IT1199962B - Ciclosporine,processi per la loro preparazione,uso farmaceutico delle stesse e composizioni farmaceutiche che le contengono - Google Patents

Ciclosporine,processi per la loro preparazione,uso farmaceutico delle stesse e composizioni farmaceutiche che le contengono

Info

Publication number
IT1199962B
IT1199962B IT47852/85A IT4785285A IT1199962B IT 1199962 B IT1199962 B IT 1199962B IT 47852/85 A IT47852/85 A IT 47852/85A IT 4785285 A IT4785285 A IT 4785285A IT 1199962 B IT1199962 B IT 1199962B
Authority
IT
Italy
Prior art keywords
cyclosporins
processes
preparation
same
compositions containing
Prior art date
Application number
IT47852/85A
Other languages
English (en)
Italian (it)
Other versions
IT8547852A0 (it
IT8547852A1 (it
Inventor
Roland Wenger
Rene P Traber
Hans Kobel
Hans Hofmann
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848407618A external-priority patent/GB8407618D0/en
Priority claimed from GB848411922A external-priority patent/GB8411922D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IT8547852A0 publication Critical patent/IT8547852A0/it
Publication of IT8547852A1 publication Critical patent/IT8547852A1/it
Application granted granted Critical
Publication of IT1199962B publication Critical patent/IT1199962B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IT47852/85A 1984-03-23 1985-03-22 Ciclosporine,processi per la loro preparazione,uso farmaceutico delle stesse e composizioni farmaceutiche che le contengono IT1199962B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848407618A GB8407618D0 (en) 1984-03-23 1984-03-23 Organic compounds
GB848411922A GB8411922D0 (en) 1984-05-10 1984-05-10 Organic compounds

Publications (3)

Publication Number Publication Date
IT8547852A0 IT8547852A0 (it) 1985-03-22
IT8547852A1 IT8547852A1 (it) 1986-09-22
IT1199962B true IT1199962B (it) 1989-01-05

Family

ID=26287502

Family Applications (1)

Application Number Title Priority Date Filing Date
IT47852/85A IT1199962B (it) 1984-03-23 1985-03-22 Ciclosporine,processi per la loro preparazione,uso farmaceutico delle stesse e composizioni farmaceutiche che le contengono

Country Status (24)

Country Link
US (1) US4639434A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH08838B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT388737B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE901980A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1247546A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH667274A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS249542B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3509809A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK128285A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8702926A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI851120L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2561651B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2155936B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR850716B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU200786B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL74681A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1199962B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU85819A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8500828A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO851160L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ211526A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (2) PH21868A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT80149B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE461334B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3587342T2 (de) 1984-10-04 1993-12-02 Sandoz Ag Cyclosporine.
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ATE95193T1 (de) * 1987-06-17 1993-10-15 Sandoz Ag Cyclosporine und deren benutzung als arzneimittel.
DE3888357T2 (de) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
ATE109970T1 (de) * 1987-09-03 1994-09-15 Univ Georgia Res Found Cyclosporin-augenmittel.
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5089390A (en) * 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
CH679119A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1988-05-13 1991-12-31 Sandoz Ag
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
SK278808B6 (sk) * 1990-11-02 1998-03-04 Novartis Ag Cyklosporíny, ich použitie pri príprave liečiva na
EP0674178B1 (en) 1990-11-20 2002-08-28 Dade Behring Marburg GmbH Cyclosporin immunoassay
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
RU2170741C2 (ru) * 1996-08-16 2001-07-20 Новартис Аг Способ получения циклоспорина
EP0991660B8 (en) 1997-10-08 2006-04-05 Isotechnika,Inc. DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US5990274A (en) * 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
MXPA04003625A (es) * 2001-10-19 2004-12-02 Sotechnika Inc Sintesis de analogos de ciclosporina.
WO2003032949A1 (en) * 2001-10-19 2003-04-24 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
EP1603512A2 (en) * 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Novel cyclosporins
WO2006039163A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
WO2006039164A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
US7361636B2 (en) * 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
ES2705750T3 (es) 2010-12-15 2019-03-26 Contravir Pharmaceuticals Inc Moléculas análogas de la ciclosporina modificadas en los aminoácidos 1 y 3
PT2683406T (pt) 2011-03-11 2019-07-08 Beth Israel Deaconess Medical Ct Inc Anticorpos anti-cd40 e utilização dos mesmos
CN104877013B (zh) * 2015-06-03 2018-04-20 兰州大学 环孢菌素t及其制备方法和应用
JP6976931B2 (ja) 2015-09-04 2021-12-08 プリマトープ・セラピューティクス・インコーポレイテッド ヒト化抗ｃｄ４０抗体及びその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056782B1 (en) * 1981-01-09 1984-08-01 Sandoz Ag Novel cyclosporins
JPS57140753A (en) * 1981-01-09 1982-08-31 Sandoz Ag Novel cyclosporine

