IT1190133B - Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche - Google Patents

Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche

Info

Publication number
IT1190133B
IT1190133B IT20846/86A IT2084686A IT1190133B IT 1190133 B IT1190133 B IT 1190133B IT 20846/86 A IT20846/86 A IT 20846/86A IT 2084686 A IT2084686 A IT 2084686A IT 1190133 B IT1190133 B IT 1190133B
Authority
IT
Italy
Prior art keywords
acid
valproenoic
procedure
preparation
pharmaceutical compositions
Prior art date
Application number
IT20846/86A
Other languages
English (en)
Italian (it)
Other versions
IT8620846A1 (it
IT8620846A0 (it
Inventor
Paolo Chiesi
Vittorino Servadio
Flavio Villani
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of IT8620846A0 publication Critical patent/IT8620846A0/it
Priority to IT20846/86A priority Critical patent/IT1190133B/it
Priority to AT87108550T priority patent/ATE74900T1/de
Priority to ES198787108550T priority patent/ES2032405T3/es
Priority to DE8787108550T priority patent/DE3778219D1/de
Priority to EP87108550A priority patent/EP0250997B1/en
Priority to US07/063,643 priority patent/US5162573A/en
Priority to CA000540031A priority patent/CA1331186C/en
Priority to JP62153215A priority patent/JPH07108881B2/ja
Publication of IT8620846A1 publication Critical patent/IT8620846A1/it
Application granted granted Critical
Publication of IT1190133B publication Critical patent/IT1190133B/it
Priority to GR920401052T priority patent/GR3004712T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C07D317/40—Vinylene carbonate; Substituted vinylene carbonates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
IT20846/86A 1986-06-19 1986-06-19 Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche IT1190133B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT20846/86A IT1190133B (it) 1986-06-19 1986-06-19 Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche
EP87108550A EP0250997B1 (en) 1986-06-19 1987-06-13 Valproic and (e)-2-valproenoic acid derivatives, processes for the preparation thereof and pharmaceutical compositions therefrom
ES198787108550T ES2032405T3 (es) 1986-06-19 1987-06-13 Derivados de los acidos valproico y (e)-2-valproenoico, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
DE8787108550T DE3778219D1 (de) 1986-06-19 1987-06-13 Valproe- und (e)-2-valproensaeureabkoemmlinge, verfahren zu deren herstellung und pharmazeutische zusammensetzungen davon.
AT87108550T ATE74900T1 (de) 1986-06-19 1987-06-13 Valproe- und (e)-2-valproensaeureabkoemmlinge, verfahren zu deren herstellung und pharmazeutische zusammensetzungen davon.
US07/063,643 US5162573A (en) 1986-06-19 1987-06-17 Valproic and (e)-2-valproenoic acid derivatives, and pharmaceutical compositions therefrom
CA000540031A CA1331186C (en) 1986-06-19 1987-06-18 Valproic and (e)-2-valproenoic acid derivatives, processes for the preparation thereof and pharmaceutical compositions therefrom
JP62153215A JPH07108881B2 (ja) 1986-06-19 1987-06-18 バルプロ酸または（ｅ）―２―バルプロ酸誘導体、それらの製造法ならびにそれらを含有する抗てんかん剤または抗けいれん剤
GR920401052T GR3004712T3 (OSRAM) 1986-06-19 1992-05-26

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20846/86A IT1190133B (it) 1986-06-19 1986-06-19 Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche

Publications (3)

Publication Number Publication Date
IT8620846A0 IT8620846A0 (it) 1986-06-19
IT8620846A1 IT8620846A1 (it) 1987-12-19
IT1190133B true IT1190133B (it) 1988-02-10

Family

ID=11172940

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20846/86A IT1190133B (it) 1986-06-19 1986-06-19 Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche

Country Status (9)

