IT9020908A0 - Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili - Google Patents
Metodo per ottenere una rapida sospensione in acqua di farmaci insolubiliInfo
- Publication number
- IT9020908A0 IT9020908A0 IT9020908A IT2090890A IT9020908A0 IT 9020908 A0 IT9020908 A0 IT 9020908A0 IT 9020908 A IT9020908 A IT 9020908A IT 2090890 A IT2090890 A IT 2090890A IT 9020908 A0 IT9020908 A0 IT 9020908A0
- Authority
- IT
- Italy
- Prior art keywords
- water
- insoluble drugs
- rapid suspension
- suspension
- rapid
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
- F02B2275/00—Other engines, components or details, not provided for in other groups of this subclass
- F02B2275/14—Direct injection into combustion chamber
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT02090890A IT1246350B (it) | 1990-07-11 | 1990-07-11 | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
| PCT/EP1991/001268 WO1992000731A1 (en) | 1990-07-11 | 1991-07-04 | Pharmaceutical composition for rapid suspension in water |
| ES91912620T ES2064112T3 (es) | 1990-07-11 | 1991-07-04 | Composicion farmaceutica para suspension rapida en agua. |
| AU81833/91A AU640253B2 (en) | 1990-07-11 | 1991-07-04 | Pharmaceutical composition for rapid suspension in water |
| DE69105106T DE69105106T2 (de) | 1990-07-11 | 1991-07-04 | Im wasser schnell suspendierbare pharmazeutische zusammensetzung. |
| EP91912620A EP0491910B1 (en) | 1990-07-11 | 1991-07-04 | Pharmaceutical composition for rapid suspension in water |
| JP3511640A JP2552785B2 (ja) | 1990-07-11 | 1991-07-04 | 水中にて迅速に懸濁する医薬組成物 |
| KR1019920700541A KR100209175B1 (ko) | 1990-07-11 | 1991-07-04 | 수중에서 신속하게 현탁되는 약제학적 조성물 |
| DK91912620.1T DK0491910T3 (da) | 1990-07-11 | 1991-07-04 | Farmaceutisk præparat til hurtig suspendering i vand |
| US07/838,818 US5306506A (en) | 1990-07-11 | 1991-07-04 | Pharmaceutical composition for rapid suspension in water |
| AT91912620T ATE113832T1 (de) | 1990-07-11 | 1991-07-04 | Im wasser schnell suspendierbare pharmazeutische zusammensetzung. |
| IE238291A IE66048B1 (en) | 1990-07-11 | 1991-07-08 | Pharmaceutical composition for rapid suspension in water |
| ZA915284A ZA915284B (en) | 1990-07-11 | 1991-07-08 | Pharmaceutical composition for rapid suspension in water |
| CA002046679A CA2046679C (en) | 1990-07-11 | 1991-07-10 | Pharmaceutical composition for rapid suspension in water |
| PT98272A PT98272B (pt) | 1990-07-11 | 1991-07-10 | Processo para a preparacao de uma composicao farmaceutica para suspensao rapida em agua |
| NZ238901A NZ238901A (en) | 1990-07-11 | 1991-07-10 | Suspension-producing pharmaceuticals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT02090890A IT1246350B (it) | 1990-07-11 | 1990-07-11 | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9020908A0 true IT9020908A0 (it) | 1990-07-11 |
| IT9020908A1 IT9020908A1 (it) | 1992-01-11 |
| IT1246350B IT1246350B (it) | 1994-11-17 |
Family
ID=11173904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT02090890A IT1246350B (it) | 1990-07-11 | 1990-07-11 | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5306506A (it) |
| EP (1) | EP0491910B1 (it) |
| JP (1) | JP2552785B2 (it) |
| KR (1) | KR100209175B1 (it) |
| AT (1) | ATE113832T1 (it) |
| AU (1) | AU640253B2 (it) |
| CA (1) | CA2046679C (it) |
| DE (1) | DE69105106T2 (it) |
| DK (1) | DK0491910T3 (it) |
| ES (1) | ES2064112T3 (it) |
| IE (1) | IE66048B1 (it) |
| IT (1) | IT1246350B (it) |
| NZ (1) | NZ238901A (it) |
| PT (1) | PT98272B (it) |
| WO (1) | WO1992000731A1 (it) |
| ZA (1) | ZA915284B (it) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993004670A1 (en) * | 1991-08-30 | 1993-03-18 | Showa Yakuhin Kako Co., Ltd. | Dry gel composition |
| US6231851B1 (en) * | 1994-05-18 | 2001-05-15 | Inhale Therapeutic Systems | Methods and compositions for the dry powder formulation of interferons |
| US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| NZ257212A (en) * | 1992-09-29 | 1996-11-26 | Inhale Therapeutic Syst | Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone |
| EP0624364B1 (de) * | 1993-04-15 | 1996-07-24 | Gerhard Dr. Gergely | Brausesystem mit einem alkali- und/oder metallempfindlichen, pharmazeutischen Wirkstoff, und Verfahren zur Herstellung |
| DK0642784T3 (da) * | 1993-09-07 | 1999-11-22 | Gergely Gerhard | Bruseblanding med alkalisalte eller lysinater af uopløseligt eller tungtopløseligt aktivstof |
