IT1398643B1 - Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa - Google Patents

Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa

Info

Publication number
IT1398643B1
IT1398643B1 ITMI2010A000345A ITMI20100345A IT1398643B1 IT 1398643 B1 IT1398643 B1 IT 1398643B1 IT MI2010A000345 A ITMI2010A000345 A IT MI2010A000345A IT MI20100345 A ITMI20100345 A IT MI20100345A IT 1398643 B1 IT1398643 B1 IT 1398643B1
Authority
IT
Italy
Prior art keywords
dyes
same
oral administration
solid composition
diagnostic use
Prior art date
Application number
ITMI2010A000345A
Other languages
English (en)
Italian (it)
Inventor
Luigi Moro
Alessandro Repici
Mauro Severino Ajani
Roberto Villa
Giuseppe Celasco
Original Assignee
Cosmo Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITMI2010A000345A priority Critical patent/IT1398643B1/it
Application filed by Cosmo Technologies Ltd filed Critical Cosmo Technologies Ltd
Priority to BR112012022373-9A priority patent/BR112012022373B1/pt
Priority to RS20160959A priority patent/RS55414B1/sr
Priority to SI201131964T priority patent/SI3011975T1/sl
Priority to ES15186682T priority patent/ES2863986T3/es
Priority to PL11714409T priority patent/PL2542268T3/pl
Priority to NZ602130A priority patent/NZ602130A/en
Priority to PL15186682T priority patent/PL3011975T3/pl
Priority to AU2011222496A priority patent/AU2011222496B2/en
Priority to PCT/IB2011/050881 priority patent/WO2011107945A1/en
Priority to CA2790143A priority patent/CA2790143C/en
Priority to EP15186682.9A priority patent/EP3011975B1/en
Priority to EP11714409.7A priority patent/EP2542268B1/en
Priority to LTEP15186682.9T priority patent/LT3011975T/lt
Priority to PT151866829T priority patent/PT3011975T/pt
Priority to LTEP11714409.7T priority patent/LT2542268T/lt
Priority to RU2012142192/15A priority patent/RU2561034C2/ru
Priority to HRP20161366TT priority patent/HRP20161366T1/hr
Priority to DK11714409.7T priority patent/DK2542268T3/en
Priority to HUE15186682A priority patent/HUE053977T2/hu
Priority to JP2012555529A priority patent/JP5770752B2/ja
Priority to MX2012010125A priority patent/MX342323B/es
Priority to CN201180012333.0A priority patent/CN102811747B/zh
Priority to RS20210391A priority patent/RS61641B1/sr
Priority to HUE11714409A priority patent/HUE030246T2/en
Priority to PT117144097T priority patent/PT2542268T/pt
Priority to KR1020127026021A priority patent/KR101763700B1/ko
Priority to ES11714409.7T priority patent/ES2602157T3/es
Priority to DK15186682.9T priority patent/DK3011975T3/da
Publication of ITMI20100345A1 publication Critical patent/ITMI20100345A1/it
Priority to IL221541A priority patent/IL221541A/en
Priority to ZA2012/06360A priority patent/ZA201206360B/en
Priority to US13/602,875 priority patent/US8545811B2/en
Application granted granted Critical
Publication of IT1398643B1 publication Critical patent/IT1398643B1/it
Priority to US13/932,328 priority patent/US9402923B2/en
Priority to US13/932,321 priority patent/US9402922B2/en
Priority to US15/061,232 priority patent/US10265420B2/en
Priority to US15/877,591 priority patent/US20180214580A1/en
Priority to US16/585,330 priority patent/US20200268909A1/en
Priority to FR21C1009C priority patent/FR21C1009I1/fr
Priority to HUS2100005C priority patent/HUS2100005I1/hu
Priority to CY20211100233T priority patent/CY1123967T1/el
Priority to HRP20210493TT priority patent/HRP20210493T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/31—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes, colonoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/003—Thiazine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0073—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form semi-solid, gel, hydrogel, ointment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/005—Devices for introducing or retaining media, e.g. remedies, in cavities of the body for contrast media

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
ITMI2010A000345A 2010-03-04 2010-03-04 Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa IT1398643B1 (it)

Priority Applications (41)

