DE69033731T2 - Depigmentierendes pharmazeutisches oder kosmetisches mittel mit kaffeinsäure - Google Patents

Depigmentierendes pharmazeutisches oder kosmetisches mittel mit kaffeinsäure

Info

Publication number
DE69033731T2
DE69033731T2 DE69033731T DE69033731T DE69033731T2 DE 69033731 T2 DE69033731 T2 DE 69033731T2 DE 69033731 T DE69033731 T DE 69033731T DE 69033731 T DE69033731 T DE 69033731T DE 69033731 T2 DE69033731 T2 DE 69033731T2
Authority
DE
Germany
Prior art keywords
depigmenting
pharmaceutical
caffeic acid
cosmetic agent
cosmetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033731T
Other languages
English (en)
Other versions
DE69033731D1 (de
Inventor
Isabelle Charpin
Didier Candau
Guyen Quang Lan N
Christiane Montastier
Francois Millecamps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LOreal SA filed Critical LOreal SA
Application granted granted Critical
Publication of DE69033731D1 publication Critical patent/DE69033731D1/de
Publication of DE69033731T2 publication Critical patent/DE69033731T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69033731T 1989-10-20 1990-10-19 Depigmentierendes pharmazeutisches oder kosmetisches mittel mit kaffeinsäure Expired - Fee Related DE69033731T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8913774A FR2653336B1 (fr) 1989-10-20 1989-10-20 Composition pharmaceutique et cosmetiques depigmentantes a base d'acide cafeique.
PCT/FR1990/000760 WO1991005543A1 (fr) 1989-10-20 1990-10-19 Compositions pharmaceutiques et cosmetiques depigmentantes a base d'acide cafeique

Publications (2)

Publication Number Publication Date
DE69033731D1 DE69033731D1 (de) 2001-06-13
DE69033731T2 true DE69033731T2 (de) 2002-02-07

Family

ID=9386619

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69033731T Expired - Fee Related DE69033731T2 (de) 1989-10-20 1990-10-19 Depigmentierendes pharmazeutisches oder kosmetisches mittel mit kaffeinsäure

Country Status (18)

Country Link
US (1) US5164185A (de)
EP (1) EP0450040B1 (de)
JP (1) JP2659618B2 (de)
AR (1) AR244545A1 (de)
AT (1) ATE200977T1 (de)
AU (1) AU638768B2 (de)
BE (1) BE1003833A3 (de)
BR (1) BR9006960A (de)
CA (1) CA2044269C (de)
CH (1) CH682129A5 (de)
DE (1) DE69033731T2 (de)
ES (1) ES2085192B1 (de)
FR (1) FR2653336B1 (de)
GB (1) GB2244005B (de)
IT (1) IT1251741B (de)
MX (1) MX173203B (de)
WO (1) WO1991005543A1 (de)
ZA (1) ZA908398B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10215055A1 (de) * 2002-04-03 2003-10-30 Univ Schiller Jena Verwendung von Kaffeesäureestern zur Herstellung von kosmetischen nutrazeutischen sowie pharmazeutischen Präparaten und Arzneimitteln