Country Link
US (1) US5162573A (OSRAM)
EP (1) EP0250997B1 (OSRAM)
JP (1) JPH07108881B2 (OSRAM)
AT (1) ATE74900T1 (OSRAM)
CA (1) CA1331186C (OSRAM)
DE (1) DE3778219D1 (OSRAM)
ES (1) ES2032405T3 (OSRAM)
GR (1) GR3004712T3 (OSRAM)
IT (1) IT1190133B (OSRAM)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2627487B1 (fr) * 1988-02-19 1991-03-29 Martin Laboratoires Nouveau derive de l'acide valproique, procede de preparation de ce compose ainsi que medicament antiepileptique le contenant
US5585358A (en) * 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
US6110955A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Metabolically stabilized oxyalkylene esters and uses thereof
US5939455A (en) * 1997-03-11 1999-08-17 Beacon Laboratories, Inc. Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
KR100843703B1 (ko) 2000-07-21 2008-07-04 이섬 리서치 디벨러프먼트 컴파니 오브 더 히브루 유니버시티 오브 예루살렘 양극성 장애에서의 조증을 치료하기 위한 벨프로익산 및 2-벨프로에닉산 아미드 유도체의 용도
US6720445B2 (en) * 2000-12-21 2004-04-13 Beacon Laboratories, Inc. Acetyloxymethyl esters and methods for using the same
US7217696B2 (en) 2002-02-28 2007-05-15 A & D Bioscience, Inc. Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
US20050107310A1 (en) * 2002-03-19 2005-05-19 Holick Michael F. Carboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
WO2003086475A1 (en) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof
EP1549323A2 (en) * 2002-05-07 2005-07-06 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
CN1829804A (zh) * 2002-11-22 2006-09-06 约翰斯·霍普金斯大学 治疗认知功能障碍的靶位
US7459280B2 (en) * 2006-02-27 2008-12-02 Picobella, Llc Methods for diagnosing and treating kidney cancer
US20080267977A1 (en) * 2007-04-26 2008-10-30 Friedrich-Alexander University Of Erlangen-Nuremberg Combined immunological agent and sensitizing agent for the treatment of cancer
ES2865504T3 (es) 2008-10-16 2021-10-15 Univ Johns Hopkins Procedimientos y composiciones para la mejora de la función cognitiva
US8921533B2 (en) 2011-07-25 2014-12-30 Chromatin Technologies Glycosylated valproic acid analogs and uses thereof
SG11201407310TA (en) * 2012-05-08 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of neurological disorders
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
NZ738682A (en) 2015-05-22 2022-01-28 Agenebio Inc Extended release pharmaceutical compositions of levetiracetam
KR101864085B1 (ko) * 2017-09-22 2018-06-01 동아대학교 산학협력단 발프로산 유도체, 이의 제조방법 및 이를 포함하는 항경련제

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES403631A1 (es) * 1972-06-08 1975-05-01 Made Labor Sa Un metodo de obtencion de dos esteres de n-(2-hidroxietil)-pirrolidina.
IT1061352B (it) * 1973-03-27 1983-02-28 Crinos Industria Farmaco Sali misti di esteri polisolforici di glicopeptidi naturali con metalli e con basi organiche e procedimento per la loro preparazione
GB1437868A (en) * 1973-05-09 1976-06-03 Synthelabo Arylpiperazinoalkyl esters
FI783743A7 (fi) * 1977-12-14 1979-06-15 Gerot Pharmazeutika Foerfarande foer framstaellning av 3-di-n-propyl-acetoxi-benzodiazepin-2-oner
IL59407A (en) * 1979-03-06 1983-12-30 Sanofi Sa Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them
US4654370A (en) * 1979-03-12 1987-03-31 Abbott Laboratories Glyceryl valproates
IT1121282B (it) * 1979-06-08 1986-04-02 Medea Res Srl Composto ad attivita'antiepilettica e anticonvulsivante,processo per la sua preparazione e composizioni farmaceutiche relative
AT365164B (de) * 1980-06-04 1981-12-28 Lagap S A Pharmaceuticals Verfahren zur herstellung des neuen pivaloyloxymethyl-2-propylpentanoats
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
IT1194343B (it) * 1983-07-26 1988-09-14 Valeas Spa Sali di endo-8,8-dialchil-8-azoniabiciclo (3.2.1) ottan-6,7-esso-epossi-3-alchilcarbossilati,processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo
JPH0713028B2 (ja) * 1986-03-31 1995-02-15 日東電工株式会社 外皮投与用組成物

