ES2032405T3 - Derivados de los acidos valproico y (e)-2-valproenoico, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents
Derivados de los acidos valproico y (e)-2-valproenoico, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2032405T3 ES2032405T3 ES198787108550T ES87108550T ES2032405T3 ES 2032405 T3 ES2032405 T3 ES 2032405T3 ES 198787108550 T ES198787108550 T ES 198787108550T ES 87108550 T ES87108550 T ES 87108550T ES 2032405 T3 ES2032405 T3 ES 2032405T3
- Authority
- ES
- Spain
- Prior art keywords
- valproenoic
- valproico
- procedures
- derivatives
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 abstract 4
- 229960000604 valproic acid Drugs 0.000 abstract 2
- 230000003556 anti-epileptic effect Effects 0.000 abstract 1
- 230000000573 anti-seizure effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/40—Vinylene carbonate; Substituted vinylene carbonates
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Furan Compounds (AREA)
Abstract
SORPRENDENTEMENTE, SE HA DEMOSTRADO QUE LOS ESTERES DEL ACIDO 2-PROPIL-2-PENTENOICO (ACIDO VALPROICO) Y LOS ESTERES DEL ACIDO (E)-2-PROPIL-2-PENTENOICO [ACIDO (E)-2-VALPROENOICO POSEEN VALIOSAS PROPIEDADES, PORQUE MUESTRAN ACTIVIDADES ANTICONVULSIVAS Y ANTIEPILEPTICAS COMPAREBLES A LAS DEL ACIDO VALPROICO, ASI COMO UNA MEJOR BIODISPONIBILIDAD Y UNA TOXICIDAD NOTABLEMENTE REDUCIDA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT20846/86A IT1190133B (it) | 1986-06-19 | 1986-06-19 | Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2032405T3 true ES2032405T3 (es) | 1993-02-16 |
Family
ID=11172940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787108550T Expired - Lifetime ES2032405T3 (es) | 1986-06-19 | 1987-06-13 | Derivados de los acidos valproico y (e)-2-valproenoico, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5162573A (es) |
EP (1) | EP0250997B1 (es) |
JP (1) | JPH07108881B2 (es) |
AT (1) | ATE74900T1 (es) |
CA (1) | CA1331186C (es) |
DE (1) | DE3778219D1 (es) |
ES (1) | ES2032405T3 (es) |
GR (1) | GR3004712T3 (es) |
IT (1) | IT1190133B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2627487B1 (fr) * | 1988-02-19 | 1991-03-29 | Martin Laboratoires | Nouveau derive de l'acide valproique, procede de preparation de ce compose ainsi que medicament antiepileptique le contenant |
US5585358A (en) * | 1993-07-06 | 1996-12-17 | Yissum Research Development Corporation Of The Hebrew University Of Jerusalem | Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents |
US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
US6110955A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Metabolically stabilized oxyalkylene esters and uses thereof |
JP2004520263A (ja) | 2000-07-21 | 2004-07-08 | テバ ファーマシューティカル インダストリーズ リミティド | 双極性障害における躁病を治療するためのバルプロ酸および2−バルプロエン酸アミド誘導体の使用 |
US6720445B2 (en) * | 2000-12-21 | 2004-04-13 | Beacon Laboratories, Inc. | Acetyloxymethyl esters and methods for using the same |
WO2003073988A2 (en) | 2002-02-28 | 2003-09-12 | A & D Bioscience, Inc. | Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof |
WO2003079980A2 (en) * | 2002-03-19 | 2003-10-02 | A & D Bioscience, Inc. | Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof |
WO2003086475A1 (en) * | 2002-04-12 | 2003-10-23 | A & D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof |
EP1549323A2 (en) * | 2002-05-07 | 2005-07-06 | A & D Bioscience, Inc. | Conjugates comprising central nervous system active drug |
US20050215487A1 (en) * | 2002-06-27 | 2005-09-29 | Holick Michael F | Conjugates comprising an nsaid and a sugar and uses thereof |
MXPA05005398A (es) * | 2002-11-22 | 2006-03-09 | Univ Johns Hopkins | Meta para terapia de deterioro cognitivo. |