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2121947T3 (es) * 1992-05-15 1998-12-16 Shiseido Co Ltd Preparacion externa para la piel.
FR2693105B1 (fr) * 1992-07-01 1994-09-02 Oreal Composition cosmétique et/ou dermatologique à action dépigmentante contenant un acide di- ou tri-caféoylquinique ou un mélange de ceux-ci.
FR2697159B1 (fr) * 1992-10-22 1995-01-13 Oreal Composition cosmétique ou dermo-pharmaceutique contenant en association un lauroylméthionate d'un amino acide basique et au moins un polyphénol.
FR2699080B1 (fr) * 1992-12-11 1995-04-07 Lvmh Rech Utilisation d'un extrait de Simarouba pour l'atténuation des taches pigmentaires cutanées ou pour renforcer la fonction protectrice de la peau, ou pour la préparation d'un milieu de culture de cellules de peau, et composition ainsi obtenue.
FR2699072B1 (fr) * 1992-12-11 1995-03-10 Lvmh Rech Utilisation d'un extrait de Simarouba pour l'atténuation des taches pigmentaires cutanées.
WO1994021591A1 (en) * 1993-03-25 1994-09-29 Kao Corporation Dermatologic preparation and novel benzoic acid derivative
FR2715844B1 (fr) * 1994-02-04 1996-03-29 Oreal Emulsion contenant de l'acide ascorbique stabilisé, procédé de traitement cosmétique la mettant en Óoeuvre, ses utilisations.
IL109012A (en) * 1994-03-17 1998-09-24 Fischer Pharma Ltd Skin whitening composition comprising glycyrrhyza glabra and hydroxy acids
US5874463A (en) 1994-10-24 1999-02-23 Ancira; Margaret Hydroxy-kojic acid skin peel
FR2732594B1 (fr) * 1995-04-07 1997-06-06 Oreal Utilisation de derives d'acide salicylique pour la depigmentation de la peau
FR2736263B1 (fr) * 1995-07-07 1997-09-26 C3D Sarl Composition dermocosmetique depigmentante et son utilisation
EP0865497B1 (de) * 1995-12-07 2002-09-25 Zylepsis Limited Herstellung von Allomelanin
FR2754253A1 (fr) * 1996-10-07 1998-04-10 Roche Posay Lab Pharma Nouvelle association de derives d'acide salicylique et d'hydroquinone comme inhibiteur de la tyrosinase pour la depigmentation de la peau, et composition la comprenant
EP1260212A1 (de) * 2001-05-21 2002-11-27 Cognis France S.A. Kosmetische Mittel
CA2457526A1 (en) * 2001-08-29 2003-03-13 Umd, Inc. Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy
US8343519B2 (en) * 2003-02-19 2013-01-01 L'oreal S.A. Chemical enhancer and method
US7527811B2 (en) * 2003-12-23 2009-05-05 Clr Chemisches Laboratorium Dr. Kurt Richter Gmbh Topical depigmenting formulations comprising an extract of Bellis perennis
TW200534875A (en) * 2004-04-23 2005-11-01 Lonza Ag Personal care compositions and concentrates for making the same
FR2870122A1 (fr) * 2004-05-14 2005-11-18 Galderma Res & Dev Composition pharmaceutique ou cosmetique comprenant du mequinol et au moins un agent depigmentant
EP1835884A2 (de) * 2005-01-14 2007-09-26 Lipo Chemicals Inc Zusammensetzung und verfahren zur behandlung von hauthyperpigmentierung
FR2892923B1 (fr) 2005-11-08 2009-01-16 Engelhard Lyon Sa Utilisatiion des derives de l'acide para-coumarique ou para- hydroxycinnamique dans des compositions cosmetiques ou dermatologiques.
US20090246292A1 (en) * 2006-02-21 2009-10-01 Syntopix Limited Antimicrobial formulations comprising a quinone and a copper salt
FR2918570B1 (fr) * 2007-07-09 2012-10-05 Engelhard Lyon DIGLYCATION DES AGEs.
CA2734523A1 (en) * 2008-09-03 2010-03-11 Bionovo, Inc. Methods and compositions for the treatment of cancer
MX338286B (es) * 2010-06-30 2016-04-11 Oreal El uso de ácido cicórico y bacteria láctica en complemento alimenticio para regular la pigmentación de la piel.
CN103025308B (zh) * 2010-06-30 2017-04-05 雀巢产品技术援助有限公司 咖啡酰酒石酸及衍生物在食品补充剂中用于调节皮肤色素沉着的用途
WO2012000963A1 (en) * 2010-06-30 2012-01-05 Nestec S.A. Use of caftaric acid and lactic bacterium in food supplement for regulating skin pigmentation
RU2012155852A (ru) * 2010-06-30 2014-06-27 Нестек С.А. Применение цикориевой кислоты и её производных для регулирования пигментации кожи
GB2497985B (en) * 2011-12-28 2014-03-12 Pangaea Lab Ltd A composition to stabilise kojic acid
JP2015140309A (ja) * 2014-01-28 2015-08-03 一丸ファルコス株式会社 カフェ酸又はカフェ酸誘導体を有効成分とするキネシン抑制剤
EP3405193B1 (de) 2016-01-19 2022-03-23 AchromaZ Pte. Ltd. Kosmetische zusammensetzung und verwendung davon zur regulierung der hautqualität
KR102475130B1 (ko) * 2016-03-31 2022-12-07 (주)아모레퍼시픽 펜타사이클릭 트리터펜 카페익 액씨드 에스터를 포함하는 피부 보습 또는 피부 미백용 조성물
TWI735652B (zh) * 2016-09-29 2021-08-11 心悅生醫股份有限公司 麴酸之共晶和/或共熔結晶、包含其之組合物與用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1533371A (fr) * 1967-06-07 1968-07-19 Produits dermo-cosmétiques à base d'extraits de caféier
US3982999A (en) * 1974-07-26 1976-09-28 Kharasch Jerome A Complexing cresolase with copper chelating agents
US4136166A (en) * 1977-04-18 1979-01-23 Helena Rubinstein, Inc. Skin lightening composition
NL7804290A (nl) * 1977-05-12 1978-11-14 Henkel Kgaa Ontsteking vertragend middel voor cosmetische prepara- ten.
JPS56161315A (en) * 1980-05-16 1981-12-11 Ichimaru Boeki Kk Oil-soluble skin anatriptic of ferulic ester
FR2581542B1 (fr) * 1985-05-07 1988-02-19 Oreal Compositions topiques destinees au traitement de la peau a base de derives de l'acide salicylique
JPH0655664B2 (ja) * 1985-11-19 1994-07-27 ポーラ化成工業株式会社 美肌化粧料
GB8600822D0 (en) * 1986-01-15 1986-02-19 Unilever Plc Treatment of skin disorders
JPH089527B2 (ja) * 1986-11-27 1996-01-31 日清製油株式会社 抗炎症性化粧料
FR2613622B1 (fr) * 1987-04-09 1990-05-25 Cariel Leon Composition pharmaceutique et/ou cosmetique a activite regulatrice de la pigmentation cutanee
FR2616325B1 (fr) * 1987-06-12 1990-11-09 Moet Hennessy Rech Composition contenant de l'hydroquinone et de l'acide kojique et composition pharmaceutique, notamment dermatologique, a activite depigmentante ou anti-inflammatoire, ou cosmetique comprenant de l'acide kojique et de l'hydroquinone
JP2565513B2 (ja) * 1987-09-25 1996-12-18 三省製薬株式会社 メラニン生成抑制外用薬剤
JP2658235B2 (ja) * 1988-08-18 1997-09-30 石川島播磨重工業株式会社 幅圧下プレス装置の幅圧下制御方法
JPH02255607A (ja) * 1989-03-29 1990-10-16 Pias Arise Kk 色白化粧料

