IT1293088B1 - Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in - Google Patents

Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in

Info

Publication number
IT1293088B1
IT1293088B1 IT97RM000418A ITRM970418A IT1293088B1 IT 1293088 B1 IT1293088 B1 IT 1293088B1 IT 97RM000418 A IT97RM000418 A IT 97RM000418A IT RM970418 A ITRM970418 A IT RM970418A IT 1293088 B1 IT1293088 B1 IT 1293088B1
Authority
IT
Italy
Prior art keywords
microparticles
biologically active
active molecules
prophylaxis
diagnostics
Prior art date
Application number
IT97RM000418A
Other languages
English (en)
Italian (it)
Inventor
Anders Carlsson
Elisabetta E Chiellini
Federica Chiellini
Jenny Cowdall
John Davies
Giuseppe Mazzanti
Mark Roberts
Erik Soderlind
Roberto Solaro
Original Assignee
Isi Ist Sierovaccinogeno Ital
Scotia Lipidteknik Ab
Polymer Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isi Ist Sierovaccinogeno Ital, Scotia Lipidteknik Ab, Polymer Lab Ltd filed Critical Isi Ist Sierovaccinogeno Ital
Priority to IT97RM000418A priority Critical patent/IT1293088B1/it
Publication of ITRM970418A0 publication Critical patent/ITRM970418A0/it
Priority to PCT/IT1998/000192 priority patent/WO1999002135A1/en
Priority to AT98932506T priority patent/ATE293958T1/de
Priority to ES98932506T priority patent/ES2242287T3/es
Priority to EP98932506A priority patent/EP1003482B1/en
Priority to DE69829975T priority patent/DE69829975T2/de
Priority to AU82409/98A priority patent/AU8240998A/en
Publication of ITRM970418A1 publication Critical patent/ITRM970418A1/it
Application granted granted Critical
Publication of IT1293088B1 publication Critical patent/IT1293088B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT97RM000418A 1997-07-10 1997-07-10 Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in IT1293088B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT97RM000418A IT1293088B1 (it) 1997-07-10 1997-07-10 Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in
PCT/IT1998/000192 WO1999002135A1 (en) 1997-07-10 1998-07-09 Microparticles for controlled delivery of biologically active molecules
AT98932506T ATE293958T1 (de) 1997-07-10 1998-07-09 Mikropartikel zur gesteuerten wirkstoffabgabe biologisch aktiver moleküle
ES98932506T ES2242287T3 (es) 1997-07-10 1998-07-09 Microparticulas para la administracion controlada de moleculas biologicamente activas.
EP98932506A EP1003482B1 (en) 1997-07-10 1998-07-09 Microparticles for controlled delivery of biologically active molecules
DE69829975T DE69829975T2 (de) 1997-07-10 1998-07-09 Mikropartikel zur gesteuerten wirkstoffabgabe biologisch aktiver moleküle
AU82409/98A AU8240998A (en) 1997-07-10 1998-07-09 Microparticles for controlled delivery of biologically active molecules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97RM000418A IT1293088B1 (it) 1997-07-10 1997-07-10 Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in

Publications (3)

Publication Number Publication Date
ITRM970418A0 ITRM970418A0 (enEXAMPLES) 1997-07-10
ITRM970418A1 ITRM970418A1 (it) 1999-01-10
IT1293088B1 true IT1293088B1 (it) 1999-02-11

Family

ID=11405168

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97RM000418A IT1293088B1 (it) 1997-07-10 1997-07-10 Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in

Country Status (7)

Country Link
EP (1) EP1003482B1 (enEXAMPLES)
AT (1) ATE293958T1 (enEXAMPLES)
AU (1) AU8240998A (enEXAMPLES)
DE (1) DE69829975T2 (enEXAMPLES)
ES (1) ES2242287T3 (enEXAMPLES)
IT (1) IT1293088B1 (enEXAMPLES)
WO (1) WO1999002135A1 (enEXAMPLES)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6932861B2 (en) 2000-11-28 2005-08-23 Fmc Corporation Edible PGA coating composition
WO2003000297A1 (fr) 2001-06-20 2003-01-03 Sumitomo Pharmaceuticals Company, Limited Procede facilitant le transfert d'acides nucleiques
JP2008067717A (ja) * 2001-06-20 2008-03-27 Dainippon Sumitomo Pharma Co Ltd 核酸導入を促進させる方法
US7166575B2 (en) 2002-12-17 2007-01-23 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
EA008829B1 (ru) 2002-12-17 2007-08-31 Нэстек Фармасьютикал Кампани Инк. Композиции и способы для усовершенствованной доставки пептидов, связывающихся с y-рецепторами, которую осуществляют через слизистые оболочки, и способы лечения и предотвращения ожирения
US7186692B2 (en) 2002-12-17 2007-03-06 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity
US7229966B2 (en) 2002-12-17 2007-06-12 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
EP3370694A1 (en) 2015-11-06 2018-09-12 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. Composition comprising a biocompatible and biodegradable polymer, nanocarries and a drug and methods of making and using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2660556B1 (fr) * 1990-04-06 1994-09-16 Rhone Poulenc Sante Microspheres, leur procede de preparation et leur utilisation.
IT1244511B (it) * 1991-04-15 1994-07-15 Isi Ist Sierovaccinogeno Ital Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione.
DE69332222T3 (de) * 1992-06-11 2007-05-10 Alkermes Controlled Therapeutics, Inc., Cambridge Enythropoietin enthaltendes arzneimittelabgabesystem
WO1994023738A1 (en) * 1993-04-19 1994-10-27 Medisorb Technologies International L.P. Encapsulation of nucleic acids with conjugates that facilitate and target cellular uptake and gene expression

Also Published As

Publication number Publication date
AU8240998A (en) 1999-02-08
EP1003482B1 (en) 2005-04-27
WO1999002135A1 (en) 1999-01-21
ATE293958T1 (de) 2005-05-15
ITRM970418A0 (enEXAMPLES) 1997-07-10
DE69829975D1 (de) 2005-06-02
DE69829975T2 (de) 2006-03-09
ES2242287T3 (es) 2005-11-01
ITRM970418A1 (it) 1999-01-10
EP1003482A1 (en) 2000-05-31

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Legal Events

Date Code Title Description
0001 Granted