IT1230592B - Derivati di monofosforil lipide a e procedimento per la loro preparazione - Google Patents
Derivati di monofosforil lipide a e procedimento per la loro preparazioneInfo
- Publication number
- IT1230592B IT1230592B IT8822399A IT2239988A IT1230592B IT 1230592 B IT1230592 B IT 1230592B IT 8822399 A IT8822399 A IT 8822399A IT 2239988 A IT2239988 A IT 2239988A IT 1230592 B IT1230592 B IT 1230592B
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- procedure
- preparation
- monophosphoryl lipid
- monophosphoryl
- Prior art date
Links
- 229940035032 monophosphoryl lipid a Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/112,742 US4987237A (en) | 1983-08-26 | 1987-10-22 | Derivatives of monophosphoryl lipid A |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8822399A0 IT8822399A0 (it) | 1988-10-21 |
IT1230592B true IT1230592B (it) | 1991-10-28 |
Family
ID=22345625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT8822399A IT1230592B (it) | 1987-10-22 | 1988-10-21 | Derivati di monofosforil lipide a e procedimento per la loro preparazione |
Country Status (10)
Country | Link |
---|---|
US (1) | US4987237A (it) |
JP (1) | JPH01146891A (it) |
BE (1) | BE1003250A5 (it) |
CA (1) | CA1308711C (it) |
CH (1) | CH676715A5 (it) |
DE (1) | DE3836006C2 (it) |
FR (1) | FR2622192A1 (it) |
GB (1) | GB2211502B (it) |
IT (1) | IT1230592B (it) |
NL (1) | NL8802595A (it) |
Families Citing this family (55)
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US5158939A (en) * | 1989-07-21 | 1992-10-27 | Wisconsin Alumni Research Foundation | Method of stimulating the immune systems of animals and compositions useful therefor |
AU651949B2 (en) * | 1989-07-14 | 1994-08-11 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
US5498708A (en) * | 1989-07-18 | 1996-03-12 | Montefiore Medical Center | Method of synthesizing polyesters |
CA2059272A1 (en) * | 1990-04-12 | 1991-10-13 | Akira Hasegawa | 4,6-0-hydroxyphosphoryl-glucosamine derivatives |
US5653974A (en) * | 1990-10-18 | 1997-08-05 | Board Of Regents,The University Of Texas System | Preparation and characterization of liposomal formulations of tumor necrosis factor |
US5164375A (en) * | 1991-09-27 | 1992-11-17 | Merck & Company, Inc. | Antifungal agent |
US5648343A (en) * | 1994-02-28 | 1997-07-15 | The University Of Georgia Research Foundation | Method for treating LPS-mediated disorders |
US6218166B1 (en) | 1994-12-09 | 2001-04-17 | John Wayne Cancer Institute | Adjuvant incorporation into antigen carrying cells: compositions and methods |
US5750664A (en) * | 1995-06-05 | 1998-05-12 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
US6290971B1 (en) * | 1995-06-15 | 2001-09-18 | Aventis Pasteur Limited | Adjuvant compositions comprising a mineral salt and another immunostimulating compound |
GB9706957D0 (en) * | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
GB9820525D0 (en) | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
US20030139356A1 (en) * | 2001-05-18 | 2003-07-24 | Persing David H. | Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds |
EP1284740B1 (en) | 2000-05-19 | 2008-05-21 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious, autoimmune and allergic diseases with monosaccharide-based compounds |
US20030138769A1 (en) * | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
US20030175863A1 (en) * | 2001-08-15 | 2003-09-18 | Birkett Ashley J. | Influenza immunogen and vaccine |
US20030185858A1 (en) * | 2001-08-15 | 2003-10-02 | Birkett Ashley J. | Immunogenic HBc chimer particles stabilized with an N-terminal cysteine |
US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
DE60234386D1 (de) * | 2002-02-04 | 2009-12-24 | Corixa Corp | Neue immuneffektor-verbindungen |
US6911434B2 (en) * | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
AU2003213640A1 (en) * | 2002-02-28 | 2003-09-16 | Corixa Corporation | Methods of modulating dendritic cells using adjuvants |
US20030224013A1 (en) * | 2002-04-19 | 2003-12-04 | Cole Garry T. | Methods for protection against Coccidioides spp. infection using Coccidioides spp. urea amidohydrolase (Ure) protein |
ES2456066T3 (es) | 2002-07-08 | 2014-04-21 | Corixa Corporation | Procesos para la producción de fosfato de aminoalquil glucosaminida e inmunoefectores disacáridos, e intermedios para ello |
US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
KR101110889B1 (ko) | 2003-01-06 | 2012-02-20 | 코릭사 코포레이션 | 특정의 아미노알킬 글루코사미나이드 포스페이트 화합물 및그들의 용도 |
DE60304989T2 (de) * | 2003-02-18 | 2007-03-29 | Clinique La Prairie Research S.A. | Zusammensetzungen enthaltend fötales Hämoglobin und bakterielles Endotoxin und fakultativ zusätzliche fötale Leberkomponenten |
WO2006073921A2 (en) * | 2004-12-30 | 2006-07-13 | The Rockefeller University | Compositions and methods for enhanced dendritic cell maturation and function |