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10215055A1 (de) * 2002-04-03 2003-10-30 Univ Schiller Jena Verwendung von Kaffeesäureestern zur Herstellung von kosmetischen nutrazeutischen sowie pharmazeutischen Präparaten und Arzneimitteln

Also Published As

Publication number Publication date
GB9113276D0 (en) 1991-08-07
IT1251741B (it) 1995-05-23
JP2659618B2 (ja) 1997-09-30
AU638768B2 (en) 1993-07-08
GB2244005A (en) 1991-11-20
EP0450040B1 (de) 2001-05-09
BR9006960A (pt) 1991-11-12
IT9021795A0 (it) 1990-10-19
FR2653336B1 (fr) 1994-04-08
GB2244005B (en) 1993-10-13
FR2653336A1 (fr) 1991-04-26
EP0450040A1 (de) 1991-10-09
ATE200977T1 (de) 2001-05-15
MX173203B (es) 1994-02-08
CA2044269A1 (fr) 1991-04-21
US5164185A (en) 1992-11-17
JPH04502476A (ja) 1992-05-07
ES2085192A1 (es) 1996-05-16
BE1003833A3 (fr) 1992-06-23
IT9021795A1 (it) 1992-04-19
ES2085192B1 (es) 1997-02-01
DE69033731D1 (de) 2001-06-13
WO1991005543A1 (fr) 1991-05-02
AR244545A1 (es) 1993-11-30
CH682129A5 (de) 1993-07-30
AU6628890A (en) 1991-05-16
CA2044269C (fr) 1999-01-05
ZA908398B (en) 1991-08-28

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Legal Events

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