Application Number Priority Date Filing Date Title
ITMI2010A000345A IT1398643B1 (it) 2010-03-04 2010-03-04 Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa
MX2012010125A MX342323B (es) 2010-03-04 2011-03-02 Composicion solida para la administracion oral de tintes y uso de diagnostico de la misma.
SI201131964T SI3011975T1 (sl) 2010-03-04 2011-03-02 Trdna sestava za oralno uporabo barvil in njihovo diagnostično uporabo
ES15186682T ES2863986T3 (es) 2010-03-04 2011-03-02 Composición sólida para la administración oral de tintes y uso diagnóstico de la misma
PL11714409T PL2542268T3 (pl) 2010-03-04 2011-03-02 Kompozycja stała do stosowania doustnego i jej zastosowanie diagnostyczne
NZ602130A NZ602130A (en) 2010-03-04 2011-03-02 Solid composition for the oral administration of dyes and diagnostic use thereof
PL15186682T PL3011975T3 (pl) 2010-03-04 2011-03-02 Kompozycja stała do stosowania doustnego i jej zastosowanie diagnostyczne
AU2011222496A AU2011222496B2 (en) 2010-03-04 2011-03-02 Solid composition for the oral administration of dyes and diagnostic use thereof
PCT/IB2011/050881 WO2011107945A1 (en) 2010-03-04 2011-03-02 Solid composition for the oral administration of dyes and diagnostic use thereof
CA2790143A CA2790143C (en) 2010-03-04 2011-03-02 Solid composition for the oral administration of dyes and diagnostic use thereof
EP15186682.9A EP3011975B1 (en) 2010-03-04 2011-03-02 Solid composition for the oral administration of dyes and diagnostic use thereof
EP11714409.7A EP2542268B1 (en) 2010-03-04 2011-03-02 Solid composition for the oral administration of dyes and diagnostic use thereof
LTEP15186682.9T LT3011975T (lt) 2010-03-04 2011-03-02 Kietoji kompozicija, skirta dažiklio vartojimui per burną ir jos diagnostinis panaudojimas
PT151866829T PT3011975T (pt) 2010-03-04 2011-03-02 Composição sólida para administração oral de corantes e a sua utilização em diagnóstico
LTEP11714409.7T LT2542268T (lt) 2010-03-04 2011-03-02 Kieta kompozicija, skirta peroraliniam dažomųjų medžiagų vartojimui, ir jos diagnostinis panaudojimas
RU2012142192/15A RU2561034C2 (ru) 2010-03-04 2011-03-02 Твердая композиция для перорального введения красителей и их диагностическое применение
HRP20161366TT HRP20161366T1 (hr) 2010-03-04 2011-03-02 Čvrsti pripravci za oralnu primjenu boja te njihova dijagnostička uporaba
RS20210391A RS61641B1 (sr) 2010-03-04 2011-03-02 Čvrsta kompozicija za oralnu primenu boja i njihova dijagnostička upotreba
HUE15186682A HUE053977T2 (hu) 2010-03-04 2011-03-02 Szilárd gyógyszer színezõanyagok orális alkalmazására és diagnosztikai felhasználásra
JP2012555529A JP5770752B2 (ja) 2010-03-04 2011-03-02 色素を経口投与するための固体組成物およびその診断使用
BR112012022373-9A BR112012022373B1 (pt) 2010-03-04 2011-03-02 Composição sólida para a administração oral de corantes e uso diagnóstico desta
DK11714409.7T DK2542268T3 (en) 2010-03-04 2011-03-02 FIXED COMPOSITION FOR ORAL ADMINISTRATION OF COLORING MATERIALS AND DIAGNOSTIC USE OF IT
RS20160959A RS55414B1 (sr) 2010-03-04 2011-03-02 Čvrsta kompozicija za oralnu primenu boja i njihova dijagnostička upotreba
HUE11714409A HUE030246T2 (en) 2010-03-04 2011-03-02 Solid composition for the oral administration of dyes and diagnostic use thereof
PT117144097T PT2542268T (pt) 2010-03-04 2011-03-02 Composição sólida para administração oral de corantes e utilização desta
KR1020127026021A KR101763700B1 (ko) 2010-03-04 2011-03-02 염료의 경구 투여를 위한 고체 조성물 및 이의 진단 용도
ES11714409.7T ES2602157T3 (es) 2010-03-04 2011-03-02 Composición sólida para la administración oral de tintes y uso diagnóstico de la misma
DK15186682.9T DK3011975T3 (da) 2010-03-04 2011-03-02 Faststofsammensætning til oral administration af farvestoffer og diagnostisk anvendelse deraf
CN201180012333.0A CN102811747B (zh) 2010-03-04 2011-03-02 用于口服施用染料的固体组合物及其诊断用途
IL221541A IL221541A (en) 2010-03-04 2012-08-20 Solid composition for the oral administration of dyes and diagnostic use thereof
ZA2012/06360A ZA201206360B (en) 2010-03-04 2012-08-23 Solid composition for the oral administration of dyes and diagnostic use thereof
US13/602,875 US8545811B2 (en) 2010-03-04 2012-09-04 Solid composition for the oral administration of dyes and diagnostic use thereof
US13/932,328 US9402923B2 (en) 2010-03-04 2013-07-01 Solid composition for the oral administration of dyes and diagnostic use thereof
US13/932,321 US9402922B2 (en) 2010-03-04 2013-07-01 Solid composition for the oral administration of dyes and diagnostic use thereof
US15/061,232 US10265420B2 (en) 2010-03-04 2016-03-04 Solid composition for the oral administration of dyes and diagnostic use thereof
US15/877,591 US20180214580A1 (en) 2010-03-04 2018-01-23 Solid composition for the oral administration of dyes and diagnostic use thereof
US16/585,330 US20200268909A1 (en) 2010-03-04 2019-09-27 Solid composition for the oral administration of dyes and diagnostic use thereof
FR21C1009C FR21C1009I1 (fr) 2010-03-04 2021-02-18 Composition solide pour administration orale de colorants et ses applications en diagnostic
HUS2100005C HUS2100005I1 (hu) 2010-03-04 2021-02-19 Metiltioninium-klorid
CY20211100233T CY1123967T1 (el) 2010-03-04 2021-03-18 Στερεη συνθεση για τη χορηγηση απο το στομα χρωστικων υλων και διαγνωστικη χρηση αυτης
HRP20210493TT HRP20210493T1 (hr) 2010-03-04 2021-03-26 Čvrsti pripravak za oralnu primjenu boja te njegova dijagnostička uporaba