| FR2712809B1 (fr) * | 1993-11-26 | 1996-04-12 | Union Pharma Scient Appl | Nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide. |
| BR9507023A (pt) * | 1994-03-07 | 1997-09-23 | Inhale Therapeutic Syst | Processos para aerossolização de uma dose de insulina para a liberação respiratória de insulina e para preparação de uma composição de insulina e composição de insulina |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| AU688856B2 (en) * | 1994-04-11 | 1998-03-19 | Gist-Brocades B.V. | Stable natamycin suspensions |
| AU2826495A (en) * | 1994-06-02 | 1996-01-04 | Enzon, Inc. | Method of solubilizing substantially water insoluble materials |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| AU3570495A (en) | 1994-09-22 | 1996-04-09 | Quadrant Holdings Cambridge Limited | Compositions for use in rehydration and nutrition during athletic exercise and methods of making same |
| US5639475A (en) * | 1995-02-03 | 1997-06-17 | Eurand America, Incorporated | Effervescent microcapsules |
| BE1009380A3 (nl) * | 1995-03-14 | 1997-03-04 | Universiteit Gent Lab Voor Far | Stabiliserend samenstelling voor suspensie. |
| US6964771B1 (en) * | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
| US5560928A (en) * | 1995-06-23 | 1996-10-01 | Defelice; Stephen L. | Nutritional and/or dietary composition and method of using the same |
| US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
| US5958455A (en) * | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
| US6632648B1 (en) * | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
| US5712310A (en) * | 1996-06-14 | 1998-01-27 | Alpharma Uspd, Inc. | Suspension of substantially water-insoluble drugs and methods of their manufacture |
| FR2753097A1 (fr) * | 1996-09-11 | 1998-03-13 | Barrau Francois | Gel aqueux ou hydroalcoolique extemporane a viscosite controlee |
| GB2318511A (en) * | 1996-10-23 | 1998-04-29 | Eurand Int | Process for the preparation of a pharmaceutical composition for rapid suspension in water |
| US6468782B1 (en) * | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
| US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
| IN186245B (it) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| NZ333474A (en) | 1998-01-02 | 1999-06-29 | Mcneil Ppc Inc | A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat |
| US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
| US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
| US6500462B1 (en) * | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| MXPA02001323A (es) | 2000-05-10 | 2004-07-16 | Alliance Pharma | Microgranulos con base fosfolipida para la liberacion de farmaco. |
| IL136899A0 (en) * | 2000-06-20 | 2001-06-14 | Caretec Ltd | Microcapsules containing arginine and the different uses thereof |
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| US6932861B2 (en) * | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
| BR0115585A (pt) | 2000-11-28 | 2005-12-13 | Fmc Corp | Composições de revestimento de pronta liberação, endurecìvel, comestìvel, seca e, úmida, forma de dosagem sólida, e, método para revestir uma forma de dosagem sólida farmacêutica ou veterinária, confeito, semente, ração animal, fertilizante, comprimido de pesticida ou alimento |
| US6869617B2 (en) | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| TWI327474B (en) | 2001-04-06 | 2010-07-21 | Neochemir Inc | Kit for preparation of carbon dioxide agent for external use. |
| JP2005504090A (ja) | 2001-09-26 | 2005-02-10 | バクスター・インターナショナル・インコーポレイテッド | 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製 |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| ATE508735T1 (de) | 2001-12-19 | 2011-05-15 | Novartis Ag | Pulmonale verabreichung von aminoglykosiden |
| ITMI20022358A1 (it) * | 2002-11-07 | 2004-05-08 | Bsd Bioscience Dev Snc | Composizioni farmaceutiche effervescenti per la realizzazione di sospensioni non convenzionali. |
| US20040170686A1 (en) * | 2003-01-31 | 2004-09-02 | Fredrickson Jennifer K. | Suspension vehicle for coated drug particles |
| US20040191326A1 (en) * | 2003-03-31 | 2004-09-30 | Reo Joseph P. | Taste-masking vehicle for coated oxazolidinone particles |
| US20050095320A1 (en) * | 2003-10-29 | 2005-05-05 | Richard Botteri | [An Isotonic Sports Drink for Female Athletes Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Nutrition During Execise and Competition] |
