GR3004712T3 - - Google Patents

Info

Publication number
GR3004712T3
GR3004712T3 GR920401052T GR920401052T GR3004712T3 GR 3004712 T3 GR3004712 T3 GR 3004712T3 GR 920401052 T GR920401052 T GR 920401052T GR 920401052 T GR920401052 T GR 920401052T GR 3004712 T3 GR3004712 T3 GR 3004712T3
Authority
GR
Greece
Prior art keywords
acid
propyl
esters
valproic
anticonvulsive
Prior art date
Application number
GR920401052T
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GR3004712T3 publication Critical patent/GR3004712T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C07D317/40—Vinylene carbonate; Substituted vinylene carbonates

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
GR920401052T 1986-06-19 1992-05-26 GR3004712T3 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20846/86A IT1190133B (it) 1986-06-19 1986-06-19 Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche

Publications (1)

Publication Number Publication Date
GR3004712T3 true GR3004712T3 (el) 1993-04-28

Family

ID=11172940

Family Applications (1)

Application Number Title Priority Date Filing Date
GR920401052T GR3004712T3 (el) 1986-06-19 1992-05-26

Country Status (9)

Country Link
US (1) US5162573A (el)
EP (1) EP0250997B1 (el)
JP (1) JPH07108881B2 (el)
AT (1) ATE74900T1 (el)
CA (1) CA1331186C (el)
DE (1) DE3778219D1 (el)
ES (1) ES2032405T3 (el)
GR (1) GR3004712T3 (el)
IT (1) IT1190133B (el)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2627487B1 (fr) * 1988-02-19 1991-03-29 Martin Laboratoires Nouveau derive de l'acide valproique, procede de preparation de ce compose ainsi que medicament antiepileptique le contenant
US5585358A (en) * 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
US6110955A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Metabolically stabilized oxyalkylene esters and uses thereof
US5939455A (en) * 1997-03-11 1999-08-17 Beacon Laboratories, Inc. Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
WO2002007677A2 (en) 2000-07-21 2002-01-31 Teva Pharmaceutical Industries, Ltd. Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder
US6720445B2 (en) * 2000-12-21 2004-04-13 Beacon Laboratories, Inc. Acetyloxymethyl esters and methods for using the same
WO2003073988A2 (en) 2002-02-28 2003-09-12 A & D Bioscience, Inc. Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
US20050107310A1 (en) * 2002-03-19 2005-05-19 Holick Michael F. Carboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
WO2003086475A1 (en) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof
US20050153928A1 (en) * 2002-05-07 2005-07-14 Holick Michael F. Conjugates comprising a central nervous system-active drug linked to glucuronic acid or glucosamine through an amide bond and uses thereof
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
CA2506194A1 (en) * 2002-11-22 2004-06-10 The Johns Hopkins University Target for therapy of cognitive impairment
US7459280B2 (en) * 2006-02-27 2008-12-02 Picobella, Llc Methods for diagnosing and treating kidney cancer
US20080267977A1 (en) * 2007-04-26 2008-10-30 Friedrich-Alexander University Of Erlangen-Nuremberg Combined immunological agent and sensitizing agent for the treatment of cancer
US20100099735A1 (en) * 2008-10-16 2010-04-22 Michela Gallagher Methods and compositions for improving cognitive function
US8921533B2 (en) 2011-07-25 2014-12-30 Chromatin Technologies Glycosylated valproic acid analogs and uses thereof
JP2015533114A (ja) * 2012-05-08 2015-11-19 セリックスビオ プライヴェート リミテッド 神経疾患の治療のための組成物及び方法
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
DK2968220T3 (da) 2013-03-15 2021-06-14 Agenebio Inc Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
CA2986598C (en) 2015-05-22 2023-09-26 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
KR101864085B1 (ko) * 2017-09-22 2018-06-01 동아대학교 산학협력단 발프로산 유도체, 이의 제조방법 및 이를 포함하는 항경련제