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2010A000345A IT1398643B1 (it) 2010-03-04 2010-03-04 Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa

Publications (2)

Publication Number Publication Date
ITMI20100345A1 ITMI20100345A1 (it) 2011-09-05
IT1398643B1 true IT1398643B1 (it) 2013-03-08

Family

ID=42647312

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2010A000345A IT1398643B1 (it) 2010-03-04 2010-03-04 Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa

Country Status (26)

Country Link
US (6) US8545811B2 (enExample)
EP (2) EP3011975B1 (enExample)
JP (1) JP5770752B2 (enExample)
KR (1) KR101763700B1 (enExample)
CN (1) CN102811747B (enExample)
AU (1) AU2011222496B2 (enExample)
BR (1) BR112012022373B1 (enExample)
CA (1) CA2790143C (enExample)
CY (1) CY1123967T1 (enExample)
DK (2) DK3011975T3 (enExample)
ES (2) ES2602157T3 (enExample)
FR (1) FR21C1009I1 (enExample)
HR (2) HRP20161366T1 (enExample)
HU (3) HUE030246T2 (enExample)
IL (1) IL221541A (enExample)
IT (1) IT1398643B1 (enExample)
LT (2) LT2542268T (enExample)
MX (1) MX342323B (enExample)
NZ (1) NZ602130A (enExample)
PL (2) PL3011975T3 (enExample)
PT (2) PT3011975T (enExample)
RS (2) RS61641B1 (enExample)
RU (1) RU2561034C2 (enExample)
SI (1) SI3011975T1 (enExample)
WO (1) WO2011107945A1 (enExample)
ZA (1) ZA201206360B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
DE60005819T2 (de) 1999-06-14 2004-05-06 Cosmo S.P.A. Geschmacksmaskierte orale pharmazeutische zusammensetzungen mit kontrollierter abgabe
US8162969B2 (en) 2008-10-16 2012-04-24 Obalon Therapeutics, Inc. Intragastric device
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
EP2722058A1 (en) * 2012-10-19 2014-04-23 Cosmo Technologies Ltd Solid oral composition containing dyes for use in endoscopic diagnosis
WO2015114548A1 (en) * 2014-01-29 2015-08-06 Cosmo Technologies Limited Liquid composition in the form of emulsion or microemulsion for rectal administration containing at least one dye, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum
US10124074B2 (en) * 2014-02-26 2018-11-13 Toufic Kachaamy Indirect chromoendoscopy with an oral indigo carmine base preparation
EP3888702A1 (en) 2014-12-08 2021-10-06 Kinnos Inc. Additive compositions for pigmented disinfection and methods thereof
EP3285701B1 (en) * 2015-04-23 2020-12-23 Obalon Therapeutics, Inc. Systems and methods for determining failure of intragastric devices
BR112018016369A2 (pt) 2016-02-12 2018-12-26 Kinnos Inc composições e métodos para uso na descontaminação de superfície
WO2017182350A1 (en) 2016-04-19 2017-10-26 Conaris Research Institute Ag Shellac microcapsule formulations and compositions
CN109715777B (zh) 2016-07-25 2022-04-19 金诺斯公司 用于表面净化的装置和相关组合物及方法
MX2019006216A (es) 2016-11-28 2019-08-22 Cosmo Technologies Ltd Composicion oral solida que contiene colorantes.
FR3059664B1 (fr) 2016-12-01 2019-01-25 Provepharm Life Solutions Procede de preparation du carmin d’indigo
CN116941998A (zh) 2018-07-12 2023-10-27 金诺斯公司 用于表面去污的装置、合成物和方法
CN108888765B (zh) * 2018-07-16 2021-02-26 山东理工大学 一种释放亚甲基蓝聚集体的含亚甲基蓝的二氧化硅/虫胶复合颗粒的制备方法
CN111184876B (zh) * 2020-02-20 2022-03-04 沈伟 一种消化道黏膜染色剂、制备方法及其应用