Also Published As

Publication number Publication date
IT8620846A1 (it) 1987-12-19
JPH07108881B2 (ja) 1995-11-22
JPS6366153A (ja) 1988-03-24
EP0250997B1 (en) 1992-04-15
EP0250997A3 (en) 1988-12-14
ES2032405T3 (es) 1993-02-16
DE3778219D1 (de) 1992-05-21
CA1331186C (en) 1994-08-02
GR3004712T3 (OSRAM) 1993-04-28
US5162573A (en) 1992-11-10
EP0250997A2 (en) 1988-01-07
IT8620846A0 (it) 1986-06-19
ATE74900T1 (de) 1992-05-15

Similar Documents

Publication Publication Date Title
IT1190133B (it) Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche
ES2061858T3 (es) Derivados sustituidos en posicion 7 del acido 3,5-dihidroxihept-6-inoico, procedimiento para su preparacion, su empleo como medicamentos, asi como productos intermedios.
ES2109219T3 (es) Derivos de acidos 7-(1-pirrolidinil)-3-quinolon- y -naftiridoncarboxilicos, procedimiento para su preparacion, asi como derivados de pirrolidina mono- y biciclicos-sustituidos como productos intermedios para su preparacion, y sus composiciones antibacterianas y como aditivos para
ES2118283T3 (es) Derivados de acidos benzofuranil- y -tiofenil-alcanocarboxilicos.
IT1256345B (it) Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
HUT49600A (en) Process for producing substituted flavonoid deriatives and salts, thereof, as well as pharmaceutical compositions comprising such compounds
AU639717B2 (en) 24-homo vitamin d derivatives, process for their production and pharmaceutical preparations obtained therefrom
RU93049997A (ru) Производные метилен-бис-фосфоновой кислоты, способ их получения, фармацевтическая композиция
LV10179A (lv) Farmaceitiski sastavi kas satur melfalanu vai melfalana hidrohloridu ka ari melfalans un melfalana hidrohlorids un panemieni to iegusanai
TNSN87012A1 (fr) Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
SE8900828L (sv) Antivirala och immunstimulerande farmaceutiska kompositioner samt foerfarande foer framstaellning av desamma
ES8606282A1 (es) Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos
IL112020A0 (en) Arylacetic acid derivatives, their preparation and their use as fungicides
IT8025159A0 (it) Preparato medicinale ad azione citostatica, nonche' derivati dell'acido isocianurico eprocedimento per la loro preparazione.
ES2038605T3 (es) Un metodo para la produccion de una preparacion de tipo no liquido para inyeccion.
CA2107150A1 (fr) Nouveaux derives chromeniques a chaine laterale trienique, leur procede de preparation et les compositions pharmaceutiques les renfermant
IT1197516B (it) Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono
FR2390424A1 (fr) Nouveaux derives d'amides de l'acide phenylacetique substitues, leur application en tant que medicament et leur application
ES478984A1 (es) Procedimiento de preparacion de productos del grupo de la e-burnamenina.
DE3781879D1 (de) Anthracyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
BE904864A (fr) Derives de la quinoleine, leur procede de preparation et compositions pharmaceutiques les contenant.
FR2703048B1 (fr) Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
IT8026179A0 (it) Procedimento per la preparazione di derivati di esteri dell'acido apovincaminico.
PT1214315E (pt) Esteres derivados do acido 1,4-di-hidropiridina-5-carboxilico e metodo para a sua preparacao
FR2614891B1 (fr) Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation