ES2064112T3 - Composicion farmaceutica para suspension rapida en agua. - Google Patents
Composicion farmaceutica para suspension rapida en agua.Info
- Publication number
- ES2064112T3 ES2064112T3 ES91912620T ES91912620T ES2064112T3 ES 2064112 T3 ES2064112 T3 ES 2064112T3 ES 91912620 T ES91912620 T ES 91912620T ES 91912620 T ES91912620 T ES 91912620T ES 2064112 T3 ES2064112 T3 ES 2064112T3
- Authority
- ES
- Spain
- Prior art keywords
- water
- suspension
- pharmaceutical composition
- medicinal product
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000725 suspension Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000375 suspending agent Substances 0.000 abstract 2
- 230000008719 thickening Effects 0.000 abstract 2
- 239000002562 thickening agent Substances 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000013029 homogenous suspension Substances 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
- F02B2275/00—Other engines, components or details, not provided for in other groups of this subclass
- F02B2275/14—Direct injection into combustion chamber
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LA INVENCION PRESENTA UNA COMPOSICION FARMACEUTICA SOLIDA PARA AÑADIRLA AL AGUA PARA PRODUCIR UNA SUSPENSION DE UN MEDICAMENTO QUE COMPRENDE (A) UN MEDICAMENTO QUE ES SUSTANCIALMENTE INDISOLUBLE EN AGUA O MICROENCAPSULADO; (B) UN AGENTE ESPESADOR O DE SUSPENSION; (C) UN ACIDO FARMACEUTICAMENTE ACEPTABLE; (D) UN CARBONATO O BICARBONATO FARMACEUTICAMENTE ACEPTABLES; QUE SE CARACTERIZA PORQUE LA RELACION DE PESO DE C+D:B ES DE 1:1,5 A 1:15 Y LA CANTIDAD DE C+D ES SUFICIENTE PARA OBTENER UNA HIDRATACION RAPIDA DEL AGENTE ESPESADOR O DE SUSPENSION (B) CUANDO LA COMPOSICION SE MEZCLA CON AGUA DE MODO QUE SE OBTIENE UNA SUSPENSION HOMOGENEA DEL MEDICAMENTO EN 30 SEGUNDOS. TAMBIEN SE DESCRIBE UN METODO PARA LA PREPARACION DE LA COMPOSICION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02090890A IT1246350B (it) | 1990-07-11 | 1990-07-11 | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064112T3 true ES2064112T3 (es) | 1995-01-16 |
Family
ID=11173904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91912620T Expired - Lifetime ES2064112T3 (es) | 1990-07-11 | 1991-07-04 | Composicion farmaceutica para suspension rapida en agua. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5306506A (es) |
EP (1) | EP0491910B1 (es) |
JP (1) | JP2552785B2 (es) |
KR (1) | KR100209175B1 (es) |
AT (1) | ATE113832T1 (es) |
AU (1) | AU640253B2 (es) |
CA (1) | CA2046679C (es) |
DE (1) | DE69105106T2 (es) |
DK (1) | DK0491910T3 (es) |
ES (1) | ES2064112T3 (es) |
IE (1) | IE66048B1 (es) |
IT (1) | IT1246350B (es) |
NZ (1) | NZ238901A (es) |
PT (1) | PT98272B (es) |
WO (1) | WO1992000731A1 (es) |
ZA (1) | ZA915284B (es) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2116563C (en) * | 1991-08-30 | 2001-07-03 | Yoji Ito | Dry gel pharmaceutical composition |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
CA2145418A1 (en) * | 1992-09-29 | 1994-04-14 | John S. Patton | Pulmonary delivery of active fragments of parathyroid hormone |
ATE140621T1 (de) * | 1993-04-15 | 1996-08-15 | Gergely Gerhard | Brausesystem mit einem alkali- und/oder metallempfindlichen, pharmazeutischen wirkstoff, und verfahren zur herstellung |
ATE180164T1 (de) * | 1993-09-07 | 1999-06-15 | Gergely Gerhard | Brausemischung mit alkalisalzen oder lysinaten saurer, unlöslicher oder schwer löslicher wirkstoffe |
FR2712809B1 (fr) * | 1993-11-26 | 1996-04-12 | Union Pharma Scient Appl | Nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide. |
US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
PT748213E (pt) * | 1994-03-07 | 2004-08-31 | Nektar Therapeutics | Metodos e composicoes para administracao pulmonar de insulina |
