酸誘導体を有効成分とするキネシン抑制剤 |
EP3405193B1 (en) * | 2016-01-19 | 2022-03-23 | AchromaZ Pte. Ltd. | A cosmetic composition and the use thereof for regulating skin quality |
KR102475130B1 (ko) * | 2016-03-31 | 2022-12-07 | (주)아모레퍼시픽 | 펜타사이클릭 트리터펜 카페익 액씨드 에스터를 포함하는 피부 보습 또는 피부 미백용 조성물 |
TWI735652B (zh) * | 2016-09-29 | 2021-08-11 | 心悅生醫股份有限公司 | 麴酸之共晶和/或共熔結晶、包含其之組合物與用途 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1533371A (fr) * | 1967-06-07 | 1968-07-19 | Produits dermo-cosmétiques à base d'extraits de caféier | |
US3982999A (en) * | 1974-07-26 | 1976-09-28 | Kharasch Jerome A | Complexing cresolase with copper chelating agents |
US4136166A (en) * | 1977-04-18 | 1979-01-23 | Helena Rubinstein, Inc. | Skin lightening composition |
NL7804290A (nl) * | 1977-05-12 | 1978-11-14 | Henkel Kgaa | Ontsteking vertragend middel voor cosmetische prepara- ten. |
JPS56161315A (en) * | 1980-05-16 | 1981-12-11 | Ichimaru Boeki Kk | Oil-soluble skin anatriptic of ferulic ester |
FR2581542B1 (fr) * | 1985-05-07 | 1988-02-19 | Oreal | Compositions topiques destinees au traitement de la peau a base de derives de l'acide salicylique |
JPH0655664B2 (ja) * | 1985-11-19 | 1994-07-27 | ポーラ化成工業株式会社 | 美肌化粧料 |
GB8600822D0 (en) * | 1986-01-15 | 1986-02-19 | Unilever Plc | Treatment of skin disorders |
JPH089527B2 (ja) * | 1986-11-27 | 1996-01-31 | 日清製油株式会社 | 抗炎症性化粧料 |
FR2613622B1 (fr) * | 1987-04-09 | 1990-05-25 | Cariel Leon | Composition pharmaceutique et/ou cosmetique a activite regulatrice de la pigmentation cutanee |
FR2616325B1 (fr) * | 1987-06-12 | 1990-11-09 | Moet Hennessy Rech | Composition contenant de l'hydroquinone et de l'acide kojique et composition pharmaceutique, notamment dermatologique, a activite depigmentante ou anti-inflammatoire, ou cosmetique comprenant de l'acide kojique et de l'hydroquinone |
JP2565513B2 (ja) * | 1987-09-25 | 1996-12-18 | 三省製薬株式会社 | メラニン生成抑制外用薬剤 |
JP2658235B2 (ja) * | 1988-08-18 | 1997-09-30 | 石川島播磨重工業株式会社 | 幅圧下プレス装置の幅圧下制御方法 |
JPH02255607A (ja) * | 1989-03-29 | 1990-10-16 | Pias Arise Kk | 色白化粧料 |
-
1989
- 1989-10-20 FR FR8913774A patent/FR2653336B1/fr not_active Expired - Fee Related
-
1990
- 1990-10-18 MX MX022905A patent/MX173203B/es unknown
- 1990-10-19 JP JP2514797A patent/JP2659618B2/ja not_active Expired - Fee Related
- 1990-10-19 DE DE69033731T patent/DE69033731T2/de not_active Expired - Fee Related
- 1990-10-19 AR AR90318119A patent/AR244545A1/es active
- 1990-10-19 ES ES09150019A patent/ES2085192B1/es not_active Expired - Fee Related
- 1990-10-19 AU AU66288/90A patent/AU638768B2/en not_active Ceased
- 1990-10-19 IT IT02179590A patent/IT1251741B/it active IP Right Grant
- 1990-10-19 BR BR909006960A patent/BR9006960A/pt not_active Application Discontinuation
- 1990-10-19 BE BE9000994A patent/BE1003833A3/fr not_active IP Right Cessation
- 1990-10-19 US US07/691,045 patent/US5164185A/en not_active Expired - Fee Related
- 1990-10-19 WO PCT/FR1990/000760 patent/WO1991005543A1/fr not_active IP Right Cessation
- 1990-10-19 CA CA002044269A patent/CA2044269C/fr not_active Expired - Fee Related
- 1990-10-19 EP EP90916095A patent/EP0450040B1/fr not_active Expired - Lifetime
- 1990-10-19 CH CH1910/91A patent/CH682129A5/fr not_active IP Right Cessation
- 1990-10-19 AT AT90916095T patent/ATE200977T1/de active
- 1990-10-19 ZA ZA908398A patent/ZA908398B/xx unknown
-
1991
- 1991-06-19 GB GB9113276A patent/GB2244005B/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU6628890A (en) | 1991-05-16 |
ES2085192A1 (es) | 1996-05-16 |
JPH04502476A (ja) | 1992-05-07 |
IT9021795A1 (it) | 1992-04-19 |
GB2244005A (en) | 1991-11-20 |
EP0450040A1 (fr) | 1991-10-09 |
BR9006960A (pt) | 1991-11-12 |
WO1991005543A1 (fr) | 1991-05-02 |
AR244545A1 (es) | 1993-11-30 |
ES2085192B1 (es) | 1997-02-01 |
DE69033731T2 (de) | 2002-02-07 |
CH682129A5 (it) | 1993-07-30 |
CA2044269C (fr) | 1999-01-05 |
GB9113276D0 (en) | 1991-08-07 |
JP2659618B2 (ja) | 1997-09-30 |
US5164185A (en) | 1992-11-17 |
GB2244005B (en) | 1993-10-13 |
MX173203B (es) | 1994-02-08 |
ZA908398B (en) | 1991-08-28 |
ATE200977T1 (de) | 2001-05-15 |
BE1003833A3 (fr) | 1992-06-23 |
CA2044269A1 (fr) | 1991-04-21 |
IT1251741B (it) | 1995-05-23 |
FR2653336B1 (fr) | 1994-04-08 |
AU638768B2 (en) | 1993-07-08 |
DE69033731D1 (de) | 2001-06-13 |
FR2653336A1 (fr) | 1991-04-26 |
EP0450040B1 (fr) | 2001-05-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971027 |