IT8467418A0 - Procedimento pe la produzione di diltiazem cloridrato - Google Patents
Procedimento pe la produzione di diltiazem cloridratoInfo
- Publication number
- IT8467418A0 IT8467418A0 IT8467418A IT6741884A IT8467418A0 IT 8467418 A0 IT8467418 A0 IT 8467418A0 IT 8467418 A IT8467418 A IT 8467418A IT 6741884 A IT6741884 A IT 6741884A IT 8467418 A0 IT8467418 A0 IT 8467418A0
- Authority
- IT
- Italy
- Prior art keywords
- procedure
- production
- diltiazem hydrochloride
- diltiazem
- hydrochloride
- Prior art date
Links
- FEDJGPQLLNQAIY-UHFFFAOYSA-N 2-[(6-oxo-1h-pyridazin-3-yl)oxy]acetic acid Chemical compound OC(=O)COC=1C=CC(=O)NN=1 FEDJGPQLLNQAIY-UHFFFAOYSA-N 0.000 title 1
- 229960005316 diltiazem hydrochloride Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7113983A JPS59196863A (ja) | 1983-04-21 | 1983-04-21 | 新規な2(s)−ヒドロキシ−3(s)−(4−アシルオキシフエニル)−3−(2−ニトロフエニルチオ)プロピオン酸類 |
JP7114083A JPS59196878A (ja) | 1983-04-21 | 1983-04-21 | 塩酸ジルチアゼムの新規製造法 |
JP7113883A JPS59196881A (ja) | 1983-04-21 | 1983-04-21 | 新規なエポキシド誘導体 |
Publications (3)
Publication Number | Publication Date |
---|---|
IT8467418A0 true IT8467418A0 (it) | 1984-04-20 |
IT8467418A1 IT8467418A1 (it) | 1985-10-20 |
IT1178928B IT1178928B (it) | 1987-09-16 |
Family
ID=27300564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT67418/84A IT1178928B (it) | 1983-04-21 | 1984-04-20 | Procedimento pe la produzione di diltiazem cloridrato |
Country Status (5)
Country | Link |
---|---|
US (1) | US4552695A (it) |
DE (1) | DE3415035A1 (it) |
FR (1) | FR2545490A1 (it) |
GB (1) | GB2139620B (it) |
IT (1) | IT1178928B (it) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL71538A (en) * | 1984-04-13 | 1987-07-31 | Abic Ltd | Process for the preparation of benzothiazepine derivatives |
US4694002A (en) * | 1986-08-21 | 1987-09-15 | E. R. Squibb & Sons, Inc. | Benzothiazepine derivatives |
US4908469A (en) * | 1988-05-18 | 1990-03-13 | Marion Laboratories, Inc. | 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines |
NL8801311A (nl) | 1988-05-20 | 1989-12-18 | Stamicarbon | Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem. |
US5008411A (en) * | 1988-05-24 | 1991-04-16 | Hoffmann-La Roche Inc. | Glycidic acid ester and process of preparation |
USRE34935E (en) * | 1989-01-11 | 1995-05-09 | Synthelabo | Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepine-4-one and chlorinated derivatives thereof |
FR2641535B1 (fr) * | 1989-01-11 | 1991-03-15 | Synthelabo | Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4 |
JPH0798813B2 (ja) * | 1989-04-28 | 1995-10-25 | 田辺製薬株式会社 | 1,5―ベンゾチアゼピン誘導体の製法 |
ES2069003T3 (es) * | 1989-04-28 | 1995-05-01 | Tanabe Seiyaku Co | Procedimiento para preparar derivados de 1,5-benzotiazepina. |
US5128469A (en) * | 1989-04-28 | 1992-07-07 | Tanabe Seiyaku Co., Ltd. | Process for preparing 1,5-benzothiazepine derivatives |
FR2649980A1 (it) * | 1989-07-18 | 1991-01-25 | Sanofi Sa | |
IT1232306B (it) * | 1989-07-27 | 1992-01-28 | Zambon Spa | Processo di risoluzione di intermedi utili per la preparazione del diltiazem |
US5250680A (en) * | 1989-08-31 | 1993-10-05 | Merrell Dow Pharmaceuticals Inc. | Heterogeneous synthesis of azepinones from esters |
US5112969A (en) * | 1990-04-02 | 1992-05-12 | Merrell Dow Pharmaceuticals Inc. | Cyano esters and azepinones |
US5055575A (en) * | 1990-04-12 | 1991-10-08 | Tanabe Seiyaku Co., Ltd. | Process for preparing 1,5-benzothiazepine derivatives |
AU644679B2 (en) * | 1990-09-07 | 1993-12-16 | Universidad De Alicante | Composition for treating ocular pain |
US5525601A (en) * | 1990-09-07 | 1996-06-11 | Universidad De Alicante | Composition for treating ocular pain |
CA2073003A1 (en) * | 1990-09-07 | 1992-03-08 | Universidad De Alicante | Composition for treating ocular pain |
FI93833C (fi) * | 1992-05-14 | 1995-06-12 | Orion Yhtymae Oy | Menetelmä propionihappojohdosten valmistamiseksi |
IL102592A (en) * | 1992-07-21 | 1996-09-12 | Teva Pharma | Optical resolution of threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propionic acid |
CN1266430A (zh) * | 1997-06-11 | 2000-09-13 | 田边制药株式会社 | 制备光学活性的苯基环氧乙烷化合物的方法 |
US6268377B1 (en) | 1998-09-28 | 2001-07-31 | Merck & Co., Inc. | Method for treating androgen-related conditions |
US8748648B2 (en) * | 2007-09-06 | 2014-06-10 | Nektar Therapeutics | Oligomer-calcium channel blocker conjugates |
WO2014030106A2 (en) | 2012-08-18 | 2014-02-27 | Unimark Remedies Ltd. | Process for preparation of optically active (2r,3s)-3-(4- methoxyphenyl)glycidic acid methyl ester and cis lactam and uses thereof |
CN106892881A (zh) * | 2017-03-01 | 2017-06-27 | 郭彦超 | 一种选择性合成地尔硫卓手性中间体的方法 |
CN116143723A (zh) * | 2022-12-07 | 2023-05-23 | 海南锦瑞制药有限公司 | 一种盐酸地尔硫卓的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57136580A (en) * | 1981-02-17 | 1982-08-23 | Agency Of Ind Science & Technol | Novel thiazolylazo compound and its preparation |
JPS57136581A (en) * | 1981-02-18 | 1982-08-23 | Nippon Kayaku Co Ltd | Preparation of 1,5-benzothiazepin derivative |
DE3263466D1 (en) * | 1981-02-27 | 1985-06-20 | Tanabe Seiyaku Co | Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester |
-
1984
- 1984-04-16 US US06/600,405 patent/US4552695A/en not_active Expired - Fee Related
- 1984-04-19 GB GB08410236A patent/GB2139620B/en not_active Expired
- 1984-04-19 DE DE19843415035 patent/DE3415035A1/de not_active Withdrawn
- 1984-04-20 IT IT67418/84A patent/IT1178928B/it active
- 1984-04-20 FR FR8406355A patent/FR2545490A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
GB8410236D0 (en) | 1984-05-31 |
GB2139620A (en) | 1984-11-14 |
IT1178928B (it) | 1987-09-16 |
DE3415035A1 (de) | 1984-10-25 |
FR2545490A1 (fr) | 1984-11-09 |
IT8467418A1 (it) | 1985-10-20 |
US4552695A (en) | 1985-11-12 |
GB2139620B (en) | 1987-05-13 |
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