EP0678241B1 (en) * | 1994-04-11 | 2001-11-07 | Dsm N.V. | Stable natamycin suspensions |
ATE299892T1 (de) * | 1994-05-18 | 2005-08-15 | Nektar Therapeutics | Methoden und zusammensetzungen für die trockenpuderarznei aus interferonen |
AU2826495A (en) * | 1994-06-02 | 1996-01-04 | Enzon, Inc. | Method of solubilizing substantially water insoluble materials |
US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
AU3570495A (en) | 1994-09-22 | 1996-04-09 | Quadrant Holdings Cambridge Limited | Compositions for use in rehydration and nutrition during athletic exercise and methods of making same |
US5639475A (en) * | 1995-02-03 | 1997-06-17 | Eurand America, Incorporated | Effervescent microcapsules |
BE1009380A3 (nl) * | 1995-03-14 | 1997-03-04 | Universiteit Gent Lab Voor Far | Stabiliserend samenstelling voor suspensie. |
US6964771B1 (en) | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
US5560928A (en) * | 1995-06-23 | 1996-10-01 | Defelice; Stephen L. | Nutritional and/or dietary composition and method of using the same |
US5958455A (en) * | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
US6632648B1 (en) * | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
US5712310A (en) * | 1996-06-14 | 1998-01-27 | Alpharma Uspd, Inc. | Suspension of substantially water-insoluble drugs and methods of their manufacture |
FR2753097A1 (fr) * | 1996-09-11 | 1998-03-13 | Barrau Francois | Gel aqueux ou hydroalcoolique extemporane a viscosite controlee |
GB2318511A (en) * | 1996-10-23 | 1998-04-29 | Eurand Int | Process for the preparation of a pharmaceutical composition for rapid suspension in water |
US6468782B1 (en) * | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
IN186245B (es) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
NZ333474A (en) * | 1998-01-02 | 1999-06-29 | Mcneil Ppc Inc | A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat |
US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
US6500462B1 (en) * | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
TWI290473B (en) | 2000-05-10 | 2007-12-01 | Alliance Pharma | Phospholipid-based powders for drug delivery |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
IL136899A0 (en) * | 2000-06-20 | 2001-06-14 | Caretec Ltd | Microcapsules containing arginine and the different uses thereof |
IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
TR200300731T2 (tr) | 2000-11-28 | 2004-08-23 | Fmc Corporation | Yenebilir PGA kaplama bileşimi |
US6932861B2 (en) * | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
TWI327474B (en) | 2001-04-06 | 2010-07-21 | Neochemir Inc | Kit for preparation of carbon dioxide agent for external use. |
BR0212833A (pt) | 2001-09-26 | 2004-10-13 | Baxter Int | Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
PT1458360E (pt) | 2001-12-19 | 2011-07-13 | Novartis Ag | Derivados de indole como agonistas do recetor s1p1 |
ITMI20022358A1 (it) * | 2002-11-07 | 2004-05-08 | Bsd Bioscience Dev Snc | Composizioni farmaceutiche effervescenti per la realizzazione di sospensioni non convenzionali. |
US20040170686A1 (en) * | 2003-01-31 | 2004-09-02 | Fredrickson Jennifer K. | Suspension vehicle for coated drug particles |
US20040191326A1 (en) * | 2003-03-31 | 2004-09-30 | Reo Joseph P. | Taste-masking vehicle for coated oxazolidinone particles |
US20050095320A1 (en) * | 2003-10-29 | 2005-05-05 | Richard Botteri | [An Isotonic Sports Drink for Female Athletes Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Nutrition During Execise and Competition] |
US20050100636A1 (en) * | 2003-11-10 | 2005-05-12 | Megan Botteri | [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity] |
US20060134210A1 (en) * | 2004-12-22 | 2006-06-22 | Astrazeneca Ab | Solid dosage form comprising proton pump inhibitor and suspension made thereof |
US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
PT2079445E (pt) * | 2007-02-20 | 2016-02-29 | Allergan Pharmaceuticals Internat Ltd | Composições de enzimas digestivas estáveis |
WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
US7782646B2 (en) * | 2008-06-30 | 2010-08-24 | International Business Machines Corporation | High density content addressable memory using phase change devices |
CN103221036A (zh) | 2010-10-01 | 2013-07-24 | 阿普塔利斯制药有限公司 | 肠溶包衣的低强度胰脂肪酶制剂 |
DK2741766T3 (en) | 2011-08-08 | 2016-01-11 | Aptalis Pharma Ltd | Process for dissolving solid compositions containing digestive enzymes |
KR101383908B1 (ko) | 2012-10-29 | 2014-04-10 | 씨앤텍 주식회사 | 이산화탄소를 피부에 공급하는 팩과 그 제조방법 |
JP5993336B2 (ja) * | 2013-04-26 | 2016-09-14 | 株式会社メディオン・リサーチ・ラボラトリーズ | 二酸化炭素経皮・経粘膜吸収用組成物 |
CA2920844A1 (en) | 2013-08-09 | 2015-02-12 | Allergan Pharmaceuticals International Limited | Digestive enzyme composition suitable for enteral administration |
AU2015275860A1 (en) | 2014-06-19 | 2016-11-03 | Aptalis Pharma Ltd. | Methods for removing viral contaminants from pancreatic extracts |
CN108368527B (zh) | 2015-11-26 | 2023-07-18 | 诺维信公司 | 研磨方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2125577A (en) * | 1936-09-10 | 1938-08-02 | Matsumae Akiyoshi | Auxiliary medical agent and method of preparing the same |
US3928252A (en) * | 1971-12-10 | 1975-12-23 | Adolph S Ltd | Thickened food |
DE3440288A1 (de) * | 1984-11-05 | 1986-05-07 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung |
IT1183574B (it) * | 1985-05-08 | 1987-10-22 | Eurand Spa | Metodo per ottenere una sospensione estemporanea omogenea di microcapsule |
GB8528195D0 (en) * | 1985-11-15 | 1985-12-18 | Boots Co Plc | Therapeutic compositions |
-
1990
- 1990-07-11 IT IT02090890A patent/IT1246350B/it active IP Right Grant
-
1991
- 1991-07-04 EP EP91912620A patent/EP0491910B1/en not_active Expired - Lifetime
- 1991-07-04 AU AU81833/91A patent/AU640253B2/en not_active Ceased
- 1991-07-04 ES ES91912620T patent/ES2064112T3/es not_active Expired - Lifetime
- 1991-07-04 JP JP3511640A patent/JP2552785B2/ja not_active Expired - Lifetime
- 1991-07-04 DE DE69105106T patent/DE69105106T2/de not_active Expired - Fee Related
- 1991-07-04 WO PCT/EP1991/001268 patent/WO1992000731A1/en active IP Right Grant
- 1991-07-04 KR KR1019920700541A patent/KR100209175B1/ko not_active IP Right Cessation
- 1991-07-04 US US07/838,818 patent/US5306506A/en not_active Expired - Fee Related
- 1991-07-04 DK DK91912620.1T patent/DK0491910T3/da active
- 1991-07-04 AT AT91912620T patent/ATE113832T1/de not_active IP Right Cessation
- 1991-07-08 IE IE238291A patent/IE66048B1/en not_active IP Right Cessation
- 1991-07-08 ZA ZA915284A patent/ZA915284B/xx unknown
- 1991-07-10 NZ NZ238901A patent/NZ238901A/en unknown
- 1991-07-10 PT PT98272A patent/PT98272B/pt active IP Right Grant
- 1991-07-10 CA CA002046679A patent/CA2046679C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69105106T2 (de) | 1995-04-27 |
JP2552785B2 (ja) | 1996-11-13 |
DE69105106D1 (de) | 1994-12-15 |
EP0491910B1 (en) | 1994-11-09 |
JPH05501421A (ja) | 1993-03-18 |
IT9020908A1 (it) | 1992-01-11 |
IE912382A1 (en) | 1992-01-15 |
IT9020908A0 (it) | 1990-07-11 |
IE66048B1 (en) | 1995-12-13 |
PT98272B (pt) | 1999-01-29 |
ATE113832T1 (de) | 1994-11-15 |
DK0491910T3 (da) | 1995-01-09 |
CA2046679A1 (en) | 1992-01-12 |
WO1992000731A1 (en) | 1992-01-23 |
IT1246350B (it) | 1994-11-17 |
PT98272A (pt) | 1992-05-29 |
AU640253B2 (en) | 1993-08-19 |
CA2046679C (en) | 2001-11-20 |
ZA915284B (en) | 1993-03-31 |
NZ238901A (en) | 1992-08-26 |
AU8183391A (en) | 1992-02-04 |
EP0491910A1 (en) | 1992-07-01 |
KR100209175B1 (ko) | 1999-07-15 |
US5306506A (en) | 1994-04-26 |
KR920702215A (ko) | 1992-09-03 |
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