KR920000316A - 젬피브로질 제제 - Google Patents

젬피브로질 제제 Download PDF

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Publication number
KR920000316A
KR920000316A KR1019910009795A KR910009795A KR920000316A KR 920000316 A KR920000316 A KR 920000316A KR 1019910009795 A KR1019910009795 A KR 1019910009795A KR 910009795 A KR910009795 A KR 910009795A KR 920000316 A KR920000316 A KR 920000316A
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KR
South Korea
Prior art keywords
gemfibrozil
pharmaceutically acceptable
acceptable surfactant
weight
oral formulation
Prior art date
Application number
KR1019910009795A
Other languages
English (en)
Inventor
게브레-셀라씨 이삭
비.파우지 마디
Original Assignee
다니엘 에이. 스콜라 2세
워너-람버트컴퍼니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 다니엘 에이. 스콜라 2세, 워너-람버트컴퍼니 filed Critical 다니엘 에이. 스콜라 2세
Publication of KR920000316A publication Critical patent/KR920000316A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

젬피브로질 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. HLB 값이 약 10－50인 1－4중량 %(젬피브로질 중량에 기준함)의 제약학적으로 허용가능한 계면활성제와 혼합된 젬피브로질을 포함하는 젬피브로질의 개선된 경구용 제제.
  2. 제1항에 있어서, 계면활성제의 양이 1－2중량 %인 젬피브로질의 개선된 경구용 제제.
  3. 제1항에 있어서, 제약학적으로 허용가능한 계면활성제의 HLB 값이 약 15－40인 젬피브로질의 개선된 경구용 제제.
  4. 제1항에 있어서, 제약학적으로 허용가능한 계면활성제가 폴리소베이트인 젬피브로질의 개설된 경구용 제제.
  5. 제1항에 있어서, 제약학적으로 허용가능한 계면활성제가 지방산 알콜 설페이트의 알칼리 금속염인 젬피브로질의 개선된 경구용 제제.
  6. 제5항에 있어서, 제약학적으로 허용가능한 계면활성제가 소듐라우릴 설페이트인 젬피브로질의 개선된 경구용 제제.
  7. 젬피브로질이 HLB 값이 약 10－50인 1－4중량 %(젬피브로질 중량에 기준함)의 제약학적으로 허용가능한 계면활성제와 혼합되는 젬피브로질 정제.
  8. 제7항에 있어서, 계면활성제의 양이 1－2중량 %인 젬피브로질 정제.
  9. 제7항에 있어서, 제약학적으로 허용가능한 계면활성제의 HLB 값이 약 15－40인 젬피브로질 정제.
  10. 제7항에 있어서, 제약학적으로 허용가능한 계면활성제가 폴리소베이트인 젬피브로질 정제.
  11. 제7항에 있어서, 제약학적으로 허용가능한 계면활성제가 지방산 알콜 설페이트의 알칼리 금속 염인 젬피브로질 정제.
  12. 제11항에 있어서, 제약학적으로 허용가능한 계면활성제가 소듐 라우릴 설페이트인 젬피브로질 정제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910009795A 1990-06-15 1991-06-14 젬피브로질 제제 KR920000316A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53915890A 1990-06-15 1990-06-15
US539,158 1995-10-04

Publications (1)

Publication Number Publication Date
KR920000316A true KR920000316A (ko) 1992-01-29

Family

ID=24150041

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910009795A KR920000316A (ko) 1990-06-15 1991-06-14 젬피브로질 제제

Country Status (9)

Country Link
US (1) US5281421A (ko)
EP (1) EP0462067A1 (ko)
JP (1) JPH04230216A (ko)
KR (1) KR920000316A (ko)
AU (1) AU641509B2 (ko)
FI (1) FI912884A (ko)
IE (1) IE912041A1 (ko)
PT (1) PT97970A (ko)
ZA (1) ZA914577B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212428B (en) * 1994-05-13 1996-06-28 Egyt Gyogyszervegyeszeti Gyar Process to prepare pharmaceutical compositions containing gemfibrozyl
EP1499296B1 (en) * 2002-04-15 2012-04-04 MAP Pharmaceuticals Inc Formulation of fine particles using liquefied or dense gases

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
US4620974A (en) * 1983-07-07 1986-11-04 American Home Products Corporation Pharmaceutical composition containing a liquid lubricant
US4753800A (en) * 1985-10-04 1988-06-28 Warner-Lambert Company Medicament adsorbates and their preparation
US4778676A (en) * 1985-12-20 1988-10-18 Warner-Lambert Company Confectionery delivery system for actives
US4716033A (en) * 1986-03-27 1987-12-29 Warner-Lambert Company Medicament adsorbates with surfactant and their preparation
US4816264A (en) * 1986-06-06 1989-03-28 Warner-Lambert Company Sustained release formulations
US4865850A (en) * 1986-09-08 1989-09-12 See/Shell Biotechnology, Inc. Dietary fat reduction
US4814354A (en) * 1986-09-26 1989-03-21 Warner-Lambert Company Lipid regulating agents
ZA876640B (en) * 1986-09-26 1988-03-08 Warner-Lambert Company Treated lipid regulator
AU1422388A (en) * 1987-01-27 1988-08-10 Warner-Lambert Company Lipid regulating compositions
US4859703A (en) * 1987-06-15 1989-08-22 Warner-Lambert Company Lipid regulating compositions
US5023088A (en) * 1987-06-25 1991-06-11 Alza Corporation Multi-unit delivery system
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
US4891220A (en) * 1988-07-14 1990-01-02 Immudyne, Inc. Method and composition for treating hyperlipidemia
US4971804A (en) * 1989-02-02 1990-11-20 Warner-Lambert Company Water dispersible gemfibrozil compositions
US4925676A (en) * 1989-02-02 1990-05-15 Warner-Lambert Company Extended release gemfibrozil composition
US4927639A (en) * 1989-02-02 1990-05-22 Warner-Lambert Company Modified release gemfibrozil composition
US5126348A (en) * 1989-09-26 1992-06-30 The University Of Colorado Foundation, Inc. Bioavailability enhancers
EP0475894A1 (en) * 1990-08-27 1992-03-18 Warner-Lambert Company Gemfibrozil formulations

Also Published As

Publication number Publication date
ZA914577B (en) 1992-03-25
IE912041A1 (en) 1991-12-18
AU7838091A (en) 1991-12-19
FI912884A (fi) 1991-12-16
AU641509B2 (en) 1993-09-23
EP0462067A1 (en) 1991-12-18
FI912884A0 (fi) 1991-06-14
US5281421A (en) 1994-01-25
PT97970A (pt) 1992-03-31
JPH04230216A (ja) 1992-08-19

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