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES403631A1 (es) * 1972-06-08 1975-05-01 Made Labor Sa Un metodo de obtencion de dos esteres de n-(2-hidroxietil)-pirrolidina.
IT1061352B (it) * 1973-03-27 1983-02-28 Crinos Industria Farmaco Sali misti di esteri polisolforici di glicopeptidi naturali con metalli e con basi organiche e procedimento per la loro preparazione
US3953449A (en) 1973-05-09 1976-04-27 Synthelabo 2-(4-M-CF3 or -SCF3 phenylpiperazino)-ethyl benzoates
FI783743A (fi) * 1977-12-14 1979-06-15 Gerot Pharmazeutika Foerfarande foer framstaellning av 3-di-n-propyl-acetoxi-benzodiazepin-2-oner
IL59407A (en) * 1979-03-06 1983-12-30 Sanofi Sa Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them
US4654370A (en) * 1979-03-12 1987-03-31 Abbott Laboratories Glyceryl valproates
IT1121282B (it) * 1979-06-08 1986-04-02 Medea Res Srl Composto ad attivita'antiepilettica e anticonvulsivante,processo per la sua preparazione e composizioni farmaceutiche relative
AT365164B (de) * 1980-06-04 1981-12-28 Lagap S A Pharmaceuticals Verfahren zur herstellung des neuen pivaloyloxymethyl-2-propylpentanoats
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
IT1194343B (it) * 1983-07-26 1988-09-14 Valeas Spa Sali di endo-8,8-dialchil-8-azoniabiciclo (3.2.1) ottan-6,7-esso-epossi-3-alchilcarbossilati,processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo
JPH0713028B2 (ja) * 1986-03-31 1995-02-15 日東電工株式会社 外皮投与用組成物

Also Published As

Publication number Publication date
EP0250997A3 (en) 1988-12-14
IT8620846A0 (it) 1986-06-19
EP0250997A2 (en) 1988-01-07
JPH07108881B2 (ja) 1995-11-22
IT8620846A1 (it) 1987-12-19
EP0250997B1 (en) 1992-04-15
CA1331186C (en) 1994-08-02
JPS6366153A (ja) 1988-03-24
DE3778219D1 (de) 1992-05-21
US5162573A (en) 1992-11-10
ATE74900T1 (de) 1992-05-15
IT1190133B (it) 1988-02-10
ES2032405T3 (es) 1993-02-16

Similar Documents

Publication Publication Date Title
GR3004712T3 (el)
MY115307A (en) Preparation for epidermis
YU69289A (en) Substituted flavonoidic compounds, their salts and process for producing thereof
EP0158212A3 (en) Citric-acid esters as blowing agents for working up plastics
EP0414007A3 (en) A novel arginine deiminase, its manufacturing method and an anti-cancer agent containing this enzyme as an effective ingredient
CA1262138C (en) PROSTAGLANDIN TETRAHYDROTHIENYL SUBSTITUTE ANALOGS
ES8501440A1 (es) Procedimiento para la preparacion de nuevas sustancias ws 6049.
WO1991001958A3 (de) 11β-ARYL-GONA-4,9-DIEN-3-ONE
AU1939188A (en) Ascorbic acid intermediates and process enzymes
EP0313517A3 (en) Aliphatic esters of 1,3,2-oxazaphospholidines
AU2072088A (en) Agent containing salicylic acid for treating lepidosis
IL76931A (en) 2-trifluoromethyl-6-haloalkyl-4-heteroatom substituted-3-pyridinecarboxylic acid esters,their preparation,herbicidal compositions comprising them,and some free acid intermediates therefor
EP0146239A3 (en) Bioconversion production of ascorbic acid
IL78604A (en) Process for the preparation of homogeneous,pure alpha-interferon,alpha-interferon produced thereby and pharmaceutical compositions containing it
EP0266690A3 (en) Method for the production of 2,2-disubstituted 3-chlorpropionic acid esters
EP0269999A3 (en) Aliphatic alcohols and esters, their preparation and use as flavouring agents
EP0218310A3 (en) Rhizoxin derivatives, their preparation and pharmaceutical use
AU591290B2 (en) Rapid detection of n. gonorrhoeae without culture
EP0194563A3 (en) Glycosides and process for preparation thereof
IT1187728B (it) Procedimento per la produzione di un integratore alimentare proteicolvitaminico da microorganismi autotrofi,in particolare da alga spirulina
FR2612186B1 (fr) Carbonyl 2,2' bis (alkyl-4 oxadiazolidines-1,2,4-diones-3,5), leur procede de preparation et leur utilisation comme intermediaires de synthese dans la preparation de carbamates
AU7772287A (en) Separation of diastereomers
IL82219A0 (en) 3-amino-2-cyano-acrylic acid esters,their preparation and their use as herbicides
AU589543B2 (en) Processes and intermediates for n-(s-3-alkylheptanoyl)-d- gamma-glutamyl-glycyl-d-alanine
EP0188007A3 (en) Process for the preparation of 2-nitro-3-aminopyridine, and of n,n'-di-(2-nitro-pyridyl) urea occurring as an intermediate product