Also Published As

Publication number Publication date
JPH08838B2 (ja) 1996-01-10
SE8501392L (sv) 1985-09-24
FI851120A0 (fi) 1985-03-20
IL74681A0 (en) 1985-06-30
SE8501392D0 (sv) 1985-03-21
GB8507270D0 (en) 1985-04-24
IT8547852A0 (it) 1985-03-22
NL8500828A (nl) 1985-10-16
GB2155936A (en) 1985-10-02
LU85819A1 (fr) 1985-12-12
PT80149B (en) 1987-03-23
PH21868A (en) 1988-03-25
PT80149A (en) 1985-04-01
AT388737B (de) 1989-08-25
CS249542B2 (en) 1987-03-12
DE3509809A1 (de) 1986-01-09
BE901980A (fr) 1985-09-23
CH667274A5 (de) 1988-09-30
PH23357A (en) 1989-07-14
FR2561651A1 (fr) 1985-09-27
ATA86385A (de) 1989-01-15
CA1247546A (en) 1988-12-28
FI851120A7 (fi) 1985-09-24
NZ211526A (en) 1988-08-30
SE461334B (sv) 1990-02-05
GB2155936B (en) 1987-09-16
ES8702926A1 (es) 1987-01-16
JPS60215700A (ja) 1985-10-29
IT8547852A1 (it) 1986-09-22
DK128285A (da) 1985-09-24
US4639434A (en) 1987-01-27
IL74681A (en) 1989-09-10
HU200786B (en) 1990-08-28
GR850716B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1985-07-19
NO851160L (no) 1985-09-24
FI851120L (fi) 1985-09-24
DK128285D0 (da) 1985-03-21
FR2561651B1 (fr) 1990-03-09
ES541465A0 (es) 1987-01-16
HUT38370A (en) 1986-05-28

Similar Documents

Publication Publication Date Title
IT1199962B (it) Ciclosporine,processi per la loro preparazione,uso farmaceutico delle stesse e composizioni farmaceutiche che le contengono
IT1213379B (it) Tiazolo [4,5-c]chinoline, procedimento per la loro preparazione e composizioni farmaceutiche che le contengono.
IT8719081A0 (it) Complessi di bioflavonoidi con fosfolipidi, loro preparazione, uso e composizioni farmaceutici e cosmetiche.
IT1201087B (it) Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
FI863971A7 (fi) Farmaseuttinen koostumus käytettäväksi leukopenian hoidossa.
IT1143047B (it) Composti diazepinici per uso farmaceutico e loro procedimento di preparazione
IT8948430A0 (it) Composti tripeptidici e loro uso farmaceutico come immuno-modulatori
IT1200944B (it) Derivati xantinici,procedimento per la loro preparazione,composizione farmaceutiche che il contengono e loro impiego terapeutico
IT9020020A0 (it) "n,n'-ditrimetossibenzoilpiperazine 2-sostituite, procedimento per la loro preparazione e composizioni terapeutiche che le contengono
PT84339A (pt) 1,6-naphthyridine derivatives process for the preparation thereof and pharmaceutical compositions containing them
IT1188185B (it) 2-piridilcarbossammide particolarmente per uso farmaceutico
IT1201523B (it) Eterociclilfenilfomramidine,processi per la loro preparazione e loro uso farmaceutico
IT1200163B (it) 8alfa-acilamminoergoline, loro preparazione e composizioni farmaceutiche che le contengono
IT8322110A0 (it) Derivati amidinici del4-fenilmidazolo 2-sostituto processi per la loro preparazione e loro uso farmaceutico.
IT8022601A0 (it) Derivati 3h-naft[1.2-d]-imidazolici il procedimento per la loro preparazione,il loro uso come agenti antiinfiammatori e le composizioni farmaceutiche che li contengono
IT8721540A0 (it) Composizioni farmaceutiche contenenti trapidil, loro procedimento di preparazione erelativo impiego terapeutico.
IT1235761B (it) Derivati biciclici del catecolo, procedimento per la loro preparazione e composizioni terapeutiche che li contengono
IL76837A0 (en) Benzimidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
IT1147733B (it) Procedimento per la preparazione di esaidro pirimido (1,2-a) azepine 3-sostitlite,composizioni farmaceutiche che le contengono e esaidro pirimido (1,2-a) azepine 3-sostituite
IT1172268B (it) Piperidinoguanidine sostituite,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
IT1205817B (it) Benzammidi sostituite,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
IT1208533B (it) Derivati di apovincaminolo, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1217192B (it) Tioeteri chinolinici,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT8622783A0 (it) Derivati imidazolici adattivita' terapeutica, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT8619751A0 (it) Composizioni farmaceutiche contenenti vinburnina e loro procedimento di preparazione.

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970324