IT1244511B - Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione. - Google Patents

Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione.

Info

Publication number
IT1244511B
IT1244511B ITRM910260A ITRM910260A IT1244511B IT 1244511 B IT1244511 B IT 1244511B IT RM910260 A ITRM910260 A IT RM910260A IT RM910260 A ITRM910260 A IT RM910260A IT 1244511 B IT1244511 B IT 1244511B
Authority
IT
Italy
Prior art keywords
controlled release
preparation
synthetic
polycarbossylate
drugs
Prior art date
Application number
ITRM910260A
Other languages
English (en)
Inventor
Emo Chiellini
Giuseppe Leonardi
Roberto Solaro
Romeo Lisciani
Giuseppe Mazzanti
Original Assignee
Isi Ist Sierovaccinogeno Ital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isi Ist Sierovaccinogeno Ital filed Critical Isi Ist Sierovaccinogeno Ital
Priority to ITRM910260A priority Critical patent/IT1244511B/it
Publication of ITRM910260A0 publication Critical patent/ITRM910260A0/it
Priority to AT92830172T priority patent/ATE120639T1/de
Priority to DE69201900T priority patent/DE69201900T2/de
Priority to EP92830172A priority patent/EP0509968B1/en
Publication of ITRM910260A1 publication Critical patent/ITRM910260A1/it
Application granted granted Critical
Publication of IT1244511B publication Critical patent/IT1244511B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

E' descritta una matrice idrogelica per il rilascio controllato di sostanze ad attività farmacologica, preferibilmente di natura proteica o polipeptidica, comprendente un polimero sintetico di formula (FORMULA I) dove R = alchile (C1-C12); R1 = alchile (C1-C4), R2 = H (m = 1,3; n = 1-12) o CH3 (m = 1; n = 1-12), un componente proteico e la sostanza ad attività farmacologica; nonché il procedimento per la sua preparazione.Tali matrici sono utilizzate per via trans-cutanea, trans-dermica e particolarmente per via oftalmica a mezzo di inserti oculari. Particolare applicazione della presente invenzione è costituita da inserti oculari per il rilascio controllato di interferone.
ITRM910260A 1991-04-15 1991-04-15 Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione. IT1244511B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITRM910260A IT1244511B (it) 1991-04-15 1991-04-15 Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione.
AT92830172T ATE120639T1 (de) 1991-04-15 1992-04-08 Synthetische polycarboxylate und proteine enthaltende hydrogele als träger von wirkstoffen mit verzögerter freisetzung und verfahren zu ihrer herstellung.
DE69201900T DE69201900T2 (de) 1991-04-15 1992-04-08 Synthetische Polycarboxylate und Proteine enthaltende Hydrogele als Träger von Wirkstoffen mit verzögerter Freisetzung und Verfahren zu ihrer Herstellung.
EP92830172A EP0509968B1 (en) 1991-04-15 1992-04-08 Synthetic polycarboxylates and proteins hydrogels for drug sustained release and process for the production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910260A IT1244511B (it) 1991-04-15 1991-04-15 Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione.

Publications (3)

Publication Number Publication Date
ITRM910260A0 ITRM910260A0 (it) 1991-04-15
ITRM910260A1 ITRM910260A1 (it) 1992-10-15
IT1244511B true IT1244511B (it) 1994-07-15

Family

ID=11400100

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM910260A IT1244511B (it) 1991-04-15 1991-04-15 Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione.

Country Status (4)

Country Link
EP (1) EP0509968B1 (it)
AT (1) ATE120639T1 (it)
DE (1) DE69201900T2 (it)
IT (1) IT1244511B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125817B1 (es) 1997-01-20 2000-01-01 Consejo Superior Investigacion Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas.
IT1293088B1 (it) * 1997-07-10 1999-02-11 Isi Ist Sierovaccinogeno Ital Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in
JP2007538048A (ja) 2004-05-17 2007-12-27 アレス トレーディング ソシエテ アノニム ヒドロゲル・インターフェロン製剤
EA010979B1 (ru) 2004-06-01 2008-12-30 Арес Трейдинг С.А. Стабилизированные жидкие препаративные формы интерферона
AU2008340058A1 (en) 2007-12-20 2009-07-02 Merck Serono S.A. PEG-interferon-beta formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61103836A (ja) * 1984-10-24 1986-05-22 Green Cross Corp:The フイブロネクチン製剤
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants

Also Published As

Publication number Publication date
DE69201900T2 (de) 1995-12-07
EP0509968A1 (en) 1992-10-21
EP0509968B1 (en) 1995-04-05
ITRM910260A0 (it) 1991-04-15
DE69201900D1 (de) 1995-05-11
ITRM910260A1 (it) 1992-10-15
ATE120639T1 (de) 1995-04-15

Similar Documents

Publication Publication Date Title
Campochiaro et al. Intravitreal chemotactic and mitogenic activity: implication of blood-retinal barrier breakdown
MD1233C2 (ro) Derivaţi de eritromicină, procedeu de preparare a lor şi compoziţie farmaceutică pe baza acestora
DK366889D0 (da) Peptidderivat
DK653688D0 (da) Stabiliserede laegemiddelaktive forbindelser, fremgangsmaade til deres frmstilling samt stabile laegemiddelpraeparater
FI113644B (fi) Menetelmä terapeuttisesti aktiivisten N-substituoitujen 3- atsabisykloalkaanijohdannaisten valmistamiseksi
DK57388A (da) Thiazolidinonderivater, fremgangsmaade til deres fremstilling samt anvendelsen heraf
DK581889A (da) Antiatherosclerotiske diarylforbindelser
NO178261C (no) Substituerte diaminoftalimider og analoger, farmasöytiske preparater inneholdende dem samt deres anvendelse i medikamenter
IT1244511B (it) Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione.
ES2109752T3 (es) Medicamento para tratamiento terapeutico y profilactico de enfermedades causadas por hiperplasia de las celulas de los musculos lisos.
AR019908A1 (es) Uso de derivados de cisteina preparar un medicamento destinado a tratar patologias que resultan de la formacion de la proteina g heterotrimerica, derivadosde cisteina usados y medicamento y composicion farmaceutica que comprenden a por lo menos uno de dichos derivados.
ATE39482T1 (de) N-(1-ethyl-2-pyrrolidinylmethyl)-benzamidderivate, verfahren und zwischenprodukte zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen.
HUP9901303A2 (hu) Gyógyszerkészítmény autoimmun betegségek kezelésére
NO980058L (no) Opthalmiske preparater
ES534859A0 (es) Procedimiento para la obtencion de derivados de 1-(4'-alquilsulfonilfenil)-2-amino-1,3-propandiol n-substituidos
Pavan-Langston et al. Idoxuridine ocular insert therapy: Use in treatment of experimental herpes simplex keratitis
CA2210579A1 (en) Benzene derivatives
BR9814496A (pt) Composto, processos para a preparação de cristais de sementes da modificação termodinamicamente estável i de ramatroban, para a preparação de uma forma termodinamicamente estável de ramatroban, medicamento, e, uso de uma modificação termodinamicamente estável de ramatroban
TR199701258T1 (xx) S�bstit�e edilmi� amidinler, ila�lar ve bunlar�n �retilmesi.
EP1206942B1 (en) Water channel opener compositions and medicinal compositions for ophthalmic use
RU94032148A (ru) Нафтоксазины и способ их получения, их применение для производства медикаментов и содержащая их фармацевтическая композиция
MX9206339A (es) Nueva proteina inhibidora de trombina a partir de chinches de monte
SU598882A1 (ru) Гидрохлорид этилового эфира -лейцил - пролил- -фенилаланина, обладающий противогрипозной активностью
US20040235742A1 (en) Water channel opener compositions and medicinal compositions for ophthalmic use
SU551327A1 (ru) Гидрохлорид 2-(аминоциклогексил-1)этенил-(п-толил)-селенида,про вл ющий психотропную активность

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960502