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Publication number Priority date Publication date Assignee Title
US3361632A (en) * 1964-05-08 1968-01-02 Hoechst Ag Medicinal preparations having a protracted activity and method of making them
CA2097695C (en) * 1991-10-31 2000-08-08 Mark J. Malmros Biological stain composition, method of preparation and method of use for delineation of epithelial cancer
US6405070B1 (en) * 1998-06-16 2002-06-11 Bhaskar Banerjee Detection of cancer using cellular autofluorescence
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
DE60005819T2 (de) 1999-06-14 2004-05-06 Cosmo S.P.A. Geschmacksmaskierte orale pharmazeutische zusammensetzungen mit kontrollierter abgabe
ITMI991316A1 (it) 1999-06-14 2000-12-14 Cip Ninety Two 92 S A Composizioni farmaceutiche orali a rilascio modificato di mesalazina
US6584630B1 (en) 2000-04-06 2003-07-01 Ohio Medical Instrument Company, Inc. Radiolucent surgical table extension assembly and method
WO2001076478A1 (en) 2000-04-10 2001-10-18 Nordisk Terapi As System for testing and exercising sensorimotoric control of the neck
FR2829933B3 (fr) * 2001-09-21 2004-03-12 Ellipse Pharmaceuticals Procede de fabrication d'un produit pharmaceutique administrable par voie orale avec des agents detrompeurs notamment de gout et produit obtenu
US7217410B2 (en) 2003-06-17 2007-05-15 The Board Of Trustees Of The Universtiy Of Illinois Surface modified protein microparticles
WO2007056439A1 (en) * 2005-11-08 2007-05-18 Collegium Pharmaceutical, Inc. Salts of methylene blue and its derivatives
FR2894253B1 (fr) * 2005-12-06 2009-11-13 Pentax Corp Composition d'histocolorant pour endoscope

Also Published As

Publication number Publication date
ES2602157T3 (es) 2017-02-17
US10265420B2 (en) 2019-04-23
HUE030246T2 (en) 2017-04-28
JP2013521271A (ja) 2013-06-10
LT2542268T (lt) 2016-12-12
RS61641B1 (sr) 2021-04-29
EP2542268A1 (en) 2013-01-09
FR21C1009I1 (fr) 2021-05-07
US20130295013A1 (en) 2013-11-07
US8545811B2 (en) 2013-10-01
CY1123967T1 (el) 2022-05-27
DK3011975T3 (da) 2021-03-29
HRP20210493T1 (hr) 2021-05-14
BR112012022373B1 (pt) 2021-12-14
HUS2100005I1 (hu) 2021-03-29
US20200268909A1 (en) 2020-08-27
RS55414B1 (sr) 2017-04-28
HRP20161366T1 (hr) 2017-02-24
PL2542268T3 (pl) 2017-05-31
RU2561034C2 (ru) 2015-08-20
CA2790143C (en) 2019-01-22
MX342323B (es) 2016-09-23
CA2790143A1 (en) 2011-09-09
BR112012022373A2 (pt) 2019-11-26
KR101763700B1 (ko) 2017-08-01
US9402922B2 (en) 2016-08-02
EP3011975B1 (en) 2021-01-20
US20180214580A1 (en) 2018-08-02
US9402923B2 (en) 2016-08-02
RU2012142192A (ru) 2014-04-10
DK2542268T3 (en) 2016-11-28
IL221541A (en) 2016-03-31
US20160184460A1 (en) 2016-06-30
AU2011222496B2 (en) 2016-08-18
ZA201206360B (en) 2013-10-30
ITMI20100345A1 (it) 2011-09-05
WO2011107945A1 (en) 2011-09-09
PT3011975T (pt) 2021-03-19
PT2542268T (pt) 2016-11-14
ES2863986T3 (es) 2021-10-13
PL3011975T3 (pl) 2021-06-28
EP3011975A1 (en) 2016-04-27
CN102811747A (zh) 2012-12-05
NZ602130A (en) 2014-07-25
AU2011222496A2 (en) 2012-09-20
KR20130015008A (ko) 2013-02-12
HUE053977T2 (hu) 2021-07-28
JP5770752B2 (ja) 2015-08-26
CN102811747B (zh) 2016-02-24
US20130058867A1 (en) 2013-03-07
LT3011975T (lt) 2021-04-26
AU2011222496A1 (en) 2012-09-20
US20130287690A1 (en) 2013-10-31
EP2542268B1 (en) 2016-08-10
SI3011975T1 (sl) 2021-05-31
MX2012010125A (es) 2013-02-26

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