| US20050100636A1 (en) * | 2003-11-10 | 2005-05-12 | Megan Botteri | [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity] |
| US20060134210A1 (en) * | 2004-12-22 | 2006-06-22 | Astrazeneca Ab | Solid dosage form comprising proton pump inhibitor and suspension made thereof |
| US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
| KR101670016B1 (ko) * | 2007-02-20 | 2016-10-27 | 앨러간 파마슈티컬스 인터내셔널 리미티드 | 안정한 소화 효소 조성물 |
| WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
| US7782646B2 (en) * | 2008-06-30 | 2010-08-24 | International Business Machines Corporation | High density content addressable memory using phase change devices |
| PT2621476E (pt) | 2010-10-01 | 2014-10-16 | Aptalis Pharma Ltd | Formulações de pancrelipase de baixa potência com revestimento entérico |
| MX351014B (es) | 2011-08-08 | 2017-09-28 | Aptalis Pharma Ltd | Metodo para la prueba de disolucion de composiciones solidas que contienen enzimas digestivas. |
| KR101383908B1 (ko) | 2012-10-29 | 2014-04-10 | 씨앤텍 주식회사 | 이산화탄소를 피부에 공급하는 팩과 그 제조방법 |
| JP5993336B2 (ja) * | 2013-04-26 | 2016-09-14 | 株式会社メディオン・リサーチ・ラボラトリーズ | 二酸化炭素経皮・経粘膜吸収用組成物 |
| WO2015020943A2 (en) | 2013-08-09 | 2015-02-12 | Aptalis Pharma Ltd. | Digestive enzyme composition suitable for enteral administration |
| WO2015193730A1 (en) | 2014-06-19 | 2015-12-23 | Aptalis Pharma Ltd. | Methods for removing viral contaminants from pancreatic extracts |
| WO2017088820A1 (en) | 2015-11-26 | 2017-06-01 | Novozymes A/S | Milling process |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2125577A (en) * | 1936-09-10 | 1938-08-02 | Matsumae Akiyoshi | Auxiliary medical agent and method of preparing the same |
| US3928252A (en) * | 1971-12-10 | 1975-12-23 | Adolph S Ltd | Thickened food |
| DE3440288C2 (de) * | 1984-11-05 | 1987-03-12 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen sowie Verfahren zu ihrer Herstellung |
| IT1183574B (it) * | 1985-05-08 | 1987-10-22 | Eurand Spa | Metodo per ottenere una sospensione estemporanea omogenea di microcapsule |
| GB8528195D0 (en) * | 1985-11-15 | 1985-12-18 | Boots Co Plc | Therapeutic compositions |
-
1990
- 1990-07-11 IT IT02090890A patent/IT1246350B/it active IP Right Grant
-
1991
- 1991-07-04 ES ES91912620T patent/ES2064112T3/es not_active Expired - Lifetime
- 1991-07-04 DK DK91912620.1T patent/DK0491910T3/da active
- 1991-07-04 AU AU81833/91A patent/AU640253B2/en not_active Ceased
- 1991-07-04 JP JP3511640A patent/JP2552785B2/ja not_active Expired - Lifetime
- 1991-07-04 EP EP91912620A patent/EP0491910B1/en not_active Expired - Lifetime
- 1991-07-04 US US07/838,818 patent/US5306506A/en not_active Expired - Fee Related
- 1991-07-04 WO PCT/EP1991/001268 patent/WO1992000731A1/en active IP Right Grant
- 1991-07-04 AT AT91912620T patent/ATE113832T1/de not_active IP Right Cessation
- 1991-07-04 DE DE69105106T patent/DE69105106T2/de not_active Expired - Fee Related
- 1991-07-04 KR KR1019920700541A patent/KR100209175B1/ko not_active Expired - Fee Related
- 1991-07-08 IE IE238291A patent/IE66048B1/en not_active IP Right Cessation
- 1991-07-08 ZA ZA915284A patent/ZA915284B/xx unknown
- 1991-07-10 PT PT98272A patent/PT98272B/pt active IP Right Grant
- 1991-07-10 CA CA002046679A patent/CA2046679C/en not_active Expired - Fee Related
- 1991-07-10 NZ NZ238901A patent/NZ238901A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0491910B1 (en) | 1994-11-09 |
| DK0491910T3 (da) | 1995-01-09 |
| AU640253B2 (en) | 1993-08-19 |
| WO1992000731A1 (en) | 1992-01-23 |
| JPH05501421A (ja) | 1993-03-18 |
| ATE113832T1 (de) | 1994-11-15 |
| DE69105106T2 (de) | 1995-04-27 |
| PT98272A (pt) | 1992-05-29 |
| KR920702215A (ko) | 1992-09-03 |
| NZ238901A (en) | 1992-08-26 |
| CA2046679C (en) | 2001-11-20 |
| KR100209175B1 (ko) | 1999-07-15 |
| ES2064112T3 (es) | 1995-01-16 |
| IE912382A1 (en) | 1992-01-15 |
| ZA915284B (en) | 1993-03-31 |
| AU8183391A (en) | 1992-02-04 |
| IT9020908A1 (it) | 1992-01-11 |
| EP0491910A1 (en) | 1992-07-01 |
| IT1246350B (it) | 1994-11-17 |
| DE69105106D1 (de) | 1994-12-15 |
| JP2552785B2 (ja) | 1996-11-13 |
| PT98272B (pt) | 1999-01-29 |
| IE66048B1 (en) | 1995-12-13 |
| CA2046679A1 (en) | 1992-01-12 |
| US5306506A (en) | 1994-04-26 |
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