US7459280B2 (en) * | 2006-02-27 | 2008-12-02 | Picobella, Llc | Methods for diagnosing and treating kidney cancer |
US20080267977A1 (en) * | 2007-04-26 | 2008-10-30 | Friedrich-Alexander University Of Erlangen-Nuremberg | Combined immunological agent and sensitizing agent for the treatment of cancer |
JP5917148B2 (ja) | 2008-10-16 | 2016-05-11 | ザ ジョーンズ ホプキンズ ユニバーシティThe Johns Hopkins University | 認知機能を改善するための方法および組成物 |
US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
CN104797568A (zh) * | 2012-05-08 | 2015-07-22 | 塞利克斯比奥私人有限公司 | 用于治疗神经障碍的组合物和方法 |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
EP2968220B1 (en) | 2013-03-15 | 2021-05-05 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
US10925834B2 (en) | 2015-05-22 | 2021-02-23 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
KR101864085B1 (ko) * | 2017-09-22 | 2018-06-01 | 동아대학교 산학협력단 | 발프로산 유도체, 이의 제조방법 및 이를 포함하는 항경련제 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES403631A1 (es) * | 1972-06-08 | 1975-05-01 | Made Labor Sa | Un metodo de obtencion de dos esteres de n-(2-hidroxietil)-pirrolidina. |
IT1061352B (it) * | 1973-03-27 | 1983-02-28 | Crinos Industria Farmaco | Sali misti di esteri polisolforici di glicopeptidi naturali con metalli e con basi organiche e procedimento per la loro preparazione |
GB1437868A (en) * | 1973-05-09 | 1976-06-03 | Synthelabo | Arylpiperazinoalkyl esters |
FI783743A (fi) * | 1977-12-14 | 1979-06-15 | Gerot Pharmazeutika | Foerfarande foer framstaellning av 3-di-n-propyl-acetoxi-benzodiazepin-2-oner |
IL59407A (en) * | 1979-03-06 | 1983-12-30 | Sanofi Sa | Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them |
US4654370A (en) * | 1979-03-12 | 1987-03-31 | Abbott Laboratories | Glyceryl valproates |
IT1121282B (it) * | 1979-06-08 | 1986-04-02 | Medea Res Srl | Composto ad attivita'antiepilettica e anticonvulsivante,processo per la sua preparazione e composizioni farmaceutiche relative |
AT365164B (de) * | 1980-06-04 | 1981-12-28 | Lagap S A Pharmaceuticals | Verfahren zur herstellung des neuen pivaloyloxymethyl-2-propylpentanoats |
IL67623A (en) * | 1983-01-05 | 1984-09-30 | Teva Pharma | 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it |
IT1194343B (it) * | 1983-07-26 | 1988-09-14 | Valeas Spa | Sali di endo-8,8-dialchil-8-azoniabiciclo (3.2.1) ottan-6,7-esso-epossi-3-alchilcarbossilati,processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo |
JPH0713028B2 (ja) * | 1986-03-31 | 1995-02-15 | 日東電工株式会社 | 外皮投与用組成物 |
-
1986
- 1986-06-19 IT IT20846/86A patent/IT1190133B/it active
-
1987
- 1987-06-13 ES ES198787108550T patent/ES2032405T3/es not_active Expired - Lifetime
- 1987-06-13 AT AT87108550T patent/ATE74900T1/de not_active IP Right Cessation
- 1987-06-13 EP EP87108550A patent/EP0250997B1/en not_active Expired - Lifetime
- 1987-06-13 DE DE8787108550T patent/DE3778219D1/de not_active Expired - Lifetime
- 1987-06-17 US US07/063,643 patent/US5162573A/en not_active Expired - Lifetime
- 1987-06-18 JP JP62153215A patent/JPH07108881B2/ja not_active Expired - Lifetime
- 1987-06-18 CA CA000540031A patent/CA1331186C/en not_active Expired - Fee Related
-
1992
- 1992-05-26 GR GR920401052T patent/GR3004712T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE3778219D1 (de) | 1992-05-21 |
IT8620846A0 (it) | 1986-06-19 |
JPH07108881B2 (ja) | 1995-11-22 |
IT1190133B (it) | 1988-02-10 |
JPS6366153A (ja) | 1988-03-24 |
EP0250997A2 (en) | 1988-01-07 |
EP0250997A3 (en) | 1988-12-14 |
EP0250997B1 (en) | 1992-04-15 |
CA1331186C (en) | 1994-08-02 |
US5162573A (en) | 1992-11-10 |
IT8620846A1 (it) | 1987-12-19 |
GR3004712T3 (es) | 1993-04-28 |
ATE74900T1 (de) | 1992-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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