US20060210590A1 (en) | 2005-02-03 | 2006-09-21 | Alk-Abello A/S | Minor allergen control to increase safety of immunotherapy |
US7622128B2 (en) * | 2005-12-13 | 2009-11-24 | University Of Washington | Porphyromonas gingivalis 1435/1449 LPS as an immune modulator |
ES2673046T3 (es) * | 2006-09-26 | 2018-06-19 | Infectious Disease Research Institute | Composición de vacuna que contiene un adyuvante sintético |
US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
ES2539818T3 (es) * | 2007-08-02 | 2015-07-06 | Biondvax Pharmaceuticals Ltd. | Vacunas contra la gripe multiepitópicas multiméricas |
US20090215908A1 (en) * | 2007-09-24 | 2009-08-27 | Reliance Life Sciences Pvt. Ltd. | Toll like receptor (tlr) signaling antagonist |
US20090215710A1 (en) * | 2007-09-24 | 2009-08-27 | Reliance Life Sciences Pvt. Ltd. | Carbohydrate based toll-like receptor (tlr) antagonists |
CA2744739A1 (en) | 2007-12-03 | 2009-06-11 | President And Fellows Of Harvard College | Chlamydia antigens |
CN102481312B (zh) | 2009-06-05 | 2015-07-15 | 传染性疾病研究院 | 合成的吡喃葡萄糖脂佐剂 |
CA2828068C (en) | 2011-02-22 | 2019-03-19 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
CA2832307A1 (en) | 2011-04-08 | 2012-10-18 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
GB201106802D0 (en) | 2011-04-21 | 2011-06-01 | Allergy Therapeutics Ltd | Process for preparing vaccine composition |
US9555099B2 (en) | 2012-05-16 | 2017-01-31 | Immune Design Corp. | Vaccines for HSV-2 |
JP6494527B2 (ja) | 2013-02-07 | 2019-04-03 | ザ チルドレンズ メディカル センター コーポレーション | 肺炎球菌のコロニー形成および/または疾患からの保護を提供するタンパク質抗原 |
EP2958935B1 (en) | 2013-02-20 | 2019-07-03 | Bergen Teknologioverforing AS | Vaccine |
KR102039520B1 (ko) | 2013-04-18 | 2019-11-01 | 이뮨 디자인 코포레이션 | 암 치료에 이용하기 위한 gla 단일요법 |
US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
EP3024476A1 (en) | 2013-07-26 | 2016-06-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of bacterial infections |
WO2016180852A1 (en) | 2015-05-12 | 2016-11-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preparing antigen-specific t cells from an umbilical cord blood sample |
EP3681534A1 (en) | 2017-09-13 | 2020-07-22 | Sanofi Pasteur | Human cytomegalovirus immunogenic composition |
WO2019175147A1 (en) | 2018-03-12 | 2019-09-19 | Janssen Vaccines & Prevention B.V. | Vaccines against intra-abdominal infections |
EP3841111A1 (en) | 2018-08-24 | 2021-06-30 | Vestlandets Innovasjonsselskap AS | Heat-stable enterotoxins mutants as antidiarrheal vaccine antigens |
KR20220107166A (ko) | 2019-10-02 | 2022-08-02 | 얀센 백신스 앤드 프리벤션 비.브이. | 스타필로코커스 펩티드 및 사용 방법 |
KR20220128372A (ko) | 2020-01-16 | 2022-09-20 | 얀센 파마슈티칼즈, 인코포레이티드 | Fimh 돌연변이체, 이를 갖는 조성물 및 이의 용도 |
MX2023008251A (es) | 2021-01-12 | 2023-07-26 | Janssen Pharmaceuticals Inc | Mutantes de fimh, composiciones con estos y uso de estos. |
JP2024514074A (ja) | 2021-04-01 | 2024-03-28 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | E.coli o18バイオコンジュゲートの産生 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0414725Y2 (it) * | 1980-09-30 | 1992-04-02 | ||
US4436727A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4436728A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
JPS62129293A (ja) * | 1985-11-28 | 1987-06-11 | Toho Yakuhin Kogyo Kk | 親水性のリピドa単糖類縁体 |
JPS62195396A (ja) * | 1986-02-20 | 1987-08-28 | Toho Yakuhin Kogyo Kk | 親水性及び疎水性の基を置換したりピドa単糖類縁体 |
-
1987
- 1987-10-22 US US07/112,742 patent/US4987237A/en not_active Expired - Lifetime
-
1988
- 1988-10-14 CA CA000580545A patent/CA1308711C/en not_active Expired - Lifetime
- 1988-10-18 GB GB8824330A patent/GB2211502B/en not_active Expired - Lifetime
- 1988-10-20 BE BE8801207A patent/BE1003250A5/fr not_active IP Right Cessation
- 1988-10-21 FR FR8813812A patent/FR2622192A1/fr active Granted
- 1988-10-21 IT IT8822399A patent/IT1230592B/it active
- 1988-10-21 CH CH3921/88A patent/CH676715A5/de not_active IP Right Cessation
- 1988-10-21 DE DE3836006A patent/DE3836006C2/de not_active Expired - Lifetime
- 1988-10-21 NL NL8802595A patent/NL8802595A/nl active Search and Examination
- 1988-10-22 JP JP63265285A patent/JPH01146891A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
GB2211502A (en) | 1989-07-05 |
CH676715A5 (it) | 1991-02-28 |
JPH01146891A (ja) | 1989-06-08 |
IT8822399A0 (it) | 1988-10-21 |
GB8824330D0 (en) | 1988-11-23 |
FR2622192B1 (it) | 1994-11-10 |
CA1308711C (en) | 1992-10-13 |
DE3836006A1 (de) | 1989-05-03 |
BE1003250A5 (fr) | 1992-02-11 |
DE3836006C2 (de) | 1996-07-11 |
FR2622192A1 (fr) | 1989-04-28 |
NL8802595A (nl) | 1989-05-16 |
JPH075623B1 (it) | 1995-01-25 |
US4987237A (en) | 1991-01-22 |
GB2211502B (en) | 1992-02-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19951027 |